Journal of Allergy and Clinical Immunology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The Definition, Acronyms, Nomenclature, and Classification of Angioedema: AAAAI, ACAAI, ACARE, and APAACI DANCE Consensus
Angioedema syndromes are clinically heterogeneous, hereditary, or acquired and caused by different pathogenetic mechanisms. The paper presents the results of a global expert consensus on the classification and terminology of various angioedema types and endotypes. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 24, 2024 Category: Allergy & Immunology Authors: Avner Reshef, Thomas Buttgereit, Stephen D. Betschel, Teresa Caballero, Henriette Farkas, Anete S. Grumach, Michihiro Hide, Ankur K. Jindal, Hilary Longhurst, Jonathan Peter, Marc A. Riedl, Yuxiang Zhi, Werner Aberer, Mohamed Abuzakouk, Tariq Al Farsi, Na Source Type: research

Alzheimer ’s Incidence and Prevalence with and without Asthma: A Medicare cohort study
International data suggest that asthma, like other inflammatory diseases, might increase Alzheimer ’s disease (AD) risk. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 24, 2024 Category: Allergy & Immunology Authors: Christie M. Bartels, Yi Chen, W. Ryan Powell, Melissa A. Rosenkranz, Barbara B. Bendlin, Joseph Kramer, William W. Busse, Amy Kind Source Type: research

Biologic and Small Molecule Therapy for Treating Moderate to Severe Atopic Dermatitis: Mechanistic Considerations
Atopic dermatitis (AD) is a complex and heterogeneous skin disease where achieving complete clinical clearance for most patients has proven challenging through single cytokine inhibition. Current studies integrate biomarkers and evaluate their role in AD, aiming to advance our understanding of the diverse molecular profiles implicated. While traditionally characterized as a Th2-driven disease, extensive research has recently revealed the involvement of Th1, Th17, and Th22 immune pathways, as well as the interplay of pivotal immune molecules, such as OX40, OX40 ligand (OX40L), thymic stromal lymphopoietin (TSLP), and IL-33....
Source: Journal of Allergy and Clinical Immunology - April 24, 2024 Category: Allergy & Immunology Authors: Camille Rothenberg-Lausell, Jonathan Bar, Dante Dahabreh, Yael Renert-Yuval, Ester del Duca, Emma Guttman-Yassky Source Type: research

Antibiotics within first year are linked to infant gut microbiome disruption and elevated atopic dermatitis risk
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 24, 2024 Category: Allergy & Immunology Authors: Courtney Hoskinson, Maria V. Medeleanu, Myrtha E. Reyna, Darlene LY. Dai, Biswajit Chowdhury, Theo J. Moraes, Piushkumar J. Mandhane, Elinor Simons, Anita L. Kozyrskyj, Meghan B. Azad, Charisse Petersen, Stuart E. Turvey, Padmaja Subbarao Source Type: research

A mutation in Themis contributes to anaphylaxis severity following oral peanut challenge in CC027 mice
The development of peanut allergy is due to a combination of genetic and environmental factors, although specific genes have proven difficult to identify. Previously, we reported that peanut-sensitized CC027/GeniUnc (CC027) mice develop anaphylaxis upon oral challenge to peanut, unlike C3H/HeJ (C3H) mice. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 24, 2024 Category: Allergy & Immunology Authors: Ellen L. Risemberg, Johanna M. Smeekens, Marta C. Cruz Cisneros, Brea K. Hampton, Pablo Hock, Colton L. Linnertz, Darla R. Miller, Kelly Orgel, Ginger D. Shaw, Fernando Pardo Manuel de Villena, A. Wesley Burks, William Valdar, Michael D. Kulis, Martin T. Source Type: research

Distinct proteomes and allergen profiles appear across the life cycle stages of Alternaria alternata
Alternaria alternata is associated with allergic respiratory diseases, which can be managed with allergen extract-based diagnostics and immunotherapy. It is not known how spores and hyphae contribute to allergen content. Commercial allergen extracts are manufactured by extracting proteins without separating the different forms of the fungus. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 23, 2024 Category: Allergy & Immunology Authors: Michael Brad Strader, Aishwarya L. Saha, Chantal Fernandes, Kavita Sharma, Christian Hadiwinarta, Daniela Calheiros, Gon çalo Conde-de-Oliveira, Teresa Gonçalves, Jay E. Slater Source Type: research

Can sputum eosinophils predict a poor response to mepolizumab?
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 23, 2024 Category: Allergy & Immunology Authors: Catherine Lemiere, James G. Martin Source Type: research

Utility of eosinophil peroxidase as a biomarker of eosinophilic inflammation in asthma
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 22, 2024 Category: Allergy & Immunology Authors: Monica Tang, Annabelle R. Charbit, Mats W. Johansson, Nizar N. Jarjour, Loren C. Denlinger, Wilfred W. Raymond, Michael C. Peters, Eleanor M. Dunican, Mario Castro, Kaharu Sumino, Serpil C. Erzurum, Suzy A. Comhair, Wendy C. Moore, Bruce D. Levy, Elliot I Source Type: research

T-cell receptor sequencing in interrogating antigen-specific T-cell responses to foreign and self-antigens
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 22, 2024 Category: Allergy & Immunology Authors: Alexandra M. Johansson, William W. Kwok Source Type: research

Inter-Alpha-Trypsin Inhibitor Heavy Chain 4 (ITIH4) as a Compensatory Protease Inhibitor in Hereditary Angioedema (HAE)
Hereditary angioedema (HAE) is a genetic disorder that manifests as recurrent angioedema attacks, most frequently due to absent or reduced C1 inhibitor (C1-INH) activity. C1-INH is a crucial regulator of enzymatic cascades in the complement, fibrinolytic, and contact systems. Inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) is an abundant plasma protease inhibitor that can inhibit enzymes in the proteolytic pathways associated with HAE. Nothing is known about its role in HAE. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 22, 2024 Category: Allergy & Immunology Authors: Anne Troldborg, Zsofia Godnic-Polai, L ászló Cervenak, Annette G. Hansen, Henriette Farkas, Steffen Thiel Source Type: research

Should ‘primary immune disorder’ replace ‘inborn error of immunity’? Names matter but there’s room for both
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 20, 2024 Category: Allergy & Immunology Authors: Stuart E. Turvey, Catherine M. Biggs, Elliot L. James, Kyla J. Hildebrand Source Type: research

Population descriptors in asthma and allergy research: Time to re-group
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 18, 2024 Category: Allergy & Immunology Authors: Carole Ober, Christine L.M. Joseph, John Novembre Source Type: research

β1 integrin-mediated mast cell immune-surveillance of blood vessel content
Immunoglobulin E, IgE)-mediated degranulation of mast cells, MCs) provides rapid protection against environmental hazards, including animal venoms. A fraction of tissue-resident MCs intimately associates with blood vessels. These perivascular MCs were reported to extend projections into the vessel lumen and to be the first MCs to acquire intravenously injected IgE, suggesting that IgE loading of MCs depends on their vascular association. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 15, 2024 Category: Allergy & Immunology Authors: Kristina Link, Lina Muhandes, Anastasia Polikarpova, Tim L ämmermann, Michael Sixt, Reinhard Fässler, Axel Roers Source Type: research

A Practical Guide for Implementing Omalizumab Therapy for Food Allergy
The recent approval of omalizumab for the treatment of IgE-mediated food allergy is an important step forward for the millions of food allergy patients in the US. Through the depletion of circulating IgE and the subsequent reduction of FC εR1 on key effector cells, patients increase their tolerance to food allergens. However, omalizumab does not permit patients to eat foods that they are allergic to with impunity. Rather, it protects them from most accidental exposures. In addition, omalizumab does not cure food allergy and has not demonstrated true immunomodulation. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 8, 2024 Category: Allergy & Immunology Authors: Thomas B. Casale, Alessandro Fiocchi, Matthew Greenhawt Source Type: research

Downregulation of otulin induces inflammasome activation in neutrophilic asthma
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 8, 2024 Category: Allergy & Immunology Authors: Quang Luu Quoc, YeJi Kim, Gunwoo Park, Thi Bich Tra Cao, Youngwoo Choi, Yong Hwan Park, Hae-Sim Park Source Type: research