Correction: Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade
(Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 29, 2024 Category: Neurology Authors: Erica Acquarone, Elentina K. Argyrousi, Manon van den Berg, Walter Gulisano, Mauro F à, Agnieszka Staniszewski, Elisa Calcagno, Elisa Zuccarello, Luciano D’Adamio, Shi-Xian Deng, Daniela Puzzo, Ottavio Arancio and Jole Fiorito Tags: Correction Source Type: research
Adaptive immune changes associate with clinical progression of Alzheimer ’s disease
Alzheimer ’s disease (AD) is the most frequent cause of dementia. Recent evidence suggests the involvement of peripheral immune cells in the disease, but the underlying mechanisms remain unclear. (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 24, 2024 Category: Neurology Authors: Lynn van Olst, Alwin Kamermans, Sem Halters, Susanne M. A. van der Pol, Ernesto Rodriguez, Inge M. W. Verberk, Sanne G. S. Verberk, Danielle W. R. Wessels, Carla Rodriguez-Mogeda, Jan Verhoeff, Dorine Wouters, Jan Van den Bossche, Juan J. Garcia-Vallejo, Tags: Research article Source Type: research
Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer ’s disease
Microglia play important roles in maintaining brain homeostasis and neurodegeneration. The discovery of genetic variants in genes predominately or exclusively expressed in myeloid cells, such as Apolipoprotein... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 24, 2024 Category: Neurology Authors: Lina Vandermeulen, Ivana Geric, Laura Fumagalli, Mohamed Kreir, Ashley Lu, Annelies Nonneman, Jessie Premereur, Leen Wolfs, Rafaela Policarpo, Nicola Fattorelli, An De Bondt, Ilse Van Den Wyngaert, Bob Asselbergh, Mark Fiers, Bart De Strooper, Constantin Tags: Research article Source Type: research
Melatonin: a ferroptosis inhibitor with potential therapeutic efficacy for the post-COVID-19 trajectory of accelerated brain aging and neurodegeneration
The unprecedented pandemic of COVID-19 swept millions of lives in a short period, yet its menace continues among its survivors in the form of post-COVID syndrome. An exponentially growing number of COVID-19 su... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 19, 2024 Category: Neurology Authors: Asmaa Yehia and Osama A. Abulseoud Tags: Review Source Type: research
Gut microbiota-host lipid crosstalk in Alzheimer ’s disease: implications for disease progression and therapeutics
Trillions of intestinal bacteria in the human body undergo dynamic transformations in response to physiological and pathological changes. Alterations in their composition and metabolites collectively contribut... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 16, 2024 Category: Neurology Authors: Ya-Xi Luo, Ling-Ling Yang and Xiu-Qing Yao Tags: Review Source Type: research
Mitovesicles secreted into the extracellular space of brains with mitochondrial dysfunction impair synaptic plasticity
Hypometabolism tied to mitochondrial dysfunction occurs in the aging brain and in neurodegenerative disorders, including in Alzheimer ’s disease, in Down syndrome, and in mouse models of these conditions. We ha... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 14, 2024 Category: Neurology Authors: Pasquale D ’Acunzo, Elentina K. Argyrousi, Jonathan M. Ungania, Yohan Kim, Steven DeRosa, Monika Pawlik, Chris N. Goulbourne, Ottavio Arancio and Efrat Levy Tags: Research article Source Type: research
The concept of resilience to Alzheimer ’s Disease: current definitions and cellular and molecular mechanisms
Some individuals are able to maintain their cognitive abilities despite the presence of significant Alzheimer ’s Disease (AD) neuropathological changes. This discrepancy between cognition and pathology has been... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 8, 2024 Category: Neurology Authors: Luuk E. de Vries, Inge Huitinga, Helmut W. Kessels, Dick F. Swaab and Joost Verhaagen Tags: Review Source Type: research
An adapted protocol to derive microglia from stem cells and its application in the study of CSF1R-related disorders
Induced pluripotent stem cell-derived microglia (iMGL) represent an excellent tool in studying microglial function in health and disease. Yet, since differentiation and survival of iMGL are highly reliant on c... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 5, 2024 Category: Neurology Authors: Marie-France Dorion, Diana Casas, Irina Shlaifer, Moein Yaqubi, Peter Fleming, Nathan Karpilovsky, Carol X.-Q. Chen, Michael Nicouleau, Valerio E. C. Piscopo, Emma J. MacDougall, Aeshah Alluli, Taylor M. Goldsmith, Alexandria Schneider, Samuel Dorion, Nat Tags: Research article Source Type: research
Regulatory T cells limit age-associated retinal inflammation and neurodegeneration
Ageing is the principal risk factor for retinal degenerative diseases, which are the commonest cause of blindness in the developed countries. These conditions include age-related macular degeneration or diabet... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 5, 2024 Category: Neurology Authors: Mar ía Llorián-Salvador, Alerie G. de Fuente, Christopher E. McMurran, Amy Dashwood, James Dooley, Adrian Liston, Rosana Penalva, Yvonne Dombrowski, Alan W. Stitt and Denise C. Fitzgerald Tags: Research article Source Type: research
The endotoxin hypothesis of Alzheimer ’s disease
Lipopolysaccharide (LPS) constitutes much of the surface of Gram-negative bacteria, and if LPS enters the human body or brain can induce inflammation and act as an endotoxin. We outline the hypothesis here tha... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 1, 2024 Category: Neurology Authors: Guy C. Brown and Michael T. Heneka Tags: Review Source Type: research
HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases
This letter demonstrates the potential of novel cryptic proteins resulting from TAR DNA-binding protein 43 (TDP-43) dysfunction as markers of TDP-43 pathology in neurodegenerative diseases. (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 27, 2024 Category: Neurology Authors: Anna Calliari, Lillian M. Daughrity, Ellen A. Albagli, Paula Castellanos Otero, Mei Yue, Karen Jansen-West, Naeyma N. Islam, Thomas Caulfield, Bailey Rawlinson, Michael DeTure, Casey Cook, Neill R. Graff-Radford, Gregory S. Day, Bradley F. Boeve, David S. Tags: Letter to the Editor Source Type: research
Correction: Unravelling cell type-specific responses to Parkinson ’s Disease at single cell resolution
(Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 25, 2024 Category: Neurology Authors: Araks Martirosyan, Rizwan Ansari, Francisco Pestana, Katja Hebestreit, Hayk Gasparyan, Razmik Aleksanyan, Silvia Hnatova, Suresh Poovathingal, Catherine Marneffe, Dietmar R. Thal, Andrew Kottick, Victor J. Hanson-Smith, Sebastian Guelfi, William Plumbly, Tags: Correction Source Type: research
Correction: Blood –brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism
(Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 22, 2024 Category: Neurology Authors: Qingyi Ma, Zhen Zhao, Abhay P. Sagare, Yingxi Wu, Min Wang, Nelly Chuqui Owens, Philip B. Verghese, Joachim Herz, David M. Holtzman and Berislav V. Zlokovic Tags: Correction Source Type: research
A partial Drp1 knockout improves autophagy flux independent of mitochondrial function
Dynamin-related protein 1 (Drp1) plays a critical role in mitochondrial dynamics. Partial inhibition of this protein is protective in experimental models of neurological disorders such as Parkinson ’s disease a... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 19, 2024 Category: Neurology Authors: Rebecca Z. Fan, Carolina Sportelli, Yanhao Lai, Said S. Salehe, Jennifer R. Pinnell, Harry J. Brown, Jason R. Richardson, Shouqing Luo and Kim Tieu Tags: Research article Source Type: research
Rejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid- β clearance in animal models of Alzheimer’s disease
Age-dependent accumulation of amyloid plaques in patients with sporadic Alzheimer ’s disease (AD) is associated with reduced amyloid clearance. Older microglia have a reduced ability to phagocytose amyloid, so ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 16, 2024 Category: Neurology Authors: Hyo Jung Shin, In Soo Kim, Seung Gyu Choi, Kayoung Lee, Hyewon Park, Juhee Shin, Dayoung Kim, Jaewon Beom, Yoon Young Yi, Deepak Prasad Gupta, Gyun Jee Song, Won-Suk Chung, C. Justin Lee and Dong Woon Kim Tags: Research article Source Type: research
