Turkish translation and transcultural validity and reliability of an assessment tool for spasticity: Leg Activity Measure (Leg A)
CONCLUSIONS: Tr-LegA is a valid and reliable multidimensional scale for passive and active function and quality of life in patients with lower limb spasticity.THE CLINICAL TRIAL NUMBER: NCT05182411.PMID:38695372 | DOI:10.1080/01616412.2024.2340878 (Source: Neurological Research)
Source: Neurological Research - May 2, 2024 Category: Neurology Authors: Zekiye İpek Katırcı Kırmacı Hatice Adig üzel Yusuf Şinasi Kırmacı Emel Ta şvuran Horata Deniz Tuncel Berkta ş Suat Erel Source Type: research
The possible causal relationship between COVID-19 and imaging markers of cerebral small vessel disease: a Mendelian randomization study
This study aims to explore the causal correlation between COVID-19 and the imaging markers of CSVD using Mendelian randomization (MR) methods.METHODS: Summary-level genome-wide association study (GWAS) statistics for COVID-19 susceptibility, hospitalization, and severity were utilized as proxies for exposure. Large-scale meta-analysis GWAS data on three neuroimaging markers of white matter hyperintensity, lacunar stroke, and brain microbleeds, were employed as outcomes. Our primary MR analysis employed the inverse variance weighted (IVW) approach, supplemented by MR-Egger, weighted median, and MR-PRESSO methods. We also co...
Source: Neurological Research - May 2, 2024 Category: Neurology Authors: Jiahao Song Da Zhou Lina Jia Mengqi Wang Duo Lan Jingrun Li Fatime Zara Hassan Hamit Yuchuan Ding Xunming Ji Ran Meng Source Type: research
Assessment of serum inflammatory parameters in RRMS and SPMS patients
DISCUSSION: Significant differences were found in BAFF, gp130, MMP-2 and osteopontin levels between RRMS and SPMS patients. Serum IL-32 levels were statistically lower in RRMS patients treated with disease-modifying therapy than in treatment-naïve patients.PMID:38697017 | DOI:10.1080/01616412.2024.2337503 (Source: Neurological Research)
Source: Neurological Research - May 2, 2024 Category: Neurology Authors: Maria Nowak-Kiczmer Natalia Niedziela Zenon P Czuba Pawe ł Sowa Krzysztof Wierzbicki Micha ł Lubczyński Monika Adamczyk-Sowa Source Type: research
Turkish translation and transcultural validity and reliability of an assessment tool for spasticity: Leg Activity Measure (Leg A)
CONCLUSIONS: Tr-LegA is a valid and reliable multidimensional scale for passive and active function and quality of life in patients with lower limb spasticity.THE CLINICAL TRIAL NUMBER: NCT05182411.PMID:38695372 | DOI:10.1080/01616412.2024.2340878 (Source: Neurological Research)
Source: Neurological Research - May 2, 2024 Category: Neurology Authors: Zekiye İpek Katırcı Kırmacı Hatice Adig üzel Yusuf Şinasi Kırmacı Emel Ta şvuran Horata Deniz Tuncel Berkta ş Suat Erel Source Type: research
The possible causal relationship between COVID-19 and imaging markers of cerebral small vessel disease: a Mendelian randomization study
This study aims to explore the causal correlation between COVID-19 and the imaging markers of CSVD using Mendelian randomization (MR) methods.METHODS: Summary-level genome-wide association study (GWAS) statistics for COVID-19 susceptibility, hospitalization, and severity were utilized as proxies for exposure. Large-scale meta-analysis GWAS data on three neuroimaging markers of white matter hyperintensity, lacunar stroke, and brain microbleeds, were employed as outcomes. Our primary MR analysis employed the inverse variance weighted (IVW) approach, supplemented by MR-Egger, weighted median, and MR-PRESSO methods. We also co...
Source: Neurological Research - May 2, 2024 Category: Neurology Authors: Jiahao Song Da Zhou Lina Jia Mengqi Wang Duo Lan Jingrun Li Fatime Zara Hassan Hamit Yuchuan Ding Xunming Ji Ran Meng Source Type: research
Assessment of serum inflammatory parameters in RRMS and SPMS patients
DISCUSSION: Significant differences were found in BAFF, gp130, MMP-2 and osteopontin levels between RRMS and SPMS patients. Serum IL-32 levels were statistically lower in RRMS patients treated with disease-modifying therapy than in treatment-naïve patients.PMID:38697017 | DOI:10.1080/01616412.2024.2337503 (Source: Neurological Research)
Source: Neurological Research - May 2, 2024 Category: Neurology Authors: Maria Nowak-Kiczmer Natalia Niedziela Zenon P Czuba Pawe ł Sowa Krzysztof Wierzbicki Micha ł Lubczyński Monika Adamczyk-Sowa Source Type: research
Piroxicam reduced the intensity of epileptic seizures in a kindling seizure model
In this study, the anticonvulsant capacity of piroxicam, an anti-inflammatory drug, was evaluated. A rat pentylenetetrazole kindling model was used.Methods: Male Wistar rats, 8-9 weeks old, received piroxicam (0.15 and 0.30 mg/kg), diazepam (2 mg/kg) or saline for 14 days, and PTZ, on alternate days. Intraperitoneal was chosen as the route of administration. The intensity of epileptic seizures was assessed using a modified Racine scale. The open field test and object recognition analysis were performed at the beginning of the study to ensure the safety of the drugs used. At the end of the protocol, the animals were euthani...
Source: Neurological Research - April 28, 2024 Category: Neurology Authors: Edson Fernando Muller Guzzo Gabriel Rosa Amanda Muliterno Domingues Louren ço de Lima Rafael Padilha Adriana Coitinho Source Type: research
Effects of extracorporeal diaphragm pacing combined with inspiratory muscle training on respiratory function in people with stroke: a randomized controlled trial
CONCLUSION: EDP combined with inspiratory muscle training in individuals with stroke provides greater benefits than EDP alone in terms of respiratory function recovery, except for the parameters of diaphragmatic excursion and FEV1/FVC%.PMID:38661091 | DOI:10.1080/01616412.2024.2347133 (Source: Neurological Research)
Source: Neurological Research - April 25, 2024 Category: Neurology Authors: Ting Zhu Hua-Ping Jin Sha-Sha Liu Hong-Jun Zhu Jing-Wen Wang Source Type: research
Hypercapnic hypoxia as a rehabilitation method for patients after ischemic stroke
CONCLUSION: Respiratory training with hypercapnic hypoxia improves the functional state of the nervous system in patients with ischemic stroke. After conducting further clarifying studies, hypercapnic hypoxia can be considered as an effective method of neurorehabilitation, which can be used as early as 48-72 hours after the onset of stroke.PMID:38643375 | DOI:10.1080/01616412.2024.2343510 (Source: Neurological Research)
Source: Neurological Research - April 21, 2024 Category: Neurology Authors: Tatiana M Alekseeva Maria P Topuzova Vladimir P Kulikov Pavel D Kovzelev Mark G Kosenko Pavel P Tregub Source Type: research
Focality in childhood absence epilepsy
CONCLUSIONS: Focal maximal electronegativity areas were frequently observed in drug-naïve CAE patients, comprising approximately half of non-generalized discharges. Focal discharges might be misleading in diagnosis. Focal areas within the brain may be responsible for and contribute to absence seizures that appear bilaterally symmetrical and generalized clinically. Although its clinical implication is unknown, this warrants further study.PMID:38643974 | DOI:10.1080/01616412.2024.2339114 (Source: Neurological Research)
Source: Neurological Research - April 21, 2024 Category: Neurology Authors: Özlem Yayıcı Köken Boran Şekeroğlu Bur çin Şanlıdağ Mehpare Sar ı Yanartaş Arzu Y ılmaz Source Type: research
