Evaluating complete response prediction rates in locally advanced rectal cancer with different radiomics segmentation approaches
CONCLUSION: Although the highest AUC result is obtained from the tumor segmentation, the highest accuracy and sensitivity are detected with tumor+mesorectum segmentation and these findings align with previous studies, suggesting that the mesorectum contains valuable insights for CR. The lowest result is obtained with CTV segmentation. More studies with mesorectum and pelvic nodal regions included in segmentation are needed.PMID:38694706 | PMC:PMC11061551 | DOI:10.3389/pore.2024.1611744 (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - May 2, 2024 Category: Pathology Authors: Gizem Kaval Merve Gulbiz Dagoglu Kartal Sena Azamat Eda Cingoz Gokhan Ertas Sule Karaman Basak Kurtuldu Metin Keskin Neslihan Berker Senem Karabulut Ethem Nezih Oral Nergiz Dagoglu Sakin Source Type: research
Evaluating complete response prediction rates in locally advanced rectal cancer with different radiomics segmentation approaches
CONCLUSION: Although the highest AUC result is obtained from the tumor segmentation, the highest accuracy and sensitivity are detected with tumor+mesorectum segmentation and these findings align with previous studies, suggesting that the mesorectum contains valuable insights for CR. The lowest result is obtained with CTV segmentation. More studies with mesorectum and pelvic nodal regions included in segmentation are needed.PMID:38694706 | PMC:PMC11061551 | DOI:10.3389/pore.2024.1611744 (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - May 2, 2024 Category: Pathology Authors: Gizem Kaval Merve Gulbiz Dagoglu Kartal Sena Azamat Eda Cingoz Gokhan Ertas Sule Karaman Basak Kurtuldu Metin Keskin Neslihan Berker Senem Karabulut Ethem Nezih Oral Nergiz Dagoglu Sakin Source Type: research
Spatial distribution of tumor-associated macrophages in an orthotopic prostate cancer mouse model
In this study, we investigated the spatial density of innate immune cell populations within NOD.SCID orthotopic prostate cancer xenografts following microinjection of human DU145 prostate cancer cells. Our laboratory has previously developed nanoscale liposomes that attach to leukocytes via conjugated E-selectin (ES) and kill cancer cells via TNF-related apoptosis inducing ligand (TRAIL). Immunohistochemistry (IHC) staining was performed on tumor samples to identify and quantify leukocyte infiltration for different periods of tumor growth and E-selectin/TRAIL (EST) liposome treatments. We examined the spatial-temporal dyna...
Source: Pathology Oncology Research - May 1, 2024 Category: Pathology Authors: Korie A Grayson Joshua D Greenlee Lauren E Himmel Lauren A Hapach Cynthia A Reinhart-King Michael R King Source Type: research
Association between pathological characteristics and recurrence score by OncotypeDX in resected T1-3 and N0-1 breast cancer: a real-life experience of a North Hungarian regional center
Conclusion: First in oncology, OOM was applied, which found some other significant characteristics associated with RS than traditional statistical methods. There were few patients, where no clinical associations were found between characteristics and RS contrary to statistically significant differences. Therefore, the results of these statistical analyses can be neither applied for individual cases nor able to provide the bases for screening patients, i.e., whether they need for OncotypeDX testing or not. OncotypeDX still provides a personalised approach in BC.PMID:38689824 | PMC:PMC11058978 | DOI:10.3389/pore.2024.1611735...
Source: Pathology Oncology Research - May 1, 2024 Category: Pathology Authors: D ániel Deme B álint Ferenc Tamaskovics Nizar Jammoul S ándor Kovács Emmanuel Oladunjoye Kayode James W Grice Andr ás Telekes Source Type: research
Spatial distribution of tumor-associated macrophages in an orthotopic prostate cancer mouse model
In this study, we investigated the spatial density of innate immune cell populations within NOD.SCID orthotopic prostate cancer xenografts following microinjection of human DU145 prostate cancer cells. Our laboratory has previously developed nanoscale liposomes that attach to leukocytes via conjugated E-selectin (ES) and kill cancer cells via TNF-related apoptosis inducing ligand (TRAIL). Immunohistochemistry (IHC) staining was performed on tumor samples to identify and quantify leukocyte infiltration for different periods of tumor growth and E-selectin/TRAIL (EST) liposome treatments. We examined the spatial-temporal dyna...
Source: Pathology Oncology Research - May 1, 2024 Category: Pathology Authors: Korie A Grayson Joshua D Greenlee Lauren E Himmel Lauren A Hapach Cynthia A Reinhart-King Michael R King Source Type: research
Association between pathological characteristics and recurrence score by OncotypeDX in resected T1-3 and N0-1 breast cancer: a real-life experience of a North Hungarian regional center
Conclusion: First in oncology, OOM was applied, which found some other significant characteristics associated with RS than traditional statistical methods. There were few patients, where no clinical associations were found between characteristics and RS contrary to statistically significant differences. Therefore, the results of these statistical analyses can be neither applied for individual cases nor able to provide the bases for screening patients, i.e., whether they need for OncotypeDX testing or not. OncotypeDX still provides a personalised approach in BC.PMID:38689824 | PMC:PMC11058978 | DOI:10.3389/pore.2024.1611735...
Source: Pathology Oncology Research - May 1, 2024 Category: Pathology Authors: D ániel Deme B álint Ferenc Tamaskovics Nizar Jammoul S ándor Kovács Emmanuel Oladunjoye Kayode James W Grice Andr ás Telekes Source Type: research
Microsatellite instability and mismatch repair protein deficiency: equal predictive markers?
Pathol Oncol Res. 2024 Apr 9;30:1611719. doi: 10.3389/pore.2024.1611719. eCollection 2024.ABSTRACTCurrent clinical guidelines recommend mismatch repair (MMR) protein immunohistochemistry (IHC) or molecular microsatellite instability (MSI) tests as predictive markers of immunotherapies. Most of the pathological guidelines consider MMR protein IHC as the gold standard test to identify cancers with MMR deficiency and recommend molecular MSI tests only in special circumstances or to screen for Lynch syndrome. However, there are data in the literature which suggest that the two test types may not be equal. For example, molecula...
Source: Pathology Oncology Research - April 24, 2024 Category: Pathology Authors: Maja L N ádorvári G ábor Lotz Janina Kulka Andr ás Kiss J ózsef Tímár Source Type: research
Microsatellite instability and mismatch repair protein deficiency: equal predictive markers?
Pathol Oncol Res. 2024 Apr 9;30:1611719. doi: 10.3389/pore.2024.1611719. eCollection 2024.ABSTRACTCurrent clinical guidelines recommend mismatch repair (MMR) protein immunohistochemistry (IHC) or molecular microsatellite instability (MSI) tests as predictive markers of immunotherapies. Most of the pathological guidelines consider MMR protein IHC as the gold standard test to identify cancers with MMR deficiency and recommend molecular MSI tests only in special circumstances or to screen for Lynch syndrome. However, there are data in the literature which suggest that the two test types may not be equal. For example, molecula...
Source: Pathology Oncology Research - April 24, 2024 Category: Pathology Authors: Maja L N ádorvári G ábor Lotz Janina Kulka Andr ás Kiss J ózsef Tímár Source Type: research
Microsatellite instability and mismatch repair protein deficiency: equal predictive markers?
Pathol Oncol Res. 2024 Apr 9;30:1611719. doi: 10.3389/pore.2024.1611719. eCollection 2024.ABSTRACTCurrent clinical guidelines recommend mismatch repair (MMR) protein immunohistochemistry (IHC) or molecular microsatellite instability (MSI) tests as predictive markers of immunotherapies. Most of the pathological guidelines consider MMR protein IHC as the gold standard test to identify cancers with MMR deficiency and recommend molecular MSI tests only in special circumstances or to screen for Lynch syndrome. However, there are data in the literature which suggest that the two test types may not be equal. For example, molecula...
Source: Pathology Oncology Research - April 24, 2024 Category: Pathology Authors: Maja L N ádorvári G ábor Lotz Janina Kulka Andr ás Kiss J ózsef Tímár Source Type: research
Microsatellite instability and mismatch repair protein deficiency: equal predictive markers?
Pathol Oncol Res. 2024 Apr 9;30:1611719. doi: 10.3389/pore.2024.1611719. eCollection 2024.ABSTRACTCurrent clinical guidelines recommend mismatch repair (MMR) protein immunohistochemistry (IHC) or molecular microsatellite instability (MSI) tests as predictive markers of immunotherapies. Most of the pathological guidelines consider MMR protein IHC as the gold standard test to identify cancers with MMR deficiency and recommend molecular MSI tests only in special circumstances or to screen for Lynch syndrome. However, there are data in the literature which suggest that the two test types may not be equal. For example, molecula...
Source: Pathology Oncology Research - April 24, 2024 Category: Pathology Authors: Maja L N ádorvári G ábor Lotz Janina Kulka Andr ás Kiss J ózsef Tímár Source Type: research
Microsatellite instability and mismatch repair protein deficiency: equal predictive markers?
Pathol Oncol Res. 2024 Apr 9;30:1611719. doi: 10.3389/pore.2024.1611719. eCollection 2024.ABSTRACTCurrent clinical guidelines recommend mismatch repair (MMR) protein immunohistochemistry (IHC) or molecular microsatellite instability (MSI) tests as predictive markers of immunotherapies. Most of the pathological guidelines consider MMR protein IHC as the gold standard test to identify cancers with MMR deficiency and recommend molecular MSI tests only in special circumstances or to screen for Lynch syndrome. However, there are data in the literature which suggest that the two test types may not be equal. For example, molecula...
Source: Pathology Oncology Research - April 24, 2024 Category: Pathology Authors: Maja L N ádorvári G ábor Lotz Janina Kulka Andr ás Kiss J ózsef Tímár Source Type: research
Microenvironment, systemic inflammatory response and tumor markers considering consensus molecular subtypes of colorectal cancer
Conclusion: More routinely available TME, SIR and tumor markers alone and in combination deliver reliable prognostic data for choosing the patients with higher risk for propagation. CMS4 is linked with high TSR and poor prognosis, but in overall, CMS-classification showed only limited effect on SIR- and tumor-markers.PMID:38645565 | PMC:PMC11026638 | DOI:10.3389/pore.2024.1611574 (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - April 22, 2024 Category: Pathology Authors: Anna Jakab Árpád V Patai M ónika Darvas Karolina Torm ássi-Bély Tam ás Micsik Source Type: research
Retraction: Case report: A rare case of tumor-to-tumor metastasis: metastatic lobular breast carcinoma to clear cell renal cell carcinoma
Pathol Oncol Res. 2024 Apr 5;30:1611784. doi: 10.3389/pore.2024.1611784. eCollection 2024.ABSTRACT[This retracts the article DOI: 10.3389/pore.2023.1611204.].PMID:38645566 | PMC:PMC11027495 | DOI:10.3389/pore.2024.1611784 (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - April 22, 2024 Category: Pathology Authors: Pathology and Oncology Research Editorial Office Source Type: research
Microenvironment, systemic inflammatory response and tumor markers considering consensus molecular subtypes of colorectal cancer
Conclusion: More routinely available TME, SIR and tumor markers alone and in combination deliver reliable prognostic data for choosing the patients with higher risk for propagation. CMS4 is linked with high TSR and poor prognosis, but in overall, CMS-classification showed only limited effect on SIR- and tumor-markers.PMID:38645565 | PMC:PMC11026638 | DOI:10.3389/pore.2024.1611574 (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - April 22, 2024 Category: Pathology Authors: Anna Jakab Árpád V Patai M ónika Darvas Karolina Torm ássi-Bély Tam ás Micsik Source Type: research
Retraction: Case report: A rare case of tumor-to-tumor metastasis: metastatic lobular breast carcinoma to clear cell renal cell carcinoma
Pathol Oncol Res. 2024 Apr 5;30:1611784. doi: 10.3389/pore.2024.1611784. eCollection 2024.ABSTRACT[This retracts the article DOI: 10.3389/pore.2023.1611204.].PMID:38645566 | PMC:PMC11027495 | DOI:10.3389/pore.2024.1611784 (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - April 22, 2024 Category: Pathology Authors: Pathology and Oncology Research Editorial Office Source Type: research
