ECMO Bridge to Lung Transplant in Children with Idiopathic Pulmonary Arterial Hypertension
AbstractIdiopathic pulmonary arterial hypertension (IPAH) represents an important clinical indication for lung transplant (LTx) in children. Recent trends show fewer children with IPAH are undergoing LTx nowadays compared to previous time periods, including those with most severe form of the disease. Using the UNOS Registry, we investigated if ECMO at the time of transplant impacts post-transplant survival in children with IPAH. A total of 74 LTx recipients while on ECMO at the time of transplant were identified (IPAH: N = 12). Children with IPAH who underwent LTx while on ECMO had shown comparable survival rates to tho...
Source: Lung - April 30, 2024 Category: Respiratory Medicine Source Type: research
Endobronchial Ultrasound Guided Transbronchial Needle Aspiration and Next Generation Sequencing Yields
ConclusionWhen a protocol of three to five dedicated needle rinses for NGS was followed, we nearly doubled our sample adequacy rate for NSG as compared to standard care. Studies are needed to determine the ideal collection and processing modality to preserve tissue samples for genetic sequencing. (Source: Lung)
Source: Lung - April 30, 2024 Category: Respiratory Medicine Source Type: research
The Synthetic Surfactant CHF5633 Restores Lung Function and Lung Architecture in Severe Acute Respiratory Distress Syndrome in Adult Rabbits
ConclusionsThis study indicates that surfactant replacement therapy with CHF5633 improves lung function and lung architecture, and attenuates inflammation in severe ARDS in adult rabbits similarly to Poractant alfa. Clinical trials have so far not yielded conclusive results, but exogenous surfactant may be a valid supportive treatment for patients with ARDS given its anti-inflammatory and lung-protectiv e effects. (Source: Lung)
Source: Lung - April 29, 2024 Category: Respiratory Medicine Source Type: research
Neutralization of CX3CL1 Attenuates TGF- β-Induced Fibroblast Differentiation Through NF-κB Activation and Mitochondrial Dysfunction in Airway Fibrosis
ConclusionsThese findings suggest that neutralizing CX3CL1 attenuates lung fibroblast activation and mitochondrial dysfunction. Understanding the impacts of CX3CL1 neutralization on fibroblast mitochondrial function could contribute to the development of therapeutic strategies for managing airway remodeling in severe asthma. (Source: Lung)
Source: Lung - April 28, 2024 Category: Respiratory Medicine Source Type: research
Elastolysis in COPD: a Target for Therapy
(Source: Lung)
Source: Lung - April 27, 2024 Category: Respiratory Medicine Source Type: research
Osteoprotegerin is an Early Marker of the Fibrotic Process and of Antifibrotic Treatment Responses in Ex Vivo Lung Fibrosis
ConclusionOPG can already be detected during the early stages of fibrosis development and responds, both in early- and late-stage fibrosis, to treatment with antifibrotic drugs currently on the market for lung fibrosis. Therefore, OPG should be further investigated as a potential biomarker for lung fibrosis and a potential surrogate marker for treatment effect. (Source: Lung)
Source: Lung - April 20, 2024 Category: Respiratory Medicine Source Type: research
Heat-Induced Secretion of Heat Shock Proteins 70 and 90 Does not Affect the Expression of the Glucocorticoid Receptor in Primary Airway Cells in COPD
ConclusionsThe results of this study indicate that primary airway cells from COPD patients respond differently to heat exposure and extracellular HSP70 or HSP90 than cells from asthma patients regarding the expression of GR and this may explain the reduced response to glucocorticoids in patients with COPD.Trial Registration: ISRCTN11017699 (Source: Lung)
Source: Lung - April 19, 2024 Category: Respiratory Medicine Source Type: research
Endobronchial Ultrasound Guided Transbronchial Needle Aspiration and PD-L1 Yields
ConclusionEBUS-TBNA offers high yields for assessing immunotherapy markers like PD-L1, with satisfactory adequacy regardless of NSCLC subtype, lesion size, or location. (Source: Lung)
Source: Lung - April 18, 2024 Category: Respiratory Medicine Source Type: research
Authors ’ Reply to Letter to the Editor Regarding the Article “Genetic Association of Circulating Adipokines with Risk of Idiopathic Pulmonary Fibrosis: a Two-Sample Mendelian Randomization Study”
(Source: Lung)
Source: Lung - April 16, 2024 Category: Respiratory Medicine Source Type: research
Commentary: Genetic Association of Circulating Adipokines with Risk of Idiopathic Pulmonary Fibrosis: A Two‑Sample Mendelian Randomization Study
(Source: Lung)
Source: Lung - April 16, 2024 Category: Respiratory Medicine Source Type: research
Genetic Spectrum and Clinical Characteristics of Patients with Primary Ciliary Dyskinesia: a Belgian Single Center Study
ConclusionThis study suggests a genotype –phenotype correlation for some of the evaluated clinical characteristics of the two most frequently involved genes in this study, namelyDNAH11 andDNAH5. (Source: Lung)
Source: Lung - April 11, 2024 Category: Respiratory Medicine Source Type: research
Dysphagia as a Missing Link Between Post-surgical- and Opioid-Related Pneumonia
ConclusionOropharyngeal swallow is impaired by the partial mu-opioid receptor agonist buprenorphine, most remarkably in the postoperative setting. These findings have implications for the prevention and management of aspiration pneumonia in vulnerable populations. (Source: Lung)
Source: Lung - March 27, 2024 Category: Respiratory Medicine Source Type: research
First Exploration of the Altered Microbial Gut –Lung Axis in the Pathogenesis of Human Refractory Chronic Cough
ConclusionSince differences in both GM and OM of RCC patients have been documented, these findings could provide new information about RCC pathogenesis and also pave the way for the development of novel nutritional or pharmacological interventions for the management of RCC through the restoration of eubiotic gut –lung communication. (Source: Lung)
Source: Lung - March 25, 2024 Category: Respiratory Medicine Source Type: research
