Efficacy and tolerability of oral semaglutide in Japanese patients with type 2 diabetes mellitus: Analysis report from diabetes specialist clinics
ConclusionsOral semaglutide treatment demonstrates efficacy and tolerability for managing type 2 diabetes mellitus in Japan. Significant improvements in metabolic factors induced by oral semaglutide are anticipated, particularly in obese patients. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 4, 2024 Category: Endocrinology Authors: Tetsuaki Inokuchi,
Yoshihide Fukumoto,
Gendai Lee,
Yoshifumi Yokomizo,
Kokichi Tanaka,
Michiko Chosa,
Masaru Doi,
Noboru Tamaki,
Seiichi Goto,
Kojiro Ichikawa,
Kazuo Kobayashi Tags: Original Article Source Type: research
Issue Information
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 30, 2024 Category: Endocrinology Tags: Issue Information Source Type: research
Glycemic variability is associated with sural nerve conduction velocity in outpatients with type 2 diabetes: Usefulness of a new point‐of‐care device for nerve conduction studies
ConclusionsIn outpatients with type 2 diabetes, multiple CGM-derived GV metrics were significantly associated with SCV obtained by DPNCheck ™. GV may have independent impacts on peripheral nerve function, particularly in patients with well-controlled HbA1c levels. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 30, 2024 Category: Endocrinology Authors: Machiko Morita,
Kentaro Sada,
Shuji Hidaka,
Miki Ogawa,
Hirotaka Shibata Tags: Original Article Source Type: research
Optimizing lipid control in Taiwanese diabetic patients: A collaborative consensus by the Diabetes Association of the Republic of China (Taiwan) and the Taiwanese Association of Diabetes Educators
We present an in-depth analysis of dyslipidemia management strategies for patients with diabetes mellitus in Taiwan. It critically examines the disparity between established guideline recommendations and actual clinical practices, particularly in the context of evolving policies affecting statin prescriptions. The focus is on synthesizing the most recent findings concerning lipid management in patients with diabetes mellitus, with a special emphasis on establishing consensus regarding low-density lipoprotein cholesterol treatment targets. The article culminates in providing comprehensive, evidence-based recommendations tai...
Source: Journal of Diabetes Investigation - April 28, 2024 Category: Endocrinology Authors: Feng ‐Chih Shen,
Chih‐Hsun Chu,
Jung‐Fu Chen,
Chin‐Sung Kuo,
Chih‐Yao Hsu,
Ching‐Han Lin,
Yi‐Jing Sheen,
Sheng‐Chiang Su,
Kai‐Jen Tien,
Chieh‐Hua Lu,
Chun‐Chuan Lee,
Yi‐Sun Yang,
Shih‐Te Tu,
Po‐Tsang Chen,
Ching Tags: Special Research Report Source Type: research
Pancreatic beta ‐cell mass and function and therapeutic implications of using antidiabetic medications in type 2 diabetes
This review article examines the decline in pancreatic β-cell mass and function as central to the pathogenesis of type 1 and advanced type 2 diabetes. It discusses the potential for β-cell regeneration in response to increased insulin demand and evaluates how various antidiabetic medications may affect this process. The therapeutic implications of the se findings for the management and treatment of diabetes are explored, offering new insights into potential interventions. AbstractNowadays, the focus of diabetes treatment has switched from lowering the glucose level to preserving glycemic homeostasis and slowing the disea...
Source: Journal of Diabetes Investigation - April 27, 2024 Category: Endocrinology Authors: Joon Ho Moon,
Hun Jee Choe,
Soo Lim Tags: REVIEW ARTICLE Source Type: research
Possible etiological role of impaired endogenous double strand RNA editing in β‐cells in type 1 diabetes
Proposed mechanisms by which disruption of endogenous dsRNA editing in β-cells leads to type 1 diabetes-like phenotypes in βAdarKO mice. Disruption of endogenous dsRNA editing in β-cells initiates IFN responses, thereby inducing pancreatic islet inflammation and β-cell dysfunction. Hyperglycemia induced by β-cell dysfunction further promotes islet inflammation, li kely via increased dsRNA resulting from increased β-cell workload, thereby producing a vicious cycle. The mechanism by which impairment of dsRNA editing is integrated with autoimmune-mediated pathogenesis of type 1 diabetes remains to be clarified. (Source:...
Source: Journal of Diabetes Investigation - April 26, 2024 Category: Endocrinology Authors: Junta Imai Tags: Commentary Source Type: research
Association between variation in hemoglobin A1c levels and diabetes therapy ‐related quality of life in patients with diabetes
ConclusionsA small variation in HbA1c level was associated with higher total DTR-QOL scores and the scores for each factor. Reducing blood glucose variability is significant when we treat diabetes. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 25, 2024 Category: Endocrinology Authors: Dan Imai,
Emi Ushigome,
Ryosuke Sakai,
Noriyuki Kitagawa,
Masahide Hamaguchi,
Masahiro Yamazaki,
Michiaki Fukui Tags: Original Article Source Type: research
Tanshinone IIA suppresses ferroptosis to attenuate renal podocyte injury in diabetic nephropathy through the embryonic lethal abnormal visual‐like protein 1 and acyl‐coenzyme A synthetase long‐chain family member 4 signaling pathway
ConclusionTIIA treatment restrained HG-caused MPC5 cell injury and ferroptosis partly through targeting the ELAVL1 –ACSL4 axis, providing a promising therapeutic target for DN treatment. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 23, 2024 Category: Endocrinology Authors: Shuai Zhu,
Zhiqiang Kang,
Fengjiao Zhang Tags: Original Article Source Type: research
Risk factors and prediction score for new ‐onset diabetes mellitus after liver transplantation
ConclusionsAge at the time of transplantation, preoperative IFG, postoperative FPG, and length of hospital stay were independent predictive factors of NODALT. The use of a simple risk prediction score can identify the patients who have the highest risk of NODALT and interventions may start early. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 20, 2024 Category: Endocrinology Authors: Ruiping Bai,
Rui An,
Siyu Chen,
Wenkang Ding,
Mengwen Xue,
Ge Zhao,
Qingyong Ma,
Xin Shen Tags: Original Article Source Type: research
Medical database analysis of the association between kidney function and achievement of glycemic control in older Japanese adults with type 2 diabetes who started with oral antidiabetic drugs
ConclusionsIn older Japanese adults with type 2 diabetes, those with a lower estimated glomerular filtration rate were more likely to achieve hemoglobin A1c of<7.0%. To safely manage blood glucose levels in older adults with chronic kidney disease, physicians should remain vigilant about the risk of iatrogenic hypoglycemia. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 19, 2024 Category: Endocrinology Authors: Ryo Suzuki,
Kiyoyasu Kazumori,
Tatsuya Usui,
Masahiko Shinohara Tags: Original Article Source Type: research
Long ‐term efficacy of encapsulated xenogeneic islet transplantation: Impact of encapsulation techniques and donor genetic traits
ConclusionThe AC-PFD capsule, designed to ameliorate both hypoxia and inflammation, showed the highest long-term efficacy in xenogeneic islet transplantation. Genetic modifications of porcine islets with GTKO or GTKO with overexpression of membrane cofactor protein did not influence naked islet transplantation outcomes, but did delay graft failure when encapsulated. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 18, 2024 Category: Endocrinology Authors: Heon ‐Seok Park,
Eun Young Lee,
Young‐Hye You,
Marie Rhee,
Jong‐Min Kim,
Seong‐Soo Hwang,
Poong‐Yeon Lee Tags: Original Article Source Type: research
Plantar pressure measurement in diabetic foot disease: A scoping review
ConclusionsPlantar pressure measurement can and will play a major role in the prevention of DFU. There is already a strong, albeit limited, evidence base in place to prove its benefit in reducing DFU recurrence. More research is required in larger populations, using remote monitoring in real-world settings, and with improved technology. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 18, 2024 Category: Endocrinology Authors: Michael Lockhart,
Sean F Dinneen,
Derek T O'Keeffe Tags: Review Source Type: research
Implementation rate of diabetic self ‐management education and support for Japanese people with diabetes using the National Database
We investigated the implementation rates of diabetes self-management education and support in outpatients using the National Database of claims data. We showed that care related to diabetes self-management education and support might not be adequately provided for Japanese patients with diabetes. Nutrition guidance (5.6%) was the most frequently provided care type, and insulin users and patients visiting large medical institutions were associated with higher implementation rates of nutrition guidance. AbstractPeople with diabetes are encouraged to receive diabetes self-management education and support (DSMES) appropriately...
Source: Journal of Diabetes Investigation - April 17, 2024 Category: Endocrinology Authors: Noriko Ihana ‐Sugiyama,
Takehiro Sugiyama,
Kenjiro Imai,
Mitsuru Ohsugi,
Kohjiro Ueki,
Toshimasa Yamauchi,
Takashi Kadowaki Tags: Short Report Source Type: research
Corrigendum to “Leucine–glycine and carnosine dipeptides prevent diabetes induced by multiple low‐doses of streptozotocin in an experimental model of adult mice”
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 14, 2024 Category: Endocrinology Tags: Corrigendum Source Type: research
Associations of fasting plasma glucose with all ‐cause mortality and cardiovascular events in older Chinese diabetes patients: A population‐based cohort study
ConclusionsIn older Chinese diabetes patients, the FPG ranges related to the minimum death and CVD event rates were 5.50 –7.50 and 4.50–7.50 mmol/L, respectively. Patients with more cardiovascular risk factors had higher optimal blood glucose ranges than those with fewer risk factors. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 10, 2024 Category: Endocrinology Authors: Linan Wang,
Wei Zhang,
Juan Dai,
Qing Deng,
Yaqiong Yan,
Qing Liu Tags: Original Article Source Type: research
