GABAergic interneurons in the hippocampal CA1 mediate contextual fear generalization in PTSD rats
In conclusion, this study provided evidence that the loss of GABAergic interneuron phenotype in CA1 may contribute to contextual fear generalization in PTSD. The PERK pathway is involved in the GABAergic interneuron injury of PTSD rats and modulating it can protect GABAergic interneurons and constrain contextual fear generalization. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - May 6, 2024 Category: Neuroscience Authors: Xiayu Gong,
Zhixin Fan,
Hanfang Xu,
Yue Qu,
Bozhi Li,
Lanxin Li,
Yuqi Yan,
Lili Wu,
Can Yan Tags: ORIGINAL ARTICLE Source Type: research
Ependymal cells undergo astrocyte ‐like reactivity in response to neuroinflammation
Ependymal cells are unique glia that regulate local cerebrospinal fluid (CSF) microcirculation and form a dynamic interface between the brain and CSF. Here, we describe an unrecognized astrocyte-like reactive transcriptomic profile that is assumed by ependymal cells in response to chronic neuroinflammation, that can be recapitulated following exposure to classical drivers of acute neuroinflammation. Description of this unique reactive glial state will inform future investigations into ependymal cell dysregulation in central nervous system disorders. AbstractEpendymal cells form a specialized brain –cerebrospinal fluid (C...
Source: Journal of Neurochemistry - May 5, 2024 Category: Neuroscience Authors: Adam M. R. Groh,
Nina Caporicci ‐Dinucci,
Elia Afanasiev,
Maxime Bigotte,
Brianna Lu,
Joshua Gertsvolf,
Matthew D. Smith,
Thomas Garton,
Liam Callahan‐Martin,
Alexis Allot,
Dale J. Hatrock,
Victoria Mamane,
Sienna Drake,
Huilin Tai,
Jun Tags: ORIGINAL ARTICLE Source Type: research
The role of age ‐associated alpha‐synuclein aggregation in a conditional transgenic mouse model of Parkinson's disease: Implications for Lewy body formation
In this study, we found that a selective expression of WT (WT-α-syn) or a modified form of α-syn (WT-α-ayn-CL1) which has an increased propensity for aggregation in the dopaminergic neurons could lead to an age-dependent neurodegeneration. We further f ound that accumulation of alpha-syn aggregates in sizes and numbers were age-associated, suggesting a possible mechanism in the formation of Lewy bodies and neurodegeneration in PD. AbstractParkinson's disease (PD) is a common neurodegenerative disorder that is affecting an increasing number of older adults. Although PD is mostly sporadic, genetic mutations have been foun...
Source: Journal of Neurochemistry - May 2, 2024 Category: Neuroscience Authors: Jiahua Li,
Ka Wai Ng,
Chun Chau Sung,
Kenny K. K. Chung Tags: ORIGINAL ARTICLE Source Type: research
Common anesthetic used in preclinical PET imaging inhibits metabolism of the PET tracer [18F]3F4AP
Differences in the brain uptake and metabolism of demyelination PET tracer [18F]3F4AP have been observed while imaging anesthetized nonhuman primates and awake human subjects. Isoflurane anesthesia was found to enhance the brain uptake and in vivo stability of [18F]3F4AP in mice. These findings underscore the critical need to examine the effect of isoflurane in PET imaging studies before translating tracers to humans that will be scanned without anesthesia. AbstractPositron emission tomography (PET) imaging studies in laboratory animals are almost always performed under isoflurane anesthesia to ensure that the subject st...
Source: Journal of Neurochemistry - May 1, 2024 Category: Neuroscience Authors: Karla Ramos ‐Torres,
Yang Sun,
Kazue Takahashi,
Yu‐Peng Zhou,
Pedro Brugarolas Tags: ORIGINAL ARTICLE Source Type: research
Translational validity of neuropsychological tasks of sustained attention between rodents and humans: A systematic review of three rodent tasks
This study provides a systematic review that assesses the translational validity of sustained attention tasks in rodents. One hundred and thirty-eight studies were included, covering the rodent Continuous Performance Task (rCPT), Sustained Attention Task (SAT), and 5-choice CPT (5C-CPT). Translatability between rodent and human studies was assessed based on methodological similarity, performance similarity, and replication of results. The 5C-CPT was found to be the most translatable cross-species paradigm with good utility, while the rCPT and SAT require further adaptation for translation. AbstractAtypical sustained attent...
Source: Journal of Neurochemistry - May 1, 2024 Category: Neuroscience Authors: Claire Salmon,
Shuting Li,
Emma L. Burrows,
Katherine A. Johnson Tags: SYSTEMATIC REVIEW Source Type: research
Noradrenaline enhances Na ‐K ATPase subunit expression by HuR‐induced mRNA stabilization and their transportation to the cell surface through PLC and PKC mediated pathway: Implications with REMS‐loss associated disorders
Rapid eye movement sleep deprivation associated elevated noradrenaline (NA) increases nucleus-to-cytoplasmic translocation of HuR. The latter then decreases degradation of the Na-K ATPase mRNA, resulting in stability of its mRNA, which in turn increased its translation without increasing the transcription. The increased Na-K ATPase subunit are then translocated to the neuronal membrane. Our findings not only explain a fundamental molecular mechanism of Na-K ATPase subunit expression, but it may also be exploited to ameliorate REMS-loss associated symptoms and disorders. AbstractRapid eye movement sleep (REMS) maintains bra...
Source: Journal of Neurochemistry - April 27, 2024 Category: Neuroscience Authors: Manjeet Kaur,
Rachna Mehta,
Rohini Muthuswami,
Birendra Nath Mallick Tags: ORIGINAL ARTICLE Source Type: research
Multiple cholinergic receptor subtypes coordinate dual modulation of acetylcholine on anterior and posterior paraventricular thalamic neurons
In this study, we used fluorescence in situ hybridization, slice electrophysiology, and pharmacological tools to reveal a differential expression of cholinergic receptor subtypes and modulation of acetylcholine (ACh) in both anterior and posterior PVT. Our results indicate that ACh predominantly excites the anterior PVT with a comparab ly higher level of excitatory cholinergic receptors but inhibits the posterior PVT neurons with more inhibitory cholinergic receptors. This finding is important in understanding a potential role of PVT cholinergic signaling for the control of motivated behaviors. AbstractParaventricular th...
Source: Journal of Neurochemistry - April 26, 2024 Category: Neuroscience Authors: Qiying Ye,
Jeremiah Nunez,
Xiaobing Zhang Tags: ORIGINAL ARTICLE Source Type: research
The complexity of extracellular vesicles: Bridging the gap between cellular communication and neuropathology
In this report, we review the roles that extracellular vesicles can play in biological processes and cellular dysfunction and pathobiology, particularly neurodegenerative diseases. We also examine the potential translational impacts of extracellular vesicles in diagnostics and therapeutic development. ER: endoplasmic reticulum; ROS: reactive oxygen species. AbstractBrain-derived extracellular vesicles (EVs) serve a prominent role in maintaining homeostasis and contributing to pathology in health and disease. This review establishes a crucial link between physiological processes leading to EV biogenesis and their impacts on...
Source: Journal of Neurochemistry - April 23, 2024 Category: Neuroscience Authors: Stephanie Tam,
Darcy Wear,
Christopher D. Morrone,
Wai Haung Yu Tags: SYSTEMATIC REVIEW Source Type: research
Variant ‐specific effects of GBA1 mutations on dopaminergic neuron proteostasis
Glucocerenrosidase1 (GBA1) mutations cause disruptions in endoplasmic reticulum (ER) and lysosome-related proteostasis pathways in induced pluripotent stem cell (iPSC)-derived dopaminergic neurons. SevereGBA1 mutations lead to increased ER stress (increased binding immunoglobulin protein (BiP) and protein disulfide isomerase (PDI) levels), total ubiquitination rates, and unfolded protein response (UPR). Defective chaperone-mediated autophagy (decreased heat-shock cognate protein 70 (HSC70) levels and decreased co-localization of lysosomal-associated membrane protein 2A (LAMP2A) and HSC70) is observed in iPSC-derived dopami...
Source: Journal of Neurochemistry - April 20, 2024 Category: Neuroscience Authors: G. Onal,
G. Yal çın‐Çakmaklı,
C. E. Özçelik,
I. Boussaad,
U. Ö. Ş. Şeker,
Hugo J. R. Fernandes,
H. Demir,
R. Krüger,
B. Elibol,
S. Dökmeci,
M. M. Salman Tags: ORIGINAL ARTICLE Source Type: research
Preface: Special issue: 14th International Conference on Brain Energy Metabolism: Energy substrates and microbiome govern brain bioenergetics and cognitive function with aging
This special issue, entitled “Energetics and cognition in aging brain: Impact of substrates and microbiome”, contains manuscripts from attendees at the 14th International Conference on Brain Energy Metabolism (ICBEM) held in Santa Fe, New Mexico, USA, October 24–27, 2022. Major topics include neuronal and mitochondrial en ergetics, higher brain functions involving astrocyte-neuron interactions, unique roles for glycogen, glycolytic upregulation during activation, determination of metabolite levels with genetically-encoded biosensors, dietary intervention in aging, gut-brain signaling, spreading depolarization and fun...
Source: Journal of Neurochemistry - April 13, 2024 Category: Neuroscience Authors: Mary C. McKenna,
In ‐Young Choi,
Arne Schousboe Tags: REVIEW Source Type: research
The following article for this Special Issue was previously published and can be found in its respective issue online: “How can I measure brain acetylcholine levels in vivo? Advantages and caveats of commonly used approaches”
Abstract:How can I measure brain acetylcholine levels in vivo? Advantages and caveats of commonly used approaches (Published in JNC 167.1 issue)https://onlinelibrary.wiley.com/doi/10.1111/jnc.15943 (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - April 12, 2024 Category: Neuroscience Tags: REVIEW Source Type: research
Issue Information
Front coverThis special issue related to the17th Symposium on Cholinergic Mechanisms (ISCM2022) highlights the progress in the molecular, neurochemical, pharmacological, toxicological, and clinical studies of the cholinergic system, underlining its complexity and impact on health and disease. The most recent ISCM2022 was organized in a hybrid format, allowing flexibility due to travel restrictions caused by the COVID pandemics.Image contentThe figure highlights the conference logo, with acetylcholine in Dubrovnik's common ornament carved in stone. Designed by Grafokor, Croatia.Read the full article‘Recent advances in cho...
Source: Journal of Neurochemistry - April 12, 2024 Category: Neuroscience Tags: ISSUE INFORMATION Source Type: research
The following article for this Special Issue was previously published and can be found in its respective issue online: “Whole‐brain neural connectivity to cholinergic neurons in the nucleus basalis of Meynert”
Abstract:Whole-brain neural connectivity to cholinergic neurons in the nucleus basalis of Meynert (Published
in JNC 166.2 issue)https://onlinelibrary.wiley.com/doi/10.1111/jnc.15873 (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - April 12, 2024 Category: Neuroscience Tags: ORIGINAL ARTICLE Source Type: research
The following article for this Special Issue was previously published and can be found in its respective issue online: “Acetylcholine release from striatal cholinergic interneurons is controlled differently depending on the firing pattern”
Abstract:Acetylcholine release from striatal cholinergic interneurons is controlled differently depending on the firing pattern (Published in JNC 167.1 issue)https://onlinelibrary.wiley.com/doi/10.1111/jnc.15950 (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - April 12, 2024 Category: Neuroscience Tags: ORIGINAL ARTICLE Source Type: research
The following article for this Special Issue was previously published and can be found in its respective issue online: “Long‐term nucleus basalis cholinergic depletion induces attentional deficits and impacts cortical neurons and BDNF levels without affecting the NGF synthesis”
Abstract:Long-term nucleus basalis cholinergic depletion induces attentional deficits and impacts cortical
neurons and BDNF levels without affecting the NGF synthesis (Published in JNC 163.2 issue)https://onlinelibrary.wiley.com/doi/10.1111/jnc.15683 (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - April 12, 2024 Category: Neuroscience Tags: ORIGINAL ARTICLE Source Type: research
