Beneficial Effects of Concomitant Long-Acting Injectable Antipsychotics on Time to Rehospitalization in Patients With Treatment-Resistant Schizophrenia Receiving Clozapine: A Retrospective Cohort Study
Conclusion: The combination of clozapine and LAI antipsychotics was associated with a significantly lower risk of rehospitalization compared to both the combination of clozapine and OAPs and clozapine monotherapy. The use of LAI antipsychotics should be considered to prevent rehospitalization in patients with TRS who are already being treated with clozapine.PMID:38696112 | DOI:10.4088/JCP.23m15071 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - May 2, 2024 Category: Psychiatry Authors: Yun Tien Xi-Yu Wang Shang-Chien Huang Hsiang-Ping Huang Source Type: research
Clozapine Use Among People With Psychotic Disorders Who Experience Specific Indications for Clozapine
Conclusions: Initiating clozapine treatment is uncommon among people with psychotic disorders who experience events suggesting clozapine is indicated, with even lower rates among Black and Hispanic patients.PMID:38696137 | DOI:10.4088/JCP.23m14833 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - May 2, 2024 Category: Psychiatry Authors: Gregory E Simon Rebecca C Rossom Esti Iturralde Brian K Ahmedani Stephen C Waring Ashli A Owen-Smith Stacy A Sterling Kathleen Miley Cheryl D Stults Yihe G Daida Frances L Lynch Arne Beck Katherine Sanchez Karen J Coleman Susan M Shortreed Source Type: research
A Fully Remote Randomized Trial of Transcranial Alternating Current Stimulation for the Acute Treatment of Major Depressive Disorder
Conclusions: Rapid, clinically significant improvement in depression in adults with MDD was associated with tACS, particularly for women. Compared to other depression therapies, tACS has 3 key advantages: rapid, clinically significant treatment effect, the ability of patients to use the treatment on their own at home, and the rarity and low impact of adverse events.Trial Registration: ClinicalTrials.gov identifier: NCT05384041.PMID:38696220 | DOI:10.4088/JCP.23m15078 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - May 2, 2024 Category: Psychiatry Authors: Philip R Gehrman Eric J Bartky Curtis Travers Kyle Lapidus Source Type: research
A Randomized, Double-Blind, Placebo-Controlled Pilot Trial of the Acute Antisuicidal and Antidepressant Effects of Intranasal (R,S)-Ketamine in Severe Unipolar and Bipolar Depression With and Without Comorbid Alcohol Use Disorder
Conclusion: IN ketamine induced rapid antidepressant effects compared to placebo but did not significantly alter SI scores. The treatment was well tolerated. Continued investigation with IN ketamine as a practical alternative to current formulations is warranted.Trial Registration: ClinicalTrials.gov identifier: NCT03539887.PMID:38696221 | DOI:10.4088/JCP.23m14974 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - May 2, 2024 Category: Psychiatry Authors: Gregory H Jones Courtney M Vecera Ana C Ruiz Hanjing E Wu Sophia I McInturff Maria J Orejarena Kacy A Smith Jair C Soares Carlos A Zarate Scott D Lane Rodrigo Machado-Vieira Source Type: research
Beneficial Effects of Concomitant Long-Acting Injectable Antipsychotics on Time to Rehospitalization in Patients With Treatment-Resistant Schizophrenia Receiving Clozapine: A Retrospective Cohort Study
Conclusion: The combination of clozapine and LAI antipsychotics was associated with a significantly lower risk of rehospitalization compared to both the combination of clozapine and OAPs and clozapine monotherapy. The use of LAI antipsychotics should be considered to prevent rehospitalization in patients with TRS who are already being treated with clozapine.PMID:38696112 | DOI:10.4088/JCP.23m15071 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - May 2, 2024 Category: Psychiatry Authors: Yun Tien Xi-Yu Wang Shang-Chien Huang Hsiang-Ping Huang Source Type: research
Clozapine Use Among People With Psychotic Disorders Who Experience Specific Indications for Clozapine
Conclusions: Initiating clozapine treatment is uncommon among people with psychotic disorders who experience events suggesting clozapine is indicated, with even lower rates among Black and Hispanic patients.PMID:38696137 | DOI:10.4088/JCP.23m14833 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - May 2, 2024 Category: Psychiatry Authors: Gregory E Simon Rebecca C Rossom Esti Iturralde Brian K Ahmedani Stephen C Waring Ashli A Owen-Smith Stacy A Sterling Kathleen Miley Cheryl D Stults Yihe G Daida Frances L Lynch Arne Beck Katherine Sanchez Karen J Coleman Susan M Shortreed Source Type: research
A Fully Remote Randomized Trial of Transcranial Alternating Current Stimulation for the Acute Treatment of Major Depressive Disorder
Conclusions: Rapid, clinically significant improvement in depression in adults with MDD was associated with tACS, particularly for women. Compared to other depression therapies, tACS has 3 key advantages: rapid, clinically significant treatment effect, the ability of patients to use the treatment on their own at home, and the rarity and low impact of adverse events.Trial Registration: ClinicalTrials.gov identifier: NCT05384041.PMID:38696220 | DOI:10.4088/JCP.23m15078 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - May 2, 2024 Category: Psychiatry Authors: Philip R Gehrman Eric J Bartky Curtis Travers Kyle Lapidus Source Type: research
A Randomized, Double-Blind, Placebo-Controlled Pilot Trial of the Acute Antisuicidal and Antidepressant Effects of Intranasal (R,S)-Ketamine in Severe Unipolar and Bipolar Depression With and Without Comorbid Alcohol Use Disorder
Conclusion: IN ketamine induced rapid antidepressant effects compared to placebo but did not significantly alter SI scores. The treatment was well tolerated. Continued investigation with IN ketamine as a practical alternative to current formulations is warranted.Trial Registration: ClinicalTrials.gov identifier: NCT03539887.PMID:38696221 | DOI:10.4088/JCP.23m14974 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - May 2, 2024 Category: Psychiatry Authors: Gregory H Jones Courtney M Vecera Ana C Ruiz Hanjing E Wu Sophia I McInturff Maria J Orejarena Kacy A Smith Jair C Soares Carlos A Zarate Scott D Lane Rodrigo Machado-Vieira Source Type: research
Severity of Antipsychotic-Induced Cervical Dystonia Assessed by the Algorithm-Based Rating System
Conclusion: While further validation with new cases is needed, the range of tilt angles in this study could provide a standard for future artificial intelligence devices for cervical dystonia.PMID:38629708 | DOI:10.4088/JCP.23m14929 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - April 17, 2024 Category: Psychiatry Authors: Toshiya Inada Yuta Tanabe Yuji Fukaya Kazuyoshi Ogasawara Nobutomo Yamamoto Source Type: research
