Retraction notice to Activation of hepatic stellate cells during liver carcinogenesis requires fibrinogen/integrin αvβ5 in zebrafish, NEO 20 (2018) 533-542
Neoplasia. 2024 Apr 27;52:101000. doi: 10.1016/j.neo.2024.101000. Online ahead of print.NO ABSTRACTPMID:38678919 | DOI:10.1016/j.neo.2024.101000 (Source: Neoplasia)
Source: Neoplasia - April 28, 2024 Category: Cancer & Oncology Authors: Chuan Yan Qiqi Yang Zhiyuan Gong Source Type: research
Cell communication pathway prognostic model identified detrimental neurodevelopmental pathways in neuroblastoma
Neoplasia. 2024 Apr 25;52:100997. doi: 10.1016/j.neo.2024.100997. Online ahead of print.ABSTRACTNeurodevelopmental cell communication plays a crucial role in neuroblastoma prognosis. However, determining the impact of these communication pathways on prognosis is challenging due to limited sample sizes and patchy clinical survival information of single cell RNA-seq data. To address this, we have developed the cell communication pathway prognostic model (CCPPM) in this study. CCPPM involves the identification of communication pathways through single-cell RNA-seq data, screening of prognosis-significant pathways using bulk RN...
Source: Neoplasia - April 26, 2024 Category: Cancer & Oncology Authors: Jiali Wang Huimin Li Yao Xue Yidan Zhang Xiaopeng Ma Chunlei Zhou Liucheng Rong Yixuan Zhang Yaping Wang Yongjun Fang Source Type: research
Cell communication pathway prognostic model identified detrimental neurodevelopmental pathways in neuroblastoma
Neoplasia. 2024 Apr 25;52:100997. doi: 10.1016/j.neo.2024.100997. Online ahead of print.ABSTRACTNeurodevelopmental cell communication plays a crucial role in neuroblastoma prognosis. However, determining the impact of these communication pathways on prognosis is challenging due to limited sample sizes and patchy clinical survival information of single cell RNA-seq data. To address this, we have developed the cell communication pathway prognostic model (CCPPM) in this study. CCPPM involves the identification of communication pathways through single-cell RNA-seq data, screening of prognosis-significant pathways using bulk RN...
Source: Neoplasia - April 26, 2024 Category: Cancer & Oncology Authors: Jiali Wang Huimin Li Yao Xue Yidan Zhang Xiaopeng Ma Chunlei Zhou Liucheng Rong Yixuan Zhang Yaping Wang Yongjun Fang Source Type: research
Modulation of mitochondrial function by extracellular acidosis in tumor cells and normal fibroblasts: Role of signaling pathways
Neoplasia. 2024 Apr 16;52:100999. doi: 10.1016/j.neo.2024.100999. Online ahead of print.ABSTRACTIn many tumors pronounced extracellular acidosis resulting from glycolytic metabolism is found. Since several environmental stress factors affect the mitochondrial activity the aim of the study was to analyze the impact of acidosis on cellular oxygen consumption and which signaling pathways may be involved in the regulation. In two tumor cell lines and normal fibroblasts cellular oxygen consumption rate (OCR) and mitochondrial function were measured after 3 h at pH 6.6. Besides the activation of ERK1/2, p38 and PI3K signaling in...
Source: Neoplasia - April 17, 2024 Category: Cancer & Oncology Authors: Carmen Degitz Sarah Reime Christina-Marie Baumbach Mandy Rauschner Oliver Thews Source Type: research
Modulation of mitochondrial function by extracellular acidosis in tumor cells and normal fibroblasts: Role of signaling pathways
Neoplasia. 2024 Apr 16;52:100999. doi: 10.1016/j.neo.2024.100999. Online ahead of print.ABSTRACTIn many tumors pronounced extracellular acidosis resulting from glycolytic metabolism is found. Since several environmental stress factors affect the mitochondrial activity the aim of the study was to analyze the impact of acidosis on cellular oxygen consumption and which signaling pathways may be involved in the regulation. In two tumor cell lines and normal fibroblasts cellular oxygen consumption rate (OCR) and mitochondrial function were measured after 3 h at pH 6.6. Besides the activation of ERK1/2, p38 and PI3K signaling in...
Source: Neoplasia - April 17, 2024 Category: Cancer & Oncology Authors: Carmen Degitz Sarah Reime Christina-Marie Baumbach Mandy Rauschner Oliver Thews Source Type: research
Modulation of mitochondrial function by extracellular acidosis in tumor cells and normal fibroblasts: Role of signaling pathways
Neoplasia. 2024 Apr 16;52:100999. doi: 10.1016/j.neo.2024.100999. Online ahead of print.ABSTRACTIn many tumors pronounced extracellular acidosis resulting from glycolytic metabolism is found. Since several environmental stress factors affect the mitochondrial activity the aim of the study was to analyze the impact of acidosis on cellular oxygen consumption and which signaling pathways may be involved in the regulation. In two tumor cell lines and normal fibroblasts cellular oxygen consumption rate (OCR) and mitochondrial function were measured after 3 h at pH 6.6. Besides the activation of ERK1/2, p38 and PI3K signaling in...
Source: Neoplasia - April 17, 2024 Category: Cancer & Oncology Authors: Carmen Degitz Sarah Reime Christina-Marie Baumbach Mandy Rauschner Oliver Thews Source Type: research
Modulation of mitochondrial function by extracellular acidosis in tumor cells and normal fibroblasts: Role of signaling pathways
Neoplasia. 2024 Apr 16;52:100999. doi: 10.1016/j.neo.2024.100999. Online ahead of print.ABSTRACTIn many tumors pronounced extracellular acidosis resulting from glycolytic metabolism is found. Since several environmental stress factors affect the mitochondrial activity the aim of the study was to analyze the impact of acidosis on cellular oxygen consumption and which signaling pathways may be involved in the regulation. In two tumor cell lines and normal fibroblasts cellular oxygen consumption rate (OCR) and mitochondrial function were measured after 3 h at pH 6.6. Besides the activation of ERK1/2, p38 and PI3K signaling in...
Source: Neoplasia - April 17, 2024 Category: Cancer & Oncology Authors: Carmen Degitz Sarah Reime Christina-Marie Baumbach Mandy Rauschner Oliver Thews Source Type: research
Modulation of mitochondrial function by extracellular acidosis in tumor cells and normal fibroblasts: Role of signaling pathways
Neoplasia. 2024 Apr 16;52:100999. doi: 10.1016/j.neo.2024.100999. Online ahead of print.ABSTRACTIn many tumors pronounced extracellular acidosis resulting from glycolytic metabolism is found. Since several environmental stress factors affect the mitochondrial activity the aim of the study was to analyze the impact of acidosis on cellular oxygen consumption and which signaling pathways may be involved in the regulation. In two tumor cell lines and normal fibroblasts cellular oxygen consumption rate (OCR) and mitochondrial function were measured after 3 h at pH 6.6. Besides the activation of ERK1/2, p38 and PI3K signaling in...
Source: Neoplasia - April 17, 2024 Category: Cancer & Oncology Authors: Carmen Degitz Sarah Reime Christina-Marie Baumbach Mandy Rauschner Oliver Thews Source Type: research
Modulation of mitochondrial function by extracellular acidosis in tumor cells and normal fibroblasts: Role of signaling pathways
Neoplasia. 2024 Apr 16;52:100999. doi: 10.1016/j.neo.2024.100999. Online ahead of print.ABSTRACTIn many tumors pronounced extracellular acidosis resulting from glycolytic metabolism is found. Since several environmental stress factors affect the mitochondrial activity the aim of the study was to analyze the impact of acidosis on cellular oxygen consumption and which signaling pathways may be involved in the regulation. In two tumor cell lines and normal fibroblasts cellular oxygen consumption rate (OCR) and mitochondrial function were measured after 3 h at pH 6.6. Besides the activation of ERK1/2, p38 and PI3K signaling in...
Source: Neoplasia - April 17, 2024 Category: Cancer & Oncology Authors: Carmen Degitz Sarah Reime Christina-Marie Baumbach Mandy Rauschner Oliver Thews Source Type: research
Combined BRAF and PIM1 inhibitory therapy for papillary thyroid carcinoma based on BRAFV600E regulation of PIM1: Synergistic effect and metabolic mechanisms
This study elucidates the role of BRAFV600E in the regulation of PIM1 in PTC and demonstrates the synergistic effect of a novel combination, BRAFi/PIMi, for the treatment of PTC. This discovery, along with the pathways that may be involved in the powerful efficacy of BRAFi/PIMi strategy from the perspective of cell metabolism, provides insight into the molecular basis of PTC progression and offers new perspectives for BRAF-resistant PTC treatment.PMID:38593698 | PMC:PMC11007432 | DOI:10.1016/j.neo.2024.100996 (Source: Neoplasia)
Source: Neoplasia - April 9, 2024 Category: Cancer & Oncology Authors: Qianqian Xu Jiaqi Wang Yuting Mao Ziyang Xuan Ke Yang Xi Tang Xin Zhu Source Type: research
Combined BRAF and PIM1 inhibitory therapy for papillary thyroid carcinoma based on BRAFV600E regulation of PIM1: Synergistic effect and metabolic mechanisms
This study elucidates the role of BRAFV600E in the regulation of PIM1 in PTC and demonstrates the synergistic effect of a novel combination, BRAFi/PIMi, for the treatment of PTC. This discovery, along with the pathways that may be involved in the powerful efficacy of BRAFi/PIMi strategy from the perspective of cell metabolism, provides insight into the molecular basis of PTC progression and offers new perspectives for BRAF-resistant PTC treatment.PMID:38593698 | PMC:PMC11007432 | DOI:10.1016/j.neo.2024.100996 (Source: Neoplasia)
Source: Neoplasia - April 9, 2024 Category: Cancer & Oncology Authors: Qianqian Xu Jiaqi Wang Yuting Mao Ziyang Xuan Ke Yang Xi Tang Xin Zhu Source Type: research
Combined BRAF and PIM1 inhibitory therapy for papillary thyroid carcinoma based on BRAFV600E regulation of PIM1: Synergistic effect and metabolic mechanisms
This study elucidates the role of BRAFV600E in the regulation of PIM1 in PTC and demonstrates the synergistic effect of a novel combination, BRAFi/PIMi, for the treatment of PTC. This discovery, along with the pathways that may be involved in the powerful efficacy of BRAFi/PIMi strategy from the perspective of cell metabolism, provides insight into the molecular basis of PTC progression and offers new perspectives for BRAF-resistant PTC treatment.PMID:38593698 | PMC:PMC11007432 | DOI:10.1016/j.neo.2024.100996 (Source: Neoplasia)
Source: Neoplasia - April 9, 2024 Category: Cancer & Oncology Authors: Qianqian Xu Jiaqi Wang Yuting Mao Ziyang Xuan Ke Yang Xi Tang Xin Zhu Source Type: research
Combined BRAF and PIM1 inhibitory therapy for papillary thyroid carcinoma based on BRAFV600E regulation of PIM1: Synergistic effect and metabolic mechanisms
This study elucidates the role of BRAFV600E in the regulation of PIM1 in PTC and demonstrates the synergistic effect of a novel combination, BRAFi/PIMi, for the treatment of PTC. This discovery, along with the pathways that may be involved in the powerful efficacy of BRAFi/PIMi strategy from the perspective of cell metabolism, provides insight into the molecular basis of PTC progression and offers new perspectives for BRAF-resistant PTC treatment.PMID:38593698 | PMC:PMC11007432 | DOI:10.1016/j.neo.2024.100996 (Source: Neoplasia)
Source: Neoplasia - April 9, 2024 Category: Cancer & Oncology Authors: Qianqian Xu Jiaqi Wang Yuting Mao Ziyang Xuan Ke Yang Xi Tang Xin Zhu Source Type: research
Combined BRAF and PIM1 inhibitory therapy for papillary thyroid carcinoma based on BRAFV600E regulation of PIM1: Synergistic effect and metabolic mechanisms
This study elucidates the role of BRAFV600E in the regulation of PIM1 in PTC and demonstrates the synergistic effect of a novel combination, BRAFi/PIMi, for the treatment of PTC. This discovery, along with the pathways that may be involved in the powerful efficacy of BRAFi/PIMi strategy from the perspective of cell metabolism, provides insight into the molecular basis of PTC progression and offers new perspectives for BRAF-resistant PTC treatment.PMID:38593698 | PMC:PMC11007432 | DOI:10.1016/j.neo.2024.100996 (Source: Neoplasia)
Source: Neoplasia - April 9, 2024 Category: Cancer & Oncology Authors: Qianqian Xu Jiaqi Wang Yuting Mao Ziyang Xuan Ke Yang Xi Tang Xin Zhu Source Type: research
Combined BRAF and PIM1 inhibitory therapy for papillary thyroid carcinoma based on BRAFV600E regulation of PIM1: Synergistic effect and metabolic mechanisms
This study elucidates the role of BRAFV600E in the regulation of PIM1 in PTC and demonstrates the synergistic effect of a novel combination, BRAFi/PIMi, for the treatment of PTC. This discovery, along with the pathways that may be involved in the powerful efficacy of BRAFi/PIMi strategy from the perspective of cell metabolism, provides insight into the molecular basis of PTC progression and offers new perspectives for BRAF-resistant PTC treatment.PMID:38593698 | DOI:10.1016/j.neo.2024.100996 (Source: Neoplasia)
Source: Neoplasia - April 9, 2024 Category: Cancer & Oncology Authors: Qianqian Xu Jiaqi Wang Yuting Mao Ziyang Xuan Ke Yang Xi Tang Xin Zhu Source Type: research
