Regulating NCOA4-Mediated Ferritinophagy for Therapeutic Intervention in Cerebral Ischemia-Reperfusion Injury
Neurochem Res. 2024 May 7. doi: 10.1007/s11064-024-04146-4. Online ahead of print.ABSTRACTIschemic stroke presents a global health challenge, necessitating an in-depth comprehension of its pathophysiology and therapeutic strategies. While reperfusion therapy salvages brain tissue, it also triggers detrimental cerebral ischemia-reperfusion injury (CIRI). In our investigation, we observed the activation of nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy in an oxygen-glucose deprivation/reoxygenation (OGD/R) model using HT22 cells (P < 0.05). This activation contributed to oxidative stress (P < 0.05), enh...
Source: Neurochemical Research - May 7, 2024 Category: Neuroscience Authors: Lan Zhao Yanan Li Wei Wang Xue Qi Su Wang Wenqin Song Ting Li Wenwei Gao Source Type: research
The IC87201 (a PSD95/nNOS Inhibitor) Attenuates Post- Stroke Injuries
Neurochem Res. 2024 Apr 24. doi: 10.1007/s11064-024-04140-w. Online ahead of print.ABSTRACTN-methyl-D-aspartate receptor-dependent excitotoxicity is one of the most important mechanisms underlying stroke injury and the resulting neuronal death. In the present study, in order to reduce post-stroke brain injury and improve behavioral performance, a new molecule named IC87201, which acts as an inhibitor of PSD95/nNOS interaction in the intracellular signaling pathway of NMDA receptors, was administered. Using the middle cerebral artery occlusion (MCAO) technique, 24 adult male rats were subjected to one hour of cerebral ische...
Source: Neurochemical Research - April 24, 2024 Category: Neuroscience Authors: Maryam Mohammadian Aminollah Bahaoddini Mohammad Reza Namavar Source Type: research
The IC87201 (a PSD95/nNOS Inhibitor) Attenuates Post- Stroke Injuries
Neurochem Res. 2024 Apr 24. doi: 10.1007/s11064-024-04140-w. Online ahead of print.ABSTRACTN-methyl-D-aspartate receptor-dependent excitotoxicity is one of the most important mechanisms underlying stroke injury and the resulting neuronal death. In the present study, in order to reduce post-stroke brain injury and improve behavioral performance, a new molecule named IC87201, which acts as an inhibitor of PSD95/nNOS interaction in the intracellular signaling pathway of NMDA receptors, was administered. Using the middle cerebral artery occlusion (MCAO) technique, 24 adult male rats were subjected to one hour of cerebral ische...
Source: Neurochemical Research - April 24, 2024 Category: Neuroscience Authors: Maryam Mohammadian Aminollah Bahaoddini Mohammad Reza Namavar Source Type: research
The IC87201 (a PSD95/nNOS Inhibitor) Attenuates Post- Stroke Injuries
Neurochem Res. 2024 Apr 24. doi: 10.1007/s11064-024-04140-w. Online ahead of print.ABSTRACTN-methyl-D-aspartate receptor-dependent excitotoxicity is one of the most important mechanisms underlying stroke injury and the resulting neuronal death. In the present study, in order to reduce post-stroke brain injury and improve behavioral performance, a new molecule named IC87201, which acts as an inhibitor of PSD95/nNOS interaction in the intracellular signaling pathway of NMDA receptors, was administered. Using the middle cerebral artery occlusion (MCAO) technique, 24 adult male rats were subjected to one hour of cerebral ische...
Source: Neurochemical Research - April 24, 2024 Category: Neuroscience Authors: Maryam Mohammadian Aminollah Bahaoddini Mohammad Reza Namavar Source Type: research
The IC87201 (a PSD95/nNOS Inhibitor) Attenuates Post- Stroke Injuries
Neurochem Res. 2024 Apr 24. doi: 10.1007/s11064-024-04140-w. Online ahead of print.ABSTRACTN-methyl-D-aspartate receptor-dependent excitotoxicity is one of the most important mechanisms underlying stroke injury and the resulting neuronal death. In the present study, in order to reduce post-stroke brain injury and improve behavioral performance, a new molecule named IC87201, which acts as an inhibitor of PSD95/nNOS interaction in the intracellular signaling pathway of NMDA receptors, was administered. Using the middle cerebral artery occlusion (MCAO) technique, 24 adult male rats were subjected to one hour of cerebral ische...
Source: Neurochemical Research - April 24, 2024 Category: Neuroscience Authors: Maryam Mohammadian Aminollah Bahaoddini Mohammad Reza Namavar Source Type: research
The IC87201 (a PSD95/nNOS Inhibitor) Attenuates Post- Stroke Injuries
Neurochem Res. 2024 Apr 24. doi: 10.1007/s11064-024-04140-w. Online ahead of print.ABSTRACTN-methyl-D-aspartate receptor-dependent excitotoxicity is one of the most important mechanisms underlying stroke injury and the resulting neuronal death. In the present study, in order to reduce post-stroke brain injury and improve behavioral performance, a new molecule named IC87201, which acts as an inhibitor of PSD95/nNOS interaction in the intracellular signaling pathway of NMDA receptors, was administered. Using the middle cerebral artery occlusion (MCAO) technique, 24 adult male rats were subjected to one hour of cerebral ische...
Source: Neurochemical Research - April 24, 2024 Category: Neuroscience Authors: Maryam Mohammadian Aminollah Bahaoddini Mohammad Reza Namavar Source Type: research
The IC87201 (a PSD95/nNOS Inhibitor) Attenuates Post- Stroke Injuries
Neurochem Res. 2024 Apr 24. doi: 10.1007/s11064-024-04140-w. Online ahead of print.ABSTRACTN-methyl-D-aspartate receptor-dependent excitotoxicity is one of the most important mechanisms underlying stroke injury and the resulting neuronal death. In the present study, in order to reduce post-stroke brain injury and improve behavioral performance, a new molecule named IC87201, which acts as an inhibitor of PSD95/nNOS interaction in the intracellular signaling pathway of NMDA receptors, was administered. Using the middle cerebral artery occlusion (MCAO) technique, 24 adult male rats were subjected to one hour of cerebral ische...
Source: Neurochemical Research - April 24, 2024 Category: Neuroscience Authors: Maryam Mohammadian Aminollah Bahaoddini Mohammad Reza Namavar Source Type: research
The IC87201 (a PSD95/nNOS Inhibitor) Attenuates Post- Stroke Injuries
Neurochem Res. 2024 Apr 24. doi: 10.1007/s11064-024-04140-w. Online ahead of print.ABSTRACTN-methyl-D-aspartate receptor-dependent excitotoxicity is one of the most important mechanisms underlying stroke injury and the resulting neuronal death. In the present study, in order to reduce post-stroke brain injury and improve behavioral performance, a new molecule named IC87201, which acts as an inhibitor of PSD95/nNOS interaction in the intracellular signaling pathway of NMDA receptors, was administered. Using the middle cerebral artery occlusion (MCAO) technique, 24 adult male rats were subjected to one hour of cerebral ische...
Source: Neurochemical Research - April 24, 2024 Category: Neuroscience Authors: Maryam Mohammadian Aminollah Bahaoddini Mohammad Reza Namavar Source Type: research
The IC87201 (a PSD95/nNOS Inhibitor) Attenuates Post- Stroke Injuries
Neurochem Res. 2024 Apr 24. doi: 10.1007/s11064-024-04140-w. Online ahead of print.ABSTRACTN-methyl-D-aspartate receptor-dependent excitotoxicity is one of the most important mechanisms underlying stroke injury and the resulting neuronal death. In the present study, in order to reduce post-stroke brain injury and improve behavioral performance, a new molecule named IC87201, which acts as an inhibitor of PSD95/nNOS interaction in the intracellular signaling pathway of NMDA receptors, was administered. Using the middle cerebral artery occlusion (MCAO) technique, 24 adult male rats were subjected to one hour of cerebral ische...
Source: Neurochemical Research - April 24, 2024 Category: Neuroscience Authors: Maryam Mohammadian Aminollah Bahaoddini Mohammad Reza Namavar Source Type: research
The IC87201 (a PSD95/nNOS Inhibitor) Attenuates Post- Stroke Injuries
Neurochem Res. 2024 Apr 24. doi: 10.1007/s11064-024-04140-w. Online ahead of print.ABSTRACTN-methyl-D-aspartate receptor-dependent excitotoxicity is one of the most important mechanisms underlying stroke injury and the resulting neuronal death. In the present study, in order to reduce post-stroke brain injury and improve behavioral performance, a new molecule named IC87201, which acts as an inhibitor of PSD95/nNOS interaction in the intracellular signaling pathway of NMDA receptors, was administered. Using the middle cerebral artery occlusion (MCAO) technique, 24 adult male rats were subjected to one hour of cerebral ische...
Source: Neurochemical Research - April 24, 2024 Category: Neuroscience Authors: Maryam Mohammadian Aminollah Bahaoddini Mohammad Reza Namavar Source Type: research
The IC87201 (a PSD95/nNOS Inhibitor) Attenuates Post- Stroke Injuries
Neurochem Res. 2024 Apr 24. doi: 10.1007/s11064-024-04140-w. Online ahead of print.ABSTRACTN-methyl-D-aspartate receptor-dependent excitotoxicity is one of the most important mechanisms underlying stroke injury and the resulting neuronal death. In the present study, in order to reduce post-stroke brain injury and improve behavioral performance, a new molecule named IC87201, which acts as an inhibitor of PSD95/nNOS interaction in the intracellular signaling pathway of NMDA receptors, was administered. Using the middle cerebral artery occlusion (MCAO) technique, 24 adult male rats were subjected to one hour of cerebral ische...
Source: Neurochemical Research - April 24, 2024 Category: Neuroscience Authors: Maryam Mohammadian Aminollah Bahaoddini Mohammad Reza Namavar Source Type: research
Preface for the Vicente Felipo Honorary Issue of Neurochemical Research
Neurochem Res. 2024 Apr 20. doi: 10.1007/s11064-024-04139-3. Online ahead of print.NO ABSTRACTPMID:38641758 | DOI:10.1007/s11064-024-04139-3 (Source: Neurochemical Research)
Source: Neurochemical Research - April 19, 2024 Category: Neuroscience Authors: Marta Llansola Source Type: research
Correction: Orientin Modulates Nrf2-ARE, PI3K/Akt, JNK-ERK1/2, and TLR4/NF-kB Pathways to Produce Neuroprotective Benefits in Parkinson's Disease
Neurochem Res. 2024 Apr 16. doi: 10.1007/s11064-024-04138-4. Online ahead of print.NO ABSTRACTPMID:38625635 | DOI:10.1007/s11064-024-04138-4 (Source: Neurochemical Research)
Source: Neurochemical Research - April 16, 2024 Category: Neuroscience Authors: Deepak Vasudevan Sajini Praveen Thaggikuppe Krishnamurthy Amritha Chakkittukandiyil Ravi Naik Mudavath Source Type: research
Correction: Orientin Modulates Nrf2-ARE, PI3K/Akt, JNK-ERK1/2, and TLR4/NF-kB Pathways to Produce Neuroprotective Benefits in Parkinson's Disease
Neurochem Res. 2024 Apr 16. doi: 10.1007/s11064-024-04138-4. Online ahead of print.NO ABSTRACTPMID:38625635 | DOI:10.1007/s11064-024-04138-4 (Source: Neurochemical Research)
Source: Neurochemical Research - April 16, 2024 Category: Neuroscience Authors: Deepak Vasudevan Sajini Praveen Thaggikuppe Krishnamurthy Amritha Chakkittukandiyil Ravi Naik Mudavath Source Type: research
Correction: Orientin Modulates Nrf2-ARE, PI3K/Akt, JNK-ERK1/2, and TLR4/NF-kB Pathways to Produce Neuroprotective Benefits in Parkinson's Disease
Neurochem Res. 2024 Apr 16. doi: 10.1007/s11064-024-04138-4. Online ahead of print.NO ABSTRACTPMID:38625635 | DOI:10.1007/s11064-024-04138-4 (Source: Neurochemical Research)
Source: Neurochemical Research - April 16, 2024 Category: Neuroscience Authors: Deepak Vasudevan Sajini Praveen Thaggikuppe Krishnamurthy Amritha Chakkittukandiyil Ravi Naik Mudavath Source Type: research
