Differentiation of neural stem cells from human olfactory mucosa into dopaminergic neuron ‐like cells
AbstractThe aim of this study was to develop an alternative treatment method for neurodegenerative diseases with dopaminergic neuron loss such as Parkinson's disease by differentiating cells obtained from human olfactory mucosa-derived neural stem cells (hOM-NSCs) with neurotrophic agentsin vitro. hOM-NSCs were isolated and subjected to immunophenotypic and MTT analyses. These hOM-NSCs were then cultured in a 3D environment to form neurospheres. The neurospheres were subjected to immunophenotypic analysis and neuronal differentiation assays. Furthermore, hOM-NSCs were differentiated into dopaminergic neuron-like cellsin vi...
Source: IUBMB Life - April 26, 2024 Category: Research Authors: Tu ğba Ertem,
Onur Uysal Tags: RESEARCH ARTICLE Source Type: research
LncRNA RP11 ‐301G19.1 is required for the maintenance of vascular smooth muscle cell contractile phenotype via sponging miR‐17‐5P/ATOH8 axis
AbstractLong noncoding RNAs (LncRNAs) play essential roles in regulating gene expression in various biological processes. However, the function of lncRNAs in vascular smooth muscle cell (VSMC) transformation remains to be explained. In this work, we discover that a new bone marrow protein (BMP) signaling target, lncRNA RP11-301G19.1, is significantly induced in BMP7-treated VSMCs through lncRNA microarray analysis. Addition of BMP signaling inhibitor LDN-193189 attenuates the expression of ACTA2 and SM-22 α, as well as the mRNA level of RP11-301G19.1. Furthermore, lncRNA RP11-301G19.1 is critical to the VSMC differentiati...
Source: IUBMB Life - April 24, 2024 Category: Research Authors: Shuning Hao,
Feifei Zuo,
Hongmin Zhang,
Ying Wang,
Liwen Huang,
Fenghui Ma,
Tiefeng Song,
Tongcun Zhang,
Xuejun Ren,
Nan Wang Tags: RESEARCH ARTICLE Source Type: research
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On the Cover: Addressing the impact of high glucose microenvironment on the immunosuppressive characteristics of human mesenchymal stem cells by Khasawneh et al.; Article first published: 28 Nov 2023;https://doi.org/10.1002/iub.2796 On the Cover: Addressing the impact of high glucose microenvironment on the immunosuppressive characteristics of human mesenchymal stem cells by Khasawneh et al.; Article first published: 28 Nov 2023;https://doi.org/10.1002/iub.2796 (Source: IUBMB Life)
Source: IUBMB Life - April 23, 2024 Category: Research Tags: COVER IMAGE Source Type: research
Issue Information
(Source: IUBMB Life)
Source: IUBMB Life - April 23, 2024 Category: Research Tags: ISSUE INFORMATION Source Type: research
Experimental evolution of extremotolerant and extremophilic fungi under osmotic stress
AbstractExperimental evolution was carried out to investigate the adaptive responses of extremotolerant fungi to a stressful environment. For 12 cultivation cycles, the halotolerant black yeastsAureobasidium pullulans andAureobasidium subglaciale were grown at high NaCl or glycerol concentrations, and the halophilic basidiomyceteWallemia ichthyophaga was grown close to its lower NaCl growth limit. All evolvedAureobasidium spp. accelerated their growth at low water activity. Whole genomes of the evolved strains were sequenced. No aneuploidies were detected in any of the genomes, contrary to previous studies on experimental ...
Source: IUBMB Life - April 23, 2024 Category: Research Authors: Farhad Hariri Akbari,
Zewei Song,
Martina Turk,
Nina Gunde ‐Cimerman,
Cene Gostinčar Tags: SPECIAL ISSUE Source Type: research
Imperative connotation of SODs in cancer: Emerging targets and multifactorial role of action
AbstractSuperoxide dismutase (SOD) is a crucial enzyme responsible for the redox homeostasis inside the cell. As a part of the antioxidant defense system, it plays a pivotal role in the dismutation of the superoxide radicals (O2 −$$ {{\mathrm{O}}_2}^{-} $$) generated mainly by the oxidative phosphorylation, which would otherwise bring out the redox dysregulation, leading to higher reactive oxygen species (ROS) generation and, ultimately, cell transformation, and malignancy. Several studies have shown the involvement of RO S in a wide range of human cancers. As SOD is the key enzyme in regulating ROS, any change, such as ...
Source: IUBMB Life - April 11, 2024 Category: Research Authors: Biswajit Panda,
Ankita Tripathy,
Srimanta Patra,
Bandana Kullu,
Shams Tabrez,
Mrutyunjay Jena Tags: CRITICAL REVIEW Source Type: research
IUBMB Life special issue: Mitochondrial biology and the yeast paradigm
(Source: IUBMB Life)
Source: IUBMB Life - April 10, 2024 Category: Research Authors: Flavia Fontanesi Tags: SPECIAL ISSUE Source Type: research
Characterization of Mitoribosomal Small Subunit unit genes related immune and pharmacogenomic landscapes in renal cell carcinoma
AbstractMitoribosomes are essential for the production of biological energy. The Human Mitoribosomal Small Subunit unit (MRPS) family, responsible for encoding mitochondrial ribosomal small subunits, is actively engaged in protein synthesis within the mitochondria. Intriguingly, MRPS family genes appear to play a role in cancer. A multistep process was employed to establish a risk model associated with MRPS genes, aiming to delineate the immune and pharmacogenomic landscapes in clear cell renal cell carcinoma (ccRCC). MRPScores were computed for individual patients to assess their responsiveness to various treatment modali...
Source: IUBMB Life - April 2, 2024 Category: Research Authors: Zhihao Wei,
Chenchen Liu,
Jiaqian Liang,
Xuan Zhou,
Kaming Xue,
Keshan Wang,
Xiaoping Zhang Tags: RESEARCH ARTICLE Source Type: research
Mitochondrial respiratory supercomplexes of the yeast Saccharomyces cerevisiae
AbstractThe functional and structural relationship among the individual components of the mitochondrial respiratory chain constitutes a central aspect of our understanding of aerobic catabolism. This interplay has been a subject of intense debate for over 50 years. It is well established that individual respiratory enzymes associate into higher-order structures known as respiratory supercomplexes, which represent the evolutionarily conserved organizing principle of the mitochondrial respiratory chain. In the yeastSaccharomyces cerevisiae, supercomplexes are formed by a complex III homodimer flanked by one or two complex...
Source: IUBMB Life - March 27, 2024 Category: Research Authors: Mazzen H. Eldeeb,
Lizeth J. Camacho Lopez,
Flavia Fontanesi Tags: CRITICAL REVIEW Source Type: research
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(Source: IUBMB Life)
Source: IUBMB Life - March 20, 2024 Category: Research Tags: ISSUE INFORMATION Source Type: research
Cover Image
On the Cover: Underlying molecular mechanisms by which 1,25(OH)2D3 on inhibition of LLC cell migration by Chen et al.; Article first published: 3 Nov 2023;https://doi.org/10.1002/iub.2789 On the Cover: Underlying molecular mechanisms by which 1,25(OH)2D3 on inhibition of LLC cell migration by Chen et al.; Article first published: 3 Nov 2023;https://doi.org/10.1002/iub.2789 (Source: IUBMB Life)
Source: IUBMB Life - March 19, 2024 Category: Research Tags: COVER IMAGE Source Type: research
Issue Information
(Source: IUBMB Life)
Source: IUBMB Life - March 19, 2024 Category: Research Tags: ISSUE INFORMATION Source Type: research
Cover Image
On the Cover: Underlying molecular mechanisms by which 1,25(OH)2D3 on inhibition of LLC cell migration by Chen et al.; Article first published: 3 Nov 2023;https://doi.org/10.1002/iub.2789 On the Cover: Underlying molecular mechanisms by which 1,25(OH)2D3 on inhibition of LLC cell migration by Chen et al.; Article first published: 3 Nov 2023;https://doi.org/10.1002/iub.2789 (Source: IUBMB Life)
Source: IUBMB Life - March 19, 2024 Category: Research Tags: COVER IMAGE Source Type: research
