Contribution of microglia to the epileptiform activity that results from neonatal hypoxia
Neuropharmacology. 2024 Apr 29:109968. doi: 10.1016/j.neuropharm.2024.109968. Online ahead of print.ABSTRACTMicroglia are described as the immune cells of the brain, their immune properties have been extensively studied since first described, however, their neural functions have only been explored over the last decade. Microglia have an important role in maintaining homeostasis in the central nervous system by surveying their surroundings to detect pathogens or damage cells. While these are the classical functions described for microglia, more recently their neural functions have been defined; they are critical to the matu...
Source: Neuropharmacology - May 1, 2024 Category: Drugs & Pharmacology Authors: Aisling Leavy Jessie Phelan Eva M Jimenez-Mateos Source Type: research
Contribution of microglia to the epileptiform activity that results from neonatal hypoxia
Neuropharmacology. 2024 Apr 29:109968. doi: 10.1016/j.neuropharm.2024.109968. Online ahead of print.ABSTRACTMicroglia are described as the immune cells of the brain, their immune properties have been extensively studied since first described, however, their neural functions have only been explored over the last decade. Microglia have an important role in maintaining homeostasis in the central nervous system by surveying their surroundings to detect pathogens or damage cells. While these are the classical functions described for microglia, more recently their neural functions have been defined; they are critical to the matu...
Source: Neuropharmacology - May 1, 2024 Category: Drugs & Pharmacology Authors: Aisling Leavy Jessie Phelan Eva M Jimenez-Mateos Source Type: research
Long-term adaptation of prefrontal circuits in a mouse model of NMDAR hypofunction
Neuropharmacology. 2024 Apr 27:109970. doi: 10.1016/j.neuropharm.2024.109970. Online ahead of print.ABSTRACTPharmacological approaches to induce N-methyl-D-aspartate receptor (NMDAR) hypofunction have been intensively used to understand the aetiology and pathophysiology of schizophrenia. Yet, the precise cellular and molecular mechanisms that relate to brain network dysfunction remain largely unknown. Here, we used a set of complementary approaches to assess the functional network abnormalities present in male mice that underwent a 7-day subchronic phencyclidine (PCP 10mg/kg, subcutaneously, once daily) treatment. Our data...
Source: Neuropharmacology - April 30, 2024 Category: Drugs & Pharmacology Authors: Marion Ponserre Tudor M Ionescu Alessa A Franz Serena Deiana Niklas Schuelert Thorsten Lamla Rh îannan H Williams Carsten T Wotjak Scott Hobson Julien Dine Azar Omrani Source Type: research
Polysorbate 80 coated chitosan nanoparticles for delivery of α-melanocyte stimulating hormone analog (NDP-MSH) to the brain reverse cognitive impairment related to neuroinflammation produced by a high-fat diet (HFD)
This study aimed to develop polysorbate 80-coated chitosan nanoparticles (PS80/CS NPs) as a delivery system for improved brain targeting of α-Melanocyte Stimulating Hormone analog (NDP-MSH). Chitosan nanoparticles loaded with NDP-MSH were surface-modified with polysorbate 80 ([NDP-MSH]-PS80/CS NP), which formed a flattened layer on their surface. Nanoparticle preparation involved ionic gelation, followed by characterization using scanning electron microscopy (SEM) for morphology, dynamic light scattering (DLS) for colloidal properties, and ATR-FTIR spectroscopy for structure. Intraperitoneal injection of FITC-PS80/CS NPs ...
Source: Neuropharmacology - April 30, 2024 Category: Drugs & Pharmacology Authors: Guadalupe Herrera Teresa Scimonelli Mercedes Lasaga Gladys Granero Ren ée Onnainty Source Type: research
Corrigendum to "Nurr1: A vital participant in the TLR4-NF- κB signal pathway stimulated by a-synuclein in BV-2 cells" [Neuropharmacol. (2019) 144 388-399] doi:10.1016/j.neuropharm.2018.04.008
Neuropharmacology. 2024 Apr 29:109962. doi: 10.1016/j.neuropharm.2024.109962. Online ahead of print.NO ABSTRACTPMID:38688816 | DOI:10.1016/j.neuropharm.2024.109962 (Source: Neuropharmacology)
Source: Neuropharmacology - April 30, 2024 Category: Drugs & Pharmacology Authors: Qian-Hang Shao Wen-Fen Yan Zhao Zhang Kai-Li Ma Shan-Ying Peng Ying-Li Cao Yu-He Yuan Nai-Hong Chen Source Type: research
Long-term adaptation of prefrontal circuits in a mouse model of NMDAR hypofunction
Neuropharmacology. 2024 Apr 27:109970. doi: 10.1016/j.neuropharm.2024.109970. Online ahead of print.ABSTRACTPharmacological approaches to induce N-methyl-D-aspartate receptor (NMDAR) hypofunction have been intensively used to understand the aetiology and pathophysiology of schizophrenia. Yet, the precise cellular and molecular mechanisms that relate to brain network dysfunction remain largely unknown. Here, we used a set of complementary approaches to assess the functional network abnormalities present in male mice that underwent a 7-day subchronic phencyclidine (PCP 10mg/kg, subcutaneously, once daily) treatment. Our data...
Source: Neuropharmacology - April 30, 2024 Category: Drugs & Pharmacology Authors: Marion Ponserre Tudor M Ionescu Alessa A Franz Serena Deiana Niklas Schuelert Thorsten Lamla Rh îannan H Williams Carsten T Wotjak Scott Hobson Julien Dine Azar Omrani Source Type: research
Corrigendum to "Nurr1: A vital participant in the TLR4-NF- κB signal pathway stimulated by a-synuclein in BV-2 cells" [Neuropharmacol. (2019) 144 388-399] doi:10.1016/j.neuropharm.2018.04.008
Neuropharmacology. 2024 Apr 29:109962. doi: 10.1016/j.neuropharm.2024.109962. Online ahead of print.NO ABSTRACTPMID:38688816 | DOI:10.1016/j.neuropharm.2024.109962 (Source: Neuropharmacology)
Source: Neuropharmacology - April 30, 2024 Category: Drugs & Pharmacology Authors: Qian-Hang Shao Wen-Fen Yan Zhao Zhang Kai-Li Ma Shan-Ying Peng Ying-Li Cao Yu-He Yuan Nai-Hong Chen Source Type: research
Polysorbate 80 coated chitosan nanoparticles for delivery of α-Melanocyte Stimulating Hormone analog (NDP-MSH) to the brain reverse cognitive impairment related to neuroinflammation produced by a high-fat diet (HFD)
This study aimed to develop polysorbate 80-coated chitosan nanoparticles (PS80/CS NPs) as a delivery system for improved brain targeting of α-Melanocyte Stimulating Hormone analog (NDP-MSH). Chitosan nanoparticles loaded with NDP-MSH were surface-modified with polysorbate 80 ([NDP-MSH]-PS80/CS NP), which formed a flattened layer on their surface. Nanoparticle preparation involved ionic gelation, followed by characterization using scanning electron microscopy (SEM) for morphology, dynamic light scattering (DLS) for colloidal properties, and ATR-FTIR spectroscopy for structure. Intraperitoneal injection of FITC-PS80/CS NPs ...
Source: Neuropharmacology - April 30, 2024 Category: Drugs & Pharmacology Authors: Guadalupe Herrera Teresa Scimonelli Lasaga Mercedes Gladys Granero Ren ée Onnainty Source Type: research
Glucagon-like peptide-1 class drugs show clear protective effects in Parkinson's and Alzheimer's disease clinical trials: A revolution in the making?
Neuropharmacology. 2024 Apr 25;253:109952. doi: 10.1016/j.neuropharm.2024.109952. Online ahead of print.ABSTRACTParkinson's disease (PD) is a complex syndrome for which there is no disease-modifying treatment on the market. However, a group of drugs from the Glucagon-like peptide-1 (GLP-1) class have shown impressive improvements in clinical phase II trials. Exendin-4 (Bydureon), Liraglutide (Victoza, Saxenda) and Lixisenatide (Adlyxin), drugs that are on the market as treatments for diabetes, have shown clear effects in improving motor activity in patients with PD in phase II clinical trials. In addition, Liraglutide has ...
Source: Neuropharmacology - April 27, 2024 Category: Drugs & Pharmacology Authors: Christian H ölscher Source Type: research
Hypothermia as Potential Therapeutic Approach to Attenuating Soman-Induced Seizure, Neuropathology, and Mortality with an Adenosine A < sub > 1 < /sub > Receptor Agonist and Body Cooling
Neuropharmacology. 2024 Apr 25:109966. doi: 10.1016/j.neuropharm.2024.109966. Online ahead of print.ABSTRACTOrganophosphorus nerve agents, such as soman (GD), produce excitotoxic effects resulting in sustained status epilepticus (SSE) and brain damage. Previous work shows that neuronal inhibitory effects of A1 adenosine receptor (A1AR) agonists, such as N6- Bicyclo(2.2.1)-hept-2-yl-5'-chloro-5'-deoxyadenosine (Cl-ENBA), suppresses GD-induced SSE and improves neuropathology. Some other physiologic effects of these agonists are hypothermia, hypotension, and sedation. Hypothermia may also shield the brain from injury by slowi...
Source: Neuropharmacology - April 27, 2024 Category: Drugs & Pharmacology Authors: Crystal Munoz Cindy Acon-Chen Zora-Maya Keith Tsung-Ming Shih Source Type: research
Glucagon-like peptide-1 class drugs show clear protective effects in Parkinson's and Alzheimer's disease clinical trials: A revolution in the making?
Neuropharmacology. 2024 Apr 25;253:109952. doi: 10.1016/j.neuropharm.2024.109952. Online ahead of print.ABSTRACTParkinson's disease (PD) is a complex syndrome for which there is no disease-modifying treatment on the market. However, a group of drugs from the Glucagon-like peptide-1 (GLP-1) class have shown impressive improvements in clinical phase II trials. Exendin-4 (Bydureon), Liraglutide (Victoza, Saxenda) and Lixisenatide (Adlyxin), drugs that are on the market as treatments for diabetes, have shown clear effects in improving motor activity in patients with PD in phase II clinical trials. In addition, Liraglutide has ...
Source: Neuropharmacology - April 27, 2024 Category: Drugs & Pharmacology Authors: Christian H ölscher Source Type: research
Hypothermia as Potential Therapeutic Approach to Attenuating Soman-Induced Seizure, Neuropathology, and Mortality with an Adenosine A < sub > 1 < /sub > Receptor Agonist and Body Cooling
Neuropharmacology. 2024 Apr 25:109966. doi: 10.1016/j.neuropharm.2024.109966. Online ahead of print.ABSTRACTOrganophosphorus nerve agents, such as soman (GD), produce excitotoxic effects resulting in sustained status epilepticus (SSE) and brain damage. Previous work shows that neuronal inhibitory effects of A1 adenosine receptor (A1AR) agonists, such as N6- Bicyclo(2.2.1)-hept-2-yl-5'-chloro-5'-deoxyadenosine (Cl-ENBA), suppresses GD-induced SSE and improves neuropathology. Some other physiologic effects of these agonists are hypothermia, hypotension, and sedation. Hypothermia may also shield the brain from injury by slowi...
Source: Neuropharmacology - April 27, 2024 Category: Drugs & Pharmacology Authors: Crystal Munoz Cindy Acon-Chen Zora-Maya Keith Tsung-Ming Shih Source Type: research
Prenatal exposure to valproic acid reduces synaptic δ-catenin levels and disrupts ultrasonic vocalization in neonates
Neuropharmacology. 2024 Apr 23;253:109963. doi: 10.1016/j.neuropharm.2024.109963. Online ahead of print.ABSTRACTValproic acid (VPA) is an effective and commonly prescribed drug for epilepsy and bipolar disorder. However, children born from mothers treated with VPA during pregnancy exhibit an increased incidence of autism spectrum disorder (ASD). Although VPA may impair brain development at the cellular level, the mechanism of VPA-induced ASD has not been completely addressed. A previous study has found that VPA treatment strongly reduces δ-catenin mRNA levels in cultured human neurons. δ-catenin is important for the cont...
Source: Neuropharmacology - April 24, 2024 Category: Drugs & Pharmacology Authors: Seung Hyun Roh Hadassah Mendez-Vazquez Matheus F Sathler Michael J Doolittle Anastasiya Zaytseva Hannah Brown Morgan Sainsbury Seonil Kim Source Type: research
Analgesic effect of Botulinum toxin in neuropathic pain is sodium channel independent
Neuropharmacology. 2024 Apr 22:109967. doi: 10.1016/j.neuropharm.2024.109967. Online ahead of print.ABSTRACTBotulinum neurotoxin type A BoNT/A is used off-label as a third line therapy for neuropathic pain. However, the mechanism of action remains unclear. In recent years, the role of voltage-gated sodium channels (Nav) in neuropathic pain became evident and it was suggested that block of sodium channels by BoNT/A would contribute to its analgesic effect. We assessed sodium channel function in the presence of BoNT/A in heterologously expressed Nav1.7, Nav1.3, and the neuronal cell line ND7/23 by high throughput automated a...
Source: Neuropharmacology - April 24, 2024 Category: Drugs & Pharmacology Authors: Aylin B Kesdo ğan Anika Neureiter Arnim J Gaebler Anil K Kalia Jannis K örner Angelika Lampert Source Type: research
Examination of the effects of vitexin and vitexin-loaded solid lipid nanoparticles on neuropathic pain and possible mechanisms of action
In conclusion, vitexin and vitexin-loaded formulation have the potential for clinical use in neuropathic pain management, and different pain pathways contributed to this effect. And also, it is thought that vitexin-loaded SLN formulation is more effective than pure vitexin, which will provide an advantage in treatment.PMID:38657947 | DOI:10.1016/j.neuropharm.2024.109961 (Source: Neuropharmacology)
Source: Neuropharmacology - April 24, 2024 Category: Drugs & Pharmacology Authors: Hazal Eken Nurcan Bektas Turkmen Behiye Senel Rana Arslan Source Type: research
