Adenomatoid odontogenic tumor: A histopathologic profile of 43 cases with evidence supporting a mixed odontogenic origin
CONCLUSION: This study highlights the diverse histopathological variation of AOT with evidence to reclassify it as a mixed odontogenic tumor based on the polarising microscopic findings with PSR staining.PMID:38688202 | DOI:10.1016/j.prp.2024.155322 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - April 30, 2024 Category: Pathology Authors: Bhaskar Narayan Priya Kumar Bhanu Priya Aadithya B Urs Jeyaseelan Augustine Source Type: research
Potential roles of PIWI-interacting RNAs in breast cancer, a new therapeutic strategy
Pathol Res Pract. 2024 Apr 17;257:155318. doi: 10.1016/j.prp.2024.155318. Online ahead of print.ABSTRACTBreast cancer (BC) has been the focus of numerous studies aimed at identifying novel biological markers for its early detection. PIWI-interacting RNAs (piRNAs), a subset of small non-coding RNAs, have emerged as potential markers due to their aberrant expression in various cancers. PiRNAs have recently gained attention due to their aberrant expression in various cancers, including BC. PiRNAs, exhibit diverse biological activities, such as epigenetic regulation of gene and protein expression and their association with cel...
Source: Pathology, Research and Practice - April 30, 2024 Category: Pathology Authors: Hongpeng Zhang Yanshu Li Source Type: research
RNA sequencing of formalin fixed paraffin-embedded heart tissue provides transcriptomic information about chemotherapy-induced cardiotoxicity
This study aimed to investigate whether DOX-induced gene expression in archival FFPE heart tissue in experimental rats would correlate with the gene expression in fresh-frozen heart tissue by applying RNA sequencing technology. The results showed RNA from FFPE samples was degraded, resulting in a lower number of uniquely mapped reads. However, DOX-induced differentially expressed genes in FFPE were related to molecular mechanisms of DOX-induced cardiotoxicity, such as inflammation, calcium binding, endothelial dysfunction, senescence, and cardiac hypertrophy signaling. Our data suggest that, despite the limitations, RNA se...
Source: Pathology, Research and Practice - April 28, 2024 Category: Pathology Authors: Valentina K Todorova Michael A Bauer Gohar Azhar Jeanne Y Wei Source Type: research
Recent advances in IgG4-related autoimmune pancreatitis
Pathol Res Pract. 2024 Apr 26;257:155331. doi: 10.1016/j.prp.2024.155331. Online ahead of print.ABSTRACTThe incidence of IgG4-related autoimmune pancreatitis (IgG4-AIP) is high in Asia and other countries, and unnecessary treatment is often undertaken due to both missed diagnosis and misdiagnosis in clinical practice. Although IgG4-AIP has attracted increasing attention, the details of IgG4-AIP pathogenesis and systemic immune response, including its relationship to tumor pathogenesis, are still unclear. In recent years, research on serum immunological detection, pathological features, clinical manifestations, diagnosis an...
Source: Pathology, Research and Practice - April 28, 2024 Category: Pathology Authors: Xisheng Yang Haikun Zhou Weidong Wang Chunyu Yan Gang Ji Source Type: research
Circular RNA hsa_circ_0094976 modulates GPR155 to inhibit gastric adenocarcinoma malignant characteristics by targeting miR-223-3p
CONCLUSION: We disclosed that circ_0094976 could act as a sponge of miR-223-3p to regulate the expression of GPR155, and further restrain the development of GA, which may provide new insight into the therapy of GA.PMID:38678850 | DOI:10.1016/j.prp.2024.155325 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - April 28, 2024 Category: Pathology Authors: Li Liu Xuefeng Li Lingli Song Yuhan Yang Binxian Li Source Type: research
Lipoic acid alters the microRNA signature in breast cancer cells
CONCLUSION: The outcome of this study provides further insights into the molecular mechanisms underlying the therapeutic benefit of LA. This in turn could assist the amelioration of LA-based anticancer therapies.PMID:38678851 | DOI:10.1016/j.prp.2024.155321 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - April 28, 2024 Category: Pathology Authors: Hoda Khalife Mohammad Fayyad-Kazan Hussein Fayyad-Kazan Elie Hadchity Nada Borghol Nader Hussein Bassam Badran Source Type: research
RNA sequencing of formalin fixed paraffin-embedded heart tissue provides transcriptomic information about chemotherapy-induced cardiotoxicity
This study aimed to investigate whether DOX-induced gene expression in archival FFPE heart tissue in experimental rats would correlate with the gene expression in fresh-frozen heart tissue by applying RNA sequencing technology. The results showed RNA from FFPE samples was degraded, resulting in a lower number of uniquely mapped reads. However, DOX-induced differentially expressed genes in FFPE were related to molecular mechanisms of DOX-induced cardiotoxicity, such as inflammation, calcium binding, endothelial dysfunction, senescence, and cardiac hypertrophy signaling. Our data suggest that, despite the limitations, RNA se...
Source: Pathology, Research and Practice - April 28, 2024 Category: Pathology Authors: Valentina K Todorova Michael A Bauer Gohar Azhar Jeanne Y Wei Source Type: research
Recent advances in IgG4-related autoimmune pancreatitis
Pathol Res Pract. 2024 Apr 26;257:155331. doi: 10.1016/j.prp.2024.155331. Online ahead of print.ABSTRACTThe incidence of IgG4-related autoimmune pancreatitis (IgG4-AIP) is high in Asia and other countries, and unnecessary treatment is often undertaken due to both missed diagnosis and misdiagnosis in clinical practice. Although IgG4-AIP has attracted increasing attention, the details of IgG4-AIP pathogenesis and systemic immune response, including its relationship to tumor pathogenesis, are still unclear. In recent years, research on serum immunological detection, pathological features, clinical manifestations, diagnosis an...
Source: Pathology, Research and Practice - April 28, 2024 Category: Pathology Authors: Xisheng Yang Haikun Zhou Weidong Wang Chunyu Yan Gang Ji Source Type: research
Circular RNA hsa_circ_0094976 modulates GPR155 to inhibit gastric adenocarcinoma malignant characteristics by targeting miR-223-3p
CONCLUSION: We disclosed that circ_0094976 could act as a sponge of miR-223-3p to regulate the expression of GPR155, and further restrain the development of GA, which may provide new insight into the therapy of GA.PMID:38678850 | DOI:10.1016/j.prp.2024.155325 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - April 28, 2024 Category: Pathology Authors: Li Liu Xuefeng Li Lingli Song Yuhan Yang Binxian Li Source Type: research
Lipoic acid alters the microRNA signature in breast cancer cells
CONCLUSION: The outcome of this study provides further insights into the molecular mechanisms underlying the therapeutic benefit of LA. This in turn could assist the amelioration of LA-based anticancer therapies.PMID:38678851 | DOI:10.1016/j.prp.2024.155321 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - April 28, 2024 Category: Pathology Authors: Hoda Khalife Mohammad Fayyad-Kazan Hussein Fayyad-Kazan Elie Hadchity Nada Borghol Nader Hussein Bassam Badran Source Type: research
Hsa_circ_0087862 contributes to the progression of colorectal cancer through regulating miR-512-3p/HK2 axis
CONCLUSION: Collectively, our data suggested that circ_0087862 knockdown impeded cell viabilities, proliferation, and glycolysis, and contributed to cell apoptosis in CRC, indicating circ_0087862 as a promising tumor promoter.PMID:38669868 | DOI:10.1016/j.prp.2024.155281 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - April 26, 2024 Category: Pathology Authors: Yu Chen Lu Chen Jieyun Wu Dazhi Su Source Type: research
Hsa_circ_0087862 contributes to the progression of colorectal cancer through regulating miR-512-3p/HK2 axis
CONCLUSION: Collectively, our data suggested that circ_0087862 knockdown impeded cell viabilities, proliferation, and glycolysis, and contributed to cell apoptosis in CRC, indicating circ_0087862 as a promising tumor promoter.PMID:38669868 | DOI:10.1016/j.prp.2024.155281 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - April 26, 2024 Category: Pathology Authors: Yu Chen Lu Chen Jieyun Wu Dazhi Su Source Type: research
Advances in exosome modulation of ferroptosis for the treatment of orthopedic diseases
Pathol Res Pract. 2024 Apr 22;257:155312. doi: 10.1016/j.prp.2024.155312. Online ahead of print.ABSTRACTCurrent treatments for orthopaedic illnesses frequently result in poor prognosis, treatment failure, numerous relapses, and other unpleasant outcomes that have a significant impact on patients' quality of life. Cell-free therapy has emerged as one of the most promising options in recent decades for improving the status quo. As a result, using exosomes produced from various cells to modulate ferroptosis has been proposed as a therapeutic method for the condition. Exosomes are extracellular vesicles that secrete various bi...
Source: Pathology, Research and Practice - April 25, 2024 Category: Pathology Authors: Hongwei Cui Yan Wang Jianxiong Ma Liyun Zhou Guang Li Yiyang Li Yadi Sun Jiahui Shen Tiancheng Ma Qiyu Wang Xiaotian Feng Benchao Dong Peichuan Yang Yan Li Xinlong Ma Source Type: research
Somatic mutations that affect early genetic progression and immune microenvironment in gastric carcinoma
Pathol Res Pract. 2024 Apr 14;257:155310. doi: 10.1016/j.prp.2024.155310. Online ahead of print.ABSTRACTGastric carcinoma (GC) is a high heterogeneity and malignant tumor with a poor prognosis. The current implementation of immunotherapy in GC is limited due to the insufficient exploration of immune-related mutations and speculated early mutation events. Therefore, we performed whole-exome sequencing on 40 patients with GC to explore their genetic characteristics, shedding light on the order of genetic events, somatic mutations impacting the immune microenvironment, and potential biomarkers for immunotherapy. Regarding gen...
Source: Pathology, Research and Practice - April 25, 2024 Category: Pathology Authors: Xiaoxiao Li Zirui Tang Zhaopeng Li Zhao Li Ping Zhao Yi Song Kexin Yang Zihan Xia Yinan Wang Dong Guo Source Type: research
Exploring the detailed role of interleukins in cancer: A comprehensive review of literature
Pathol Res Pract. 2024 Apr 8;257:155284. doi: 10.1016/j.prp.2024.155284. Online ahead of print.ABSTRACTThe cancer cells that are not normal can grow into tumors, invade surrounding tissues, and travel to other parts of the body via the lymphatic or circulatory systems. Interleukins, a vital class of signaling proteins, facilitate cell-to-cell contact within the immune system. A type of non-coding RNA known as lncRNAs mediates its actions by regulating miRNA-mRNA roles (Interleukins). Because of their dual function in controlling the growth of tumors and altering the immune system's response to cancer cells, interleukins ha...
Source: Pathology, Research and Practice - April 25, 2024 Category: Pathology Authors: Raed Obaid Saleh Saade Abdalkareem Jasim Wesam R Kadhum Ahmed Hjazi Ali Faraz Mohammed Kadhem Abid Alexey Yumashev Ahmed Alawadi Ibrahim Ahmed Zaki Aiad Ali Alsalamy Source Type: research
