Emerging evidence of context-dependent synapse elimination by phagocytes in the CNS
J Leukoc Biol. 2024 May 3:qiae098. doi: 10.1093/jleuko/qiae098. Online ahead of print.ABSTRACTPrecise synapse elimination is essential for the establishment of a fully developed neural circuit during brain development and higher function in adult brain. Beyond immune and nutrition support, recent groundbreaking studies have revealed that phagocytic microglia and astrocytes can actively and selectively eliminate synapses in normal and diseased brains, thereby mediating synapse loss and maintaining circuit homeostasis. Multiple lines of evidence indicate that the mechanisms of synapse elimination by phagocytic glia are not u...
Source: Journal of Leukocyte Biology - May 3, 2024 Category: Hematology Authors: Fang-Shuai Shen Cui Liu Hui-Zhe Sun Xin-Yi Chen Yan Xue Lei Chen Source Type: research
Eosinophil biology from the standpoint of metabolism: implications for metabolic disorders and asthma
J Leukoc Biol. 2024 May 3:qiae100. doi: 10.1093/jleuko/qiae100. Online ahead of print.ABSTRACTEosinophils, recognized for their immune and remodeling functions and participation in allergic inflammation, have recently garnered attention due to their impact on host metabolism, especially in the regulation of adipose tissue. Eosinophils are now known for their role in adipocyte beiging, adipokine secretion, and adipose tissue inflammation. This intricate interaction involves complex immune and metabolic processes, carrying significant implications for systemic metabolic health. Importantly, the interplay between eosinophils ...
Source: Journal of Leukocyte Biology - May 3, 2024 Category: Hematology Authors: Nana-Fatima Haruna Sergejs Berdnikovs Zhenying Nie Source Type: research
The aryl hydrocarbon receptor (AHR) repressor limits expression of antimicrobial genes but not AHR-dependent genes in intestinal eosinophils
J Leukoc Biol. 2024 May 3:qiae105. doi: 10.1093/jleuko/qiae105. Online ahead of print.ABSTRACTIntestinal eosinophils express the aryl hydrocarbon receptor (AHR), an environmental sensor and ligand-activated transcription factor that responds to dietary or environmental ligands. AHR regulates tissue adaptation, survival, adhesion, and immune functions in intestinal eosinophils. The AHR repressor (AHRR) is itself induced by AHR and believed to limit AHR activity in a negative feedback loop. We analysed gene expression in intestinal eosinophils from WT and AHRR-KO mice and found that AHRR did not suppress most AHR-dependent g...
Source: Journal of Leukocyte Biology - May 3, 2024 Category: Hematology Authors: Heike Weighardt Michael Shapiro Michelle Mayer Irmgard F örster Brigitta Stockinger Nicola Laura Diny Source Type: research
Not just for lymphoid cells: The role of the noncanonical NF- κB signaling pathway in early and late myelopoiesis with a focus on hypereosinophilic disorders
J Leukoc Biol. 2024 Apr 29:qiae101. doi: 10.1093/jleuko/qiae101. Online ahead of print.ABSTRACTThe noncanonical NF-κB pathway is involved in lymphoid organ development, B cell maturation, and cytokine production. However, new research has demonstrated that this pathway is also key for the orderly and sequential maturation of myeloid cells, including neutrophils and eosinophils. When this pathway is disrupted or constitutively activated, aberrations in hematopoietic stem and progenitor cell (HSPC) survival and proliferation, as well as subsequent granulopoiesis and eosinophilopoiesis are affected. Disturbance of such a coo...
Source: Journal of Leukocyte Biology - April 29, 2024 Category: Hematology Authors: Brie Trusiano Kurt L Zimmerman Holly A Morrison Irving C Allen Source Type: research
Not just for lymphoid cells: The role of the noncanonical NF- κB signaling pathway in early and late myelopoiesis with a focus on hypereosinophilic disorders
J Leukoc Biol. 2024 Apr 29:qiae101. doi: 10.1093/jleuko/qiae101. Online ahead of print.ABSTRACTThe noncanonical NF-κB pathway is involved in lymphoid organ development, B cell maturation, and cytokine production. However, new research has demonstrated that this pathway is also key for the orderly and sequential maturation of myeloid cells, including neutrophils and eosinophils. When this pathway is disrupted or constitutively activated, aberrations in hematopoietic stem and progenitor cell (HSPC) survival and proliferation, as well as subsequent granulopoiesis and eosinophilopoiesis are affected. Disturbance of such a coo...
Source: Journal of Leukocyte Biology - April 29, 2024 Category: Hematology Authors: Brie Trusiano Kurt L Zimmerman Holly A Morrison Irving C Allen Source Type: research
Not just for lymphoid cells: The role of the noncanonical NF- κB signaling pathway in early and late myelopoiesis with a focus on hypereosinophilic disorders
J Leukoc Biol. 2024 Apr 29:qiae101. doi: 10.1093/jleuko/qiae101. Online ahead of print.ABSTRACTThe noncanonical NF-κB pathway is involved in lymphoid organ development, B cell maturation, and cytokine production. However, new research has demonstrated that this pathway is also key for the orderly and sequential maturation of myeloid cells, including neutrophils and eosinophils. When this pathway is disrupted or constitutively activated, aberrations in hematopoietic stem and progenitor cell (HSPC) survival and proliferation, as well as subsequent granulopoiesis and eosinophilopoiesis are affected. Disturbance of such a coo...
Source: Journal of Leukocyte Biology - April 29, 2024 Category: Hematology Authors: Brie Trusiano Kurt L Zimmerman Holly A Morrison Irving C Allen Source Type: research
Not just for lymphoid cells: The role of the noncanonical NF- κB signaling pathway in early and late myelopoiesis with a focus on hypereosinophilic disorders
J Leukoc Biol. 2024 Apr 29:qiae101. doi: 10.1093/jleuko/qiae101. Online ahead of print.ABSTRACTThe noncanonical NF-κB pathway is involved in lymphoid organ development, B cell maturation, and cytokine production. However, new research has demonstrated that this pathway is also key for the orderly and sequential maturation of myeloid cells, including neutrophils and eosinophils. When this pathway is disrupted or constitutively activated, aberrations in hematopoietic stem and progenitor cell (HSPC) survival and proliferation, as well as subsequent granulopoiesis and eosinophilopoiesis are affected. Disturbance of such a coo...
Source: Journal of Leukocyte Biology - April 29, 2024 Category: Hematology Authors: Brie Trusiano Kurt L Zimmerman Holly A Morrison Irving C Allen Source Type: research
CD226 promotes renal fibrosis by regulating macrophage activation and migration
J Leukoc Biol. 2024 Apr 25:qiae054. doi: 10.1093/jleuko/qiae054. Online ahead of print.ABSTRACTIt has been found that CD226 plays an important role in regulating macrophage function, but its expression and function in macrophages during renal fibrogenesis have not been studied. Our data demonstrated that CD226 expression in macrophages was obviously upregulated in the unilateral ureteral obstruction model, while CD226 deficiency attenuated collagen deposition in renal interstitium along with fewer M1 within renal cortex and renal medulla and a lower level of proinflammatory factors compared to that of control littermates. ...
Source: Journal of Leukocyte Biology - April 25, 2024 Category: Hematology Authors: Yun Song Yazhen Wang Juan Li Yuting Shen Yongli Hou Zhaoyue Fu Liang Fang Boquan Jin Lihua Chen Source Type: research
CD226 promotes renal fibrosis by regulating macrophage activation and migration
J Leukoc Biol. 2024 Apr 25:qiae054. doi: 10.1093/jleuko/qiae054. Online ahead of print.ABSTRACTIt has been found that CD226 plays an important role in regulating macrophage function, but its expression and function in macrophages during renal fibrogenesis have not been studied. Our data demonstrated that CD226 expression in macrophages was obviously upregulated in the unilateral ureteral obstruction model, while CD226 deficiency attenuated collagen deposition in renal interstitium along with fewer M1 within renal cortex and renal medulla and a lower level of proinflammatory factors compared to that of control littermates. ...
Source: Journal of Leukocyte Biology - April 25, 2024 Category: Hematology Authors: Yun Song Yazhen Wang Juan Li Yuting Shen Yongli Hou Zhaoyue Fu Liang Fang Boquan Jin Lihua Chen Source Type: research
CD226 promotes renal fibrosis by regulating macrophage activation and migration
J Leukoc Biol. 2024 Apr 25:qiae054. doi: 10.1093/jleuko/qiae054. Online ahead of print.ABSTRACTIt has been found that CD226 plays an important role in regulating macrophage function, but its expression and function in macrophages during renal fibrogenesis have not been studied. Our data demonstrated that CD226 expression in macrophages was obviously upregulated in the unilateral ureteral obstruction model, while CD226 deficiency attenuated collagen deposition in renal interstitium along with fewer M1 within renal cortex and renal medulla and a lower level of proinflammatory factors compared to that of control littermates. ...
Source: Journal of Leukocyte Biology - April 25, 2024 Category: Hematology Authors: Yun Song Yazhen Wang Juan Li Yuting Shen Yongli Hou Zhaoyue Fu Liang Fang Boquan Jin Lihua Chen Source Type: research
CD226 promotes renal fibrosis by regulating macrophage activation and migration
J Leukoc Biol. 2024 Apr 25:qiae054. doi: 10.1093/jleuko/qiae054. Online ahead of print.ABSTRACTIt has been found that CD226 plays an important role in regulating macrophage function, but its expression and function in macrophages during renal fibrogenesis have not been studied. Our data demonstrated that CD226 expression in macrophages was obviously upregulated in the unilateral ureteral obstruction model, while CD226 deficiency attenuated collagen deposition in renal interstitium along with fewer M1 within renal cortex and renal medulla and a lower level of proinflammatory factors compared to that of control littermates. ...
Source: Journal of Leukocyte Biology - April 25, 2024 Category: Hematology Authors: Yun Song Yazhen Wang Juan Li Yuting Shen Yongli Hou Zhaoyue Fu Liang Fang Boquan Jin Lihua Chen Source Type: research
N6-Methyladenosine Promotes TNF mRNA Degradation In CD4+ T Lymphocytes
J Leukoc Biol. 2024 Apr 24:qiae087. doi: 10.1093/jleuko/qiae087. Online ahead of print.ABSTRACTN6-methyladenosine (m6A) is a RNA modification that can regulate post-transcriptional processes including RNA stability, translation, splicing and nuclear export. In CD4+ lymphocytes, m6A modifications have been demonstrated to play a role in early differentiation processes. The role of m6A in CD4+ T cell activation and effector function remains incompletely understood. To assess the role of m6A in CD4+ T lymphocyte activation and function, we assessed the transcriptome-wide m6A landscape of human primary CD4+ T cells by methylat...
Source: Journal of Leukocyte Biology - April 24, 2024 Category: Hematology Authors: Ellen C N van Vroonhoven Lucas W Picavet Rianne C Scholman Lyanne J P M Sijbers Corlinda R E Kievit Noortje A M van den Dungen Michal Mokry Anouk Evers Robert J Lebbink Enric Mocholi Paul J Coffer Jorg J A Calis Sebastiaan J Vastert Jorg van Loosdregt Source Type: research
Lack of mTORC2 signalling in CD11c+ myeloid cells inhibits their migration and ameliorates experimental colitis
J Leukoc Biol. 2024 Apr 23:qiae084. doi: 10.1093/jleuko/qiae084. Online ahead of print.ABSTRACTThe Mammalian Target of Rapamycin (mTOR) pathway plays a key role in determining immune cells function through modulation of their metabolic status. By specific deletion of Rictor in CD11c+ myeloid cells (referred to here as CD11cRicΔ/Δ), this study investigated the role of mTOR complex 2 (mTORC2) signalling in dendritic cells (DCs) function in mice. We showed that upon DSS-induced colitis, lack of mTORC2 signalling CD11c+ cells diminishes colitis score, and abrogates dendritic cell (DC) migration to the mesenteric lymph nodes ...
Source: Journal of Leukocyte Biology - April 23, 2024 Category: Hematology Authors: Aline Ignacio Marcella Cipelli Tatiane Takiishi Cristhiane Favero Aguiar Fernanda Fernandes Terra Bruno Ghirotto Eloisa Martins Silva Angela Castoldi Yuli Thamires Magalh ães Tiago Antonio Barbara Nunes Padovani Meire Ioshie Hiyane Vinicius Andrade-Olive Source Type: research
Comprehensive Analysis of Immune Signatures in Primary Biliary Cholangitis and Autoimmune Hepatitis
In conclusion, our analyses reveal that PBC and AIH share similarities and differences regarding to immune profiles. And γδ T, TIGIT+Vδ2 T, and Tfh1 cell frequencies are potential noninvasive immunological markers that can differentiate PBC from AIH.PMID:38652703 | DOI:10.1093/jleuko/qiae085 (Source: Journal of Leukocyte Biology)
Source: Journal of Leukocyte Biology - April 23, 2024 Category: Hematology Authors: Xiaoxue Yang Jiawei Li Meiling Ren Xuemei Pan Huiling Liu Jie Jiang Man Li Zhe Yang Bingyu Han Lina Ma Jianlei Hao Yuanyuan Duan Zhinan Yin Yan Xu Zheng Xiang Bin Wu Source Type: research
Lack of mTORC2 signalling in CD11c+ myeloid cells inhibits their migration and ameliorates experimental colitis
J Leukoc Biol. 2024 Apr 23:qiae084. doi: 10.1093/jleuko/qiae084. Online ahead of print.ABSTRACTThe Mammalian Target of Rapamycin (mTOR) pathway plays a key role in determining immune cells function through modulation of their metabolic status. By specific deletion of Rictor in CD11c+ myeloid cells (referred to here as CD11cRicΔ/Δ), this study investigated the role of mTOR complex 2 (mTORC2) signalling in dendritic cells (DCs) function in mice. We showed that upon DSS-induced colitis, lack of mTORC2 signalling CD11c+ cells diminishes colitis score, and abrogates dendritic cell (DC) migration to the mesenteric lymph nodes ...
Source: Journal of Leukocyte Biology - April 23, 2024 Category: Hematology Authors: Aline Ignacio Marcella Cipelli Tatiane Takiishi Cristhiane Favero Aguiar Fernanda Fernandes Terra Bruno Ghirotto Eloisa Martins Silva Angela Castoldi Yuli Thamires Magalh ães Tiago Antonio Barbara Nunes Padovani Meire Ioshie Hiyane Vinicius Andrade-Olive Source Type: research
