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Drugging the undruggable: Advances in targeting KRAS signaling in solid tumors
Int Rev Cell Mol Biol. 2024;385:1-39. doi: 10.1016/bs.ircmb.2023.11.004. Epub 2024 Jan 9.ABSTRACTCancer remains the leading cause of global mortality, prompting a paradigm shift in its treatment and outcomes with the advent of targeted therapies. Among the most prevalent mutations in RAS-driven cancers, Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations account for approximately 86% of cases worldwide, particularly in lung, pancreatic, and colon cancers, contributing to poor prognosis and reduced overall survival. Despite numerous efforts to understand the biology of KRAS mutants and their pivotal role in cancer d...
Source: International Review of Cell and Molecular Biology - April 25, 2024 Category: Cytology Authors: Prajna Tripathi Rajni Kumari Rajiv Pathak Source Type: research

Importance of targeting various cell signaling pathways in solid cancers
Int Rev Cell Mol Biol. 2024;385:101-155. doi: 10.1016/bs.ircmb.2024.02.002. Epub 2024 Feb 24.ABSTRACTMost adult human cancers are solid tumors prevailing in vital organs and lead to mortality all over the globe. Genetic and epigenetic alterations in cancer genes or genes of associated signaling pathways impart the most common characteristic of malignancy, that is, uncontrolled proliferation. Unless the mechanism of action of these cells signaling pathways (involved in cell proliferation, apoptosis, metastasis, and the maintenance of the stemness of cancer stem cells and cancer microenvironment) and their physiologic altera...
Source: International Review of Cell and Molecular Biology - April 25, 2024 Category: Cytology Authors: Chandrayee Ghosh Jiangnan Hu Source Type: research

Targeting signaling pathways in cancer stem cells: A potential approach for developing novel anti-cancer therapeutics
Int Rev Cell Mol Biol. 2024;385:157-209. doi: 10.1016/bs.ircmb.2024.01.001. Epub 2024 Feb 10.ABSTRACTCancer stem cells (CSCs) have emerged as prime players in the intricate landscape of cancer development, progression, and resistance to traditional treatments. These unique cellular subpopulations own the remarkable capability of self-renewal and differentiation, giving rise to the diverse cellular makeup of tumors and fostering their recurrence following conventional therapies. In the quest for developing more effective cancer therapeutics, the focus has now shifted toward targeting the signaling pathways that govern CSCs ...
Source: International Review of Cell and Molecular Biology - April 25, 2024 Category: Cytology Authors: Saptarshi Sinha Krushna Chandra Hembram Subhajit Chatterjee Source Type: research

Factors affecting heterogeneity in breast cancer microenvironment: A narrative mini review
Int Rev Cell Mol Biol. 2024;385:211-226. doi: 10.1016/bs.ircmb.2024.01.002. Epub 2024 Feb 15.ABSTRACTBreast cancer (BC) heterogeneity is a key trait of BC tumors with crucial implications on tumorigenesis, diagnosis, and therapeutic modalities. It is influenced by tumor intrinsic features and by the tumor microenvironment (TME) composition of different intra-tumoral regions, which in turn affect cancer progression within patients. In this mini review, we will highlight the mechanisms that generate cancer heterogeneity in BC and how they affect the responses to cancer therapies.PMID:38663960 | DOI:10.1016/bs.ircmb.2024.01.0...
Source: International Review of Cell and Molecular Biology - April 25, 2024 Category: Cytology Authors: Anirban Ganguly Sumit Mukherjee Kaushiki Chatterjee Sheila Spada Source Type: research

Exploring TLR signaling pathways as promising targets in cervical cancer: The road less traveled
Int Rev Cell Mol Biol. 2024;385:227-261. doi: 10.1016/bs.ircmb.2023.11.005. Epub 2024 Jan 12.ABSTRACTCervical cancer is the leading cause of cancer-related deaths for women globally. Despite notable advancements in prevention and treatment, the identification of novel therapeutic targets remains crucial for cervical cancer. Toll-like receptors (TLRs) play an essential role in innate immunity as pattern-recognition receptors. There are several types of pathogen-associated molecular patterns (PAMPs), including those present in cervical cancer cells, which have the ability to activate toll-like receptors (TLRs). Recent studie...
Source: International Review of Cell and Molecular Biology - April 25, 2024 Category: Cytology Authors: Mohini Agarwal Manish Kumar Rajiv Pathak Kumud Bala Anoop Kumar Source Type: research

Emerging trends in gastrointestinal cancers: Targeting developmental pathways in carcinogenesis and tumor progression
Int Rev Cell Mol Biol. 2024;385:41-99. doi: 10.1016/bs.ircmb.2023.11.006. Epub 2024 Jan 15.ABSTRACTGastrointestinal carcinomas are a group of cancers associated with the digestive system and its accessory organs. The most prevalent cancers related to the gastrointestinal tract are colorectal, gall bladder, gastric, hepatocellular, and esophageal cancers, respectively. Molecular aberrations in different signaling pathways, such as signal transduction systems or developmental pathways are the chief triggering mechanisms in different cancers Though a massive advancement in diagnostic and therapeutic interventions results in i...
Source: International Review of Cell and Molecular Biology - April 25, 2024 Category: Cytology Authors: Afza Ahmad Rohit Kumar Tiwari Saleha Siddiqui Muskan Chadha Ratnakar Shukla Vivek Srivastava Source Type: research