Are the criteria for PD-MCI diagnosis comprehensive? A Machine Learning study with modified criteria
Mild cognitive impairment in Parkinson's disease (PD-MCI) includes deficits in different cognitive domains, and one domain to explore for neurocognitive impairment following the DSM-V is social cognition. However, this domain is not included in current criteria for PD-MCI diagnosis. Moreover, tests vary across studies. It is, therefore, crucial to optimize cognitive assessment in PD-MCI. We aimed to do so by using Machine Learning. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - April 29, 2024 Category: Neurology Authors: Chiara Longo, Daniele Luigi Romano, Maria Pennacchio, Maria Chiara Malaguti, Raffaella Di Giacopo, Bruno Giometto, Costanza Papagno Source Type: research
Severity of sleep apnea as a prognostic factor for mortality in patients with multiple system atrophy
We determined whether the severity of sleep apnea increases the risk of mortality in patients with multiple system atrophy (MSA) with and without stridor.MethodsThis retrospective study included patients who underwent polysomnography within one year after diagnosis of probable MSA. Stridor, sleep apnea, and arousal from sleep were determined using full-night polysomnography. Disease severity was measured using the Unified MSA Rating Scale (UMSARS). Survival data were collected and analyzed using Cox regression analysis. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - April 29, 2024 Category: Neurology Authors: Sungyang Jo, Tae-Young Kim, Yong Seok Lee, Eun-Jae Lee, Sangjin Lee, Jihyun Lee, Sun Ju Chung, Sang-Ahm Lee Source Type: research
Support Group for Parkinson ’s Disease Patients in Chicagoland of African Ancestry
Parkinson's disease (PD) patients from the Black community comprise a smaller percentage of patients in subspecialty movement disorder clinics despite being located in geographic areas with a high population of Black individuals.[1] In addition, few studies have been conducted to understand the specific needs of Parkinson ’s disease (PD) patients from the Black community. However, it has been shown that there are potential health benefits to receiving and providing social support among older African Americans [2]. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - April 28, 2024 Category: Neurology Authors: Deborah A. Hall, Staci Davis, Titane Johnson, Devonda Chambliss, Sharlet Anderson Source Type: research
Machine learning models for diagnosis of essential tremor and dystonic tremor using grey matter morphological networks
In this study, we explore the structural network mechanisms of ET and DT using brain grey matter (GM) morphological networks and combine those with machine learning models. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - April 28, 2024 Category: Neurology Authors: Honge Gui, Pan Xiao, Bintao Xu, Xiaole Zhao, Hongyu Wang, Li Tao, Xiaoyu Zhang, Qin Li, Xueyan Zhang, Huiyue Chen, Hansheng Wang, Fajin Lv, Tianyou Luo, Oumei Cheng, Jin Luo, Yun Man, Zheng Xiao, Weidong Fang Source Type: research
Illustration of the Long-Term Efficacy of Pallidal Deep Brain Stimulation in a Patient with PKAN Dystonia
Pantothenate kinase-associated neurodegeneration (PKAN, PANK2, OMIM ID: 234200) represents the most common subtype of neurodegeneration associated with brain iron accumulation (NBIA). Treatment could be challenging due to the combination of severe motor and nonmotor features. Deep Brain Stimulation (DBS) may be a promising treatment for dystonia in selected PKAN patients [1]; however, due to the rarity of this genetic condition, the long-term efficacy of DBS on symptoms and disease evolution is unclear, as is its impact on patient independence. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - April 24, 2024 Category: Neurology Authors: Luigi M. Romito, Fabiana Colucci, Giovanna Zorzi, Barbara Garavaglia, Ahmet Kaymak, Alberto Mazzoni, Celeste Panteghini, Nico Golfr è Andreasi, Sara Rinaldo, Vincenzo Levi, Miryam Carecchio, Roberto Eleopra Source Type: research
Combined blood Neurofilament light chain and third ventricle width to differentiate Progressive Supranuclear Palsy from Parkinson's Disease: a machine learning study
In this study, we explored the performance of machine learning models based on MR imaging and blood molecular biomarkers in distinguishing between these two neurodegenerative diseases. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - April 24, 2024 Category: Neurology Authors: Maria Giovanna Bianco, Costanza Maria Cristiani, Luana Scaramuzzino, Alessia Sarica, Antonio Augimeri, Ilaria Chimento, Jolanda Buonocore, Elvira Immacolata Parrotta, Andrea Quattrone, Gianni Cuda, Aldo Quattrone Source Type: research
Surgicogenomics in GBA1-Related Parkinson Disease: Is the Glass Half Full or Half Empty?
Genetic markers have been instrumental in our pursuit to fully understand Parkinson disease (PD), and “surgicogenomics” offers a promising new approach to further improve our decision-making for deep brain stimulation (DBS). But could this emerging knowledge be a game-changer in our clinical practice? So far, expectations seem to exceed applicability. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - April 23, 2024 Category: Neurology Authors: Philippe A. Salles, Hubert H. Fern ández, Ignacio M. Mata Source Type: research
Unveiling the nexus: Understanding post-COVID parkinsonism and its neurological ramifications
This article explores the potential link between COVID-19 and parkinsonism, synthesizing existing evidence and recent research findings. It highlights limitations in current understanding, emphasizes the direct impact of the virus on dopamine neurons, and calls for continued research to elucidate long-term neurological implications and optimize patient care strategies. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - April 22, 2024 Category: Neurology Authors: Chia Siang Kow, Dinesh Sangarran Ramachandram, Syed Shahzad Hasan, Kaeshaelya Thiruchelvam Source Type: research
PPP2R5D heterozygous pathogenic variant causes early-onset parkinsonism and treatment implications: a case report
We report the clinical evaluation and neuroimaging studies of a woman with intellectual disability and levodopa-responsive akinetic rigid parkinsonism. Whole-genome sequencing of family trio identified a de novo missense variant in PPP2R5D in the proband. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - April 22, 2024 Category: Neurology Authors: Wai Yan Yau, Srimathy Vijayan, Gianina Ravenscroft Source Type: research
Combined Diagnosis for Parkinson ’s Disease via Gait and Eye Movement Disorders
With the discovery of the potential role of gait and eye movement disorders in Parkinson ’s disease (PD) recognition, we intend to investigate the combined diagnostic value of gait and eye movement disorders for PD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - April 22, 2024 Category: Neurology Authors: Han Li, Wenqi Ma, Chengqian Li, Qiqing He, Yuting Zhou, Anmu Xie Source Type: research
Orthostatic Hypotension in Parkinson's disease: Sit-to-Stand vs. Supine-to-Stand Protocol and Clinical Correlates
Screening for orthostatic hypotension (OH) is integral in Parkinson ’s disease (PD) management, yet evidence-based guidelines on best practice methods for diagnosing OH in PD are lacking. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - April 22, 2024 Category: Neurology Authors: Kai Bin Lim, Shen-Yang Lim, Jia Wei Hor, Heamah Krishnan, Firdaus Mortadza, Jia Lun Lim, Karuthan Chinna, Nor Izzati Saedon, Ai Huey Tan Source Type: research
The p.Val234Met LRP10 likely pathogenic variant associated with Parkinson ’s Disease: possible molecular implications.
the LRP10 gene has been associated with Lewy Body Diseases, including PD, Parkinson ’s Disease Dementia (PDD) and Dementia with Lewy Bodies (DLB) and it is characterised by autosomal dominant inheritance. In recent years, multiple studies have linked LRP10 pathogenic variants to PD, but the role played by the protein in the pathogenetic process is still unclear [1, 2]. Studies on patients carrying LRP10 pathological variants showed co-staining between LRP10 and α-synuclein in Levi’s Bodies present Substantia nigra pars compacta and in the core of brainstem type, but functional significance of this interaction remains ...
Source: Parkinsonism and Related Disorders - April 17, 2024 Category: Neurology Authors: Andrea Pilotto, Mattia Carini, Alessandro Lupini, Alessio di Fonzo, Eugenio Monti, Roberto Bresciani, Alessandro Padovani, Giorgio Biasiotto Source Type: research
Cerebellar blood perfusion is a diagnostic, but not a prognostic, marker for parkinsonian-dominant type multiple system atrophy.
Multiple system atrophy (MSA) is clinically characterized by various neurological symptoms. According to the diagnostic criteria, MSA is classified into parkinsonian-dominant type (MSA-P) or cerebellar ataxia-dominant type (MSA-C) based on the predominant signs displayed. Recently, N-isopropyl-p-[123I] iodoamphetamine (123I-IMP) single-photon emission computed tomography (SPECT), a radiological examination evaluating brain perfusion, has been successful in detecting cerebellar hypoperfusion in MSA-P patients, demonstrating its utility in the early detection of cerebellar dysfunction. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - April 16, 2024 Category: Neurology Authors: Kenta Shiina, Taiji Tsunemi, Nobutaka Hattori Source Type: research
Mild Cognitive Impairment among LRRK2 and GBA1 patients with Parkinson's Disease
Mild cognitive impairment (MCI) is common in Parkinson ’s disease (PD). We aimed to assess the incidence of MCI among patients with PD, carriers of mutations in LRRK2 and GBA1 genes, based on the movement disorder society (MDS) criteria for the diagnosis of MCI in early-stage PD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - April 16, 2024 Category: Neurology Authors: Avner Thaler, Vered Livne, Einat Rubinstein, Nurit Omer, Achinoam Socher, Batsheva Cohen, Nir Giladi, Julia C. Shirvan, Jesse M. Cedarbaum, Mali Gana-Weisz, Orly Goldstein, Avi Orr-Urtreger, Roy N. Alcalay, Anat Mirelman Source Type: research
Ethnic background and distribution of clinical phenotypes in patients with probable progressive supranuclear palsy
We describe the ethnic and racial background of PSP patients in the Greater Toronto Area (GTA), Canada. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - April 15, 2024 Category: Neurology Authors: Blas Couto, Daniel G. Di Luca, Jeffrey Antwi, Puja Bhakta, Susan Fox, Maria Carmela Tartaglia, Gabor G. Kovacs, Anthony E. Lang Tags: Short communication Source Type: research
