Dietary Intake of Yeast ‐Derived β‐Glucan and Rice‐Derived Arabinoxylan Induces Dose‐Dependent Innate Immune Priming in Mice
This study demonstr ates dietary yWGP and rice bran-1 induce innate immune priming in mouse blood and bone marrow. AbstractBeta-glucans and arabinoxylans are known for their immunostimulatory properties. However, in vivo these have been documented almost exclusively following parenteral administration, underemphasizing oral intake.C57BL/6 mice are fed either a control diet or a diet supplemented with yeast-derived whole β-glucan particle (yWGP) or with rice-derived arabinoxylan (rice bran-1) at a concentration of 1%, 2.5%, or 5% weight/weight (w/w) for 2 weeks. Thereafter, cells from blood, bone marrow, and spleen are co...
Source: Molecular Nutrition and Food Research - April 30, 2024 Category: Food Science Authors: Bart G. J. Moerings, Jurriaan J. Mes, Jeroen van Bergenhenegouwen, Coen Govers, Miriam van Dijk, Renger F. Witkamp, Klaske van Norren, Suzanne Abbring Tags: Research Article Source Type: research

The Effect of Broccoli Glucoraphanin Supplementation on Ameliorating High ‐Fat‐Diet‐Induced Obesity through the Gut Microbiome and Metabolome Interface
ConclusionThese results indicate that beneficial effects of broccoli GRN on reversing HFD-induced adverse metabolic parameters may be attributed to its impacts on reprogramming microbial community and metabolites. Identification of the mechanistic functions of GRN further warrants it as a dietary candidate for obesity prevention. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - April 28, 2024 Category: Food Science Authors: Taiwo Bankole, Tianzhou Ma, Itika Arora, Zhentian Lei, Murugesan Raju, Zhenhai Li, Yuanyuan Li Tags: Research Article Source Type: research

Dietary Hemin Remodels Gut Microbiota and Mediates Tissue Inflammation and Injury in the Small Intestine
ConclusionModerate intake of myoglobin or hemin is beneficial to intestinal health and microbiota, but too high amounts lead to tissue inflammation and injury in the small intestine by reshaping ileal microbiota. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - April 27, 2024 Category: Food Science Authors: Qian Li, Weixin Ke, Shuai Jiang, Miao Zhang, Kai Shan, Chunbao Li Tags: Research Article Source Type: research

Polyphenols and Lactation: Molecular Evidence to Support the Use of Botanical Galactagogues
Ruminant, rodent, and in vitro models provide insight into the molecular pathways of botanical breastfeeding supplements. Breastfeeding mothers often use herbs, foods, and supplements containing polyphenols to improve lactation. Some examples include fenugreek (quercetin), grapes (resveratrol), and green tea (epigallocatechin). Studies using ruminant, rodent, and in vitro assays are useful in understanding effects of polyphenols on molecular pathways such as the activation of insulin/growth hormone/Iinsulin growth factor 1 signaling and deactivation of NF κβ signaling in mammary epithelial cells. AbstractBotanicals and h...
Source: Molecular Nutrition and Food Research - April 27, 2024 Category: Food Science Authors: Shannon L. Kelleher, Serena Burkinshaw, Seun Elizabeth Kuyooro Tags: Review Source Type: research

Issue Information: Mol. Nutr. Food Res. 8'24
(Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - April 26, 2024 Category: Food Science Tags: Issue Information Source Type: research

Protective Effect of Egg Yolk Lipids against Dextran Sulfate Sodium ‐Induced Colitis: The Key Role of Gut Microbiota and Short‐Chain Fatty Acids
Egg yolk lipids alleviate DSS-induced colitis by regulating gut microbiota and increasing SCFAs production. NLRP3(NOD-like receptor family pyrin domain containing 3). AbstractEgg yolk lipids significantly alleviate dextran sulfate sodium (DSS)-induced colitis by inhibiting NLRP3 inflammasome, reversing gut microbiota dysbiosis, and increasing short chain fatty acids (SCFAs) concentrations. However, the role of gut microbiota and the relationship between SCFAs and NLRP3 inflammasome are still unknown. Here, this study confirms that antibiotic treatment abolishes the protective effect of egg yolk lipids on DSS-induced coloni...
Source: Molecular Nutrition and Food Research - April 25, 2024 Category: Food Science Authors: Nanhai Xiao, Wen He, Shuping Chen, Yao Yao, Na Wu, Mingsheng Xu, Huaying Du, Yan Zhao, Yonggang Tu Tags: Research Article Source Type: research

The Relationship between Diet, Gut Mycobiome, and Functional Gastrointestinal Disorders: Evidence, Doubts, and Prospects
Dietary ingredients and patterns have the potential to regulate the structure of gut fungi. The relationship between mycobiome and diet may have important implications for the pathogenesis of funcitonal gastrointestinal disorders (FGIDs). AbstractGut fungi are important parts of intestinal microbes. Dietary ingredients have the potential to regulate the structure of gut fungi in different directions and modulate mycobiome composition by changing dietary patterns, which have been applied to neurological disorders. Emerging pieces of evidence have revealed the regulatory functions of gut mycobiome in gastrointestinal disease...
Source: Molecular Nutrition and Food Research - April 25, 2024 Category: Food Science Authors: Tianxu Liu, Ismail Muhammad Asif, Yan Chen, Meixue Zhang, Bin Li, Ling Wang Tags: Review Source Type: research

L ‐Glutamine Substantially Improves 5‐Fluorouracil‐Induced Intestinal Mucositis by Modulating Gut Microbiota and Maintaining the Integrity of the Gut Barrier in Mice
ConclusionsThese findings underscore glutamine's potential in preventing 5-FU-induced mucositis by modulating gut microbiota and inflammation pathways. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - April 24, 2024 Category: Food Science Authors: Ya ‐Ru Kuo, Cheng‐Hung Lin, Wei‐Sheng Lin, Min‐Hsiung Pan Tags: Research Article Source Type: research

Tolypocladium sinense Mycelium Polysaccharide Alleviates Obesity, Lipid Metabolism Disorder, and Inflammation Caused by High Fat Diet via Improving Intestinal Barrier and Modulating Gut Microbiota
ConclusionThe findings show that TSMP can inhibit obesity and alleviates obesity-related lipid metabolism disorders, inflammatory responses, and oxidative stress by modulating the gut microbiota and improving intestinal barrier. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - April 24, 2024 Category: Food Science Authors: Mingjian Bai, Xiaolong Wang, Dongyang Liu, Aofeng Xu, Hao Cheng, Lin Li, Chunjing Zhang Tags: Research Article Source Type: research

Human Breast Milk Exosomal miRNAs are Influenced by Premature Delivery and Affect Neurodevelopment
ConclusionThis study demonstrates that miRNA expression in breast milk exosomes can be influenced by preterm delivery, thereby potentially impacting neurodevelopment in preterm infants. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - April 22, 2024 Category: Food Science Authors: Ling Ma, Yanyan Huo, Qingyuan Tang, Xiulian Wang, Weiqin Wang, Dan Wu, Yicheng Li, Lingyan Chen, Shasha Wang, Yiwen Zhu, Wenli Wang, Yuan Liu, Nanjie Xu, Li Chen, Guangjun Yu, Jinjin Chen Tags: Research Article Source Type: research

The Effect of Coenzyme Q10 Supplementation on Bile Acid Metabolism: Insights from Network Pharmacology, Molecular Docking, and Experimental Validation
ConclusionThis study sheds light on the impact of CoQ10 in bile acids metabolism and offers a new perspective on the application of CoQ10 in metabolic health. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - April 21, 2024 Category: Food Science Authors: Mengcheng Jin, Tangbin Zou, Hairong Huang, Ming Chen, Haoqi Zou, Baoyan Chen, Chengze Lai, Huawen Li, Peiwen Zhang Tags: Research Article Source Type: research

Association of Ultraprocessed Food Consumption with Risk of Cardiovascular Disease Among Individuals with Type 2 Diabetes: Findings from the UK Biobank
ConclusionHigher UPF intakes are associated with increased hazards of CVD among individuals with T2D, and the association is partly mediated through worsening biomarkers of renal function, lipid metabolism, inflammation, and body weight. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - April 20, 2024 Category: Food Science Authors: Yue Li, Yuwei Lai, Tingting Geng, Peng ‐Fei Xia, Jun‐Xiang Chen, Zhou‐Zheng Tu, Kun Yang, Yun‐Fei Liao, Gang Liu, An Pan Tags: Research Article Source Type: research

Fructooligosaccharides Intake during Pregnancy Improves Metabolic Phenotype of Offspring in High Fat Diet ‐Induced Obese Mice
ConclusionThe findings highlight the link between the maternal gut environment and the developmental origin of metabolic syndrome in offspring. These results open novel research avenues into preemptive therapies for metabolic disorders by targeting the maternal gut microbiota. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - April 19, 2024 Category: Food Science Authors: Junki Miyamoto, Yuna Ando, Akari Nishida, Mayu Yamano, Shunsuke Suzuki, Hiromi Takada, Ikuo Kimura Tags: Research Article Source Type: research

High Fat Diet –Wheat Gliadin Interaction and its Implication for Obesity and Celiac Disease Onset: In Vivo Studies
Wheat gluten may play a role for development of life-style related diseases in populations on a high fat diet. Mice feed high fat diet show that wheat gliadin consumption affects glucose and lipid metabolic homeostasis, alters the gut microbiota and the immune cell profile in liver. AbstractThe intestinal immune system plays a crucial role in obesity and insulin resistance. An altered intestinal immunity is associated with changes to the gut microbiota, barrier function, and tolerance to luminal antigens. Lipid metabolism and its unbalance can also contribute to acute and chronic inflammation in different conditions. In ce...
Source: Molecular Nutrition and Food Research - April 18, 2024 Category: Food Science Authors: Yuri Haneishi, Lucia Treppiccione, Francesco Maurano, Diomira Luongo, Junki Miyamoto, Mauro Rossi Tags: Review Source Type: research

Molecular Characterization of the Allergenic Arginine Kinase from the Edible Insect Hermetia illucens (Black Soldier Fly)
ConclusionThe results indicate that the possible allergenicity of AK should be taken in consideration when dealing with novel foods containingH. illucens or its derivatives. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - April 17, 2024 Category: Food Science Authors: Danila Delfino, Barbara Prandi, Luisa Calcinai, Erminia Ridolo, Luca Dellafiora, Lorenzo Pedroni, Francesca Nicoletta, Davide Cavazzini, Tullia Tedeschi, Claudia Folli Tags: Research Article Source Type: research