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Terpenoids from Alpinia galanga and their acetylcholinesterase inhibitory activity
Nat Prod Res. 2024 Apr 29:1-8. doi: 10.1080/14786419.2024.2346269. Online ahead of print.ABSTRACTA new labdane diterpene (1), two new norsesquiterpenoids (2-3), as well as eight known terpenoids (4-11) were isolated from the seeds of Alpinia galanga (Zingiberaceae). Their structures and absolute configurations were elucidated by 1D, 2D NMR, MS, and comparison of their experimental and calculated electronic circular dichroism (ECD). The acetylcholinesterase (AChE) inhibitory activities of all the isolated compounds (1-11) were evaluated and the result showed that compounds 6 and 9 had inhibitory activity against AChE, with ...
Source: Natural Product Research - April 29, 2024 Category: Biochemistry Authors: Bo Zhou Meng-Jia Guo Xin-Man Zhao Xiao-Long Li Shao-Huan Liu Xiang-Chun Shen Nen-Ling Zhang Source Type: research

Glycosides constituents from Codonopsis pilosula 
Nat Prod Res. 2024 Apr 29:1-4. doi: 10.1080/14786419.2024.2344738. Online ahead of print.ABSTRACTA new glycoside (1) along with six known analogues (1-7) were isolated from Codonopsis pilosula collected at Shanxi in China. The structure of 1 was established based on comprehensive spectroscopic data and literature comparison. The anti-inflammatory effects of isolated compounds were further investigated in LPS-induced RAW264.7 macrophage.PMID:38684008 | DOI:10.1080/14786419.2024.2344738 (Source: Natural Product Research)
Source: Natural Product Research - April 29, 2024 Category: Biochemistry Authors: Yan-Gang Cheng Si-Qi Yang Pei Li Yan Wang Hui-Feng Li Xiang-Peng Kong Jin-Yan Tan Ying-Li Wang Source Type: research

Isolation, purification, and biological activities of polysaccharides from Amorpha fruticosa flowers
Nat Prod Res. 2024 Apr 29:1-8. doi: 10.1080/14786419.2024.2346272. Online ahead of print.ABSTRACTThe extraction, isolation, structural characterisation and biological activities of polysaccharides from Amorpha fruticosa flowers were investigated. First, the crude polysaccharide AFP was extracted, and two major purified polysaccharide fractions AFP-2 and AFP-3 were isolated. The molecular weight and monosaccharide compositions of AFP-2 and AFP-3 were determined. Then the antioxidant activities of AFP, AFP-2 and AFP-3 were assessed by DPPH radical, β-Carotene bleaching and hydroxyl radical assays. All three tested polysacch...
Source: Natural Product Research - April 29, 2024 Category: Biochemistry Authors: Yixian Liu Ying Zhao Huiping Chen Weidong Wang Min Zou Source Type: research

NMR fingerprinting of depolymerised durian rind pectin and its antibacterial activity
This study investigated the effect of commercial sterilisation treatment (121 °C for 15 min) on durian rind pectin. The change of structure was observed by NMR (nuclear magnetic resonance) and the antibacterial activity was assessed by microdilution method to obtain the minimum inhibitory concentration (MIC) value. NMR spectra revealed the rhamnogalacturonan-I and homogalacturonan structure, with lower methyl-ester in sterilised pectin. Native pectin was unable to inhibit Escherichia coli and Staphylococcus aureus at the highest tested concentration (MIC > 25 mg/mL), but sterilised pectin showed inhibitory effect again...
Source: Natural Product Research - April 29, 2024 Category: Biochemistry Authors: Inas Suci Rahmawati Nancy Dewi Yuliana Azis Boing Sitanggang Harsi Dewantari Kusumaningrum Source Type: research

Preclinical safety evaluation of the ethanolic extract from campomanesia guazumifolia (cambess.) O. Berg fruits peels in rats
Nat Prod Res. 2024 Apr 29:1-5. doi: 10.1080/14786419.2024.2347447. Online ahead of print.ABSTRACTThe toxicological potential of the ethanolic extract from Campomanesia guazumifolia (EECG), a species traditionally recognised for its antidiabetic, anti-inflammatory and hypercholesterolemic properties, was investigated in acute and subacute toxicity models in rats. In the acute toxicity test, 2000 mg/kg of EECG was administered orally in female rats, while male and female rats received 250, 500 or 750 mg/kg of EECG for the subacute toxicity test. No evidence of toxicity was observed in the animals acutely exposed, indicating ...
Source: Natural Product Research - April 29, 2024 Category: Biochemistry Authors: Laura Leonel de Toledo B árbara Campos Jorge J úlia Stein Livia Trippe Nagaoka Beatriz de Matos Manoel Claudia Andrea Lima Cardoso C ândida Aparecida Leite Kassuya Arielle Cristina Arena Source Type: research

Structurally diverse oxygen-containing aromatic compounds with anti-inflammatory activity from Aspergillus sp. LY-1-2
Nat Prod Res. 2024 Apr 29:1-9. doi: 10.1080/14786419.2024.2347451. Online ahead of print.ABSTRACTThree isocoumarins, ascoisocoumarin A (1), embeurekol (2), and sclerotinin A (3), and five biosynthetically related derivatives, ascospinols A-C (4, 6, and 7), and talaflavuols C and B (5 and 8), together with twelve polyketides or terpenes (9-20) were isolated from the fungus Aspergillus sp. LY-1-2 inhabited in a sample of Cordyceps sp. Most of them belong to the family of oxygen-containing aromatic compounds and compounds 1, 4, 6, and 7 are previously undescribed compounds. Their planar structures were established by a combin...
Source: Natural Product Research - April 29, 2024 Category: Biochemistry Authors: Chu-Qiao Wang Jinzhi Pan Shuang-Zhi Yuan Chao Yuan Fei-Xiang Ji Dan Feng Xiao-Ping Peng Qian Luo Hong-Xiang Lou Gang Li Source Type: research

Silymarin inhibits dermal gelatinolytic activity and reduces cutaneous inflammation
Nat Prod Res. 2024 Apr 29:1-12. doi: 10.1080/14786419.2024.2347452. Online ahead of print.ABSTRACTMilk thistle (Silybum marianum) is well-known for its antioxidant activity due to the presence of silymarin. Albeit some studies show a potential for skin inflammation, its activity against dermal MMP-9 and MMP-2 remains to be studied. Silymarin isolated from an S. marianum herbal extract was tested for gelatinase inhibition in the presence of isolated MMP-9 and in dermal adenocarcinome HaCaT cells. Silymarin was then further tested in vivo, using a cutaneous inflammation mice model mediated by reactive oxygen species. Silymar...
Source: Natural Product Research - April 29, 2024 Category: Biochemistry Authors: Joana Mota Catarina Faria-Silva Ana Resendes Maria Isabel Santos Manuela Colla Carvalheiro Ana Lima Sandra Sim ões Source Type: research

Synthesis and bioevaluation of water-soluble β -cyclodextrin-diterpene acid conjugates
This study suggested that the multivalent diterpene acid derivatives may have potential application against coronaviruses as entry inhibitors.PMID:38684026 | DOI:10.1080/14786419.2024.2347449 (Source: Natural Product Research)
Source: Natural Product Research - April 29, 2024 Category: Biochemistry Authors: Hua LiWen Yi Yanliang Elena V Tretyakova Anna A Smirnova Oxana B Kazakova Sulong Xiao Source Type: research

Two new N -containing heterocyclic compounds from the roots of Platycodon grandiflorus 
Nat Prod Res. 2024 Apr 29:1-8. doi: 10.1080/14786419.2024.2347453. Online ahead of print.ABSTRACTTwo unusual N-containing heterocyclic compounds, Plagranlines B-C, were isolated from the roots of Platycodon grandiflorus. Plagranline B (1) was consisted of neolignane and monomeric quinoline constituent units and plagranline C (2) possessed pyridinone ring that was not commonly discovered in natural product. Their planar structures were elucidated based on analysis of NMR and HRESIMS spectroscopy data, and their absolute configurations were determined by quantum chemical calculations, including GIAO 13C NMR (DP4+) calculatio...
Source: Natural Product Research - April 29, 2024 Category: Biochemistry Authors: Lan Ding Xin-Yin Cai Ren-Nai Yang Liang-Ping Zha Shuang-Ying Gui Jin-Song Liu Ju-Tao Wang Yang Yu Source Type: research

Alkaloids from Zanthoxylum nitidum and their anti-proliferative activity against A549 cells by regulating the EGFR/AKT/mTOR pathway
Nat Prod Res. 2024 Apr 29:1-7. doi: 10.1080/14786419.2024.2347463. Online ahead of print.ABSTRACTZanthoxylum nitidum is frequently used as a traditional Chinese medicine and food supplement. Our previous study revealed that its constituent compounds were able to inhibit cancer cell proliferation. In our continuous exploration of bioactive compounds in Z. nitidum, we isolated ten alkaloids (1-10), including one new natural compound (1), and nine known alkaloids (2-10), from an ethanolic extract of the whole plant. The chemical structures were elucidated based on a combination of comprehensive NMR and HRESIMS analyses. Compo...
Source: Natural Product Research - April 29, 2024 Category: Biochemistry Authors: Fan-Fan Wang Ping-Fang Tao Yu-Jun Zhong Yun-Qiong Gu Cai Yi Wang Feng Qin Source Type: research

Phytochemical investigation of Nigella sativa seed extract by HPTLC, HPLC and GC-MS: a comparative geographical study
This study aimed to ensure the quality of the seed as well as determine the phytochemical composition of Nigella sativa seed extract (NSSE) obtained from three different geographical locations. Pharmacognostic evaluation of the seed includes preliminary phytochemical screening, physicochemical evaluation, and study of heavy metal content, in addition to HPTLC, HPLC, and GC-MS studies of the extract obtained from the seed of the Nigella sativa (NS). HPTLC fingerprinting studies revealed the presence of various bioactive compounds. HPLC analysis confirms the quantitative variation of thymoquinone (TQ) in the extracts, i.e. t...
Source: Natural Product Research - April 29, 2024 Category: Biochemistry Authors: Rini Singhal Shweta Verma Vijender Singh Source Type: research

Secondary metabolites from the stem bark of Alstonia boonei and the seeds of Picralima nitida with antibacterial activities
Nat Prod Res. 2024 Apr 29:1-6. doi: 10.1080/14786419.2024.2349254. Online ahead of print.ABSTRACTThe methanol stem bark extract of A. boonei and methanol seed extract of P. nitida, were subjected to purification using chromatographic techniques. A. boonei yielded loganic acid (1), sweroside (2) and secoxyloganin (3), while P. nitida afforded (1), akuammidine (4), akuammicine (5) and alstonine (6). The structures of the compounds were elucidated based on their nuclear magnetic resonance (NMR), high-resolution mass spectrometry (HRMS) profiles and comparison with literature data. The antibacterial activities of the compounds...
Source: Natural Product Research - April 29, 2024 Category: Biochemistry Authors: Awodayo Oluwatoyin Adepiti Divinah Kwamboka Nyamboki Gebreheiwot Bedane Kibrom Anthony Adebolu Elujoba Michael Spiteller Josphat Clement Matasyoh Source Type: research

Bromelain as a natural anti-inflammatory drug: a systematic review
Nat Prod Res. 2024 Apr 27:1-14. doi: 10.1080/14786419.2024.2342553. Online ahead of print.ABSTRACTInflammation is a complex and necessary mechanism of an organ's response to biological, chemical and/or physical stimuli. In recent years, investigations on natural compounds with therapeutic actions for the treatment of different diseases have increased. Among these compounds, bromelain is highlighted, as a cysteine protease isolated from the Ananas comosus (pineapple) stem. This review aimed to evaluate the anti-inflammatory activity of bromelain, as well as its pathways on inflammatory mediators, through a systematic review...
Source: Natural Product Research - April 27, 2024 Category: Biochemistry Authors: Taline Alves Nobre Athanara Alves de Sousa Irislene Costa Pereira Álina Mara Carvalho Pedrosa-Santos Luana de Oliveira Lopes Nicole Debia Heba A S El-Nashar Mohamed El-Shazly Muhammad Torequl Islam Jo ão Marcelo de Castro E Sousa Francisco Leonardo Torr Source Type: research