Beneficial mechanisms of dimethyl fumarate in autoimmune uveitis: insights from single-cell RNA sequencing
Dimethyl fumarate (DMF) is a fumaric acid ester that exhibits immunoregulatory and anti-inflammatory properties. However, the function of DMF in autoimmune uveitis (AU) is incompletely understood, and studies ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 29, 2024 Category: Neurology Authors: Lei Zhu, He Li, Xuening Peng, Zhaohuai Li, Sichen Zhao, Dongting Wu, Jialing Chen, Si Li, Renbing Jia, Zuohong Li and Wenru Su Tags: Research Source Type: research
Interaction of high-fat diet and brain trauma alters adipose tissue macrophages and brain microglia associated with exacerbated cognitive dysfunction
Obesity increases the morbidity and mortality of traumatic brain injury (TBI). Detailed analyses of transcriptomic changes in the brain and adipose tissue were performed to elucidate the interactive effects be... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 29, 2024 Category: Neurology Authors: Rebecca J. Henry, James P. Barrett, Maria Vaida, Niaz Z. Khan, Oleg Makarevich, Rodney M. Ritzel, Alan I. Faden and Bogdan A. Stoica Tags: Research Source Type: research
Bone-derived PDGF-BB enhances hippocampal non-specific transcytosis through microglia-endothelial crosstalk in HFD-induced metabolic syndrome
It is well known that high-fat diet (HFD)-induced metabolic syndrome plays a crucial role in cognitive decline and brain-blood barrier (BBB) breakdown. However, whether the bone-brain axis participates in this... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 29, 2024 Category: Neurology Authors: Guanqiao Liu, Wen Shu, Yingqi Chen, Yong Fu, Shuai Fang, Haonan Zheng, Weike Cheng, Qingrong Lin, Yanjun Hu, Nan Jiang and Bin Yu Tags: Research Source Type: research
Chronic immunosuppression across 12 months and high ability of acute and subacute CNS-injury biomarker concentrations to identify individuals with complicated mTBI on acute CT and MRI
Identifying individuals with intracranial injuries following mild traumatic brain injury (mTBI), i.e. complicated mTBI cases, is important for follow-up and prognostication. The main aims of our study were (1)... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 27, 2024 Category: Neurology Authors: Gerard Janez Brett Clarke, Turid Follestad, Toril Skandsen, Henrik Zetterberg, Anne Vik, Kaj Blennow, Alexander Olsen and Asta Kristine H åberg Tags: Research Source Type: research
Obesity-induced blood-brain barrier dysfunction: phenotypes and mechanisms
Obesity, a burgeoning global health issue, is increasingly recognized for its detrimental effects on the central nervous system, particularly concerning the integrity of the blood-brain barrier (BBB). This man... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 27, 2024 Category: Neurology Authors: Ziying Feng, Cheng Fang, Yinzhong Ma and Junlei Chang Tags: Review Source Type: research
Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition
Parkinson ’s disease (PD) is a neurodegenerative disorder that is characterized by the presence of proteinaceous alpha-synuclein (α-syn) inclusions (Lewy bodies), markers of neuroinflammation and the progressiv... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 25, 2024 Category: Neurology Authors: Anna C. Stoll, Christopher J. Kemp, Joseph R. Patterson, Michael Kubik, Nathan Kuhn, Matthew Benskey, Megan F. Duffy, Kelvin C. Luk and Caryl E. Sortwell Tags: Research Source Type: research
Neuroinflammation driven by human immunodeficiency virus-1 (HIV-1) directs the expression of long noncoding RNA RP11-677M14.2 resulting in dysregulation of neurogranin in vivo and in vitro
Neuroinflammation and synaptodendritic damage represent the pathological hallmarks of HIV-1 associated cognitive disorders (HAND). The post-synaptic protein neurogranin (Nrgn) is significantly reduced in the f... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 24, 2024 Category: Neurology Authors: Roberta S. dos Reis, Marc C. E. Wagner, Savannah McKenna and Velpandi Ayyavoo Tags: Research Source Type: research
Mas receptor activation facilitates innate hematoma resolution and neurological recovery after hemorrhagic stroke in mice
Intracerebral hemorrhage (ICH) is a devastating neurological disease causing severe sensorimotor dysfunction and cognitive decline, yet there is no effective treatment strategy to alleviate outcomes of these p... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 24, 2024 Category: Neurology Authors: Xiangyang Deng, Junwei Ren, Kezhu Chen, Jin Zhang, Quan Zhang, Jun Zeng, Tianwen Li, Qisheng Tang, Jian Lin and Jianhong Zhu Tags: Research Source Type: research
Itaconate alleviates anesthesia/surgery-induced cognitive impairment by activating a Nrf2-dependent anti-neuroinflammation and neurogenesis via gut-brain axis
Postoperative cognitive dysfunction (POCD) is a common neurological complication of anesthesia and surgery in aging individuals. Neuroinflammation has been identified as a hallmark of POCD. However, safe and e... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 22, 2024 Category: Neurology Authors: Xiangyi Kong, Wenyuan Lyu, Xiaojie Lin, Chunlong Lin, Hao Feng, Lin Xu, Kaiyue Shan, Penghui Wei and Jianjun Li Tags: Research Source Type: research
Pathological high intraocular pressure induces glial cell reactive proliferation contributing to neuroinflammation of the blood-retinal barrier via the NOX2/ET-1 axis-controlled ERK1/2 pathway
NADPH oxidase (NOX), a primary source of endothelial reactive oxygen species (ROS), is considered a key event in disrupting the integrity of the blood-retinal barrier. Abnormalities in neurovascular-coupled im... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 22, 2024 Category: Neurology Authors: Xin Shi, Panpan Li, Marc Herb, Hanhan Liu, Maoren Wang, Xiaosha Wang, Yuan Feng, Tim van Beers, Ning Xia, Huige Li and Verena Prokosch Tags: Research Source Type: research
CSF1R antagonism results in increased supraspinal infiltration in EAE
Colony stimulating factor 1 receptor (CSF1R) signaling is crucial for the maintenance and function of various myeloid subsets. CSF1R antagonism was previously shown to mitigate clinical severity in experimenta... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 20, 2024 Category: Neurology Authors: Marilyn Wang, Sofia E. Caryotakis, Glendalyn G. Smith, Alan V. Nguyen, David E. Pleasure and Athena M. Soulika Tags: Research Source Type: research
Microbiota-derived acetate attenuates neuroinflammation in rostral ventrolateral medulla of spontaneously hypertensive rats
Increased neuroinflammation in brain regions regulating sympathetic nerves is associated with hypertension. Emerging evidence from both human and animal studies suggests a link between hypertension and gut mic... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 18, 2024 Category: Neurology Authors: Xiaopeng Yin, Changhao Duan, Lin Zhang, Yufang Zhu, Yueyao Qiu, Kaiyi Shi, Sen Wang, Xiaoguang Zhang, Huaxing Zhang, Yinchao Hao, Fang Yuan and Yanming Tian Tags: Research Source Type: research
Targeting brain-peripheral immune responses for secondary brain injury after ischemic and hemorrhagic stroke
The notion that the central nervous system is an immunologically immune-exempt organ has changed over the past two decades, with increasing evidence of strong links and interactions between the central nervous... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 18, 2024 Category: Neurology Authors: Mingxu Duan, Ya Xu, Yuanshu Li, Hua Feng and Yujie Chen Tags: Review Source Type: research
Schwann cell-derived extracellular vesicles promote memory impairment associated with chronic neuropathic pain
The pathogenesis of memory impairment, a common complication of chronic neuropathic pain (CNP), has not been fully elucidated. Schwann cell (SC)-derived extracellular vesicles (EVs) contribute to remote organ ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 17, 2024 Category: Neurology Authors: Yidan Tang, Jiahui Wu, Changliang Liu, Lu Gan, Hai Chen, Ya-Lan Sun, Jin Liu, Yuan-Xiang Tao, Tao Zhu and Chan Chen Tags: Research Source Type: research
IgM anti-GM2 antibodies in patients with multifocal motor neuropathy target Schwann cells and are associated with early onset
Multifocal motor neuropathy (MMN) is a rare, chronic immune-mediated polyneuropathy characterized by asymmetric distal limb weakness. An important feature of MMN is the presence of IgM antibodies against gangl... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 17, 2024 Category: Neurology Authors: Kevin Budding, Jeroen W. Bos, Kim Dijkxhoorn, Elisabeth de Zeeuw, Lauri M. Bloemenkamp, Eva M. Zekveld, Ewout J.N. Groen, Bart C. Jacobs, Ruth Huizinga, H. Stephan Goedee, Elisabeth A. Cats, Jeanette H.W. Leusen, Leonard H. van den Berg, C. Erik Hack and Tags: Research Source Type: research
