TNF- α–TNFR1 Signaling Mediates Inflammation and Bone Resorption in Apical Periodontitis
The aim of this study was to investigate the role of the proinflammatory axis TNF- α–TNFR1 in experimentally induced periapical inflammation and bone resorption in mice. (Source: Journal of Endodontics)
Source: Journal of Endodontics - July 25, 2023 Category: Dentistry Authors: Luciano Aparecido Almeida-Junior, Marcio Santos de Carvalho, Lana Kei Yamamoto Almeida, Alice Corr êa Silva-Sousa, Manoel Damião Sousa-Neto, Raquel Assed Bezerra Silva, Léa Assed Bezerra Silva, Francisco Wanderley Garcia Paula-Silva Tags: Basic Research Source Type: research
Current Management of Dens Evaginatus Teeth based on Pulpal Diagnosis
Dens evaginatus (DE) is a dental anomaly with a supernumerary tubercle projection that typically contains dentin and pulp tissue. However, the tubercle projection can fracture, exposing the dentin and potentially the dental pulp, which induces pulpal diseases. Managing DE should be primarily based on the clinical diagnosis of the pulp. The prophylactic management of the tubercle of DE teeth with a normal pulp should be performed as early as possible by the prep-and-fill technique or the reinforcement technique to preserve tooth vitality and continued root development, with the former reported to be superior compared with t...
Source: Journal of Endodontics - July 25, 2023 Category: Dentistry Authors: Kittipun Lerdrungroj, Danuchit Banomyong, Kamolthip Songtrakul, Patcharin Porkaew, Siriruk Nakornchai Tags: Review Article Source Type: research
TNF- α-TNFR1 Signaling Mediates Inflammation and Bone Resorption in Apical Periodontitis
The aim of this study was to investigate the role of the pro-inflammatory axis TNF- α-TNFR1 in experimentally-induced periapical inflammation and bone resorption in mice. (Source: Journal of Endodontics)
Source: Journal of Endodontics - July 25, 2023 Category: Dentistry Authors: Luciano Aparecido de Almeida-Junior, Marcio Santos de Carvalho, Lana Kei Yamamoto Almeida, Alice Corr êa Silva-Sousa, Manoel Damião Sousa-Neto, Raquel Assed Bezerra Silva, Léa Assed Bezerra Silva, Francisco Wanderley Garcia de Paula-Silva Tags: Basic Research-Biology Source Type: research
Genome-wide association study identifies novel risk loci for apical periodontitis
Apical periodontitis (AP) is a common consequence of root canal infection leading to periapical bone resorption. Microbial and host genetic factors, and their interactions, have been shown to play a role in AP development and progression. Variations in a few genes have been reported in association with AP, however, the lack of genome-wide studies has hindered progress in understanding the mechanisms involved in AP. Here, we report the first genome-wide association study of AP in a large and well-characterized population. (Source: Journal of Endodontics)
Source: Journal of Endodontics - July 25, 2023 Category: Dentistry Authors: L.E. Petty, R. Silva, L. Chaves de Souza, A.R. Vieira, D.M. Shaw, J.E. Below, A. Letra Tags: Clinical Research Source Type: research
Process-Related Factors are as Important as Outcomes for Patients Undergoing Nonsurgical Root Canal Treatment, Nonsurgical Root Canal Retreatment, and Endodontic Microsurgery
There is considerable variation in the reporting of treatment outcomes in endodontics. Patient-centered outcomes are often inadequately reported in endodontic outcome studies. This paper explores patients ’ expectations and reported outcomes in nonsurgical root canal treatment (NS-RCT), nonsurgical root canal retreatment (NS-ReTx), and endodontic microsurgery (EMS). (Source: Journal of Endodontics)
Source: Journal of Endodontics - July 21, 2023 Category: Dentistry Authors: Maryam Zanjir, Amir Azarpazhooh, Yasaman Hosseini, Elaine Cardoso, Carilynne Yarascavitch, Prakesh S. Shah, Joanna Sale Tags: Clinical Research Source Type: research
Enhancement of Antimicrobial Effect of Endodontic Sealers Using Nanoparticles: A Systematic Review
The elimination of biofilms during root canal therapy continues to pose a challenge due to complex anatomies and un-instrumented portions of the root canal system. The incorporation of nanoparticles in endodontic sealers is an area of interest for potentially enhancing antimicrobial activity and improving treatment outcomes. This systematic review evaluated the antimicrobial effects of various nanoparticles in endodontic sealers. (Source: Journal of Endodontics)
Source: Journal of Endodontics - July 20, 2023 Category: Dentistry Authors: Kisa Iqbal, Rami Alhomrany, Louis H. Berman, Sami Chogle Tags: Review Article Source Type: research
Influence of a Metal Artifact Reduction Filter on The Diagnostic Accuracy of Complete and Incomplete Vertical Root Fractures
This study aimed to assess the influence of the e-vol DX BAR filter on the diagnostic accuracy of complete and incomplete vertical root fractures (VRFs). (Source: Journal of Endodontics)
Source: Journal of Endodontics - July 19, 2023 Category: Dentistry Authors: Luiz Carlos de Lima Dias-Junior, Marcio Correa, Olavo Cesar Lyra Porto, Carlos Estrela, Cleonice da Silveira Teixeira, Lucas da Fonseca Roberti Garcia, Eduardo Antunes Bortoluzzi Tags: Basic Research-Technology Source Type: research
Successful root canal treatment of an atypical mandibular canine with a boomerang-shaped root and canal system with a large periapical lesion —A case report with 9-year follow-up
This report describes an atypical mandibular canine with a single boomerang-shaped root and root canal system with a large periapical lesion managed by root canal treatment. (Source: Journal of Endodontics)
Source: Journal of Endodontics - July 17, 2023 Category: Dentistry Authors: Jos é Antonio González Sánchez, Montserrat Munill Ferrer, Nandini Suresh, Venkateshbabu Nagendrababu, Paul M.H. Dummer, Marc Garcia-Font, Francesc Abella Sans Tags: Case Report/Clinical Techniques Source Type: research
Management of apico-marginal defects with endodontic microsurgery and guided tissue regeneration: a report of thirteen cases
The loss of periodontal tissue support and vertical buccal bone loss in apico-marginal defects can often be mistaken for features indicative of vertical root fractures and this study reports thirteen cases with persistent symptomatic apical periodontitis, apico-marginal defects, and large periapical lesions that were managed with endodontic microsurgery in conjunction with bone grafts and barrier placements with a follow-up period of up to 9 years. At the recall sessions, all cases were asymptomatic with radiographical success with only two cases exhibiting residual apical radiolucency, but with evident reduction in the le...
Source: Journal of Endodontics - July 17, 2023 Category: Dentistry Authors: Abayomi O. Baruwa, Jorge N.R. Martins, Mariana D. Pires, Beatriz Pereira, Pedro May Cruz, Ant ónio Ginjeira Tags: Case Report/Clinical Techniques Source Type: research
Metformin reduces bone resorption in apical periodontitis through regulation of osteoblast and osteoclast differentiation
We have previously demonstrated that auxiliary metformin therapy promotes healing of apical periodontitis. Here we aimed to investigate the effects of metformin on osteoblast differentiation and osteoclast formation in cultured cells and rat apical periodontitis. (Source: Journal of Endodontics)
Source: Journal of Endodontics - July 13, 2023 Category: Dentistry Authors: Chi-Yuan Hong, Sze-Kwan Lin, Han-Wei Wang, Chia-Tung Shun, Cheng-Ning Yang, Eddie Hsiang-Hua Lai, Shih-Jung Cheng, Mu-Hsiung Chen, Hsiang Yang, Hung-Ying Lin, Fang-Yu Wu, Sang-Heng Kok Tags: Basic Research-Biology Source Type: research
Augmented Reality and 3-dimensional Dynamic Navigation System Integration for Osteotomy and Root-end Resection
This study investigates the feasibility of integrating an augmented reality head-mounted device (AR) into a 3-dimensional dynamic navigation system (3D-DNS) for osteotomy and root-end resection (RER). It compares the accuracy and efficiency of AR + 3D-DNS to 3D-DNS for osteotomy and RER. (Source: Journal of Endodontics)
Source: Journal of Endodontics - July 13, 2023 Category: Dentistry Authors: Frederico C. Martinho, Ina L. Griffin, Jeffery B. Price, Patricia A. Tordik Tags: Basic Research-Technology Source Type: research
Flare-ups After Nonsurgical Retreatments: Incidence, Associated Factors, and Prediction
The aims of this study were to determine the incidence, associated factors, and predictability of flare-ups after nonsurgical retreatments (NSRetx). (Source: Journal of Endodontics)
Source: Journal of Endodontics - July 12, 2023 Category: Dentistry Authors: Ali Nosrat, Michael Valancius, Sahar Mehrzad, Omid Dianat, Prashant Verma, Anita Aminoshariae, Ashraf F. Fouad Tags: Clinical Research Source Type: research
Flare-ups after Non-surgical Retreatments: Incidence, Associated Factors, and Prediction
The aims of this study were to determine the incidence, associated factors, and predictability of flare-ups after non-surgical retreatments (NSRetx). (Source: Journal of Endodontics)
Source: Journal of Endodontics - July 12, 2023 Category: Dentistry Authors: Ali Nosrat, Michael Valancius, Sahar Mehrzad, Omid Dianat, Prashant Verma, Anita Aminoshariae, Ashraf F. Fouad Tags: Clinical Research Source Type: research
Could low-dose cone-beam ct be used for endodontic intraoperative diagnosis?
Cone-beam CT (CBCT) allows three-dimensional evaluation and has high diagnostic accuracy of endodontic conditions. Considering that the most indicated protocol for endodontics should have smaller field-of-view and higher spatial resolution, a higher radiation dose may be associated. Thus, this study evaluated the accuracy of an optimized CBCT protocol for the detection of intraoperative endodontic complications. (Source: Journal of Endodontics)
Source: Journal of Endodontics - July 12, 2023 Category: Dentistry Authors: Jo ão Pedro de Lima, Jardel Francisco Mazzi-Chaves, Manoel Damião de Sousa-Neto, Amanda Pelegrin Candemil Tags: Basic Research-Technology Source Type: research
Outcome of Partial Pulpotomy in Immature Permanent Teeth with Symptomatic Irreversible Pulpitis: A Prospective Case Series Assessment
The aim of this prospective case series was to assess the clinical and radiographic outcome of partial pulpotomy in caries-exposed symptomatic, vital, immature, permanent molars. (Source: Journal of Endodontics)
Source: Journal of Endodontics - July 11, 2023 Category: Dentistry Authors: Giorgos N. Tzanetakis, Stela Papanakou, Despina Koletsi, Maria Georgopoulou Tags: Regenerative Endodontics Source Type: research
