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POEMS syndrome associated with IgM lambda paraprotein. A case report and review of the literature
Dear Editor, (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 29, 2024 Category: Neurology Authors: Massarotti Luca, Salvalaggio Alessandro, Branca Antonio, Berno Tamara, Visentin Andrea, Marco Rossato, Renzo Manara, Altinier Sara, Briani Chiara Source Type: research

Putaminal hypointensity on T2-weighted MRI mimicking multiple system atrophy in amyotrophic lateral sclerosis: An autopsy case report
Dear editor, (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 29, 2024 Category: Neurology Authors: Ai Ishikawa, Takahiro Takeda, Sayuri Kokubun, Yumiko Saito, Sagiri Isose, Kimiko Ito, Kimihito Arai, Atsuhiko Sugiyama, Satoshi Kuwabara, Kazuhiro Honda Source Type: research

Headache management in traumatic brain injury
Traumatic brain injury (TBI) is estimated to rank as the third most important disease burden worldwide. About 60% of the survivors develop chronic headaches and visual symptoms, and the long-term management of headaches in these patients is controversial. Importantly, the care pathway of most patients is fragmented, complicating conclusive headache management. Here we review the epidemiology and aetiology of post traumatic headaches (PTH), discuss the diagnostic work up and summarise the acute and long –term management. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 23, 2024 Category: Neurology Authors: Parisa Teli, Niaz Islam, Axel Petzold Source Type: research

Letter to the editor
We read Ebina and colleagues' article with great interest [1]. Biomarker based classification of Parkinson's disease (PD) subtypes is a recently featured research topic [2], and the authors provided additional insights into the utility of 123I-metaiodobenzylguanidine (MIBG) scintigraphy in the PD subtype classification. However, abnormal MIBG uptake in the major salivary gland, one of their main results, seemed not specific for PD and needs further verification to discuss the pathophysiological implication of MIBG accumulation in the salivary glands. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 22, 2024 Category: Neurology Authors: Toru Baba, Tomoko Totsune, Atsushi Takeda Source Type: research

Diaphragm weakness in late-onset Pompe disease: A complex interplay between lower motor neuron and muscle fibre degeneration
Late-onset Pompe disease (LOPD) patients may still need ventilation support at some point of their disease course, despite regular recombinant human alglucosidase alfa treatment. This suggest that other pathophysiological mechanisms than muscle fibre lesion can contribute to the respiratory failure process. We investigate through neurophysiology whether spinal phrenic motor neuron dysfunction could contribute to diaphragm weakness in LOPD patients. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 18, 2024 Category: Neurology Authors: Miguel Oliveira Santos, Sara Domingues, Catarina Falc ão de Campos, Susana Moreira, Mamede de Carvalho Tags: Clinical short communication Source Type: research

Novel findings in a Swedish primary familial brain calcification cohort
Brain calcifications are frequent findings on imaging. In a small proportion of cases, these calcifications are associated with pathogenic gene variants, hence termed familial brain calcification (PFBC). The clinical penetrance is incomplete and phenotypic variability is substantial. This paper aims to characterize a Swedish PFBC cohort including 25 patients: 20 from seven families and five sporadic cases. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 17, 2024 Category: Neurology Authors: Stefan Sennf ält, Peter Gustavsson, Helena Malmgren, Eric Gilland, Håkan Almqvist, Mikael Oscarson, Martin Engvall, Ingemar Björkhem, Daniel Nilsson, Kristina Lagerstedt-Robinson, Per Svenningsson, Martin Paucar Source Type: research

Ten-year fracture risk in Japanese patients with myasthenia gravis: A comprehensive assessment using the fracture risk assessment tool
Myasthenia gravis (MG) is an immune disorder that causes muscle weakness with an increasing prevalence, particularly among the elderly in Japan. Glucocorticoid treatment for MG is problematic for bone health because of reduced bone density and increased fracture risk. The fracture risk assessment tool (FRAX ®) can estimate fracture risk, but its applicability in patients with MG remains uncertain. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 16, 2024 Category: Neurology Authors: Shingo Konno, Takafumi Uchi, Hideo Kihara, Hideki Sugimoto Source Type: research

Emotion recognition in amyotrophic lateral sclerosis in a dynamic environment
The aim of our study was to measure the ability of ALS patients to process dynamic facial expressions as compared to a control group of healthy subjects and to correlate this ability in ALS patients with neuropsychological, clinical and neurological measures of the disease. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 16, 2024 Category: Neurology Authors: Marco Ceccanti, Laura Libonati, Federica Moret, Edoardo D'Andrea, Maria Cristina Gori, Francesco Saverio Bersani, Maurizio Inghilleri, Chiara Cambieri Source Type: research

Adalimumab as treatment for neurosarcoidosis: A case series
Sarcoidosis is a disease characterized by non-caseating granulomas that can involve the central nervous system as neurosarcoidosis. This challenging disease is currently managed with high dose steroids, and sometimes the addition of infliximab. Other TNA-alpha inhibitors have not been studied as rigorously. We discovered ten neurosarcoidosis patients who were on an alternative TNA-alpha inhibitor, adalimumab. Eight patients had a positive response clinically and radiographically to adalimumab. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 15, 2024 Category: Neurology Authors: Jeffrey Shen, Megumi Sugita, Andrea Linares-Lopez, Suma Shah, Christopher Eckstein, Elijah Lackey Tags: Clinical short communication Source Type: research

Editorial Board
(Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 13, 2024 Category: Neurology Source Type: research

Serum Neurofilament light chain, inflammatory markers, and kynurenine metabolites in patients with persistent post-concussion symptoms: A cohort study
This study aims to investigate these biomarkers in PPCS patients, elucidating their relevance in the prolonged phase of concussion. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 13, 2024 Category: Neurology Authors: Peter Preben Eggertsen, Johan Palmfeldt, Asger Roer Pedersen, Oana-Veronica Frederiksen, Rikke Katrine Jentoft Olsen, J ørgen Feldbæk Nielsen Source Type: research

Clinical and genetic features of dominant Essential Tremor in Tuscany, Italy: FUS, CAMTA1, ATXN1 and beyond
Essential Tremor (ET) is one of the most common neurological disorders. In most instances ET is inherited as an autosomal dominant trait with age-related penetrance (virtually complete in advanced age); however, ET genetics remains elusive. The current study aims to identify possibly pathogenic genetic variants in a group of well-characterized ET families. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 12, 2024 Category: Neurology Authors: D. Orsucci, A. Tessa, E. Caldarazzo Ienco, R. Trovato, G. Natale, G. Bilancieri, M. Giuntini, A. Napolitano, S. Salvetti, M. Vista, F.M. Santorelli Tags: Clinical short communication Source Type: research

Clinical significance of intracranial hemorrhage after thrombectomy detected solely by magnetic resonance imaging and not by computed tomography
This study investigated the clinical features of ICH after MT detected solely by MRI. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 12, 2024 Category: Neurology Authors: Kentaro Suzuki, Takehiro Katano, Shinichiro Numao, Yuji Nishi, Akihito Kutsuna, Takuya Kanamaru, Tomonari Saito, Junya Aoki, Yasuhiro Nishiyama, Kazumi Kimura Source Type: research

The search for blood-biomarkers of persistent post-concussion symptoms
Prolonged symptoms following concussion, commonly called persistent post-concussion symptoms (PPCS), are a major public health burden that occur in up to an estimated 30% of all individuals that experience a concussion (a form of mild traumatic brain injury; mTBI) [1]. Despite this prevalence, the underlying pathophysiology and mechanism of PPCS are still unknown. This lack of knowledge significantly impairs clinician's abilities to identify patients at risk for developing PPCS and objectively monitor patients with PPCS and has also prevented development of therapeutics to reduce symptoms and thus limit the significant per...
Source: Journal of the Neurological Sciences - April 12, 2024 Category: Neurology Authors: Timothy B. Meier Source Type: research

Corrigendum to “Incorporating health equity in the neurology curriculum: Our experience” [Journal of the Neurological Science (2023) 120665]
The authors regret that we neglected to include LaShyra Nolen as an author. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 11, 2024 Category: Neurology Authors: Tamara B. Kaplan, Christopher Doughty, LaShyra Nolan, Joshua Budhu Source Type: research