Unraveling sex-specific risks of knee osteoarthritis before menopause: Do sex differences start early in life?
Sufficient evidence within the past two decades have shown that osteoarthritis (OA) has a sex-specific component. However, efforts to reveal the biological causes of this disparity have emerged more gradually. In this narrative review, we discuss anatomical differences within the knee, incidence of injuries in youth sports, and metabolic factors that present early in life (childhood and early adulthood) that can contribute to a higher risk of OA in females. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - May 1, 2024 Category: Rheumatology Authors: Paula A. Hernandez, John Churchill Bradford, Priyanka Brahmachary, Sophia Ulman, Jennifer L. Robinson, Ronald K. June, Magali Cucchiarini Tags: Review Source Type: research
The efficacy and safety of a fixed-dose combination of apocynin and paeonol, APPA, in symptomatic knee OA: A double-blind, randomized, placebo-controlled, clinical trial
This study assessed of a fixed-dose combination of APPA in people with symptomatic knee osteoarthritis (OA). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 30, 2024 Category: Rheumatology Authors: Asger Reinstrup Bihlet, Inger Byrjalsen, Jeppe Ragnar Andersen, Alan Reynolds, Nicholas Larkins, Peter Alexandersen, Helene Rovsing, Robert Moots, Philip G. Conaghan Source Type: research
Hand osteoarthritis phenotypes based on a biopsychosocial approach, and their associations with cross-sectional and longitudinal pain
Hand osteoarthritis (OA) pain is characterized as heterogeneous and multifactorial. Differences in pain may be explained by underlying phenotypes, which have not been previously explored. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 30, 2024 Category: Rheumatology Authors: Elisabeth Mulrooney, Tuhina Neogi, Hanne Dagfinrud, Hilde Berner Hammer, Pernille Steen Pettersen, Tore K Kvien, Karin Magnusson, Ida K Haugen Source Type: research
Surgical restabilization reduces the progression of post-traumatic osteoarthritis initiated by ACL rupture in mice
People who sustain joint injuries such as anterior cruciate ligament (ACL) rupture often develop post-traumatic osteoarthritis (PTOA). In human patients, ACL injuries are often treated with ACL reconstruction. However, it is still unclear how effective joint restabilization is for reducing the progression of PTOA. The goal of this study was to determine how surgical restabilization of a mouse knee joint following non-invasive ACL injury affects PTOA progression. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 30, 2024 Category: Rheumatology Authors: Yu-Yang , Elias H. , Priscilla M. , Michael C. , Michael , Seif B. , Connor M. , Kristin K. , Heejung , Jill L. , Cassandra A. , Blaine A. Source Type: research
Gender differences in patterns of cartilage loss: Data from the Osteoarthritis Initiative
Understanding gender-specific differences in patterns of cartilage loss can improve our knowledge of the pathogenesis of knee osteoarthritis (KOA) development and progression and may inform clinical trials of treatments for KOA. The goal of our observational study was to examine gender differences in patterns of cartilage loss in the central weight-bearing regions of the femur. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 28, 2024 Category: Rheumatology Authors: Rebecca Amesbury, Hedieh Ragati-Haghi, Alexander Mathiessen, Todd Laffaye, Rebekkah I. Stein, Jamie E. Collins, C. Kent Kwoh, Jeffrey Duryea Source Type: research
Comparative effectiveness of different placebos and comparator groups for hand osteoarthritis exploring the impact of contextual factors: A systematic review and meta-analysis of randomised trials
To examine the pain relief effects of comparators (placebos and untreated control groups) in hand osteoarthritis trials and the impact of contextual factors. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 26, 2024 Category: Rheumatology Authors: Ida Maria Balsby, Sabrina M. Nielsen, Robin Christensen, Marius Henriksen, Louise Ulff-M øller Dahl, Johannes Iuel Berg, Simon Tarp, Féline Kroon, Margreet Kloppenburg, Weiya Zhang, David J. Hunter, Henning Bliddal, Anna Døssing Source Type: research
Non-invasive electroarthrography measures cartilage in live horses and correlates to direct measurements of cartilage streaming potentials in weight bearing regions of equine metacarpophalangeal joints
To perform non-invasive Electroarthrography (EAG) on live horses and establish relationships between EAG and direct measurements of cartilage streaming potentials in weight bearing areas of the equine metacarpophalangeal joint. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 26, 2024 Category: Rheumatology Authors: Adele Changoor, Martin Garon, Eric Quenneville, Pierre Savard, Michael D. Buschmann, Mark B. Hurtig Source Type: research
HSP70 — A Key Regulator in Chondrocyte Homeostasis Under Naturally Coupled Hydrostatic Pressure-Thermal Stimuli
During physical activities, chondrocytes experience coupled stimulation of hydrostatic pressure (HP) and a transient increase in temperature (T), with the latter varying within a physiological range from 32.5 °C to 38.7 °C. Previous short-term in vitro studies have demonstrated that the combined HP-T stimuli more significantly enhance chondroinduction and chondroprotection of chondrocytes than isolated applications. Interestingly, this combined benefit is associated with a corresponding increase in HSP 70 levels when HP and T are combined. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 26, 2024 Category: Rheumatology Authors: Yanheng Guo, Theofanis Stampoultzis, Peyman Karami, Naser Nasrollahzadeh, Vijay Kumar Rana, Dominique P. Pioletti Source Type: research
Comment on: How effective are exercises delivered digitally (requiring internet), amongst patients with hip or knee osteoarthritis? A systematic review and meta-analysis
Dear Editor, (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 24, 2024 Category: Rheumatology Authors: Yingang You, Qiufang Wei, Yuepeng Teng, Miaomiao Miao Source Type: research
Corrigendum to ‘Advances in organ-on-a-chip systems for modelling joint tissue and osteoarthritic diseases’ Osteoarthritis Cartilage 30 (2022) 1050-1061
The authors have notified us that there were minor errors in Table I of the above published article which are as follows: (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 21, 2024 Category: Rheumatology Authors: L. Banh, K.K. Cheung, M.W.Y. Chan, E.W.K. Young, S. Viswanathan Tags: Corrigendum Source Type: research
Serum levels of hydroxylated metabolites of arachidonic acid cross-sectionally and longitudinally predict knee pain progression: an observational cohort study.
To examine associations between serum oxylipins, which regulate tissue repair and pain signalling, and knee pain/radiographic osteoarthritis (OA) at baseline and knee pain at 3 year follow-up. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 20, 2024 Category: Rheumatology Authors: James Turnbull, Rakesh R. Jha, Peter R.W. Gowler, Rose Ferrands-Bentley, Dong-Hyun Kim, David A. Barrett, Aliya Sarmanova, Gwen S. Fernandes, Michael Doherty, Weiya Zhang, David A. Walsh, Ana M. Valdes, Victoria Chapman Source Type: research
Association between hip muscle strength/function and hip cartilage defects in sub-elite football players with hip/groin pain.
To explore associations between hip muscle strength and cartilage defects (presence and severity) on magnetic resonance imaging (MRI) in young adults with hip/groin pain participating in sub-elite football. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 20, 2024 Category: Rheumatology Authors: SL Coburn, KM Crossley, JL Kemp, F Gassert, J Luitjens, SJ Warden, AG Culvenor, MJ Scholes, MG King, P Lawrenson, T Link, JJ Heerey Source Type: research
Mild Exercise Expedites Joint Clearance and Slows Joint Degradation in a Joint Instability Model of Osteoarthritis in Male Rats
In this study, we hypothesized that exercise could slow progression of preclinical PTOA in part by enhancing knee joint clearance. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 17, 2024 Category: Rheumatology Authors: Jarred M Kaiser, Fabrice C Bernard, Krishna Pucha, Sarvgna K Raval, Tracy Eng, Travis Fulton, Shannon E Anderson, Kyle D Allen, J Brandon Dixon, Nick J Willett Source Type: research
Osteochondral fluid transport in an ex vivo system
The objectives of this study were to (1) test for diffusion of 3kDa molecular tracers from bone-to-cartilage and (2) assess potential differences in bone-to-cartilage fluid transport between different loading conditions. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 15, 2024 Category: Rheumatology Authors: Brady David Hislop, Ara K. Mercer, Alexandria G. Whitley, Erik P. Myers, Marie Mackin, Chelsea M. Heveran, Ronald K. June Tags: Brief Report Source Type: research
Adiposity and cartilage lesions following ACL reconstruction
To determine if global, central, or peripheral adiposity is associated with prevalent and worsening cartilage lesions following anterior cruciate ligament reconstruction (ACLR). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 14, 2024 Category: Rheumatology Authors: Harvi F. Hart, Kay M. Crossley, Brooke E. Patterson, Ali Guermazi, Trevor B. Birmingham, Chris Koskoletos, Am élie Michaud, Alysha De Livera, Adam G. Culvenor Source Type: research
