Clinical Characteristics of EGPA Patients in Comparison to GPA Subgroup with Increased Blood Eosinophilia from POLVAS Registry
CONCLUSION: Cardiovascular symptoms were more prevalent in the ANCA-negative subset than in the MPO-ANCA-positive one. Since EGPA and GPE HE share similarities in clinics, diagnostic misleading may result in an inappropriate therapeutic approach. Further studies are needed to optimize their differentiation and tailored therapy, including biologics.PMID:38699219 | PMC:PMC11065486 | DOI:10.1155/2024/4283928 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - May 3, 2024 Category: Allergy & Immunology Authors: Anna Drynda Agnieszka Padjas Krzysztof W ójcik Rados ław Dziedzic Grzegorz Biedro ń Katarzyna Wawrzycka-Adamczyk Anna W łudarczyk Joanna Wila ńska Jacek Musia ł Zbigniew Zdrojewski Zenobia Czuszy ńska Anna Masiak Maria Majdan Rados ław Jeleniewicz Source Type: research
CD4 < sup > + < /sup > T and CD8 < sup > + < /sup > T Cells in Uterus Exhibit Both Selective Dysfunction and Residency Signatures
In this study, we fully compared the immunological properties of αβT cells between uterus and blood using mouse and human sample. It showed that most of CD4+T cells and CD8+T cells in murine uterus and human endometrium were tissue resident memory T cells which highly expressed tissue residence markers CD69 and/or CD103. In addition, both CD4+T cells and CD8+T cells in uterus highly expressed inhibitory molecular PD-1 and cytokine IFN-γ. Uterine CD4+T cells highly expressed IL-17 and modulated by transcription factor pSTAT3. Moreover, we compared the similarities and differences between human and murine uterine T cell p...
Source: Journal of Immunology Research - May 1, 2024 Category: Allergy & Immunology Authors: Shuangpeng Kang Shuiping Jin Xueying Mao BinSheng He Changyou Wu Source Type: research
Protein Expression of TLR2, TLR4, and TLR9 on Monocytes in TB, HIV, and TB/HIV
J Immunol Res. 2024 Apr 17;2024:9399524. doi: 10.1155/2024/9399524. eCollection 2024.ABSTRACTToll-like receptors (TLRs) have a critical role in recognizing pathogenic patterns and initiating immune responses against TB and HIV. Previously, studies described the gene expression of TLRs in patients with TB and HIV. Here, we demonstrated TLRs protein expressions and their association with clinical status and plasma markers in TB, HIV, and TB/HIV coinfection. The phenotyping of TLR2, TLR4, and TLR9 on CD14+ monocytes and their subsets were determined by multicolor flow cytometry. Host plasma biomarkers and microbial indices we...
Source: Journal of Immunology Research - April 25, 2024 Category: Allergy & Immunology Authors: Wegene Tamene Liya Wassie Vincent C Marconi Meseret Abebe Amha Kebede Ulrich Sack Rawleigh Howe Source Type: research
The Question of HIV Vaccine: Why Is a Solution Not Yet Available?
J Immunol Res. 2024 Apr 8;2024:2147912. doi: 10.1155/2024/2147912. eCollection 2024.ABSTRACTEver since its discovery, human immunodeficiency virus type 1 (HIV-1) infection has remained a significant public health concern. The number of HIV-1 seropositive individuals currently stands at 40.1 million, yet definitive treatment for the virus is still unavailable on the market. Vaccination has proven to be a potent tool in combating infectious diseases, as evidenced by its success against other pathogens. However, despite ongoing efforts and research, the unique viral characteristics have prevented the development of an effecti...
Source: Journal of Immunology Research - April 17, 2024 Category: Allergy & Immunology Authors: Martina Libera Valeria Caputo Giulia Laterza Louiza Moudoud Alessio Soggiu Luigi Bonizzi Roberta A Diotti Source Type: research
Dendritic Cell-Based Immunotherapy: The Importance of Dendritic Cell Migration
J Immunol Res. 2024 Apr 8;2024:7827246. doi: 10.1155/2024/7827246. eCollection 2024.ABSTRACTDendritic cells (DCs) are specialized antigen-presenting cells that are crucial for maintaining self-tolerance, initiating immune responses against pathogens, and patrolling body compartments. Despite promising aspects, DC-based immunotherapy faces challenges that include limited availability, immune escape in tumors, immunosuppression in the tumor microenvironment, and the need for effective combination therapies. A further limitation in DC-based immunotherapy is the low population of migratory DC (around 5%-10%) that migrate to ly...
Source: Journal of Immunology Research - April 17, 2024 Category: Allergy & Immunology Authors: Min-Seon Song Ji-Hee Nam Kyung-Eun Noh Dae-Seog Lim Source Type: research
The Question of HIV Vaccine: Why Is a Solution Not Yet Available?
J Immunol Res. 2024 Apr 8;2024:2147912. doi: 10.1155/2024/2147912. eCollection 2024.ABSTRACTEver since its discovery, human immunodeficiency virus type 1 (HIV-1) infection has remained a significant public health concern. The number of HIV-1 seropositive individuals currently stands at 40.1 million, yet definitive treatment for the virus is still unavailable on the market. Vaccination has proven to be a potent tool in combating infectious diseases, as evidenced by its success against other pathogens. However, despite ongoing efforts and research, the unique viral characteristics have prevented the development of an effecti...
Source: Journal of Immunology Research - April 17, 2024 Category: Allergy & Immunology Authors: Martina Libera Valeria Caputo Giulia Laterza Louiza Moudoud Alessio Soggiu Luigi Bonizzi Roberta A Diotti Source Type: research
Dendritic Cell-Based Immunotherapy: The Importance of Dendritic Cell Migration
J Immunol Res. 2024 Apr 8;2024:7827246. doi: 10.1155/2024/7827246. eCollection 2024.ABSTRACTDendritic cells (DCs) are specialized antigen-presenting cells that are crucial for maintaining self-tolerance, initiating immune responses against pathogens, and patrolling body compartments. Despite promising aspects, DC-based immunotherapy faces challenges that include limited availability, immune escape in tumors, immunosuppression in the tumor microenvironment, and the need for effective combination therapies. A further limitation in DC-based immunotherapy is the low population of migratory DC (around 5%-10%) that migrate to ly...
Source: Journal of Immunology Research - April 17, 2024 Category: Allergy & Immunology Authors: Min-Seon Song Ji-Hee Nam Kyung-Eun Noh Dae-Seog Lim Source Type: research
The Question of HIV Vaccine: Why Is a Solution Not Yet Available?
J Immunol Res. 2024 Apr 8;2024:2147912. doi: 10.1155/2024/2147912. eCollection 2024.ABSTRACTEver since its discovery, human immunodeficiency virus type 1 (HIV-1) infection has remained a significant public health concern. The number of HIV-1 seropositive individuals currently stands at 40.1 million, yet definitive treatment for the virus is still unavailable on the market. Vaccination has proven to be a potent tool in combating infectious diseases, as evidenced by its success against other pathogens. However, despite ongoing efforts and research, the unique viral characteristics have prevented the development of an effecti...
Source: Journal of Immunology Research - April 17, 2024 Category: Allergy & Immunology Authors: Martina Libera Valeria Caputo Giulia Laterza Louiza Moudoud Alessio Soggiu Luigi Bonizzi Roberta A Diotti Source Type: research
