Age-related differences in functional connectivity associated with pain modulation
Neurobiol Aging. 2024 Apr 25;140:1-11. doi: 10.1016/j.neurobiolaging.2024.04.008. Online ahead of print.ABSTRACTGrowing evidence suggests that aging is associated with impaired endogenous pain modulation, and that this likely underlies the increased transition from acute to chronic pain in older individuals. Resting-state functional connectivity (rsFC) offers a valuable tool to examine the neural mechanisms behind these age-related changes in pain modulation. RsFC studies generally observe decreased within-network connectivity due to aging, but its relevance for pain modulation remains unknown. We compared rsFC within a se...
Source: Neurobiology of Aging - May 1, 2024 Category: Geriatrics Authors: Marian van der Meulen Katharina M Rischer Ana Mar ía González Roldán Juan Lorenzo Terrasa Pedro Montoya Fernand Anton Source Type: research
The hippocampus as a structural and functional network epicentre for distant cortical thinning in neurocognitive aging
Neurobiol Aging. 2024 Apr 18;139:82-89. doi: 10.1016/j.neurobiolaging.2024.04.004. Online ahead of print.ABSTRACTAlterations in grey matter (GM) and white matter (WM) are associated with memory impairment across the neurocognitive aging spectrum and theorised to spread throughout brain networks. Functional and structural connectivity (FC,SC) may explain widespread atrophy. We tested the effect of SC and FC to the hippocampus on cortical thickness (CT) of connected areas. In 419 (223 F) participants (agemean=73 ± 8) from the Alzheimer's Disease Neuroimaging Initiative, cortical regions associated with memory (Rey Auditory ...
Source: Neurobiology of Aging - April 24, 2024 Category: Geriatrics Authors: Charly Hugo Alexandre Billaud Junhong Yu Source Type: research
The hippocampus as a structural and functional network epicentre for distant cortical thinning in neurocognitive aging
Neurobiol Aging. 2024 Apr 18;139:82-89. doi: 10.1016/j.neurobiolaging.2024.04.004. Online ahead of print.ABSTRACTAlterations in grey matter (GM) and white matter (WM) are associated with memory impairment across the neurocognitive aging spectrum and theorised to spread throughout brain networks. Functional and structural connectivity (FC,SC) may explain widespread atrophy. We tested the effect of SC and FC to the hippocampus on cortical thickness (CT) of connected areas. In 419 (223 F) participants (agemean=73 ± 8) from the Alzheimer's Disease Neuroimaging Initiative, cortical regions associated with memory (Rey Auditory ...
Source: Neurobiology of Aging - April 24, 2024 Category: Geriatrics Authors: Charly Hugo Alexandre Billaud Junhong Yu Source Type: research
The hippocampus as a structural and functional network epicentre for distant cortical thinning in neurocognitive aging
Neurobiol Aging. 2024 Apr 18;139:82-89. doi: 10.1016/j.neurobiolaging.2024.04.004. Online ahead of print.ABSTRACTAlterations in grey matter (GM) and white matter (WM) are associated with memory impairment across the neurocognitive aging spectrum and theorised to spread throughout brain networks. Functional and structural connectivity (FC,SC) may explain widespread atrophy. We tested the effect of SC and FC to the hippocampus on cortical thickness (CT) of connected areas. In 419 (223 F) participants (agemean=73 ± 8) from the Alzheimer's Disease Neuroimaging Initiative, cortical regions associated with memory (Rey Auditory ...
Source: Neurobiology of Aging - April 24, 2024 Category: Geriatrics Authors: Charly Hugo Alexandre Billaud Junhong Yu Source Type: research
The hippocampus as a structural and functional network epicentre for distant cortical thinning in neurocognitive aging
Neurobiol Aging. 2024 Apr 18;139:82-89. doi: 10.1016/j.neurobiolaging.2024.04.004. Online ahead of print.ABSTRACTAlterations in grey matter (GM) and white matter (WM) are associated with memory impairment across the neurocognitive aging spectrum and theorised to spread throughout brain networks. Functional and structural connectivity (FC,SC) may explain widespread atrophy. We tested the effect of SC and FC to the hippocampus on cortical thickness (CT) of connected areas. In 419 (223 F) participants (agemean=73 ± 8) from the Alzheimer's Disease Neuroimaging Initiative, cortical regions associated with memory (Rey Auditory ...
Source: Neurobiology of Aging - April 24, 2024 Category: Geriatrics Authors: Charly Hugo Alexandre Billaud Junhong Yu Source Type: research
The hippocampus as a structural and functional network epicentre for distant cortical thinning in neurocognitive aging
Neurobiol Aging. 2024 Apr 18;139:82-89. doi: 10.1016/j.neurobiolaging.2024.04.004. Online ahead of print.ABSTRACTAlterations in grey matter (GM) and white matter (WM) are associated with memory impairment across the neurocognitive aging spectrum and theorised to spread throughout brain networks. Functional and structural connectivity (FC,SC) may explain widespread atrophy. We tested the effect of SC and FC to the hippocampus on cortical thickness (CT) of connected areas. In 419 (223 F) participants (agemean=73 ± 8) from the Alzheimer's Disease Neuroimaging Initiative, cortical regions associated with memory (Rey Auditory ...
Source: Neurobiology of Aging - April 24, 2024 Category: Geriatrics Authors: Charly Hugo Alexandre Billaud Junhong Yu Source Type: research
The hippocampus as a structural and functional network epicentre for distant cortical thinning in neurocognitive aging
Neurobiol Aging. 2024 Apr 18;139:82-89. doi: 10.1016/j.neurobiolaging.2024.04.004. Online ahead of print.ABSTRACTAlterations in grey matter (GM) and white matter (WM) are associated with memory impairment across the neurocognitive aging spectrum and theorised to spread throughout brain networks. Functional and structural connectivity (FC,SC) may explain widespread atrophy. We tested the effect of SC and FC to the hippocampus on cortical thickness (CT) of connected areas. In 419 (223 F) participants (agemean=73 ± 8) from the Alzheimer's Disease Neuroimaging Initiative, cortical regions associated with memory (Rey Auditory ...
Source: Neurobiology of Aging - April 24, 2024 Category: Geriatrics Authors: Charly Hugo Alexandre Billaud Junhong Yu Source Type: research
Brain age of rhesus macaques over the lifespan
In this study, we present the methodology of constructing a rhesus macaque brain age model using a machine learning algorithm and discuss the key predictive brain regions in comparison to the human brain, to shed light on cross-species primate similarities and differences. Structural information of the brain (e.g., parcellated volumes) from brain magnetic resonance imaging of 43 rhesus macaques were used to develop brain atlas-based features to build a brain age model that predicts biological age. The best-performing model used 22 selected features and achieved an R2 of 0.72. We also identified interpretable predictive bra...
Source: Neurobiology of Aging - April 21, 2024 Category: Geriatrics Authors: Yang S Liu Madhura Baxi Christopher R Madan Kevin Zhan Nikolaos Makris Douglas L Rosene Ronald J Killiany Suheyla Cetin-Karayumak Ofer Pasternak Marek Kubicki Bo Cao Source Type: research
Brain age of rhesus macaques over the lifespan
In this study, we present the methodology of constructing a rhesus macaque brain age model using a machine learning algorithm and discuss the key predictive brain regions in comparison to the human brain, to shed light on cross-species primate similarities and differences. Structural information of the brain (e.g., parcellated volumes) from brain magnetic resonance imaging of 43 rhesus macaques were used to develop brain atlas-based features to build a brain age model that predicts biological age. The best-performing model used 22 selected features and achieved an R2 of 0.72. We also identified interpretable predictive bra...
Source: Neurobiology of Aging - April 21, 2024 Category: Geriatrics Authors: Yang S Liu Madhura Baxi Christopher R Madan Kevin Zhan Nikolaos Makris Douglas L Rosene Ronald J Killiany Suheyla Cetin-Karayumak Ofer Pasternak Marek Kubicki Bo Cao Source Type: research
Brain oscillatory processes related to sequence memory in healthy older adults
Neurobiol Aging. 2024 Apr 6;139:64-72. doi: 10.1016/j.neurobiolaging.2024.04.001. Online ahead of print.ABSTRACTSequence memory is subject to age-related decline, but the underlying processes are not yet fully understood. We analyzed electroencephalography (EEG) in 21 healthy older (60-80 years) and 26 young participants (20-30 years) and compared time-frequency spectra and theta-gamma phase-amplitude-coupling (PAC) during encoding of the order of visually presented items. In older adults, desynchronization in theta (4-8 Hz) and synchronization in gamma (30-45 Hz) power did not distinguish between subsequently correctly an...
Source: Neurobiology of Aging - April 16, 2024 Category: Geriatrics Authors: Nina M Ehrhardt Agnes Fl öel Shu-Chen Li Guglielmo Lucchese Daria Antonenko Source Type: research
Brain oscillatory processes related to sequence memory in healthy older adults
Neurobiol Aging. 2024 Apr 6;139:64-72. doi: 10.1016/j.neurobiolaging.2024.04.001. Online ahead of print.ABSTRACTSequence memory is subject to age-related decline, but the underlying processes are not yet fully understood. We analyzed electroencephalography (EEG) in 21 healthy older (60-80 years) and 26 young participants (20-30 years) and compared time-frequency spectra and theta-gamma phase-amplitude-coupling (PAC) during encoding of the order of visually presented items. In older adults, desynchronization in theta (4-8 Hz) and synchronization in gamma (30-45 Hz) power did not distinguish between subsequently correctly an...
Source: Neurobiology of Aging - April 16, 2024 Category: Geriatrics Authors: Nina M Ehrhardt Agnes Fl öel Shu-Chen Li Guglielmo Lucchese Daria Antonenko Source Type: research
Degeneration in Nucleus basalis of Meynert signals earliest stage of Alzheimer's disease progression
Neurobiol Aging. 2024 Mar 15;139:54-63. doi: 10.1016/j.neurobiolaging.2024.03.003. Online ahead of print.ABSTRACTNucleus Basalis of Meynert (NbM), a crucial source of cholinergic projection to the entorhinal cortex (EC) and hippocampus (HC), has shown sensitivity to neurofibrillary degeneration in the early stages of Alzheimer's Disease. Using deformation-based morphometry (DBM) on up-sampled MRI scans from 1447 Alzheimer's Disease Neuroimaging Initiative participants, we aimed to quantify NbM degeneration along the disease trajectory. Results from cross-sectional analysis revealed significant differences of NbM volume bet...
Source: Neurobiology of Aging - April 12, 2024 Category: Geriatrics Authors: Neda Shafiee Vladimir Fonov Mahsa Dadar R Nathan Spreng D Louis Collins Source Type: research
Degeneration in Nucleus basalis of Meynert signals earliest stage of Alzheimer's disease progression
Neurobiol Aging. 2024 Mar 15;139:54-63. doi: 10.1016/j.neurobiolaging.2024.03.003. Online ahead of print.ABSTRACTNucleus Basalis of Meynert (NbM), a crucial source of cholinergic projection to the entorhinal cortex (EC) and hippocampus (HC), has shown sensitivity to neurofibrillary degeneration in the early stages of Alzheimer's Disease. Using deformation-based morphometry (DBM) on up-sampled MRI scans from 1447 Alzheimer's Disease Neuroimaging Initiative participants, we aimed to quantify NbM degeneration along the disease trajectory. Results from cross-sectional analysis revealed significant differences of NbM volume bet...
Source: Neurobiology of Aging - April 12, 2024 Category: Geriatrics Authors: Neda Shafiee Vladimir Fonov Mahsa Dadar R Nathan Spreng D Louis Collins Source Type: research
Degeneration in Nucleus basalis of Meynert signals earliest stage of Alzheimer's disease progression
Neurobiol Aging. 2024 Mar 15;139:54-63. doi: 10.1016/j.neurobiolaging.2024.03.003. Online ahead of print.ABSTRACTNucleus Basalis of Meynert (NbM), a crucial source of cholinergic projection to the entorhinal cortex (EC) and hippocampus (HC), has shown sensitivity to neurofibrillary degeneration in the early stages of Alzheimer's Disease. Using deformation-based morphometry (DBM) on up-sampled MRI scans from 1447 Alzheimer's Disease Neuroimaging Initiative participants, we aimed to quantify NbM degeneration along the disease trajectory. Results from cross-sectional analysis revealed significant differences of NbM volume bet...
Source: Neurobiology of Aging - April 12, 2024 Category: Geriatrics Authors: Neda Shafiee Vladimir Fonov Mahsa Dadar R Nathan Spreng D Louis Collins Source Type: research
Degeneration in Nucleus basalis of Meynert signals earliest stage of Alzheimer's disease progression
Neurobiol Aging. 2024 Mar 15;139:54-63. doi: 10.1016/j.neurobiolaging.2024.03.003. Online ahead of print.ABSTRACTNucleus Basalis of Meynert (NbM), a crucial source of cholinergic projection to the entorhinal cortex (EC) and hippocampus (HC), has shown sensitivity to neurofibrillary degeneration in the early stages of Alzheimer's Disease. Using deformation-based morphometry (DBM) on up-sampled MRI scans from 1447 Alzheimer's Disease Neuroimaging Initiative participants, we aimed to quantify NbM degeneration along the disease trajectory. Results from cross-sectional analysis revealed significant differences of NbM volume bet...
Source: Neurobiology of Aging - April 12, 2024 Category: Geriatrics Authors: Neda Shafiee Vladimir Fonov Mahsa Dadar R Nathan Spreng D Louis Collins Source Type: research
