Endothelial dysfunction in neurodegenerative disease: Is endothelial inflammation an overlooked druggable target?
Neurological diseases with a neurodegenerative component have been associated with alterations in the cerebrovasculature. At the anatomical level, these are centred around changes in cerebral blood flow and vessel organisation. At the molecular level, there is extensive expression of cellular adhesion molecules and increased release of pro-inflammatory mediators. Together, these has been found to negatively impact blood-brain barrier integrity. Systemic inflammation has been found to accelerate and exacerbate endothelial dysfunction, neuroinflammation and degeneration. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - May 3, 2024 Category: Allergy & Immunology Authors: Megan Ritson, Caroline Wheeler-Jones, Helen B. Stolp Source Type: research
Mitigation of CXCL10 secretion by metabolic disorder drugs in microglial-mediated neuroinflammation
Metabolic disorders are associated with several neurodegenerative diseases. We previously identified C-X-C motif chemokine ligand 10 (CXCL10), also known as interferon gamma-induced protein 10 (IP-10), as a major contributor to the type I interferon response in microglial-mediated neuroinflammation. Therefore, we hypothesized FDA-approved metabolic disorder drugs that attenuate CXCL10 secretion may be repurposed as a treatment for neurodegenerative diseases. Screening, dose curves, and cytotoxicity assays in LPS-stimulated microglia yielded treprostinil (hypertension), pitavastatin (hyperlipidemia), and eplerenone (hyperte...
Source: Journal of Neuroimmunology - May 3, 2024 Category: Allergy & Immunology Authors: Sophia F. Oliai, Daniel C. Shippy, Tyler K. Ulland Source Type: research
Causal association between multiple sclerosis and severe COVID-19: A bidirectional Mendelian randomization study
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), poses a significant threat to human health, particularly the severe form of COVID-19 (Baranova et al., 2023). Multiple sclerosis (MS) is an autoimmune disease that leads to demyelination and axonal loss in the central nervous system (Sun et al., 2024a). The COVID-19 pandemic has created significant challenges for neurologists, particularly in MS, a disease that affects millions of people worldwide (Sun et al., 2024a). (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - April 29, 2024 Category: Allergy & Immunology Authors: Shuangjie Li, Dongren Sun, Rui Wang, Qin Du, Hongxi Chen, Ziyan Shi, Hongyu Zhou Tags: Letter to the Editor Source Type: research
A protective effect of lower MHC-II expression in MOGAD
Myelin oligodendrocyte glycoprotein-antibody-associated disease (MOGAD) is a demyelinating central nervous system disorder. We aimed to uncover immune pathways altered in MOGAD to predict disease progression. Using nanostring nCounter technology, we analyzed immune gene expression in PBMCs from MOGAD patients and compare it with healthy controls (HCs). We found 35 genes that distinguished MOGAD patients and HCs. We then validated those results in a larger cohort including MS and NMOSD patients. Expressions of HLA-DRA was significantly lower in MOGAD patients. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - April 26, 2024 Category: Allergy & Immunology Authors: Ariel Rechtman, Omri Zveik, Nitsan Haham, Livnat Brill, Adi Vaknin-Dembinsky Source Type: research
Unilateral cortical autoimmune encephalitis: A case series and comparison to late-onset Rasmussen's encephalitis
To report a novel anatomical pattern of autoimmune encephalitis characterized by strictly unilateral cortical inflammation and a clinical picture overlapping with late-onset Rasmussen's encephalitis. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - April 25, 2024 Category: Allergy & Immunology Authors: Sophia Damman, Persen Sukpornchairak, Amit Ahituv, Alex Chen, David Wang, Komal Sawlani, Claude Steriade, Hesham Abboud Tags: Short Communication Source Type: research
Superior oblique palsy as the initial manifestation of anti-contactin-1 IgG4 autoimmune nodopathy: A case report
We report a case of anti-contactin-1 neuropathy initially manifesting as isolated superior oblique palsy, aiming to broaden the clinical spectrum of the disease. A 68-year-old male with well-controlled diabetes, hypertension, and hyperlipidemia developed acute binocular vertical diplopia, progressing over two months to include distal paresthesia, sensory ataxia, ageusia, and dysarthria. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - April 22, 2024 Category: Allergy & Immunology Authors: Young Gi Min, Woohee Ju, Jung-Joon Sung Tags: Short Communication Source Type: research
Atractylodin ameliorates lipopolysaccharide-induced depressive-like behaviors in mice through reducing neuroinflammation and neuronal damage
In this study, the lipopolysaccharide (LPS)-induced mouse model was used to explore the antidepressant effects and molecular mechanisms of atractylodin. The results showed that atractylodin increased sugar preference, also reduced immobility time in FST and TST. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - April 22, 2024 Category: Allergy & Immunology Authors: Feng Liu, Yaping Wang, Dongbo Li, Tao Yang Source Type: research
Antigen-specific immunotherapy via delivery of tolerogenic dendritic cells for multiple sclerosis
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system resulting from loss of immune tolerance. Many disease-modifying therapies for MS have broad immunosuppressive effects on peripheral immune cells, but this can increase risks of infection and attenuate vaccine-elicited immunity. A more targeted approach is to re-establish immune tolerance in an autoantigen-specific manner. This review discusses methods to achieve this, focusing on tolerogenic dendritic cells. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - April 19, 2024 Category: Allergy & Immunology Authors: Vivien Li, Michele Binder, Anthony W. Purcell, Trevor J. Kilpatrick Tags: Review Article Source Type: research
V-set and immunoglobulin domain containing 4 inhibits oxidative stress, mitochondrial dysfunction, and inflammation to attenuate Parkinson's disease progression by activating the JAK2/STAT3 pathway
V-set and immunoglobulin domain containing 4 (VSIG4) inhibits neurological dysfunction, microglial M1 polarization, and inflammation to participate in the progression of neurological disorders, but evidence regarding Parkinson's disease (PD) is scarce. The present study intended to investigate the engagement of VSIG4 in PD progression, and the potential mechanism. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - April 17, 2024 Category: Allergy & Immunology Authors: Pingping Cai, Junmei Wang, Jiangtao Xu, Min Zhang, Xinxin Yin, Shengquan He, Jingcong Zhuang Source Type: research
Corticospinal tract hyperintensity in patients with LGI1-antibody encephalitis and other central nervous system disorders with neuroglial antibodies
The frequency of corticospinal tract (CST) T2/FLAIR hyperintensity in disorders with neuroglial antibodies is unclear. Herein, we retrospectively reviewed brain MRIs of 101 LGI1-antibody encephalitis patients, and observed CST hyperintensity in 30/101(30%). It was mostly bilateral (93%), not associated with upper motor neuron signs/symptoms (7%), and frequently decreased over time (39%). In a systematic review including patients with other neuroglial antibodies, CST hyperintensity was reported in 110 with neuromyelitis optica (94%), myelin oligodendrocyte glycoprotein-associated disease (2%), Ma2-antibody (3%) and GAD65-an...
Source: Journal of Neuroimmunology - April 17, 2024 Category: Allergy & Immunology Authors: Lucia Campetella, Macarena Villagran Garc ía, Antonio Farina, Marie Benaiteau, Raffaele Iorio, Paolo Calabresi, Alberto Vogrig, Salvatore Versace, Nicolás Lundahl Ciano-Petersen, Elodie Bicilli Brotelle, Pierre Branger, Clotilde Verlut, Sophie Langner-L Tags: Short Communication Source Type: research
MiR-24-3p enhances the Treg/Th17 balance to improve cerebral ischemic injury by suppressing acetyl-CoA carboxylase 1 expression
We examined the roles of potential miRNAs in regulating ACC1 expression in Tregs and treating ischemic stroke. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - April 11, 2024 Category: Allergy & Immunology Authors: Yong Wang, Yan Yang, Lijun Xie, Xiaona An, Lu Zhang Source Type: research
Offspring behavioral outcomes following maternal allergic asthma in the IL-4-deficient mouse
Maternal allergic asthma (MAA) during pregnancy has been associated with increased risk of neurodevelopmental disorders in humans, and rodent studies have demonstrated that inducing a T helper-2-mediated allergic response during pregnancy leads to an offspring behavioral phenotype characterized by decreased social interaction and increased stereotypies. The interleukin (IL)-4 cytokine is hypothesized to mediate the neurobehavioral impact of MAA on offspring. Utilizing IL-4 knockout mice, this study assessed whether MAA without IL-4 signaling would still impart behavioral deficits. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - April 8, 2024 Category: Allergy & Immunology Authors: Jared J. Schwartzer, Jamie S. Church, Jenna N. Russo, Shanthini Ragoonaden Source Type: research
Altered EBV specific immune control in multiple sclerosis
Since the 1980s it is known that immune responses to the Epstein-Barr virus (EBV) are elevated in multiple sclerosis (MS) patients. Recent seroepidemiologial data have shown that this alteration after primary EBV infection identifies individuals with a more than 30-fold increased risk to develop MS. The mechanisms by which EBV infection might erode tolerance for the central nervous system (CNS) in these individuals, years prior to clinical MS onset, remain unclear. In this review I will discuss altered frequencies of EBV life cycle stages and their tissue distribution, EBV with CNS autoantigen cross-reactive immune respons...
Source: Journal of Neuroimmunology - April 5, 2024 Category: Allergy & Immunology Authors: Christian M ünz Source Type: research
Editorial Board
(Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - April 4, 2024 Category: Allergy & Immunology Source Type: research
Microglia and amyloid plaque formation in Alzheimer's disease – Evidence, possible mechanisms, and future challenges
Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive decline that severely affects patients and their families. Genetic and environmental risk factors, such as viral infections, synergize to accelerate the aging-associated neurodegeneration. Genetic risk factors for late-onset AD (LOAD), which accounts for most AD cases, are predominantly implicated in microglial and immune cell functions. As such, microglia play a major role in amyloid beta (A β) plaque (the major pathological hallmark of AD) formation. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - April 4, 2024 Category: Allergy & Immunology Authors: Stefanie Fruhw ürth, Henrik Zetterberg, Søren R. Paludan Source Type: research
