Selenoprotein W engages in overactive osteoclast differentiation in multiple myeloma
CONCLUSION: Our findings suggest a possibility that feedforward signaling of osteoclastogenic SELENOW by TNFα derived from multiple myeloma induces overactive osteoclast differentiation, leading to bone loss during multiple myeloma.PMID:38683225 | DOI:10.1007/s11033-024-09517-2 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 29, 2024 Category: Molecular Biology Authors: Hyunsoo Kim Jiin Oh Min Kyoung Kim Kyung Hee Lee Daewon Jeong Source Type: research
Comparative evaluation of hesperetin-loaded graphene oxide nanosheets (Hsp-GO) as a drug delivery system for colon cancer: synthesis and anticancer efficiency assessment
CONCLUSIONS: These study highlight the potential of Hsp-GO as a promising anti-cancer nano-drug for colon cancer therapy.PMID:38683228 | DOI:10.1007/s11033-024-09504-7 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 29, 2024 Category: Molecular Biology Authors: Arezou Sabbagh Hadi Mehdi Haghi Abolfazl Barzegar Mohammad Ali Hosseinpour Feizi Source Type: research
Scalable, Cost-Effective, and Decentralized DNA Barcoding with Oxford Nanopore Sequencing
Methods Mol Biol. 2024;2744:223-238. doi: 10.1007/978-1-0716-3581-0_14.ABSTRACTDNA barcodes are useful in biodiversity research, but sequencing barcodes with dye termination methods ("Sanger sequencing") has been so time-consuming and expensive that DNA barcodes are not as widely used as they should be. Fortunately, MinION sequencers from Oxford Nanopore Technologies have recently emerged as a cost-effective and efficient alternative for barcoding. MinION barcodes are now suitable for large-scale species discovery and enable specimen identification when the target species are represented in barcode databases. With a MinION...
Source: Mol Biol Cell - April 29, 2024 Category: Molecular Biology Authors: Amrita Srivathsan Rudolf Meier Source Type: research
Analyses of Nuclear Reads Obtained Using Genome Skimming
Methods Mol Biol. 2024;2744:247-265. doi: 10.1007/978-1-0716-3581-0_16.ABSTRACTIn this protocol paper, we review a set of methods developed in recent years for analyzing nuclear reads obtained from genome skimming. As the cost of sequencing drops, genome skimming (low-coverage shotgun sequencing of a sample) becomes increasingly a cost-effective method of measuring biodiversity at high resolution. While most practitioners only use assembled over-represented organelle reads from a genome skim, the vast majority of the reads are nuclear. Using assembly-free and alignment-free methods described in this protocol, we can compar...
Source: Mol Biol Cell - April 29, 2024 Category: Molecular Biology Authors: Siavash Mirarab Vineet Bafna Source Type: research
Insights into metastatic roadmap of head and neck cancer squamous cell carcinoma based on clinical, histopathological and molecular profiles
Mol Biol Rep. 2024 Apr 29;51(1):597. doi: 10.1007/s11033-024-09476-8.ABSTRACTThe incidence of head and neck cancer (HNC), constituting approximately one in ten cancer cases worldwide, affects approximately 644,000 individuals annually. Managing this complex disease involves various treatment modalities such as systemic therapy, radiation, and surgery, particularly for patients with locally advanced disease. HNC treatment necessitates a multidisciplinary approach due to alterations in patients' genomes affecting their functionality. Predominantly, squamous cell carcinomas (SCCs), the majority of HNCs, arise from the upper a...
Source: Mol Biol Cell - April 29, 2024 Category: Molecular Biology Authors: Nicholas S Mastronikolis Alexander Delides Efthymios Kyrodimos Zoi Piperigkou Despoina Spyropoulou Evangelos Giotakis Evangelos Tsiambas Nikos K Karamanos Source Type: research
Profile of metacaspase gene expression in Plasmodium vivax field isolates from the Brazilian Amazon
CONCLUSION: The detection of metacaspases in P. vivax blood-stage parasites reported herein, allows the inclusion of these proteases as a potential candidate drug target for vivax malaria, while further investigations are still required to evaluate the activity, role and essentiality of metacaspases in P. vivax biology.PMID:38683374 | DOI:10.1007/s11033-024-09538-x (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 29, 2024 Category: Molecular Biology Authors: Carolina Moreira Blanco Hugo Amorim Dos Santos de Souza Priscilla da Costa Martins Camila Fabbri Fernanda Souza de Souza Josu é da Costa Lima-Junior Stefanie Costa Pinto Lopes Lilian Rose Pratt-Riccio Cl áudio Tadeu Daniel-Ribeiro Paulo Renato Rivas Tot Source Type: research
Cytotoxic and apoptotic effects of Ferula gummosa Boiss: extract on human breast adenocarcinoma cell line
CONCLUSION: F. gummosa exhibited pro-apoptotic, anti-proliferative, and anti-metastatic effects on MCF-7 cells. It is therefore recommended that detailed future research be done on different parts of the plant or its secondary metabolites to find anti-cancer lead compounds.PMID:38683376 | DOI:10.1007/s11033-024-09364-1 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 29, 2024 Category: Molecular Biology Authors: Roghayeh Rashidi Ali Roohbakhsh Leila Mohtashami Leila Mobasheri Hamidreza Kheradmand Mohammad Sadegh Amiri Ahmad Ghorbani Seyed Hadi Mousavi Source Type: research
In vitro anti-leukemic effect of Wharton's jelly derived mesenchymal stem cells
CONCLUSIONS: MSCs are known to inhibit the growth of tumors of both hematopoietic and non-hematopoietic origin in vitro. In our study, WJ-MSC treatment strongly inhibited the viability of HL-60 and K562 and induced apoptosis. Our results also provided new insights into the inhibition of tumor growth by WJ-MSCs in vitro. In the future, WJ-MSCs could be used to inhibit cancer cells in clinical applications.PMID:38683436 | DOI:10.1007/s11033-024-09512-7 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 29, 2024 Category: Molecular Biology Authors: Mediha S üleymanoğlu Ay şe Erol Bozkurt Figen Abatay Sel İsa Aykut Özdemir Fatma Savran O ğuz D ürdane Serap Kuruca Zerrin Akta ş Zeynep Karaka ş Mustafa Oral Öncül Source Type: research
Enhanced osteogenic differentiation potential of Arnica montana and Bellis perennis in C3H10T1/2 multipotent mesenchymal stem cells
CONCLUSIONS: Our findings suggest that homoeopathic compounds Arnica montana and Bellis perennis can augment osteogenesis individually as well as in combination.PMID:38683461 | DOI:10.1007/s11033-024-09509-2 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 29, 2024 Category: Molecular Biology Authors: Bhat K Deepika Nagendra H Apoorva Pinto R Joel Bipasha B Shenoy P Sudheer Source Type: research
Targeted protein degradation: from mechanisms to clinic
Nat Rev Mol Cell Biol. 2024 Apr 29. doi: 10.1038/s41580-024-00729-9. Online ahead of print.ABSTRACTTargeted protein degradation refers to the use of small molecules to induce the selective degradation of proteins. In its most common form, this degradation is achieved through ligand-mediated neo-interactions between ubiquitin E3 ligases - the principal waste disposal machines of a cell - and the protein targets of interest, resulting in ubiquitylation and subsequent proteasomal degradation. Notable advances have been made in biological and mechanistic understanding of serendipitously discovered degraders. This improved unde...
Source: Mol Biol Cell - April 29, 2024 Category: Molecular Biology Authors: Jonathan M Tsai Rados ław P Nowak Benjamin L Ebert Eric S Fischer Source Type: research
Epithelial-mesenchymal transition in tissue repair and degeneration
Nat Rev Mol Cell Biol. 2024 Apr 29. doi: 10.1038/s41580-024-00733-z. Online ahead of print.ABSTRACTEpithelial-mesenchymal transitions (EMTs) are the epitome of cell plasticity in embryonic development and cancer; during EMT, epithelial cells undergo dramatic phenotypic changes and become able to migrate to form different tissues or give rise to metastases, respectively. The importance of EMTs in other contexts, such as tissue repair and fibrosis in the adult, has become increasingly recognized and studied. In this Review, we discuss the function of EMT in the adult after tissue damage and compare features of embryonic and ...
Source: Mol Biol Cell - April 29, 2024 Category: Molecular Biology Authors: Khalil Kass Youssef M Angela Nieto Source Type: research
NEAT1 inhibits the angiogenic activity of cerebral arterial endothelial cells by inducing the M1 polarization of microglia through the AMPK signaling pathway
CONCLUSIONS: NEAT1 inhibits the angiogenic activity of mCAECs by inducing M1 polarization of BV-2 cells through the AMPK signaling pathway. This study further clarified the impact and mechanism of NEAT1 on microglia and the angiogenic ability of cerebrovascular endothelial cells.PMID:38684954 | DOI:10.1186/s11658-024-00579-5 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 29, 2024 Category: Molecular Biology Authors: Ting Chen Xin Huang Yi-Xuan Zhao Zhi-Wen Zhou Wen-Sheng Zhou Source Type: research
NestedBD: Bayesian inference of phylogenetic trees from single-cell copy number profiles under a birth-death model
Algorithms Mol Biol. 2024 Apr 29;19(1):18. doi: 10.1186/s13015-024-00264-4.ABSTRACTCopy number aberrations (CNAs) are ubiquitous in many types of cancer. Inferring CNAs from cancer genomic data could help shed light on the initiation, progression, and potential treatment of cancer. While such data have traditionally been available via "bulk sequencing," the more recently introduced techniques for single-cell DNA sequencing (scDNAseq) provide the type of data that makes CNA inference possible at the single-cell resolution. We introduce a new birth-death evolutionary model of CNAs and a Bayesian method, NestedBD, for the inf...
Source: Mol Biol Cell - April 29, 2024 Category: Molecular Biology Authors: Yushu Liu Mohammadamin Edrisi Zhi Yan Huw A Ogilvie Luay Nakhleh Source Type: research
MiR-18 regulates lipid metabolism of non-alcoholic fatty liver disease via IGF1
Cell Mol Biol (Noisy-le-grand). 2024 Apr 28;70(4):237-241. doi: 10.14715/cmb/2024.70.4.37.ABSTRACTWe aimed to illustrate the regulatory effect of miR-18 on the onset of non-alcoholic fatty liver disease (NAFLD). MiR-18 level in liver tissues collected from NAFLD patients and mice was detected. In vivo and in vitro influences of miR-18 on biochemical indexes, glucose tolerance and insulin resistance (IR) in NAFLD were determined. H&E staining was conducted to observe hepatic steatosis in NAFLD mice. The downstream target of miR-18 was finally detected by luciferase assay. MiR-18 was upregulated in liver tissues collecte...
Source: Mol Biol Cell - April 28, 2024 Category: Molecular Biology Authors: Hong Yang Bin Zhang Chun Yu Source Type: research
Comparison of the efficacy and safety of warfarin anticoagulation and left atrial appendage transcatheter occlusion in the treatment of non-valvular atrial fibrillation and investigation of ET-1, hs-CRP and PDGFs
This study compared the therapeutic effect and safety between warfarin anticoagulation and percutaneous left atrial appendage transcatheter occlusion (PLAATO) in non-valvular atrial fibrillation (NVAF). A total of 110 patients were selected and assigned to Control group (n=55) and Observation group (n=55). The control patients were used warfarin, while the observation patients were performed PLAATO. The coagulation function, stroke and bleeding scores were compared between the two groups at different times. Left ventricular function before therapy and 1 year after therapy and adverse events during follow-up were compared b...
Source: Mol Biol Cell - April 28, 2024 Category: Molecular Biology Authors: Yujie Zhang Yali Yao Ling Tao Tao Du Binbin Jia Mi Zhou Zhen Zhang Source Type: research
