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Indirect functional connectivity does not predict overall survival in glioblastoma
CONCLUSIONS: Compared with indirect structural measures, functional indirect mapping does not provide significant predictive power for OS in patients with GBM. These findings are consistent with previous research that demonstrated the limitations of indirect functional measures in predicting clinical outcomes, underscoring the need for more comprehensive methodologies and a deeper understanding of the factors influencing clinical outcomes in this challenging disease.PMID:38697575 | DOI:10.1016/j.nbd.2024.106521 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - May 2, 2024 Category: Neurology Authors: Lorenzo Pini Giuseppe Lombardi Giulio Sansone Matteo Gaiola Marta Padovan Francesco Volpin Luca Denaro Maurizio Corbetta Alessandro Salvalaggio Source Type: research

Corrigendum to "RIP3 participates in early brain injury after experimental subarachnoid hemorrhage in rats by inducing necroptosis" [Neurobiology of Disease 129(2019) 144-158]
Neurobiol Dis. 2024 Apr 30:106507. doi: 10.1016/j.nbd.2024.106507. Online ahead of print.NO ABSTRACTPMID:38693020 | DOI:10.1016/j.nbd.2024.106507 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - May 1, 2024 Category: Neurology Authors: Shuai Yuan Zhengquan Yu Zhuwei Zhang Juyi Zhang Peng Zhang Xiang Li Haiying Li Haitao Shen Gang Chen Source Type: research

Quantifying local field potential dynamics with amplitude and frequency stability between ON and OFF medication and stimulation in Parkinson's disease
In this study, we proposed a method based on the stationary wavelet transform to quantify the amplitude and frequency stability of subthalamic nucleus beta oscillations and evaluated the method using simulation and real data for Parkinson's disease patients. The results suggest that the amplitude and frequency stability quantification has enhanced sensitivity in distinguishing pathological conditions in Parkinson's disease patients. Our quantification shows the benefit of combining frequency stability information with amplitude and provides a new potential feedback signal for adaptive deep brain stimulation.PMID:38685358 |...
Source: Neurobiology of Disease - April 30, 2024 Category: Neurology Authors: Xuanjun Guo Shenghong He Xinyi Geng Pan Yao Christoph Wiest Yingnan Nie Huiling Tan Shouyan Wang Source Type: research

Age-dependent dynamics of neuronal VAPB ALS inclusions in the adult brain
Neurobiol Dis. 2024 Apr 26:106517. doi: 10.1016/j.nbd.2024.106517. Online ahead of print.ABSTRACTAmyotrophic Lateral Sclerosis (ALS) is a relentlessly progressive and fatal disease, caused by the degeneration of upper and lower motor neurons within the brain and spinal cord in the ageing human. The dying neurons contain cytoplasmic inclusions linked to the onset and progression of the disease. Here, we use a Drosophila model of ALS8 (VAPP58S) to understand the modulation of these inclusions in the ageing adult brain. The adult VAPP58S fly shows progressive deterioration in motor function till its demise 25 days post-eclosi...
Source: Neurobiology of Disease - April 28, 2024 Category: Neurology Authors: Aparna Thulasidharan Lovleen Garg Shweta Tendulkar Girish S Ratnaparkhi Source Type: research

Cortico-cortical connectivity is influenced by levodopa in tremor-dominant Parkinson's disease
This study investigated SMA-M1 connectivity in individuals with PD ON and OFF dopamine medication, and whether SMA-M1 connectivity is implicated in resting tremor. Dual-site transcranial magnetic stimulation was used to measure SMA-M1 connectivity in PD participants ON and OFF levodopa. Resting tremor was measured using electromyography and accelerometry. Stimulating SMA inhibited M1 excitability OFF levodopa, and facilitated M1 excitability ON levodopa. ON medication, SMA-M1 facilitation was significantly associated with smaller tremor than SMA-M1 inhibition. The current findings contribute to our understanding of the neu...
Source: Neurobiology of Disease - April 28, 2024 Category: Neurology Authors: B K Rurak J Tan J P Rodrigues B D Power P D Drummond A M Vallence Source Type: research

CK1 δ/ε kinases regulate TDP-43 phosphorylation and are therapeutic targets for ALS-related TDP-43 hyperphosphorylation
Neurobiol Dis. 2024 Apr 25;196:106516. doi: 10.1016/j.nbd.2024.106516. Online ahead of print.ABSTRACTHyperphosphorylated TAR DNA-binding protein 43 (TDP-43) aggregates in the cytoplasm of neurons is the neuropathological hallmark of amyotrophic lateral sclerosis (ALS) and a group of neurodegenerative diseases collectively referred to as TDP-43 proteinopathies that includes frontotemporal dementia, Alzheimer's disease, and limbic onset age-related TDP-43 encephalopathy. The mechanism of TDP-43 phosphorylation is poorly understood. Previously we reported casein kinase 1 epsilon gene (CSNK1E gene encoding CK1ε protein) as be...
Source: Neurobiology of Disease - April 27, 2024 Category: Neurology Authors: Vivian I Ko Kailee Ong Don W Cleveland Haiyang Yu John M Ravits Source Type: research

CK1 δ/ε kinases regulate TDP-43 phosphorylation and are therapeutic targets for ALS-related TDP-43 hyperphosphorylation
Neurobiol Dis. 2024 Apr 25:106516. doi: 10.1016/j.nbd.2024.106516. Online ahead of print.ABSTRACTHyperphosphorylated TAR DNA-binding protein 43 (TDP-43) aggregates in the cytoplasm of neurons is the neuropathological hallmark of amyotrophic lateral sclerosis (ALS) and a group of neurodegenerative diseases collectively referred to as TDP-43 proteinopathies that includes frontotemporal dementia, Alzheimer's disease, and limbic onset age-related TDP-43 encephalopathy. The mechanism of TDP-43 phosphorylation is poorly understood. Previously we reported casein kinase 1 epsilon gene (CSNK1E gene encoding CK1ε protein) as being ...
Source: Neurobiology of Disease - April 27, 2024 Category: Neurology Authors: Vivian I Ko Kailee Ong Don W Cleveland Haiyang Yu John M Ravits Source Type: research

Diet-induced metabolic and immune impairments are sex-specifically modulated by soluble TNF signaling in the 5xFAD mouse model of Alzheimer's disease
Neurobiol Dis. 2024 Apr 24:106511. doi: 10.1016/j.nbd.2024.106511. Online ahead of print.ABSTRACTEmerging evidence indicates that high-fat, high carbohydrate diet (HFHC) impacts central pathological features of Alzheimer's disease (AD) across both human incidences and animal models. However, the mechanisms underlying this association are poorly understood. Here, we identify compartment-specific metabolic and inflammatory dysregulations that are induced by HFHC diet in the 5xFAD mouse model of AD pathology. We observe that both male and female 5xFAD mice display exacerbated adiposity, cholesterolemia, and dysregulated insul...
Source: Neurobiology of Disease - April 26, 2024 Category: Neurology Authors: Maria Elizabeth De Sousa Rodrigues MacKenzie L Bolen Lisa Blackmer-Raynolds Noah Schwartz Jianjun Chang Mal ú Gámez Tansey Timothy Robert Sampson Source Type: research

Dopamine depletion weakens direct pathway modulation of SNr neurons
Neurobiol Dis. 2024 Apr 24:106512. doi: 10.1016/j.nbd.2024.106512. Online ahead of print.ABSTRACTNeurons in the substantia nigra reticulata (SNr) transmit information about basal ganglia output to dozens of brain regions in thalamocortical and brainstem motor networks. Activity of SNr neurons is regulated by convergent input from upstream basal ganglia nuclei, including GABAergic inputs from the striatum and the external globus pallidus (GPe). GABAergic inputs from the striatum convey information from the direct pathway, while GABAergic inputs from the GPe convey information from the indirect pathway. Chronic loss of dopam...
Source: Neurobiology of Disease - April 26, 2024 Category: Neurology Authors: Asier Aristieta John E Parker Ya Emma Gao Jonathan E Rubin Aryn H Gittis Source Type: research

RNA sequencing of olfactory bulb in Parkinson's disease reveals gene alterations associated with olfactory dysfunction
In conclusion, this study reveals gene alterations associated with neuroinflammation, neurotransmitter dysfunction, and disruptions of factors involved in the initiation of olfactory transduction signaling that may be involved in PD-related olfactory dysfunction.PMID:38663633 | DOI:10.1016/j.nbd.2024.106514 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - April 25, 2024 Category: Neurology Authors: C écilia Tremblay Sidra Aslam Jessica E Walker Ileana Lorenzini Anthony J Intorcia Richard A Arce Parichita Choudhury Charles H Adler Holly A Shill Erika Driver-Dunckley Shyamal Mehta Ignazio S Piras Christine M Belden Alireza Atri Thomas G Beach Geidy E Source Type: research

The downregulation of Kv 1 channels in Lgi1 -/- mice is accompanied by a profound modification of its interactome and a parallel decrease in Kv 2 channels
In this study we analyse by immunofluorescence the modifications in neuronal Kv1.1 and Kv1.2 distribution throughout the hippocampal formation of LGI1 knock-out mice. We show that Kv1 downregulation is not restricted to the axonal compartment, but also takes place in the somatodendritic region and is accompanied by a drastic decrease in Kv2 expression levels. Moreover, we find that the downregulation of these Kv channels is associated with a marked increase in bursting patterns. Finally, mass spectrometry uncovered key modifications in the Kv1 interactome that highlight the epileptogenic implication of Kv1 downregulation i...
Source: Neurobiology of Disease - April 25, 2024 Category: Neurology Authors: Jorge Ramirez-Franco K évin Debreux Marion Sangiardi Maya Belghazi Yujin Kim Suk-Ho Lee Christian L évêque Michael Seagar Oussama El Far Source Type: research