Elevated blood homocysteine increases the risk of incident Motoric Cognitive Risk syndrome: A two cohort study
CONCLUSIONS: Higher blood homocysteine levels are associated with increased risk of developing MCR in older adults, particularly in men with vascular disease or vascular risk factors.PMID:38671552 | DOI:10.1093/gerona/glae114 (Source: Molecular Medicine)
Source: Molecular Medicine - April 27, 2024 Category: Molecular Biology Authors: Kelly Cotton Emmeline Ayers Ying Jin Olivier Beauchet Carol A Derby Richard B Lipton Mindy Katz Kevin Galery Pierrette Gaudreau Joe Verghese Source Type: research
The Development of < em > Toxoplasma gondii < /em > Recombinant Trivalent Chimeric Proteins as an Alternative to < em > Toxoplasma < /em > Lysate Antigen (TLA) in Enzyme-Linked Immunosorbent Assay (ELISA) for the Detection of Immunoglobulin G (IgG) in Small Ruminants
This study presents an evaluation of seventeen newly produced recombinant trivalent chimeric proteins (containing the same immunodominant fragment of SAG1 and SAG2 of Toxoplasma gondii antigens, and an additional immunodominant fragment of one of the parasite antigens, such as AMA1, GRA1, GRA2, GRA5, GRA6, GRA7, GRA9, LDH2, MAG1, MIC1, MIC3, P35, and ROP1) as a potential alternative to the whole-cell tachyzoite lysate (TLA) used in the detection of infection in small ruminants. These recombinant proteins, obtained by genetic engineering and molecular biology methods, were tested for their reactivity with specific anti-Toxo...
Source: Molecular Medicine - April 27, 2024 Category: Molecular Biology Authors: Bart łomiej Tomasz Ferra Maciej Chyb Karolina So łowińska Lucyna Holec-G ąsior Marta Skwarecka Karolina Baranowicz Justyna Gatkowska Source Type: research
Ferroptosis, Inflammation, and Microbiome Alterations in the Intestine in the G öttingen Minipig Model of Hematopoietic-Acute Radiation Syndrome
Int J Mol Sci. 2024 Apr 20;25(8):4535. doi: 10.3390/ijms25084535.ABSTRACTHematopoietic acute radiation syndrome (H-ARS) involves injury to multiple organ systems following total body irradiation (TBI). Our laboratory demonstrated that captopril, an angiotensin-converting enzyme inhibitor, mitigates H-ARS in Göttingen minipigs, with improved survival and hematopoietic recovery, as well as the suppression of acute inflammation. However, the effects of captopril on the gastrointestinal (GI) system after TBI are not well known. We used a Göttingen minipig H-ARS model to investigate captopril's effects on the GI following TBI...
Source: Molecular Medicine - April 27, 2024 Category: Molecular Biology Authors: Timothy Horseman W Bradley Rittase John E Slaven Dmitry T Bradfield Andrew M Frank Joseph A Anderson Evelyn C Hays Andrew C Ott Anjali E Thomas Alison R Huppmann Sang-Ho Lee David M Burmeister Regina M Day Source Type: research
Dexamethasone promotes renal fibrosis by upregulating ILT4 expression in myeloid-derived suppressor cells
In this study, we found that adoptive transfer of MDSCs to doxorubicin-induced focal segmental glomerulosclerosis (FSGS) mice for eight consecutive weeks led to an increase in serum creatinine and proteinuria and aggravation of renal interstitial fibrosis. Similarly, 8 weeks of high-dose dexamethasone administration exacerbated renal interstitial injury and interstitial fibrosis in doxorubicin-induced mice, manifested as an increase in serum creatinine and proteinuria, collagen deposition and α-SMA expression. On this basis, we found that dexamethasone could enhance MDSC expression and secretion of the fibrosis-related cy...
Source: Molecular Medicine - April 27, 2024 Category: Molecular Biology Authors: Xiaowen Gu Lianmei Zhang Min Sun Ying Zhou Jinling Ji YunFang Xu Jianguo You Zhikui Deng Source Type: research
The physiological role of TRP channels in sleep and circadian rhythm
J Cell Mol Med. 2024 May;28(9):e18274. doi: 10.1111/jcmm.18274.ABSTRACTTRP channels, are non-specific cationic channels that are involved in multiple physiological processes that include salivation, cellular secretions, memory extinction and consolidation, temperature, pain, store-operated calcium entry, thermosensation and functionality of the nervous system. Here we choose to look at the evidence that decisively shows how TRP channels modulate human neuron plasticity as it relates to the molecular neurobiology of sleep/circadian rhythm. There are numerous model organisms of sleep and circadian rhythm that are the results...
Source: Molecular Medicine - April 27, 2024 Category: Molecular Biology Authors: Geoffrey Woodard Juan A Rosado He Li Source Type: research
Irisin attenuates ventilator-induced diaphragmatic dysfunction by inhibiting endoplasmic reticulum stress through activation of AMPK
J Cell Mol Med. 2024 May;28(9):e18259. doi: 10.1111/jcmm.18259.ABSTRACTMechanical ventilation (MV) is an essential life-saving technique, but prolonged MV can cause significant diaphragmatic dysfunction due to atrophy and decreased contractility of the diaphragm fibres, called ventilator-induced diaphragmatic dysfunction (VIDD). It is not clear about the mechanism of occurrence and prevention measures of VIDD. Irisin is a newly discovered muscle factor that regulates energy metabolism. Studies have shown that irisin can exhibit protective effects by downregulating endoplasmic reticulum (ER) stress in a variety of diseases;...
Source: Molecular Medicine - April 27, 2024 Category: Molecular Biology Authors: Jumei Zhang Rui Tu Fasheng Guan Jianguo Feng Jing Jia Jun Zhou Xiaobin Wang Li Liu Source Type: research
Improving olaparib exposure to optimize adverse effects management
CONCLUSION: Based on real-world data, we were able to properly describe the time course of haemoglobinaemia and plasma creatininaemia during olaparib treatment.PMID:38665845 | PMC:PMC11044803 | DOI:10.1177/17588359241248328 (Source: Molecular Medicine)
Source: Molecular Medicine - April 26, 2024 Category: Molecular Biology Authors: Marylise Sterl é Alicja Puszkiel Chlo é Burlot Eva Pereira Audrey Bellesoeur Sixtine De Percin Guillaume Beinse Jean-David Fumet Laure Favier Julie Niogret Benoit Blanchet Bernard Royer Le ïla Bengrine-Lefevre Antonin Schmitt Source Type: research
Mother's smoking habits affects IL10 methylation but not asthma in Ecuadorian children
CONCLUSION: Smoking habit could be essential as an environmental exposure factor in regulating gene expression in children with asthma.PMID:38666495 | DOI:10.1002/mgg3.2438 (Source: Molecular Medicine)
Source: Molecular Medicine - April 26, 2024 Category: Molecular Biology Authors: Cristina Ochoa-Avil és Ang élica Ochoa-Avilés Roque Rivas-P árraga Samuel Escand ón Talita Dos Santos-Jesus Milca de J Silva Valderiene Le ão Marco Salinas Yosselin Vicu ña Lucy Balde ón Mar ía José Molina-Cando Diana Morillo Marcos Machuca Clau Source Type: research
[Corrigendum] MicroRNA ‑222‑3p promotes tumor cell migration and invasion and inhibits apoptosis, and is correlated with an unfavorable prognosis of patients with renal cell carcinoma
Int J Mol Med. 2024 Jun;53(6):53. doi: 10.3892/ijmm.2024.5377. Epub 2024 Apr 26.ABSTRACTFollowing the publication of the above article, an interested reader drew to the attention of the Editorial Office that, in Fig. 3A on p. 530, two pairs of data panels were overlapping, such that certain of the panels appeared to have been derived from the same original sources where the results from differently performed experiments were intended to have been portrayed. The authors have examined their original data, and realize that errors associated with data handling/labelling during the preparation of the representative images in Fi...
Source: Molecular Medicine - April 26, 2024 Category: Molecular Biology Authors: Liwen Zhao Jing Quan Zuwei Li Xiang Pan Jingyao Wang Jinling Xu Weijie Xu Xin Guan Hang Li Shangqi Yang Yaoting Gui Yun Chen Yongqing Lai Source Type: research
[Retracted] lncRNA ROR promotes the progression of renal cell carcinoma through the miR ‑206/VEGF axis
Mol Med Rep. 2024 Jun;29(6):105. doi: 10.3892/mmr.2024.13229. Epub 2024 Apr 26.ABSTRACTFollowing the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the Transwell cell invasion and migration assay data shown in Fig. 2D and F on p. 3786 were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes, which had already been published. Owing to the fact that the contentious data in the above article had already been published prior to its submission to Molecular Medicine Reports, the Editor has d...
Source: Molecular Medicine - April 26, 2024 Category: Molecular Biology Authors: Jianguo Shi Datian Zhang Zhenhai Zhong Wen Zhang Source Type: research
Ultrasound ‑targeted microbubble destruction technology delivering β‑klotho to the heart enhances FGF21 sensitivity and attenuates heart remodeling post‑myocardial infarction
Int J Mol Med. 2024 Jun;53(6):54. doi: 10.3892/ijmm.2024.5378. Epub 2024 Apr 26.ABSTRACTFibroblast growth factor (FGF)21 is a peptide hormone that improves mitochondrial function and energy metabolism, and the deficiency of its co‑receptor β‑klotho (KLB) causes decreased FGF21 sensitivity. The present study examined whether the cardiac delivery of plasmids containing the KLB gene via ultrasound‑targeted microbubble destruction (UTMD) enhances the efficacy of FGF21 against heart failure post‑acute myocardial infarction (AMI). For this purpose, the levels of FGF21 in patients and rats with heart dysfunction post‑i...
Source: Molecular Medicine - April 26, 2024 Category: Molecular Biology Authors: Chaofu Yue Rong Li Chunyan Li Taoxian Yang Xian Huang Rong Lei Yongjun Yan Yuan Liu Qiaolin Li Qinyong Yan Dingrong Zuo Shisheng Liu Mei Yang Source Type: research
Tenascin C activates the toll ‑like receptor 4/NF‑κB signaling pathway to promote the development of polycystic ovary syndrome
In conclusion, knockdown of TNC could ameliorate PCOS in both rats and a cell model by inhibiting cell apoptosis, oxidative stress and inflammation via the suppression of the TLR4/NF‑κB signaling pathway.PMID:38666538 | DOI:10.3892/mmr.2024.13230 (Source: Molecular Medicine)
Source: Molecular Medicine - April 26, 2024 Category: Molecular Biology Authors: Han Wu Mo Yang Cuiping Yan Mengchen Liu Haoran Wang Wenjuan Zhang Source Type: research
Cell death ‑related molecules and targets in the progression of urolithiasis (Review)
Int J Mol Med. 2024 Jun;53(6):52. doi: 10.3892/ijmm.2024.5376. Epub 2024 Apr 26.ABSTRACTUrolithiasis is a high‑incidence disease caused by calcium oxalate (mainly), uric acid, calcium phosphate, struvite, apatite, cystine and other stones. The development of kidney stones is closely related to renal tubule cell damage and crystal adhesion and aggregation. Cell death, comprising the core steps of cell damage, can be classified into various types (i.e., apoptosis, ferroptosis, necroptosis and pyroptosis). Different crystal types, concentrations, morphologies and sizes cause tubular cell damage via the regulation of differe...
Source: Molecular Medicine - April 26, 2024 Category: Molecular Biology Authors: Liping Wu Xiaoyan Xue Chengwu He Yongchang Lai Lingfei Tong Source Type: research
Mechanistic complement of autosomal dominant polycystic kidney disease: the role of aquaporins
J Mol Med (Berl). 2024 Apr 26. doi: 10.1007/s00109-024-02446-4. Online ahead of print.ABSTRACTAutosomal dominant polycystic kidney disease is a genetic kidney disease caused by mutations in the genes PKD1 or PKD2. Its course is characterized by the formation of progressively enlarged cysts in the renal tubules bilaterally. The basic genetic explanation for autosomal dominant polycystic kidney disease is the double-hit theory, and many of its mechanistic issues can be explained by the cilia doctrine. However, the precise molecular mechanisms underpinning this condition's occurrence are still not completely understood. Exper...
Source: Molecular Medicine - April 26, 2024 Category: Molecular Biology Authors: Qiumei Lan Jie Li Hanqing Zhang Zijun Zhou Yaxuan Fang Bo Yang Source Type: research
Anti-inflammatory effect of Trichospira verticillata via suppression of the NLRP3 inflammasome in neutrophilic asthma
This study demonstrates that TVE modulates the binding of NLPR3 to NEK7, thereby reporting novel insights into the mechanism by which TVE inhibits NLRP3 inflammasome. These findings suggest TVE as a potential therapeutic of NLRP3 inflammasome-mediated diseases, particularly NA.PMID:38668995 | PMC:PMC11048967 | DOI:10.1111/jcmm.18356 (Source: Molecular Medicine)
Source: Molecular Medicine - April 26, 2024 Category: Molecular Biology Authors: Hyeyun Yang Gunwoo Park Sojung Lee Sumin Lee YeJi Kim Nelson A Zamora Dong-Keun Yi Soo-Yong Kim Chun Whan Choi Sangho Choi Yong Hwan Park Source Type: research
