Chronic pain enhances excitability of corticotropin-releasing factor-expressing neurons in the oval part of the bed nucleus of the stria terminalis
We previously reported that enhanced corticotropin-releasing factor (CRF) signaling in the bed nucleus of the stria terminalis (BNST) caused the aversive responses during acute pain and suppressed the brain re... (Source: Molecular Brain)
Source: Molecular Brain - May 3, 2024 Category: Neuroscience Authors: Ryoko Uchida, Yasutaka Mukai, Taiju Amano, Kenji Sakimura, Keiichi Itoi, Akihiro Yamanaka and Masabumi Minami Tags: Micro report Source Type: research
L-DOPA regulates neuroinflammation and A β pathology through NEP and ADAM17 in a mouse model of AD
Dopamine plays important roles in cognitive function and inflammation and therefore is involved in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD). Drugs that increase or mai... (Source: Molecular Brain)
Source: Molecular Brain - April 30, 2024 Category: Neuroscience Authors: Hyun-ju Lee, JinHan Nam, Jeong-Woo Hwang, Jin-Hee Park, Yoo Joo Jeong, Ji-Yeong Jang, Su-Jeong Kim, A-Ran Jo and Hyang-Sook Hoe Tags: Micro report Source Type: research
Peripheral-central network analysis of cancer cachexia status accompanied by the polarization of hypothalamic microglia with low expression of inhibitory immune checkpoint receptors
While the excessive inflammation in cancer cachexia is well-known to be induced by the overproduction of inflammatory mediators in the periphery, microflora disruption and brain dysfunction are also considered... (Source: Molecular Brain)
Source: Molecular Brain - April 29, 2024 Category: Neuroscience Authors: Yukari Suda, Keiko Nakamura, Fukiko Matsuyama, Yusuke Hamada, Hitoshi Makabe, Michiko Narita, Yasuyuki Nagumo, Tomohisa Mori, Naoko Kuzumaki and Minoru Narita Tags: Research Source Type: research
Correction to: Toll-like receptor 4 deficiency ameliorates β2-microglobulin induced age-related cognition decline due to neuroinflammation in mice
(Source: Molecular Brain)
Source: Molecular Brain - April 23, 2024 Category: Neuroscience Authors: Qi Zhong, Yufeng Zou, Hongchao Liu, Ting Chen, Feng Zheng, Yifei Huang, Chang Chen and Zongze Zhang Tags: Correction Source Type: research
The 37TrillionCells initiative for improving global healthcare via cell-based interception and precision medicine: focus on neurodegenerative diseases
One of the main burdens in the treatment of diseases is imputable to the delay between the appearance of molecular dysfunctions in the first affected disease cells and their presence in sufficient number for d... (Source: Molecular Brain)
Source: Molecular Brain - April 11, 2024 Category: Neuroscience Authors: Benoit Coulombe, Thomas M. Durcan, Genevi ève Bernard, Asmae Moursli, Christian Poitras, Denis Faubert and Maxime Pinard Tags: Review Source Type: research
Synaptopodin is required for long-term depression at Schaffer collateral-CA1 synapses
Synaptopodin (SP), an actin-associated protein found in telencephalic neurons, affects activity-dependant synaptic plasticity and dynamic changes of dendritic spines. While being required for long-term depress... (Source: Molecular Brain)
Source: Molecular Brain - April 2, 2024 Category: Neuroscience Authors: Yanis Inglebert, Pei You Wu, Julia Tourbina-Kolomiets, Cong Loc Dang and R. Anne McKinney Tags: Research Source Type: research
Differential contribution of canonical and noncanonical NLGN3 pathways to early social development and memory performance
Neuroligin (NLGN) 3 is a postsynaptic cell adhesion protein organizing synapse formation through two different types of transsynaptic interactions, canonical interaction with neurexins (NRXNs) and a recently i... (Source: Molecular Brain)
Source: Molecular Brain - March 12, 2024 Category: Neuroscience Authors: Lin-Yu Li, Ayako Imai, Hironori Izumi, Ran Inoue, Yumie Koshidaka, Keizo Takao, Hisashi Mori and Tomoyuki Yoshida Tags: Research Source Type: research
Mutant α-synuclein causes death of human cortical neurons via ERK1/2 and JNK activation
Synucleinopathies refer to a group of disorders characterized by SNCA/ α-synuclein (α-Syn)-containing cytoplasmic inclusions and neuronal cell loss in the nervous system including the cortex, a common feature b... (Source: Molecular Brain)
Source: Molecular Brain - March 5, 2024 Category: Neuroscience Authors: Hidefumi Suzuki, Naohiro Egawa, Keiko Imamura, Takayuki Kondo, Takako Enami, Kayoko Tsukita, Mika Suga, Yuichiro Yada, Ran Shibukawa, Ryosuke Takahashi and Haruhisa Inoue Tags: Research Source Type: research
Spermidine treatment: induction of autophagy but also apoptosis?
Machado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3, is a fatal neurodegenerative disease that causes loss of balance and motor co-ordination, eventually leading to paralysis. It is cause... (Source: Molecular Brain)
Source: Molecular Brain - March 5, 2024 Category: Neuroscience Authors: Maxinne Watchon, Amanda L. Wright, Holly I. Ahel, Katherine J. Robinson, Stuart K. Plenderleith, Andrea Kuriakose, Kristy C. Yuan and Angela S. Laird Tags: Research Source Type: research
Crucial role of TFAP2B in the nervous system for regulating NREM sleep
The AP-2 transcription factors are crucial for regulating sleep in both vertebrate and invertebrate animals. In mice, loss of function of the transcription factor AP-2 β (TFAP2B) reduces non-rapid eye movement ... (Source: Molecular Brain)
Source: Molecular Brain - February 27, 2024 Category: Neuroscience Authors: Ayaka Nakai, Mitsuaki Kashiwagi, Tomoyuki Fujiyama, Kanako Iwasaki, Arisa Hirano, Hiromasa Funato, Masashi Yanagisawa, Takeshi Sakurai and Yu Hayashi Tags: Short report Source Type: research
TREM2 improves microglia function and synaptic development in autism spectrum disorders by regulating P38 MAPK signaling pathway
This study aim to explore the potential mechanism of TREM2 i... (Source: Molecular Brain)
Source: Molecular Brain - February 26, 2024 Category: Neuroscience Authors: Yi Tian, Xiao Xiao, Weiliang Liu, Shanqing Cheng, Na Qian, Ling Wang, Yang Liu, Rong Ai and Xiaoping Zhu Tags: Research Source Type: research
Selective enhancement of fear extinction by inhibiting neuronal adenylyl cyclase 1 (AC1) in aged mice
Adenylyl cyclase 1 (AC1) is a selective subtype of ACs, which is selectively expressed in neurons. The activation of AC1 is activity-dependent, and AC1 plays an important role in cortical excitation that contr... (Source: Molecular Brain)
Source: Molecular Brain - February 22, 2024 Category: Neuroscience Authors: Wantong Shi, Qi-Yu Chen, Yujie Ma, Jinjin Wan, Xu-Hui Li and Min Zhuo Tags: Research Source Type: research
A simple and reliable method for claustrum localization across age in mice
The anatomical organization of the rodent claustrum remains obscure due to lack of clear borders that distinguish it from neighboring forebrain structures. Defining what constitutes the claustrum is imperative... (Source: Molecular Brain)
Source: Molecular Brain - February 17, 2024 Category: Neuroscience Authors: Tarek Shaker, Gwyneth J. Dagpa, Vanessa Cattaud, Brian A. Marriott, Mariam Sultan, Mohammed Almokdad and Jesse Jackson Tags: Methodology Source Type: research
In vitro modulation of mTOR and mGlur5 influence α-synuclein accumulation
One of the main hallmarks of Parkinson ’s disease (PD) is abnormal alpha-synuclein (α-syn) aggregation which forms the main component of intracellular Lewy body inclusions. This short report used preformed α-sy... (Source: Molecular Brain)
Source: Molecular Brain - February 15, 2024 Category: Neuroscience Authors: Viktoria Xing, Kyle Biggar, Stephen S. G. Ferguson and Shawn Hayley Tags: Short report Source Type: research
Deleting IP6K1 stabilizes neuronal sodium –potassium pumps and suppresses excitability
Inositol pyrophosphates are key signaling molecules that regulate diverse neurobiological processes. We previously reported that the inositol pyrophosphate 5-InsP7, generated by inositol hexakisphosphate kinase 1... (Source: Molecular Brain)
Source: Molecular Brain - February 13, 2024 Category: Neuroscience Authors: Hongfu Jin, Aili Liu, Alfred C. Chin, Chenglai Fu, Hui Shen and Weiwei Cheng Tags: Micro report Source Type: research
