Downstream Biomarker Effects of Gantenerumab or Solanezumab in Dominantly Inherited Alzheimer Disease
This randomized clinical trial investigates the effects of solanezumab and ganterenumab on downstream biomarkers in individuals with dominantly inherited Alzheimer disease. (Source: JAMA Neurology)
Source: JAMA Neurology - April 29, 2024 Category: Neurology Source Type: research
Association of New-Onset Seizures With SARS-CoV-2 Vaccines
This systematic review and meta-analysis reviews data from randomized clinical trials to determine the incidence of new-onset seizures (Source: JAMA Neurology)
Source: JAMA Neurology - April 29, 2024 Category: Neurology Source Type: research
APOE Genotype and White Matter Hyperintensities in Sporadic Alzheimer Disease —Reply
In Reply We thank Mirza et al for their close reading of our research article in JAMA Neurology and appreciate the questions raised. We agree that APOE- ε4 carrier status is an important issue to consider. Indeed, we examined APOE-ε4 status (carrier vs noncarrier) as a potential covariate of interest in analyses of data from all 3 cohorts reported here (the Alzheimer Disease Neuroimaging Initiative [ADNI]; the Dominantly Inherited Alzheimer Networ k Observational Study [DIAN]; and the Harvard Aging Brain Study [HABS]). After accounting for age, the presence of cerebral microbleeds (CMBs), amyloid positron emission tomogr...
Source: JAMA Neurology - April 29, 2024 Category: Neurology Source Type: research
APOE Genotype and White Matter Hyperintensities in Sporadic Alzheimer Disease
To The Editor We read with interest the article entitled, “Etiology of White Matter Hyperintensities (WMH) in Autosomal Dominant and Sporadic Alzheimer Disease (AD)” in JAMA Neurology. Using multimodal imaging data from 3 complimentary cohorts (the Dominantly Inherited Alzheimer Network, the Alzheimer’s Disease Neuroimaging Initiative [ADNI], and th e Harvard Aging Brain Study), the authors concluded that the results strongly suggest cerebral amyloid angiopathy (CAA) as the likely etiology for WMH in AD. (Source: JAMA Neurology)
Source: JAMA Neurology - April 29, 2024 Category: Neurology Source Type: research
Errors in Tables in Systematic Review of Perinatal Outcomes for Women With and Without Epilepsy
To the Editor On behalf of my coauthors, I write to address some errors identified in our Original Investigation, “Comparison of Perinatal Outcomes for Women With and Without Epilepsy: A Systematic Review and Meta-Analysis” published online on March 13, 2023, and in the May 2023 issue of JAMA Neurology. A researcher/colleague brought these errors to our attention. (Source: JAMA Neurology)
Source: JAMA Neurology - April 29, 2024 Category: Neurology Source Type: research
Selenosis in a Woman With Systemic Lupus Erythematosus
This case report describes hypointensity in the cerebellum and midbrain in a 56-year-old woman with double vision and weakness and ptosis of eyelids. (Source: JAMA Neurology)
Source: JAMA Neurology - April 29, 2024 Category: Neurology Source Type: research
Fluid Biomarker Changes After Amyloid- β–Targeting Drugs
Recent scientific advancements in the field of Alzheimer disease (AD) have led to numerous questions and challenges. On the one hand, with the emergence of robust methodologies for measuring in vivo brain changes in biofluids, like cerebrospinal fluid (CSF) and plasma, accurate detection of the hallmark neuropathological features of AD (ie, amyloid- β and tau proteins) has become feasible. Additionally, these methodologies enable the identification of various downstream and co-occurring processes, including neuroinflammation, synaptic dysfunction, and axonal degeneration. Furthermore, we have recently entered a new era wh...
Source: JAMA Neurology - April 29, 2024 Category: Neurology Source Type: research
Errors in Tables 1 and 2
In the Original Investigation titled “Comparison of Perinatal Outcomes for Women With and Without Epilepsy: A Systematic Review and Meta-Analysis” published online on March 13, 2023, and in the May 2023 issue of JAMA Neurology, there were multiple errors in Tables 1 and 2. A copy-and-paste error led to discrepancies between the rep orted odds ratios and 95% CIs, and sample sizes were not updated after additional articles were included in the review and meta-analyses. Corrections have been made to Tables 1 and 2 in the article online. The authors have published a Letter of explanation and confirmed that the error did no...
Source: JAMA Neurology - April 29, 2024 Category: Neurology Source Type: research
Effects of Tirofiban on Neurological Deterioration in Patients With Acute Ischemic Stroke
This randomized clinical trial analyzes data for patients with acute noncardioembolic stroke who were given intravenous tirofiban within 24 hours of stroke onset to gauge its effect on early neurological deterioration compared with oral aspirin. (Source: JAMA Neurology)
Source: JAMA Neurology - April 22, 2024 Category: Neurology Source Type: research
Cold-Induced Reflex Epilepsy
This case report describes a woman cold-induced reflex seizures. (Source: JAMA Neurology)
Source: JAMA Neurology - April 22, 2024 Category: Neurology Source Type: research
A 24-Year-Old Man With Spastic Ataxia and Hypodontia
A 24-year-old man presented with progressive gait instability, marked spinal cord atrophy, and dental radiography showing the absence of several elements, microdontia, and taurodontia. What is your diagnosis? (Source: JAMA Neurology)
Source: JAMA Neurology - April 22, 2024 Category: Neurology Source Type: research
Entering Medicine as a Physician and a Patient
This essay describes the author ’s experience with the line between life and death and what the fragility of life means for patients and their medical teams. (Source: JAMA Neurology)
Source: JAMA Neurology - April 15, 2024 Category: Neurology Source Type: research
Clinicopathologic Heterogeneity and Glial Activation Patterns in Alzheimer Disease
This cross-sectional study evaluates the association between corticolimbic vulnerability to tau pathology as a continuous trait with clinicalpathologic heterogeneity and glial activation patterns in neuropathologically diagnosed Alzheimer disease. (Source: JAMA Neurology)
Source: JAMA Neurology - April 15, 2024 Category: Neurology Source Type: research
A Rare Neurological Presentation of Kikuchi-Fujimoto Disease
This case report describes a 17-year-old boy with reduced consciousness and T2-weighted hyperintensity, focal diffusion restriction, and microhemorrhages within the deep gray nuclei and surrounding white matter. (Source: JAMA Neurology)
Source: JAMA Neurology - April 15, 2024 Category: Neurology Source Type: research
Personalized Management of Device-Detected Atrial Fibrillation
This Viewpoint discusses the need to individualize the management of subclinical atrial fibrillation according to burden (among other factors) by modeling stroke risk. (Source: JAMA Neurology)
Source: JAMA Neurology - April 8, 2024 Category: Neurology Source Type: research
