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Pre-clinical evaluation of < sup > 99m < /sup > Tc-labeled chalcone derivative for amyloid- β imaging post-head trauma
J Biol Inorg Chem. 2024 Apr 12. doi: 10.1007/s00775-024-02049-x. Online ahead of print.ABSTRACTAβ42 plaque formation is one of the preliminary pathologic events that occur post traumatic brain injury (TBI) which is also among the most noteworthy hallmarks of AD. Their pre symptomatic detection is therefore vital for better disease management. Chalcone-picolinic acid chelator derivative, 6-({[(6-carboxypyridin-2-yl)methyl](2-{4-[(2E)-3-[4-(dimethyl amino)phenyl]prop-2-enoyl]phenoxy}ethyl)amino}methyl)pyridine-2-carboxylic acid, Py-chal was synthesized to selectively identify amyloid plaques formed post head trauma using SP...
Source: Journal of Biological Inorganic Chemistry : JBIC - April 12, 2024 Category: Chemistry Authors: Garima Mann Shivani Daksh Nikhil Kumar Ankur Kaul B G Roy M Thirumal Anupama Datta Source Type: research

Pre-clinical evaluation of < sup > 99m < /sup > Tc-labeled chalcone derivative for amyloid- β imaging post-head trauma
J Biol Inorg Chem. 2024 Apr 12. doi: 10.1007/s00775-024-02049-x. Online ahead of print.ABSTRACTAβ42 plaque formation is one of the preliminary pathologic events that occur post traumatic brain injury (TBI) which is also among the most noteworthy hallmarks of AD. Their pre symptomatic detection is therefore vital for better disease management. Chalcone-picolinic acid chelator derivative, 6-({[(6-carboxypyridin-2-yl)methyl](2-{4-[(2E)-3-[4-(dimethyl amino)phenyl]prop-2-enoyl]phenoxy}ethyl)amino}methyl)pyridine-2-carboxylic acid, Py-chal was synthesized to selectively identify amyloid plaques formed post head trauma using SP...
Source: Journal of Biological Inorganic Chemistry : JBIC - April 12, 2024 Category: Chemistry Authors: Garima Mann Shivani Daksh Nikhil Kumar Ankur Kaul B G Roy M Thirumal Anupama Datta Source Type: research

Pre-clinical evaluation of < sup > 99m < /sup > Tc-labeled chalcone derivative for amyloid- β imaging post-head trauma
J Biol Inorg Chem. 2024 Apr 12. doi: 10.1007/s00775-024-02049-x. Online ahead of print.ABSTRACTAβ42 plaque formation is one of the preliminary pathologic events that occur post traumatic brain injury (TBI) which is also among the most noteworthy hallmarks of AD. Their pre symptomatic detection is therefore vital for better disease management. Chalcone-picolinic acid chelator derivative, 6-({[(6-carboxypyridin-2-yl)methyl](2-{4-[(2E)-3-[4-(dimethyl amino)phenyl]prop-2-enoyl]phenoxy}ethyl)amino}methyl)pyridine-2-carboxylic acid, Py-chal was synthesized to selectively identify amyloid plaques formed post head trauma using SP...
Source: Journal of Biological Inorganic Chemistry : JBIC - April 12, 2024 Category: Chemistry Authors: Garima Mann Shivani Daksh Nikhil Kumar Ankur Kaul B G Roy M Thirumal Anupama Datta Source Type: research

Pre-clinical evaluation of < sup > 99m < /sup > Tc-labeled chalcone derivative for amyloid- β imaging post-head trauma
J Biol Inorg Chem. 2024 Apr 12. doi: 10.1007/s00775-024-02049-x. Online ahead of print.ABSTRACTAβ42 plaque formation is one of the preliminary pathologic events that occur post traumatic brain injury (TBI) which is also among the most noteworthy hallmarks of AD. Their pre symptomatic detection is therefore vital for better disease management. Chalcone-picolinic acid chelator derivative, 6-({[(6-carboxypyridin-2-yl)methyl](2-{4-[(2E)-3-[4-(dimethyl amino)phenyl]prop-2-enoyl]phenoxy}ethyl)amino}methyl)pyridine-2-carboxylic acid, Py-chal was synthesized to selectively identify amyloid plaques formed post head trauma using SP...
Source: Journal of Biological Inorganic Chemistry : JBIC - April 12, 2024 Category: Chemistry Authors: Garima Mann Shivani Daksh Nikhil Kumar Ankur Kaul B G Roy M Thirumal Anupama Datta Source Type: research

Pre-clinical evaluation of < sup > 99m < /sup > Tc-labeled chalcone derivative for amyloid- β imaging post-head trauma
J Biol Inorg Chem. 2024 Apr 12. doi: 10.1007/s00775-024-02049-x. Online ahead of print.ABSTRACTAβ42 plaque formation is one of the preliminary pathologic events that occur post traumatic brain injury (TBI) which is also among the most noteworthy hallmarks of AD. Their pre symptomatic detection is therefore vital for better disease management. Chalcone-picolinic acid chelator derivative, 6-({[(6-carboxypyridin-2-yl)methyl](2-{4-[(2E)-3-[4-(dimethyl amino)phenyl]prop-2-enoyl]phenoxy}ethyl)amino}methyl)pyridine-2-carboxylic acid, Py-chal was synthesized to selectively identify amyloid plaques formed post head trauma using SP...
Source: Journal of Biological Inorganic Chemistry : JBIC - April 12, 2024 Category: Chemistry Authors: Garima Mann Shivani Daksh Nikhil Kumar Ankur Kaul B G Roy M Thirumal Anupama Datta Source Type: research

Pre-clinical evaluation of < sup > 99m < /sup > Tc-labeled chalcone derivative for amyloid- β imaging post-head trauma
J Biol Inorg Chem. 2024 Apr 12. doi: 10.1007/s00775-024-02049-x. Online ahead of print.ABSTRACTAβ42 plaque formation is one of the preliminary pathologic events that occur post traumatic brain injury (TBI) which is also among the most noteworthy hallmarks of AD. Their pre symptomatic detection is therefore vital for better disease management. Chalcone-picolinic acid chelator derivative, 6-({[(6-carboxypyridin-2-yl)methyl](2-{4-[(2E)-3-[4-(dimethyl amino)phenyl]prop-2-enoyl]phenoxy}ethyl)amino}methyl)pyridine-2-carboxylic acid, Py-chal was synthesized to selectively identify amyloid plaques formed post head trauma using SP...
Source: Journal of Biological Inorganic Chemistry : JBIC - April 12, 2024 Category: Chemistry Authors: Garima Mann Shivani Daksh Nikhil Kumar Ankur Kaul B G Roy M Thirumal Anupama Datta Source Type: research

Pre-clinical evaluation of < sup > 99m < /sup > Tc-labeled chalcone derivative for amyloid- β imaging post-head trauma
J Biol Inorg Chem. 2024 Apr 12. doi: 10.1007/s00775-024-02049-x. Online ahead of print.ABSTRACTAβ42 plaque formation is one of the preliminary pathologic events that occur post traumatic brain injury (TBI) which is also among the most noteworthy hallmarks of AD. Their pre symptomatic detection is therefore vital for better disease management. Chalcone-picolinic acid chelator derivative, 6-({[(6-carboxypyridin-2-yl)methyl](2-{4-[(2E)-3-[4-(dimethyl amino)phenyl]prop-2-enoyl]phenoxy}ethyl)amino}methyl)pyridine-2-carboxylic acid, Py-chal was synthesized to selectively identify amyloid plaques formed post head trauma using SP...
Source: Journal of Biological Inorganic Chemistry : JBIC - April 12, 2024 Category: Chemistry Authors: Garima Mann Shivani Daksh Nikhil Kumar Ankur Kaul B G Roy M Thirumal Anupama Datta Source Type: research

Pre-clinical evaluation of < sup > 99m < /sup > Tc-labeled chalcone derivative for amyloid- β imaging post-head trauma
J Biol Inorg Chem. 2024 Apr 12. doi: 10.1007/s00775-024-02049-x. Online ahead of print.ABSTRACTAβ42 plaque formation is one of the preliminary pathologic events that occur post traumatic brain injury (TBI) which is also among the most noteworthy hallmarks of AD. Their pre symptomatic detection is therefore vital for better disease management. Chalcone-picolinic acid chelator derivative, 6-({[(6-carboxypyridin-2-yl)methyl](2-{4-[(2E)-3-[4-(dimethyl amino)phenyl]prop-2-enoyl]phenoxy}ethyl)amino}methyl)pyridine-2-carboxylic acid, Py-chal was synthesized to selectively identify amyloid plaques formed post head trauma using SP...
Source: Journal of Biological Inorganic Chemistry : JBIC - April 12, 2024 Category: Chemistry Authors: Garima Mann Shivani Daksh Nikhil Kumar Ankur Kaul B G Roy M Thirumal Anupama Datta Source Type: research

Pre-clinical evaluation of < sup > 99m < /sup > Tc-labeled chalcone derivative for amyloid- β imaging post-head trauma
J Biol Inorg Chem. 2024 Apr 12. doi: 10.1007/s00775-024-02049-x. Online ahead of print.ABSTRACTAβ42 plaque formation is one of the preliminary pathologic events that occur post traumatic brain injury (TBI) which is also among the most noteworthy hallmarks of AD. Their pre symptomatic detection is therefore vital for better disease management. Chalcone-picolinic acid chelator derivative, 6-({[(6-carboxypyridin-2-yl)methyl](2-{4-[(2E)-3-[4-(dimethyl amino)phenyl]prop-2-enoyl]phenoxy}ethyl)amino}methyl)pyridine-2-carboxylic acid, Py-chal was synthesized to selectively identify amyloid plaques formed post head trauma using SP...
Source: Journal of Biological Inorganic Chemistry : JBIC - April 12, 2024 Category: Chemistry Authors: Garima Mann Shivani Daksh Nikhil Kumar Ankur Kaul B G Roy M Thirumal Anupama Datta Source Type: research

Pre-clinical evaluation of < sup > 99m < /sup > Tc-labeled chalcone derivative for amyloid- β imaging post-head trauma
J Biol Inorg Chem. 2024 Apr 12. doi: 10.1007/s00775-024-02049-x. Online ahead of print.ABSTRACTAβ42 plaque formation is one of the preliminary pathologic events that occur post traumatic brain injury (TBI) which is also among the most noteworthy hallmarks of AD. Their pre symptomatic detection is therefore vital for better disease management. Chalcone-picolinic acid chelator derivative, 6-({[(6-carboxypyridin-2-yl)methyl](2-{4-[(2E)-3-[4-(dimethyl amino)phenyl]prop-2-enoyl]phenoxy}ethyl)amino}methyl)pyridine-2-carboxylic acid, Py-chal was synthesized to selectively identify amyloid plaques formed post head trauma using SP...
Source: Journal of Biological Inorganic Chemistry : JBIC - April 12, 2024 Category: Chemistry Authors: Garima Mann Shivani Daksh Nikhil Kumar Ankur Kaul B G Roy M Thirumal Anupama Datta Source Type: research

Pre-clinical evaluation of < sup > 99m < /sup > Tc-labeled chalcone derivative for amyloid- β imaging post-head trauma
J Biol Inorg Chem. 2024 Apr 12. doi: 10.1007/s00775-024-02049-x. Online ahead of print.ABSTRACTAβ42 plaque formation is one of the preliminary pathologic events that occur post traumatic brain injury (TBI) which is also among the most noteworthy hallmarks of AD. Their pre symptomatic detection is therefore vital for better disease management. Chalcone-picolinic acid chelator derivative, 6-({[(6-carboxypyridin-2-yl)methyl](2-{4-[(2E)-3-[4-(dimethyl amino)phenyl]prop-2-enoyl]phenoxy}ethyl)amino}methyl)pyridine-2-carboxylic acid, Py-chal was synthesized to selectively identify amyloid plaques formed post head trauma using SP...
Source: Journal of Biological Inorganic Chemistry : JBIC - April 12, 2024 Category: Chemistry Authors: Garima Mann Shivani Daksh Nikhil Kumar Ankur Kaul B G Roy M Thirumal Anupama Datta Source Type: research

Pre-clinical evaluation of < sup > 99m < /sup > Tc-labeled chalcone derivative for amyloid- β imaging post-head trauma
J Biol Inorg Chem. 2024 Apr 12. doi: 10.1007/s00775-024-02049-x. Online ahead of print.ABSTRACTAβ42 plaque formation is one of the preliminary pathologic events that occur post traumatic brain injury (TBI) which is also among the most noteworthy hallmarks of AD. Their pre symptomatic detection is therefore vital for better disease management. Chalcone-picolinic acid chelator derivative, 6-({[(6-carboxypyridin-2-yl)methyl](2-{4-[(2E)-3-[4-(dimethyl amino)phenyl]prop-2-enoyl]phenoxy}ethyl)amino}methyl)pyridine-2-carboxylic acid, Py-chal was synthesized to selectively identify amyloid plaques formed post head trauma using SP...
Source: Journal of Biological Inorganic Chemistry : JBIC - April 12, 2024 Category: Chemistry Authors: Garima Mann Shivani Daksh Nikhil Kumar Ankur Kaul B G Roy M Thirumal Anupama Datta Source Type: research

Triggering antibacterial activity of a common plant by biosorption of selected heavy metals
J Biol Inorg Chem. 2024 Apr 8. doi: 10.1007/s00775-024-02045-1. Online ahead of print.ABSTRACTThe presented study proposes an efficient utilization of a common Thymus serpyllum L. (wild thyme) plant as a highly potent biosorbent of Cu(II) and Pb(II) ions and the efficient interaction of the copper-laden plant with two opportunistic bacteria. Apart from biochars that are commonly used for adsorption, here we report the direct use of native plant, which is potentially interesting also for soil remediation. The highest adsorption capacity for Cu(II) and Pb(II) ions (qe = 12.66 and 53.13 mg g-1, respectively) was achieved afte...
Source: Journal of Biological Inorganic Chemistry : JBIC - April 8, 2024 Category: Chemistry Authors: M ária Kováčová Halyna Bodn ár Yankovych Adrian Augustyniak Mariano Casas-Luna Michaela Reme šová Lenka Findor áková Martin Stahorsk ý Ladislav Čelko Matej Bal áž Source Type: research

Triggering antibacterial activity of a common plant by biosorption of selected heavy metals
J Biol Inorg Chem. 2024 Apr 8. doi: 10.1007/s00775-024-02045-1. Online ahead of print.ABSTRACTThe presented study proposes an efficient utilization of a common Thymus serpyllum L. (wild thyme) plant as a highly potent biosorbent of Cu(II) and Pb(II) ions and the efficient interaction of the copper-laden plant with two opportunistic bacteria. Apart from biochars that are commonly used for adsorption, here we report the direct use of native plant, which is potentially interesting also for soil remediation. The highest adsorption capacity for Cu(II) and Pb(II) ions (qe = 12.66 and 53.13 mg g-1, respectively) was achieved afte...
Source: Journal of Biological Inorganic Chemistry : JBIC - April 8, 2024 Category: Chemistry Authors: M ária Kováčová Halyna Bodn ár Yankovych Adrian Augustyniak Mariano Casas-Luna Michaela Reme šová Lenka Findor áková Martin Stahorsk ý Ladislav Čelko Matej Bal áž Source Type: research

Triggering antibacterial activity of a common plant by biosorption of selected heavy metals
J Biol Inorg Chem. 2024 Apr 8. doi: 10.1007/s00775-024-02045-1. Online ahead of print.ABSTRACTThe presented study proposes an efficient utilization of a common Thymus serpyllum L. (wild thyme) plant as a highly potent biosorbent of Cu(II) and Pb(II) ions and the efficient interaction of the copper-laden plant with two opportunistic bacteria. Apart from biochars that are commonly used for adsorption, here we report the direct use of native plant, which is potentially interesting also for soil remediation. The highest adsorption capacity for Cu(II) and Pb(II) ions (qe = 12.66 and 53.13 mg g-1, respectively) was achieved afte...
Source: Journal of Biological Inorganic Chemistry : JBIC - April 8, 2024 Category: Chemistry Authors: M ária Kováčová Halyna Bodn ár Yankovych Adrian Augustyniak Mariano Casas-Luna Michaela Reme šová Lenka Findor áková Martin Stahorsk ý Ladislav Čelko Matej Bal áž Source Type: research