Identification and analysis of MAPK cascade gene families of Camellia oleifera and their roles in response to cold stress
CONCLUSION: In this study, 21 MAPKs, 4 MAPKKs and 55 MAPKKKs genes were identified in the leaf transcriptome of C. oleifera. According to the phylogenetic results, MAPKs were divided into 4 groups (A, B, C and D), MAPKKs were divided into 3 groups (A, B and D), and MAPKKKs were divided into 2 groups (MEKK and Raf). Motif analysis showed that the motifs in each subfamily were conserved, and most of the motifs in the same subfamily were basically the same. The protein interaction network based on Arabidopsis thaliana (A. thaliana) homologs revealed that MAPK, MAPKK, and MAPKKK genes were widely involved in C. oleifera growth...
Source: Molecular Biology Reports - May 2, 2024 Category: Molecular Biology Authors: Kaifeng Xing Jian Zhang Haoxing Xie Lidong Zhang Huaxuan Zhang Liyun Feng Jun Zhou Yao Zhao Jun Rong Source Type: research
Apoptotic effect of 5-fluorouracil-doxorubicin combination on colorectal cancer cell monolayers and spheroids
CONCLUSION: The results indicated that the 5-FU + DOX combination therapy induces apoptosis and renders 5-FU and DOX more effective at lower concentrations compared to their alone use. This study reveals promising results in reducing the potential side effects of treatment by enabling the use of lower drug doses.PMID:38698270 | DOI:10.1007/s11033-024-09562-x (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - May 2, 2024 Category: Molecular Biology Authors: Sema Bilgin Source Type: research
Complete mitochondrial genome of critically endangered catfish Hemibagrus punctatus (Jerdon, 1849) and comparative analysis for insights into the phylogeny of hemibagrids through mitogenomic approach
CONCLUSIONS: The study's findings contribute to a better understanding of the mitogenome of H. punctatus and provide insights into the evolutionary relationships within other Hemibagrids.PMID:38693276 | DOI:10.1007/s11033-024-09490-w (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - May 1, 2024 Category: Molecular Biology Authors: Labrechai Mog Chowdhury Divya Pr Sangeeta Mandal Charan Ravi Vindhya Mohindra U K Sarkar Source Type: research
Single-cell transcriptomics: background, technologies, applications, and challenges
Mol Biol Rep. 2024 Apr 30;51(1):600. doi: 10.1007/s11033-024-09553-y.ABSTRACTSingle-cell sequencing was developed as a high-throughput tool to elucidate unusual and transient cell states that are barely visible in the bulk. This technology reveals the evolutionary status of cells and differences between populations, helps to identify unique cell subtypes and states, reveals regulatory relationships between genes, targets and molecular mechanisms in disease processes, tumor heterogeneity, the state of the immune environment, etc. However, the high cost and technical limitations of single-cell sequencing initially prevented ...
Source: Molecular Biology Reports - April 30, 2024 Category: Molecular Biology Authors: Lucky Duhan Deepika Kumari Mohammad Naime Virinder S Parmar Anil K Chhillar Mehak Dangi Ritu Pasrija Source Type: research
The modulation of autophagy and unfolded protein response by ent-kaurenoid derivative CPUK02 in human colorectal cancer cells
CONCLUSIONS: The study findings suggest CPUK02 may exert its cytotoxic effects by inhibiting UPR and autophagy flux in colorectal cancer cells.PMID:38689181 | DOI:10.1007/s11033-024-09541-2 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 30, 2024 Category: Molecular Biology Authors: Sedigheh Rezayi Morvarid Siri Nasim Rahmani-Kukia Mozhdeh Zamani Sanaz Dastghaib Pooneh Mokarram Source Type: research
Single-cell transcriptomics: background, technologies, applications, and challenges
Mol Biol Rep. 2024 Apr 30;51(1):600. doi: 10.1007/s11033-024-09553-y.ABSTRACTSingle-cell sequencing was developed as a high-throughput tool to elucidate unusual and transient cell states that are barely visible in the bulk. This technology reveals the evolutionary status of cells and differences between populations, helps to identify unique cell subtypes and states, reveals regulatory relationships between genes, targets and molecular mechanisms in disease processes, tumor heterogeneity, the state of the immune environment, etc. However, the high cost and technical limitations of single-cell sequencing initially prevented ...
Source: Molecular Biology Reports - April 30, 2024 Category: Molecular Biology Authors: Lucky Duhan Deepika Kumari Mohammad Naime Virinder S Parmar Anil K Chhillar Mehak Dangi Ritu Pasrija Source Type: research
The modulation of autophagy and unfolded protein response by ent-kaurenoid derivative CPUK02 in human colorectal cancer cells
CONCLUSIONS: The study findings suggest CPUK02 may exert its cytotoxic effects by inhibiting UPR and autophagy flux in colorectal cancer cells.PMID:38689181 | DOI:10.1007/s11033-024-09541-2 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 30, 2024 Category: Molecular Biology Authors: Sedigheh Rezayi Morvarid Siri Nasim Rahmani-Kukia Mozhdeh Zamani Sanaz Dastghaib Pooneh Mokarram Source Type: research
Selenoprotein W engages in overactive osteoclast differentiation in multiple myeloma
CONCLUSION: Our findings suggest a possibility that feedforward signaling of osteoclastogenic SELENOW by TNFα derived from multiple myeloma induces overactive osteoclast differentiation, leading to bone loss during multiple myeloma.PMID:38683225 | PMC:PMC11058866 | DOI:10.1007/s11033-024-09517-2 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 29, 2024 Category: Molecular Biology Authors: Hyunsoo Kim Jiin Oh Min Kyoung Kim Kyung Hee Lee Daewon Jeong Source Type: research
Comparative evaluation of hesperetin-loaded graphene oxide nanosheets (Hsp-GO) as a drug delivery system for colon cancer: synthesis and anticancer efficiency assessment
CONCLUSIONS: These study highlight the potential of Hsp-GO as a promising anti-cancer nano-drug for colon cancer therapy.PMID:38683228 | DOI:10.1007/s11033-024-09504-7 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 29, 2024 Category: Molecular Biology Authors: Arezou Sabbagh Hadi Mehdi Haghi Abolfazl Barzegar Mohammad Ali Hosseinpour Feizi Source Type: research
Applicability of SCoT markers in unraveling genetic variation and population structure among sugar beet (Beta vulgaris L.) germplasm
CONCLUSION: The utilization of SCoT markers unveiled a noteworthy degree of genetic variation within the sugar beet germplasm in this study. These findings can be used in future breeding programs with the objective of enhancing both sugar beet yield and quality.PMID:38683231 | DOI:10.1007/s11033-024-09526-1 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 29, 2024 Category: Molecular Biology Authors: Nazl ı Aybar Yalinkiliç Sema Ba şbağ Muhammad Tanveer Altaf Amjad Ali Muhammad Azhar Nadeem Faheem Shehzad Baloch Source Type: research
Investigation of sperm hsa-mir-145-5p and MLH1 expressions, seminal oxidative stress and sperm DNA fragmentation in varicocele
CONCLUSION: This is the first study investigating the expressions of sperm miR-145 and MLH1 in varicocele patients. Further studies are needed to clarify the potential effect of miR-145 on male fertility.PMID:38683237 | DOI:10.1007/s11033-024-09534-1 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 29, 2024 Category: Molecular Biology Authors: Neslihan Hekim Sezgin Gunes Sercan Ergun Elzem Nisa Barhan Ramazan Asci Source Type: research
Two case reports of a novel missense mutation in the PNPLA6 gene in two siblings with chorioretinal dystrophy, hypogonadotropic hypogonadism, and cerebellar ataxia
CONCLUSIONS: This highlights the importance of considering rare inherited causes of visual loss, spinocerebellar ataxia, or/and HH in a neurology clinic and the significant role of genetic sequencing in the diagnostic process.PMID:38683245 | DOI:10.1007/s11033-024-09515-4 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 29, 2024 Category: Molecular Biology Authors: Andreas Liampas Paschalis Nicolaou Christina Votsi Anthi Georghiou Kyproula Christodoulou George A Tanteles Marios Pantzaris Source Type: research
Interplay between α-synuclein and parkin genes: Insights of Parkinson's disease
Mol Biol Rep. 2024 Apr 29;51(1):586. doi: 10.1007/s11033-024-09520-7.ABSTRACTParkinson's disease (PD) is a complex and debilitating neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra. The pathogenesis of PD is intimately linked to the roles of two key molecular players, α-synuclein (α-syn) and Parkin. Understanding the intricate interplay between α-syn and Parkin is essential for unravelling the molecular underpinnings of PD. Their roles in synaptic function and protein quality control underscore their significance in neuronal health. Dysregulation of these p...
Source: Molecular Biology Reports - April 29, 2024 Category: Molecular Biology Authors: Kajal Sharma Shivani Chib Aniket Gupta Randhir Singh Rishabh Chalotra Source Type: research
Insights into metastatic roadmap of head and neck cancer squamous cell carcinoma based on clinical, histopathological and molecular profiles
Mol Biol Rep. 2024 Apr 29;51(1):597. doi: 10.1007/s11033-024-09476-8.ABSTRACTThe incidence of head and neck cancer (HNC), constituting approximately one in ten cancer cases worldwide, affects approximately 644,000 individuals annually. Managing this complex disease involves various treatment modalities such as systemic therapy, radiation, and surgery, particularly for patients with locally advanced disease. HNC treatment necessitates a multidisciplinary approach due to alterations in patients' genomes affecting their functionality. Predominantly, squamous cell carcinomas (SCCs), the majority of HNCs, arise from the upper a...
Source: Molecular Biology Reports - April 29, 2024 Category: Molecular Biology Authors: Nicholas S Mastronikolis Alexander Delides Efthymios Kyrodimos Zoi Piperigkou Despoina Spyropoulou Evangelos Giotakis Evangelos Tsiambas Nikos K Karamanos Source Type: research
Profile of metacaspase gene expression in Plasmodium vivax field isolates from the Brazilian Amazon
CONCLUSION: The detection of metacaspases in P. vivax blood-stage parasites reported herein, allows the inclusion of these proteases as a potential candidate drug target for vivax malaria, while further investigations are still required to evaluate the activity, role and essentiality of metacaspases in P. vivax biology.PMID:38683374 | PMC:PMC11058907 | DOI:10.1007/s11033-024-09538-x (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 29, 2024 Category: Molecular Biology Authors: Carolina Moreira Blanco Hugo Amorim Dos Santos de Souza Priscilla da Costa Martins Camila Fabbri Fernanda Souza de Souza Josu é da Costa Lima-Junior Stefanie Costa Pinto Lopes Lilian Rose Pratt-Riccio Cl áudio Tadeu Daniel-Ribeiro Paulo Renato Rivas Tot Source Type: research
