Paclitaxel Inhibits Proliferation by Negatively Regulating Cdk1-Cell Cycle Axis in Rat Airway Smooth Muscle Cells
CONCLUSIONS: Our study demonstrated that paclitaxel inhibits the proliferation of ASMCs at least partly by negatively regulating Cdk1-cell cycle axis.PMID:38696283 | DOI:10.1080/02770903.2024.2349599 (Source: Journal of Asthma)
Source: Journal of Asthma - May 2, 2024 Category: Respiratory Medicine Authors: Bo Xiao Zhiheng Huang Liangxian Li Lixia Hou Dong Yao Biwen Mo Source Type: research
Early response to Tezepelumab in type-2 severe asthma patients non-responders to other biological treatments: a real-life study
CONCLUSION. In real-world scenarios, despite the study's limitations, our results underscore Tezepelumab's promise as a therapeutic option for uncontrolled severe asthma, and may be useful for non-responders to other mAbs. Further studies are needed to corroborate these findings.PMID:38686823 | DOI:10.1080/02770903.2024.2349605 (Source: Journal of Asthma)
Source: Journal of Asthma - April 30, 2024 Category: Respiratory Medicine Authors: Miguel Jim énez-Gómez Roc ío Magdalena Díaz-Campos Álvaro Gimeno-Díaz-De-Atauri Consuelo Fern ández-Rodríguez Jes ús Fernández-Crespo Ismael Garc ía-Moguel Source Type: research
A Meta-Analysis Investigating the Efficacy and Safety of Allergen-Specific Immunotherapy in the Management of Respiratory Allergies
Conclusion: The results of our meta-analysis suggest that specific immunotherapy, while associated with some adverse effects, effectively reduces the symptoms of asthma and rhinitis. Therefore, we recommend its use in the treatment of respiratory allergies.PMID:38687911 | DOI:10.1080/02770903.2024.2349604 (Source: Journal of Asthma)
Source: Journal of Asthma - April 30, 2024 Category: Respiratory Medicine Authors: Xue Li Juju Shang Jian Liu Yong Zhu Source Type: research
Deciphering Cuproptosis-related Signatures in Pediatric Allergic Asthma using Integrated scRNA-seq and Bulk RNA-seq Analysis
Conclusion This work provided a machine learning model containing five important variables, which may have good diagnostic efficiency for pediatric AA.PMID:38687912 | DOI:10.1080/02770903.2024.2349596 (Source: Journal of Asthma)
Source: Journal of Asthma - April 30, 2024 Category: Respiratory Medicine Authors: Jingping Liu Yujia Sun Chunxin Tian Dong Qin Lanying Gao Source Type: research
Early response to Tezepelumab in type-2 severe asthma patients non-responders to other biological treatments: a real-life study
CONCLUSION. In real-world scenarios, despite the study's limitations, our results underscore Tezepelumab's promise as a therapeutic option for uncontrolled severe asthma, and may be useful for non-responders to other mAbs. Further studies are needed to corroborate these findings.PMID:38686823 | DOI:10.1080/02770903.2024.2349605 (Source: Journal of Asthma)
Source: Journal of Asthma - April 30, 2024 Category: Respiratory Medicine Authors: Miguel Jim énez-Gómez Roc ío Magdalena Díaz-Campos Álvaro Gimeno-Díaz-De-Atauri Consuelo Fern ández-Rodríguez Jes ús Fernández-Crespo Ismael Garc ía-Moguel Source Type: research
A Meta-Analysis Investigating the Efficacy and Safety of Allergen-Specific Immunotherapy in the Management of Respiratory Allergies
Conclusion: The results of our meta-analysis suggest that specific immunotherapy, while associated with some adverse effects, effectively reduces the symptoms of asthma and rhinitis. Therefore, we recommend its use in the treatment of respiratory allergies.PMID:38687911 | DOI:10.1080/02770903.2024.2349604 (Source: Journal of Asthma)
Source: Journal of Asthma - April 30, 2024 Category: Respiratory Medicine Authors: Xue Li Juju Shang Jian Liu Yong Zhu Source Type: research
Deciphering Cuproptosis-related Signatures in Pediatric Allergic Asthma using Integrated scRNA-seq and Bulk RNA-seq Analysis
Conclusion This work provided a machine learning model containing five important variables, which may have good diagnostic efficiency for pediatric AA.PMID:38687912 | DOI:10.1080/02770903.2024.2349596 (Source: Journal of Asthma)
Source: Journal of Asthma - April 30, 2024 Category: Respiratory Medicine Authors: Jingping Liu Yujia Sun Chunxin Tian Dong Qin Lanying Gao Source Type: research
Early response to Tezepelumab in type-2 severe asthma patients non-responders to other biological treatments: a real-life study
CONCLUSION. In real-world scenarios, despite the study's limitations, our results underscore Tezepelumab's promise as a therapeutic option for uncontrolled severe asthma, and may be useful for non-responders to other mAbs. Further studies are needed to corroborate these findings.PMID:38686823 | DOI:10.1080/02770903.2024.2349605 (Source: Journal of Asthma)
Source: Journal of Asthma - April 30, 2024 Category: Respiratory Medicine Authors: Miguel Jim énez-Gómez Roc ío Magdalena Díaz-Campos Álvaro Gimeno-Díaz-De-Atauri Consuelo Fern ández-Rodríguez Jes ús Fernández-Crespo Ismael Garc ía-Moguel Source Type: research
A Meta-Analysis Investigating the Efficacy and Safety of Allergen-Specific Immunotherapy in the Management of Respiratory Allergies
Conclusion: The results of our meta-analysis suggest that specific immunotherapy, while associated with some adverse effects, effectively reduces the symptoms of asthma and rhinitis. Therefore, we recommend its use in the treatment of respiratory allergies.PMID:38687911 | DOI:10.1080/02770903.2024.2349604 (Source: Journal of Asthma)
Source: Journal of Asthma - April 30, 2024 Category: Respiratory Medicine Authors: Xue Li Juju Shang Jian Liu Yong Zhu Source Type: research
Deciphering Cuproptosis-related Signatures in Pediatric Allergic Asthma using Integrated scRNA-seq and Bulk RNA-seq Analysis
Conclusion This work provided a machine learning model containing five important variables, which may have good diagnostic efficiency for pediatric AA.PMID:38687912 | DOI:10.1080/02770903.2024.2349596 (Source: Journal of Asthma)
Source: Journal of Asthma - April 30, 2024 Category: Respiratory Medicine Authors: Jingping Liu Yujia Sun Chunxin Tian Dong Qin Lanying Gao Source Type: research
Machine Learning and Bioinformatics Approaches to Identify the Candidate Biomarkers in Severe Asthma
J Asthma. 2024 Apr 22:1-31. doi: 10.1080/02770903.2024.2335562. Online ahead of print.ABSTRACTSevere asthma is characterized by a poor level of control that severely affects the patient's life and prognosis. However, the underlying pathogenic mechanisms remain unknown. Here, we identified differentially expressed genes from the microarray datasets(GSE130499 and GSE63142) of severe asthma, and then constructed models to screen the most relevant biomarkers to severe asthma by machine learning algorithms(LASSO and SVM-RFE), with further validation of the results by GSE43696. Three genes (BCL3, DDIT4 and S100A14) are considere...
Source: Journal of Asthma - April 22, 2024 Category: Respiratory Medicine Authors: Fuying Zhang Xiang Weng Jiabao Zhu Qin Tang Mingsheng Lei Weimin Zhou Source Type: research
YiQi GuBen capsule alleviates OVA-induced asthma through improving mitochondrial dysfunction
Conclusion: This study suggests YiQi GuBen capsule can effectively improve mitochondrial dysfunction in the OVA-induced mouse model.PMID:38647486 | DOI:10.1080/02770903.2024.2303755 (Source: Journal of Asthma)
Source: Journal of Asthma - April 22, 2024 Category: Respiratory Medicine Authors: Xiaoting Ren Yibu Kong Hongjun Yu Aiai Dong Yongji Wang Lina Wei Yongfu Song Zhongtian Wang Lie Wang Yinan Guo Liping Sun Source Type: research
Machine Learning and Bioinformatics Approaches to Identify the Candidate Biomarkers in Severe Asthma
J Asthma. 2024 Apr 22:1-31. doi: 10.1080/02770903.2024.2335562. Online ahead of print.ABSTRACTSevere asthma is characterized by a poor level of control that severely affects the patient's life and prognosis. However, the underlying pathogenic mechanisms remain unknown. Here, we identified differentially expressed genes from the microarray datasets(GSE130499 and GSE63142) of severe asthma, and then constructed models to screen the most relevant biomarkers to severe asthma by machine learning algorithms(LASSO and SVM-RFE), with further validation of the results by GSE43696. Three genes (BCL3, DDIT4 and S100A14) are considere...
Source: Journal of Asthma - April 22, 2024 Category: Respiratory Medicine Authors: Fuying Zhang Xiang Weng Jiabao Zhu Qin Tang Mingsheng Lei Weimin Zhou Source Type: research
