Deubiquitination of CDC6 by OTUD6A promotes tumour progression and chemoresistance
CDC6 is an oncogenic protein whose expression level fluctuates during the cell cycle. Although several E3 ubiquitin ligases responsible for the ubiquitin-mediated proteolysis of CDC6 have been identified, the ... (Source: Molecular Cancer)
Source: Molecular Cancer - April 29, 2024 Category: Cancer & Oncology Authors: Jianfeng Cui, Xiaochen Liu, Qinghong Shang, Shuna Sun, Shouzhen Chen, Jianping Dong, Yaofeng Zhu, Lei Liu, Yangyang Xia, Yong Wang, Lu Xiang, Bowen Fan, Jiafeng Zhan, Yadi Zhou, Pengxiang Chen, Renchang Zhao & hellip; Tags: Research Source Type: research
R-loop and diseases: the cell cycle matters
The cell cycle is a crucial biological process that is involved in cell growth, development, and reproduction. It can be divided into G1, S, G2, and M phases, and each period is closely regulated to ensure the... (Source: Molecular Cancer)
Source: Molecular Cancer - April 27, 2024 Category: Cancer & Oncology Authors: Yuqin Xu, Yue Jiao, Chengbin Liu, Rui Miao, Chunyan Liu, Yilong Wang, Chunming Ma and Jiao Liu Tags: Review Source Type: research
Exclusion of HDAC1/2 complexes by oncogenic nuclear condensates
Nuclear condensates have been shown to regulate cell fate control, but its role in oncogenic transformation remains largely unknown. Here we show acquisition of oncogenic potential by nuclear condensate remode... (Source: Molecular Cancer)
Source: Molecular Cancer - April 27, 2024 Category: Cancer & Oncology Authors: Junqi Kuang, Pengli Li, Ziwei Zhai, Yixin Fan, HuaiYuan Xu, Chengchen Zhao, Wei Li, Xiaoxi Li, Zechuan Liang, Tao Huang, Yue Qin, Huiru Gao, Zhaoyi Ma, Dong Liu, Guifa Zhong, Bo Wang & hellip; Tags: Research Source Type: research
Mutation of neurotrophic tyrosine receptor kinase can promote pan-cancer immunity and the efficacy of immunotherapy
The Neurotrophic tyrosine receptor kinase (NTRK) family plays important roles in tumor progression and is involved in tumor immunogenicity. Here, we conducted a comprehensive bioinformatic and clinical analysis t... (Source: Molecular Cancer)
Source: Molecular Cancer - April 25, 2024 Category: Cancer & Oncology Authors: Congren Wang, Yingying Li, Jinyuan Huang, Huimeng Yan and Bin Zhao Tags: Correspondence Source Type: research
The incorporation of acetylated LAP-TGF- β1 proteins into exosomes promotes TNBC cell dissemination in lung micro-metastasis
Triple-negative breast cancer (TNBC) stands as the breast cancer subtype with the highest recurrence and mortality rates, with the lungs being the common site of metastasis. The pulmonary microenvironment play... (Source: Molecular Cancer)
Source: Molecular Cancer - April 25, 2024 Category: Cancer & Oncology Authors: Pei Yu, Yubao Han, Lulu Meng, Zengying Tang, Zhiwei Jin, Zhenzhen Zhang, Yunjiang Zhou, Jun Luo, Jianguang Luo, Chao Han, Chao Zhang and Lingyi Kong Tags: Research Source Type: research
Co-transcriptional R-loops-mediated epigenetic regulation drives growth retardation and docetaxel chemosensitivity enhancement in advanced prostate cancer
R-loops are prevalent three-stranded nucleic acid structures, comprising a DNA-RNA hybrid and a displaced single-stranded DNA, that frequently form during transcription and may be attributed to genomic stabili... (Source: Molecular Cancer)
Source: Molecular Cancer - April 24, 2024 Category: Cancer & Oncology Authors: Yufan Ying, Yuqing Wu, Fenghao Zhang, Yijie Tang, Jiahe Yi, Xueyou Ma, Jiangfeng Li, Danni Chen, Xiao Wang, Xiaoyan Liu, Ben Liu, Jindan Luo, Xiangyi Zheng and Liping Xie Tags: Research Source Type: research
Evolving insights into the improvement of adoptive T-cell immunotherapy through PD-1/PD-L1 blockade in the clinical spectrum of lung cancer
Undeniably, cancer immunotherapies have expanded the spectrum of cancer treatment, however, some patients do not respond to immunotherapies. This scenario is no different for lung cancer, whose two main types,... (Source: Molecular Cancer)
Source: Molecular Cancer - April 24, 2024 Category: Cancer & Oncology Authors: Yutao Li, Amit Sharma and Ingo G.H. Schmidt-Wolf Tags: Review Source Type: research
Trametinib sensitizes KRAS-mutant lung adenocarcinoma tumors to PD-1/PD-L1 axis blockade via Id1 downregulation
This study analyzes the effects of trametinib on... (Source: Molecular Cancer)
Source: Molecular Cancer - April 20, 2024 Category: Cancer & Oncology Authors: Ander Puyalto, Mar ía Rodríguez-Remírez, Inés López, Irati Macaya, Elizabeth Guruceaga, María Olmedo, Anna Vilalta-Lacarra, Connor Welch, Sergio Sandiego, Silvestre Vicent, Karmele Valencia, Alfonso Calvo, Ruben Pio, Luis E. Raez, Christian Rolfo, D Tags: Research Source Type: research
Efficacy and safety of bispecific antibodies vs. immune checkpoint blockade combination therapy in cancer: a real-world comparison
Emerging tumor immunotherapy methods encompass bispecific antibodies (BSABs), immune checkpoint inhibitors (ICIs), and adoptive cell immunotherapy. BSABs belong to the antibody family that can specifically rec... (Source: Molecular Cancer)
Source: Molecular Cancer - April 16, 2024 Category: Cancer & Oncology Authors: Linyan Cheng, Lujun Chen, Yuan Shi, Weiying Gu, Weidong Ding, Xiao Zheng, Yan Liu, Jingting Jiang and Zhuojun Zheng Tags: Review Source Type: research
tRNA-derived small RNAs in human cancers: roles, mechanisms, and clinical application
Transfer RNA (tRNA)-derived small RNAs (tsRNAs) are a new type of non-coding RNAs (ncRNAs) produced by the specific cleavage of precursor or mature tRNAs. tsRNAs are involved in various basic biological proces... (Source: Molecular Cancer)
Source: Molecular Cancer - April 15, 2024 Category: Cancer & Oncology Authors: Manli Zhou, Xiaoyun He, Jing Zhang, Cheng Mei, Baiyun Zhong and Chunlin Ou Tags: Review Source Type: research
Loss of lncRNA LINC01056 leads to sorafenib resistance in HCC
Sorafenib is a major nonsurgical option for patients with advanced hepatocellular carcinoma (HCC); however, its clinical efficacy is largely undermined by the acquisition of resistance. The aim of this study w... (Source: Molecular Cancer)
Source: Molecular Cancer - April 6, 2024 Category: Cancer & Oncology Authors: Yau-Tuen Chan, Junyu Wu, Yuanjun Lu, Qiucheng Li, Zixin Feng, Lin Xu, Hongchao Yuan, Tingyuan Xing, Cheng Zhang, Hor-Yue Tan, Yibin Feng and Ning Wang Tags: Research Source Type: research
Tertiary lymphoid structural heterogeneity determines tumour immunity and prospects for clinical application
Tertiary lymphoid structures (TLS) are clusters of immune cells that resemble and function similarly to secondary lymphoid organs (SLOs). While TLS is generally associated with an anti-tumour immune response i... (Source: Molecular Cancer)
Source: Molecular Cancer - April 6, 2024 Category: Cancer & Oncology Authors: Yuyuan Zhang, Mengjun Xu, Yuqing Ren, Yuhao Ba, Shutong Liu, Anning Zuo, Hui Xu, Siyuan Weng, Xinwei Han and Zaoqu Liu Tags: Review Source Type: research
Cancer immunometabolism: advent, challenges, and perspective
For decades, great strides have been made in the field of immunometabolism. A plethora of evidence ranging from basic mechanisms to clinical transformation has gradually embarked on immunometabolism to the cen... (Source: Molecular Cancer)
Source: Molecular Cancer - April 5, 2024 Category: Cancer & Oncology Authors: Qin Dang, Borui Li, Bing Jin, Zeng Ye, Xin Lou, Ting Wang, Yan Wang, Xuan Pan, Qiangsheng Hu, Zheng Li, Shunrong Ji, Chenjie Zhou, Xianjun Yu, Yi Qin and Xiaowu Xu Tags: Review Source Type: research
Functional CRISPR screens in T cells reveal new opportunities for cancer immunotherapies
T cells are fundamental components in tumour immunity and cancer immunotherapies, which have made immense strides and revolutionized cancer treatment paradigm. However, recent studies delineate the predicament... (Source: Molecular Cancer)
Source: Molecular Cancer - April 5, 2024 Category: Cancer & Oncology Authors: Minghua Xiang, Huayi Li, Yuanyuan Zhan, Ding Ma, Qinglei Gao and Yong Fang Tags: Review Source Type: research
Therapy-induced senescent tumor cell-derived extracellular vesicles promote colorectal cancer progression through SERPINE1-mediated NF- κB p65 nuclear translocation
Cellular senescence frequently occurs during anti-cancer treatment, and persistent senescent tumor cells (STCs) unfavorably promote tumor progression through paracrine secretion of the senescence-associated se... (Source: Molecular Cancer)
Source: Molecular Cancer - April 4, 2024 Category: Cancer & Oncology Authors: Dan Zhang, Jian-Wei Zhang, Hui Xu, Xin Chen, Yu Gao, Huan-Gang Jiang, You Wang, Han Wu, Lei Yang, Wen-Bo Wang, Jing Dai, Ling Xia, Jin Peng and Fu-Xiang Zhou Tags: Research Source Type: research
