Machine learning and deep learning to identifying subarachnoid haemorrhage macrophage-associated biomarkers by bulk and single-cell sequencing
J Cell Mol Med. 2024 May;28(9):e18296. doi: 10.1111/jcmm.18296.ABSTRACTWe investigated subarachnoid haemorrhage (SAH) macrophage subpopulations and identified relevant key genes for improving diagnostic and therapeutic strategies. SAH rat models were established, and brain tissue samples underwent single-cell transcriptome sequencing and bulk RNA-seq. Using single-cell data, distinct macrophage subpopulations, including a unique SAH subset, were identified. The hdWGCNA method revealed 160 key macrophage-related genes. Univariate analysis and lasso regression selected 10 genes for constructing a diagnostic model. Machine le...
Source: J Cell Mol Med - May 4, 2024 Category: Molecular Biology Authors: Sha Yang Yunjia Hu Xiang Wang Mei Deng Jun Ma Yin Hao Zhongying Ran Tao Luo Guoqiang Han Xin Xiang Jian Liu Hui Shi Ying Tan Source Type: research
Macrophage M2 polarization promotes pulpal inflammation resolution during orthodontic tooth movement
In conclusion, our findings suggest that macrophages promote pulpal inflammation resolution by enhancing M2 polarization and maintaining dental health during orthodontic tooth movement.PMID:38700030 | DOI:10.1111/jcmm.18350 (Source: J Cell Mol Med)
Source: J Cell Mol Med - May 3, 2024 Category: Molecular Biology Authors: Jichang Li Huiying Ren Zijie Zhang Jin Zhang Fulan Wei Source Type: research
SCPLPA: An miRNA-disease association prediction model based on spatial consistency projection and label propagation algorithm
J Cell Mol Med. 2024 May;28(9):e18345. doi: 10.1111/jcmm.18345.ABSTRACTIdentifying the association between miRNA and diseases is helpful for disease prevention, diagnosis and treatment. It is of great significance to use computational methods to predict potential human miRNA disease associations. Considering the shortcomings of existing computational methods, such as low prediction accuracy and weak generalization, we propose a new method called SCPLPA to predict miRNA-disease associations. First, a heterogeneous disease similarity network was constructed using the disease semantic similarity network and the disease Gaussi...
Source: J Cell Mol Med - May 2, 2024 Category: Molecular Biology Authors: Min Chen Yingwei Deng Zejun Li Yifan Ye Lijun Zeng Ziyi He Guofang Peng Source Type: research
New synergistic combination therapy approaches with HDAC inhibitor quisinostat, cisplatin or PARP inhibitor talazoparib for urothelial carcinoma
In conclusion, our results suggest new promising combination regimes for treatment of UC, also in the cisplatin-resistant setting.PMID:38693852 | DOI:10.1111/jcmm.18342 (Source: J Cell Mol Med)
Source: J Cell Mol Med - May 2, 2024 Category: Molecular Biology Authors: Sarah Meneceur Caroline E De Vos Patrick Petzsch Karl K öhrer G ünter Niegisch Mich èle J Hoffmann Source Type: research
Prognostic and immunotherapeutic implications of bilirubin metabolism-associated genes in lung adenocarcinoma
This study aimed to develop a prognostic signature of bilirubin metabolism-associated genes (BMAGs) to predict outcomes and efficacy of immunotherapy in LUAD. We analysed gene expression data from The Cancer Genome Atlas (TCGA) to identify survival-related BMAGs and construct a prognostic model in LUAD. The prognostic efficacy of our model was corroborated by employing TCGA-LUAD and five Gene Expression Omnibus datasets, effectively stratifying patients into risk-defined cohorts with marked disparities in survival. The BMAG signature was indeed an independent prognostic determinant, outperforming established clinical param...
Source: J Cell Mol Med - May 2, 2024 Category: Molecular Biology Authors: Kangqi Ren Xiean Ling Lin Chen Zeyao Li Tonghai Huang Source Type: research
Improved therapeutic effects on vascular intimal hyperplasia by mesenchymal stem cells expressing MIR155HG that function as a ceRNA for microRNA-205
J Cell Mol Med. 2024 May;28(9):e18351. doi: 10.1111/jcmm.18351.ABSTRACTCoronary artery bypass grafting (CABG) is an effective treatment for coronary heart disease, with vascular transplantation as the key procedure. Intimal hyperplasia (IH) gradually leads to vascular stenosis, seriously affecting the curative effect of CABG. Mesenchymal stem cells (MSCs) were used to alleviate IH, but the effect was not satisfactory. This work aimed to investigate whether lncRNA MIR155HG could improve the efficacy of MSCs in the treatment of IH and to elucidate the role of the competing endogenous RNA (ceRNA). The effect of MIR155HG on MS...
Source: J Cell Mol Med - May 2, 2024 Category: Molecular Biology Authors: Xiao Bai Zaiwen Qi Chuanliang Cai Hao Song Guangmin Song Xin Zhao Source Type: research
Exploring the influence of microgravity on chemotherapeutic drug response in cancer: Unveiling new perspectives
J Cell Mol Med. 2024 May;28(9):e18347. doi: 10.1111/jcmm.18347.ABSTRACTMicrogravity, an altered gravity condition prevailing in space, has been reported to have a profound impact on human health. Researchers are very keen to comprehensively investigate the impact of microgravity and its intricate involvement in inducing physiological changes. Evidenced transformations were observed in the internal architecture including cytoskeletal organization and cell membrane morphology. These alterations can significantly influence cellular function, signalling pathways and overall cellular behaviour. Further, microgravity has been re...
Source: J Cell Mol Med - May 2, 2024 Category: Molecular Biology Authors: Preksha Manish Vora Sudharshan Prabhu Source Type: research
Molecular and functional characterization of reversible-sunitinib-tolerance state in human renal cell carcinoma
J Cell Mol Med. 2024 May;28(9):e18329. doi: 10.1111/jcmm.18329.ABSTRACTTherapy failure with the tyrosine kinase inhibitor (TKI) sunitinib remains a great challenge in metastatic renal cell carcinoma (mRCC). Growing evidence indicates that the tumour subpopulation can enter a transient, non-mutagenic drug-tolerant state to endure the treatment underlying the minimal residual disease and tumour relapse. Drug tolerance to sunitinib remains largely unexplored in RCC. Here, we show that sunitinib-tolerant 786-O/S and Caki-2/S cells are induced by prolonged drug treatment showing reduced drug sensitivity, enhanced clonogenicity,...
Source: J Cell Mol Med - May 2, 2024 Category: Molecular Biology Authors: Angela Zaccagnino Bozhena Vynnytska-Myronovska Michael St öckle Kerstin Junker Source Type: research
Identification of Helicobacter pylori-carcinogenic TNF-alpha-inducing protein inhibitors via daidzein derivatives through computational approaches
In this study, a total of 45 daidzein derivatives were investigated and the best 10 molecules were comprehensively investigated using in silico approaches for drug development, namely pass prediction, quantum calculations, molecular docking, molecular dynamics simulations, Lipinski rule evaluation, and prediction of pharmacokinetics. The molecular docking study was performed to evaluate the binding affinity between the target protein and the ligands. In addition, the stability of ligand-protein complexes was investigated by molecular dynamics simulations. Various parameters were analysed, including root-mean-square deviati...
Source: J Cell Mol Med - May 2, 2024 Category: Molecular Biology Authors: Jehad Zuhair Tayyeb Shibam Mondal Md Anisur Rahman Swapon Kumar Imren Bay ıl Shopnil Akash Md Sarowar Hossain Taha Alqahtani Magdi E A Zaki Jonas Ivan Nobre Oliveira Source Type: research
SCPLPA: An miRNA-disease association prediction model based on spatial consistency projection and label propagation algorithm
J Cell Mol Med. 2024 May;28(9):e18345. doi: 10.1111/jcmm.18345.ABSTRACTIdentifying the association between miRNA and diseases is helpful for disease prevention, diagnosis and treatment. It is of great significance to use computational methods to predict potential human miRNA disease associations. Considering the shortcomings of existing computational methods, such as low prediction accuracy and weak generalization, we propose a new method called SCPLPA to predict miRNA-disease associations. First, a heterogeneous disease similarity network was constructed using the disease semantic similarity network and the disease Gaussi...
Source: J Cell Mol Med - May 2, 2024 Category: Molecular Biology Authors: Min Chen Yingwei Deng Zejun Li Yifan Ye Lijun Zeng Ziyi He Guofang Peng Source Type: research
New synergistic combination therapy approaches with HDAC inhibitor quisinostat, cisplatin or PARP inhibitor talazoparib for urothelial carcinoma
In conclusion, our results suggest new promising combination regimes for treatment of UC, also in the cisplatin-resistant setting.PMID:38693852 | DOI:10.1111/jcmm.18342 (Source: J Cell Mol Med)
Source: J Cell Mol Med - May 2, 2024 Category: Molecular Biology Authors: Sarah Meneceur Caroline E De Vos Patrick Petzsch Karl K öhrer G ünter Niegisch Mich èle J Hoffmann Source Type: research
Prognostic and immunotherapeutic implications of bilirubin metabolism-associated genes in lung adenocarcinoma
This study aimed to develop a prognostic signature of bilirubin metabolism-associated genes (BMAGs) to predict outcomes and efficacy of immunotherapy in LUAD. We analysed gene expression data from The Cancer Genome Atlas (TCGA) to identify survival-related BMAGs and construct a prognostic model in LUAD. The prognostic efficacy of our model was corroborated by employing TCGA-LUAD and five Gene Expression Omnibus datasets, effectively stratifying patients into risk-defined cohorts with marked disparities in survival. The BMAG signature was indeed an independent prognostic determinant, outperforming established clinical param...
Source: J Cell Mol Med - May 2, 2024 Category: Molecular Biology Authors: Kangqi Ren Xiean Ling Lin Chen Zeyao Li Tonghai Huang Source Type: research
Improved therapeutic effects on vascular intimal hyperplasia by mesenchymal stem cells expressing MIR155HG that function as a ceRNA for microRNA-205
J Cell Mol Med. 2024 May;28(9):e18351. doi: 10.1111/jcmm.18351.ABSTRACTCoronary artery bypass grafting (CABG) is an effective treatment for coronary heart disease, with vascular transplantation as the key procedure. Intimal hyperplasia (IH) gradually leads to vascular stenosis, seriously affecting the curative effect of CABG. Mesenchymal stem cells (MSCs) were used to alleviate IH, but the effect was not satisfactory. This work aimed to investigate whether lncRNA MIR155HG could improve the efficacy of MSCs in the treatment of IH and to elucidate the role of the competing endogenous RNA (ceRNA). The effect of MIR155HG on MS...
Source: J Cell Mol Med - May 2, 2024 Category: Molecular Biology Authors: Xiao Bai Zaiwen Qi Chuanliang Cai Hao Song Guangmin Song Xin Zhao Source Type: research
Exploring the influence of microgravity on chemotherapeutic drug response in cancer: Unveiling new perspectives
J Cell Mol Med. 2024 May;28(9):e18347. doi: 10.1111/jcmm.18347.ABSTRACTMicrogravity, an altered gravity condition prevailing in space, has been reported to have a profound impact on human health. Researchers are very keen to comprehensively investigate the impact of microgravity and its intricate involvement in inducing physiological changes. Evidenced transformations were observed in the internal architecture including cytoskeletal organization and cell membrane morphology. These alterations can significantly influence cellular function, signalling pathways and overall cellular behaviour. Further, microgravity has been re...
Source: J Cell Mol Med - May 2, 2024 Category: Molecular Biology Authors: Preksha Manish Vora Sudharshan Prabhu Source Type: research
Molecular and functional characterization of reversible-sunitinib-tolerance state in human renal cell carcinoma
J Cell Mol Med. 2024 May;28(9):e18329. doi: 10.1111/jcmm.18329.ABSTRACTTherapy failure with the tyrosine kinase inhibitor (TKI) sunitinib remains a great challenge in metastatic renal cell carcinoma (mRCC). Growing evidence indicates that the tumour subpopulation can enter a transient, non-mutagenic drug-tolerant state to endure the treatment underlying the minimal residual disease and tumour relapse. Drug tolerance to sunitinib remains largely unexplored in RCC. Here, we show that sunitinib-tolerant 786-O/S and Caki-2/S cells are induced by prolonged drug treatment showing reduced drug sensitivity, enhanced clonogenicity,...
Source: J Cell Mol Med - May 2, 2024 Category: Molecular Biology Authors: Angela Zaccagnino Bozhena Vynnytska-Myronovska Michael St öckle Kerstin Junker Source Type: research
