Safety of empirical antibiotic therapy discontinuing for fever of unknown origin during high-risk neutropenia in children
ECIL-2021 recommends discontinuing empirical antibiotic therapy (EAT) in febrile-neutropenic children after 72h of treatment and at least 24-48h of apyrexia in the case of fever of unknown origin (FUO). These guidelines are rarely applied to high-risk children's neutropenia. (Source: Journal of Infection)
Source: Journal of Infection - April 30, 2024 Category: Infectious Diseases Authors: Lemaigre Cl ément, Deutch Hélène, Meligne Maud, Dupraz Chrystelle, Bridonneau Constance, Millot Fréderic, Roblot France, Gallego-Hernanz Maria Pilar, Torregrosa-Diaz José-Miguel, Rammaert Blandine Source Type: research
Enteropathogenic Viruses associated with Acute Gastroenteritis among African Children under 5 years of age: A Systematic Review and Meta-analysis
We present data from thirty-three (33) eligible studies published between 2003 and 2023 from African countries bearing the brunt of the virus-associated diarrheal mortality. Random effects meta-analysis with proportion, subgroups, and meta-regression analyses were employed. Overall, rotavirus with estimated pooled prevalence of 31.0% (95% CI 24.0 –39.0) predominated in all primary care visits and hospitalizations, followed by norovirus, adenovirus, sapovirus, astrovirus, and aichivirus with pooled prevalence estimated at 15.0% (95% CI 12.0–20.0), 10% (95% CI 6-15), 4.0% (95% CI 2.0–6.0), 4% (95% CI 3-6), and 2.3% (95...
Source: Journal of Infection - April 29, 2024 Category: Infectious Diseases Authors: Cornelius Arome Omatola, Ropo Ebenezer Ogunsakin, Anyebe Bernard Onoja, Martin-Luther Oseni Okolo, Joseph Abraham-Oyiguh, Kehinde Charles Mofolorunso, Phoebe Queen Akoh, Omebije Patience Adejo, Joshua Idakwo, Therisa Ojomideju Okeme, Danjuma Muhammed, Dav Source Type: research
Nanopore sequencing of influenza A and B in Oxfordshire and the United Kingdom, 2022-23
We evaluated Nanopore sequencing for influenza surveillance. (Source: Journal of Infection)
Source: Journal of Infection - April 29, 2024 Category: Infectious Diseases Authors: Jennifer Cane, Nicholas Sanderson, Sophie Barnett, Ali Vaughan, Megan Pott, Natalia Kapel, Marcus Morgan, Gerald Jesuthasan, Reggie Samuel, Muhammad Ehsaan, Hugh Boothe, Eric Haduli, Ruth Studley, Emma Rourke, Ian Diamond, Tom Fowler, Conall Watson, Nicol Source Type: research
Population incidence and associated mortality of urinary tract infection in people living with dementia
Urinary tract infections (UTIs) frequently cause hospitalisation and death in people living with dementia (PLWD). We examine UTI incidence and associated mortality among PLWD relative to matched controls and people with diabetes and investigate whether delayed or withheld treatment further impacts mortality. (Source: Journal of Infection)
Source: Journal of Infection - April 26, 2024 Category: Infectious Diseases Authors: Helen Lai, Magdalena Kolanko, Lucia M Li, Megan E Parkinson, Niall J Bourke, Neil SN Graham, Michael CB David, Emma-Jane Mallas, Bowen Su, Sarah Daniels, Danielle Wilson, Mara Golemme, Claire Norman, Kirsten Jensen, Raphaella Jackson, Martin Tran, Paul S Source Type: research
Corrigendum to: “People living with HIV who have poor immune status are a key population for SARS-CoV-2 prevention” Journal of Infection, Volume 88, Issue 3, March 2024, 106122
The authors regret that the originally published acknowledgements section was missing some information. Please see the correct version below: (Source: Journal of Infection)
Source: Journal of Infection - April 24, 2024 Category: Infectious Diseases Authors: Jie Zhou, Liuyan Lan, Sufang Ai, Jianyan Lin, Ningmei Liu, Yulan Xie, Ping Cui, Hao Liang, Li Ye, Jiegang Huang, Zhiman Xie Source Type: research
Temporal variations in the serogroup distribution of invasive meningococcal disease in Quebec, Canada, due to emerging unique clade of serogroup Y strain belonging to the Sequence Type-23 clonal complex.
To identify recent trends in invasive meningococcal diseases (IMD) in Quebec, Canada, with a focus on MenY cases and MenY strains. (Source: Journal of Infection)
Source: Journal of Infection - April 23, 2024 Category: Infectious Diseases Authors: Raymond S.W. Tsang, Genevieve Deceuninck, Courtney Meilleur, Jianwei Zhou, Brigitte Lefebvre, Philippe De Wals Tags: Bacteria and Bacterial Diseases Source Type: research
Heterologous and BNT162b2 boosters are more effective than non-mRNA homologous boosters for Omicron
Dear Editor, (Source: Journal of Infection)
Source: Journal of Infection - April 23, 2024 Category: Infectious Diseases Authors: Angel Paternina-Caicedo, David Santiago Quevedo, Diana Sof ía Ríos, Diane Moyano, Nelson Alvis-Guzmán, Nelson Rafael Alviz-Zakzuk, Fernando Salcedo, Javier Ramírez-Suarez, Adrian D Smith, Fernando De la Hoz-Restrepo Source Type: research
Molecular Rapid Diagnostic Testing for Bloodstream Infections: Nanopore Targeted Sequencing with Pathogen-Specific Primers
Nanopore sequencing, known for real-time analysis, shows promise for rapid clinical infection diagnosis but lacks effective assays for bloodstream infections (BSIs). (Source: Journal of Infection)
Source: Journal of Infection - April 23, 2024 Category: Infectious Diseases Authors: Dongsheng Han, Fei Yu, Dan Zhang, Juan Hu, Xuan Zhang, Dairong Xiang, Bin Lou, Yu Chen, Shufa Zheng Source Type: research
Understanding the potential role of whole genome sequencing (WGS) in managing patients with gonorrhoea: A systematic review of WGS use on human pathogens in individual patient care
The utility of whole genome sequencing (WGS) to inform sexually transmitted infection (STI) patient management is unclear. Timely WGS data might support clinical management of STIs by characterising epidemiological links and antimicrobial resistance profiles. We conducted a systematic review of clinical application of WGS to any human pathogen that may be transposable to gonorrhoea. (Source: Journal of Infection)
Source: Journal of Infection - April 23, 2024 Category: Infectious Diseases Authors: Roeann Osman, Emily Dema, Alexandra David, Gwenda Hughes, Nigel Field, Michelle Cole, Xavier Didelot, John Saunders Source Type: research
No evidence of difference in mortality with amoxicillin versus co-amoxiclav for hospital treatment of community-acquired pneumonia
Current guidelines recommend broad-spectrum antibiotics for high-severity community-acquired pneumonia (CAP), potentially contributing to antimicrobial resistance (AMR). We aim to compare outcomes in CAP patients treated with amoxicillin (narrow-spectrum) versus co-amoxiclav (broad-spectrum), to understand if narrow-spectrum antibiotics could be used more widely. (Source: Journal of Infection)
Source: Journal of Infection - April 23, 2024 Category: Infectious Diseases Authors: Jia Wei, Aashna Uppal, Christy Nganjimi, Hermione Warr, Yasin Ibrahim, Qingze Gu, Hang Yuan, Najib M Rahman, Nicola Jones, A Sarah Walker, David W Eyre Source Type: research
Risk factors for Nocardia infection among allogeneic hematopoietic cell transplant recipients: A case-control study of the Infectious Diseases Working Party of the European Society for Blood and Marrow Transplantation
Nocardiosis is a rare but life-threatening infection after hematopoietic cell transplantation (HCT). We aimed at identifying risk factors for nocardiosis after allogeneic HCT and clarifying the effect of trimethoprim-sulfamethoxazole prophylaxis on its occurrence. (Source: Journal of Infection)
Source: Journal of Infection - April 23, 2024 Category: Infectious Diseases Authors: Julien De Greef, Dina Averbuch, Laura Tondeur, Am élie Duréault, Tsila Zuckerman, Xavier Roussel, Christine Robin, Alienor Xhaard, Simona Pagliuca, Yves Beguin, Carmen Botella-Garcia, Nina Khanna, Amandine Le Bourgeois, Jens Van Praet, Aloysius Ho, Nico Source Type: research
Infections in preschool and school-aged children are driving the recent rise in pertussis in China
Dear editor, (Source: Journal of Infection)
Source: Journal of Infection - April 23, 2024 Category: Infectious Diseases Authors: Yahong Hu, Mengyang Guo, Kaihu Yao Source Type: research
Integrated single-cell transcriptome and T cell receptor profiling reveals defects of T cell exhaustion in pulmonary tuberculosis
Tuberculosis-affected lungs with chronic inflammation harbor abundant immunosuppressive immune cells but the nature of such inflammation is unclear. Dysfunction in T cell exhaustion, while implicated in chronic inflammatory diseases, remains unexplored in tuberculosis. Given that immunotherapy targeting exhaustion checkpoints exacerbates tuberculosis, we speculate that T cell exhaustion is dysfunctional in tuberculosis. Using integrated single-cell RNA sequencing and T cell receptor profiling we reported defects in exhaustion responses within inflamed tuberculosis-affected lungs. (Source: Journal of Infection)
Source: Journal of Infection - April 18, 2024 Category: Infectious Diseases Authors: Zilu Wen, Lin Wang, Hui Ma, Leilei Li, Laiyi Wan, Lei Shi, Hongwei Li, Hui Chen, Wentao Hao, Shu Song, Qinghua Xue, Yutong Wei, Feng Li, Jianqing Xu, Shulin Zhang, Ka-Wing Wong, Yanzheng Song Tags: Bacteria and Bacterial Diseases Source Type: research
Performance of the Galactomannan Test for the Diagnosis of Invasive Pulmonary Aspergillosis using Non-invasive Proximal Airway Samples
To diagnose invasive pulmonary aspergillosis (IPA), galactomannan (GM) detection in serum or bronchoalveolar lavage fluid (BALF) is widely used. However, the utility of proximal airway GM test (from induced sputum or tracheal aspirate) has not been well elucidated. (Source: Journal of Infection)
Source: Journal of Infection - April 17, 2024 Category: Infectious Diseases Authors: June Young Chun, Sahng-Joon Jeong, Sinae Kim, Soyoung Choi, Jong Hyuk Lee, Hyun Sung Chung, Seungman Park, Hyewon Lee, Hyae Young Kim, Bin Hwangbo, Young Ju Choi Source Type: research
The Potential Value of a Quantitative PCR Assay for Assessing Respiratory Samples in Approaching a Laboratory Diagnosis of Pulmonary Mucormycosis
Dear Editor, (Source: Journal of Infection)
Source: Journal of Infection - April 17, 2024 Category: Infectious Diseases Authors: Ya-Ping Chen, Cong-Tat Cia, Ya-Ting Hsu, Po-Lin Chen, Tsai-Yun Chen, Jen-Chieh Lee, Sin-Syue Li, Ming-I Hsieh, Hsuan-Chen Wang, Chi-Jung Wu Tags: Letter to the Editor Source Type: research
