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Chemistry, Analysis, and Biological Aspects of Daprodustat, A New Hypoxia Inducible Factor Prolyl Hydroxylase Inhibitor: A Comprehensive Review
CONCLUSION: This review examines therapeutic, pharmacological, and analytical aspects related to the novel drug Daprodustat.PMID:38685804 | DOI:10.2174/0113895575293447240424052516 (Source: Mini Reviews in Medicinal Chemistry)
Source: Mini Reviews in Medicinal Chemistry - April 30, 2024 Category: Chemistry Authors: Roshani Patil Sanjay Sharma Source Type: research

Evaluation of Melatonin and its Nanostructures Effects on Skin Disorders Focused on Wound Healing
Mini Rev Med Chem. 2024 Apr 29. doi: 10.2174/0113895575299255240422055203. Online ahead of print.ABSTRACTSkin is the largest organ of the human body functioning as a great primitive defensive barrier against different harmful environmental factors. However, it is damaged through varying injuries such as different wounds, burns, and skin cancers that cause disruption in internal organs and essential mechanisms of the body through inflammation, oxidation, coagulation problems, infection, etc. Melatonin is the major hormone of the pineal gland that is also effective in skin disorders due to strong antioxidant and anti-inflamm...
Source: Mini Reviews in Medicinal Chemistry - April 30, 2024 Category: Chemistry Authors: Seyedeh Mohaddeseh Mousavi Leila Etemad Davood Yari Maryam Hashemi Zahra Salmasi Source Type: research

Nanoparticle-based Gene Therapy for Neurodegenerative Disorders
In conclusion, nanoparticle-based gene therapy emerges as a promising avenue in the pursuit of effective treatments for neurological disorders. This abstract advocates for continued research efforts to bridge existing knowledge gaps, unlocking the full potential of this innovative approach and paving the way for transformative solutions in the realm of neurological health.PMID:38676491 | DOI:10.2174/0113895575301011240407082559 (Source: Mini Reviews in Medicinal Chemistry)
Source: Mini Reviews in Medicinal Chemistry - April 27, 2024 Category: Chemistry Authors: Nelofer Ereej Huma Hameed Mahtab Ahmad Khan Saleha Faheem Anam Hameed Source Type: research

Structure-property Relationships Reported for the New Drugs Approved in 2023
Mini Rev Med Chem. 2024 Apr 25. doi: 10.2174/0113895575308674240415074629. Online ahead of print.ABSTRACTDrug-like properties play pivotal roles in drug adsorption, distribution, metabolism, excretion, and toxicity. Therefore, efficiently optimizing these properties is essential for the successful development of novel therapeutics. Understanding the structure-property relationships of clinically approved drugs can provide valuable insights for drug design and optimization strategies. Among the new drugs approved in 2023, which include 31 small-molecule drugs in the US, the structure-property relationships of nine drugs wer...
Source: Mini Reviews in Medicinal Chemistry - April 27, 2024 Category: Chemistry Authors: Kihang Choi Source Type: research

1,3,4-Oxadiazole Scaffold in Antidiabetic Drug Discovery: An Overview
Mini Rev Med Chem. 2024 Apr 19. doi: 10.2174/0113895575298181240410041029. Online ahead of print.ABSTRACTDiabetes mellitus is one of the biggest challenges for the scientific community in the 21st century. With the increasing number of cases of diabetes and drug-resistant diabetes, there is an urgent need to develop new potent molecules capable of combating this cruel disease. Medicinal chemistry concerns the discovery, development, identification, and interpretation of the mode of action of biologically active compounds at the molecular level. Oxadiazole-based derivatives have come up as a potential option for antidiabeti...
Source: Mini Reviews in Medicinal Chemistry - April 22, 2024 Category: Chemistry Authors: Ojasvi Gupta Gita Chawla Tathagata Pradhan Source Type: research