Pediatric Research ECI highlight: Matthew S. Pantell
Pediatr Res. 2024 Apr 25. doi: 10.1038/s41390-024-03214-3. Online ahead of print.NO ABSTRACTPMID:38664595 | DOI:10.1038/s41390-024-03214-3 (Source: Pediatric Research)
Source: Pediatric Research - April 25, 2024 Category: Pediatrics Authors: Matthew S Pantell Source Type: research
ECI biocommentary: Shiraz Badurdeen
Pediatr Res. 2024 Apr 24. doi: 10.1038/s41390-024-03218-z. Online ahead of print.NO ABSTRACTPMID:38658661 | DOI:10.1038/s41390-024-03218-z (Source: Pediatric Research)
Source: Pediatric Research - April 24, 2024 Category: Pediatrics Authors: Shiraz Badurdeen Source Type: research
Hirschsprung's disease: m6A methylase VIRMA suppresses cell migration and proliferation by regulating GSK3 β
CONCLUSION: VIRMA can inhibit cell migration and proliferation by upregulating the expression of GSK3β, contributing to the onset of HSCR.IMPACT: The expressions of VIRMA were significantly reduced in HSCR, while GSK3β expression was increased in HSCR, and can be used as a molecular marker. VIRMA overexpression promoted the proliferation and migration of SH-SY5Y and HEK-293T cells. VIRMA can inhibit the degradation of GSK3β mRNA and increase the expression of GSK3β.PMID:38658662 | DOI:10.1038/s41390-024-03136-0 (Source: Pediatric Research)
Source: Pediatric Research - April 24, 2024 Category: Pediatrics Authors: Yang Yang Mengzhen Zhang Nan Li Chen Wang Huirong Yang Xinwei Hou Jiaming Yang Kaisi Fan Liucheng Yang Kai Wu Source Type: research
Young hearts, early risks: novel cardiovascular biomarkers in former very preterm infants at kindergarten age
CONCLUSION: In preterm-born children, iFGF-23 and secretoneurin both offer prospects as valuable cardiovascular biomarkers, potentially allowing for risk stratification and timely implementation of preventive measures.IMPACT: Former very preterm infants have increased plasma concentrations of the novel cardiovascular biomarkers intact fibroblast growth factor-23 (iFGF-23) and secretoneurin at kindergarten age. Increases in iFGF-23 concentrations are associated with decreased distensibility of the descending aorta even at this early age. Monitoring of cardiovascular risk factors is essential in individuals with a history of...
Source: Pediatric Research - April 24, 2024 Category: Pediatrics Authors: Wolfgang Mitterer Irena Odri Komazec Eva Huber Benedikt Schaefer Anna Posod Ursula Kiechl-Kohlendorfer Source Type: research
GFRA4 improves the neurogenic potential of enteric neural crest stem cells via hedgehog pathway
CONCLUSION: GFRA4 promotes proliferation and differentiation but inhibits apoptosis of ENCSCs via the hedgehog pathway in HSCR.IMPACT: This study confirms that GFRA4 improves the proliferation and differentiation of ENCSCs via modulation of the hedgehog pathway. This study for the first time revealed the role and the mechanism of the action of GFRA4 in HSCR, which indicates that GFRA4 may play a role in the pathological development of HSCR. Our findings may lay the foundation for further investigation of the mechanisms underlying HSCR development and into targets of HSCR treatment.PMID:38658664 | DOI:10.1038/s41390-024-031...
Source: Pediatric Research - April 24, 2024 Category: Pediatrics Authors: Fangfang Zhang Mingyu Cui Lijuan Zhang Bangzhen Ma Feng Guo Gang Wang Source Type: research
Is choline deficiency an unrecognized factor in necrotizing enterocolitis of preterm infants?
In conclusion, this review supports the need for randomized clinical trials to test the hypothesis that additional choline or PC provided parenterally or enterally can reduce the incidence of NEC in preterm infants. IMPACT STATEMENT: Low choline status in preterm infants who are managed by conventional nutrition is plausibly linked to the risk of developing necrotizing enterocolitis.PMID:38658665 | DOI:10.1038/s41390-024-03212-5 (Source: Pediatric Research)
Source: Pediatric Research - April 24, 2024 Category: Pediatrics Authors: Douglas C Drenckpohl Danielle N Christifano Susan E Carlson Source Type: research
ECI biocommentary: Shiraz Badurdeen
Pediatr Res. 2024 Apr 24. doi: 10.1038/s41390-024-03218-z. Online ahead of print.NO ABSTRACTPMID:38658661 | DOI:10.1038/s41390-024-03218-z (Source: Pediatric Research)
Source: Pediatric Research - April 24, 2024 Category: Pediatrics Authors: Shiraz Badurdeen Source Type: research
Hirschsprung's disease: m6A methylase VIRMA suppresses cell migration and proliferation by regulating GSK3 β
CONCLUSION: VIRMA can inhibit cell migration and proliferation by upregulating the expression of GSK3β, contributing to the onset of HSCR.IMPACT: The expressions of VIRMA were significantly reduced in HSCR, while GSK3β expression was increased in HSCR, and can be used as a molecular marker. VIRMA overexpression promoted the proliferation and migration of SH-SY5Y and HEK-293T cells. VIRMA can inhibit the degradation of GSK3β mRNA and increase the expression of GSK3β.PMID:38658662 | DOI:10.1038/s41390-024-03136-0 (Source: Pediatric Research)
Source: Pediatric Research - April 24, 2024 Category: Pediatrics Authors: Yang Yang Mengzhen Zhang Nan Li Chen Wang Huirong Yang Xinwei Hou Jiaming Yang Kaisi Fan Liucheng Yang Kai Wu Source Type: research
Young hearts, early risks: novel cardiovascular biomarkers in former very preterm infants at kindergarten age
CONCLUSION: In preterm-born children, iFGF-23 and secretoneurin both offer prospects as valuable cardiovascular biomarkers, potentially allowing for risk stratification and timely implementation of preventive measures.IMPACT: Former very preterm infants have increased plasma concentrations of the novel cardiovascular biomarkers intact fibroblast growth factor-23 (iFGF-23) and secretoneurin at kindergarten age. Increases in iFGF-23 concentrations are associated with decreased distensibility of the descending aorta even at this early age. Monitoring of cardiovascular risk factors is essential in individuals with a history of...
Source: Pediatric Research - April 24, 2024 Category: Pediatrics Authors: Wolfgang Mitterer Irena Odri Komazec Eva Huber Benedikt Schaefer Anna Posod Ursula Kiechl-Kohlendorfer Source Type: research
GFRA4 improves the neurogenic potential of enteric neural crest stem cells via hedgehog pathway
CONCLUSION: GFRA4 promotes proliferation and differentiation but inhibits apoptosis of ENCSCs via the hedgehog pathway in HSCR.IMPACT: This study confirms that GFRA4 improves the proliferation and differentiation of ENCSCs via modulation of the hedgehog pathway. This study for the first time revealed the role and the mechanism of the action of GFRA4 in HSCR, which indicates that GFRA4 may play a role in the pathological development of HSCR. Our findings may lay the foundation for further investigation of the mechanisms underlying HSCR development and into targets of HSCR treatment.PMID:38658664 | DOI:10.1038/s41390-024-031...
Source: Pediatric Research - April 24, 2024 Category: Pediatrics Authors: Fangfang Zhang Mingyu Cui Lijuan Zhang Bangzhen Ma Feng Guo Gang Wang Source Type: research
Is choline deficiency an unrecognized factor in necrotizing enterocolitis of preterm infants?
In conclusion, this review supports the need for randomized clinical trials to test the hypothesis that additional choline or PC provided parenterally or enterally can reduce the incidence of NEC in preterm infants. IMPACT STATEMENT: Low choline status in preterm infants who are managed by conventional nutrition is plausibly linked to the risk of developing necrotizing enterocolitis.PMID:38658665 | DOI:10.1038/s41390-024-03212-5 (Source: Pediatric Research)
Source: Pediatric Research - April 24, 2024 Category: Pediatrics Authors: Douglas C Drenckpohl Danielle N Christifano Susan E Carlson Source Type: research
Early career investigator biocommentary: Lauren Erdman
Pediatr Res. 2024 Apr 23. doi: 10.1038/s41390-024-03216-1. Online ahead of print.NO ABSTRACTPMID:38654094 | DOI:10.1038/s41390-024-03216-1 (Source: Pediatric Research)
Source: Pediatric Research - April 23, 2024 Category: Pediatrics Authors: Lauren Erdman Source Type: research
Early career investigator biocommentary: Lauren Erdman
Pediatr Res. 2024 Apr 23. doi: 10.1038/s41390-024-03216-1. Online ahead of print.NO ABSTRACTPMID:38654094 | DOI:10.1038/s41390-024-03216-1 (Source: Pediatric Research)
Source: Pediatric Research - April 23, 2024 Category: Pediatrics Authors: Lauren Erdman Source Type: research
Association of obesity and menarche SNPs and interaction with environmental factors on precocious puberty
CONCLUSIONS: The obesity risk gene polymorphisms MC4R rs571312 and rs12970134 were associated with precocious puberty in Chinese girls with obesity, and girls with risk genotypes and high socioeconomic status should be given extra attention.IMPACT: This is the first study that identified the association between rs571312 and rs12970134 of MC4R gene and precocious puberty in Chinese children. We found that when girls were in the high socioeconomic status, the risk genotypes of rs571312 and rs12970134 had a greater effect on precocious puberty. The results of this study have great public health implications. It is recommended...
Source: Pediatric Research - April 22, 2024 Category: Pediatrics Authors: Peng Xue Jianfei Lin Jingyi Tang Yao Chen Tingting Yu Chang Chen Huijun Kong Cuilan Lin Shijian Liu Source Type: research
Commentary on the challenges of modeling hepatoblastoma in-vivo
Pediatr Res. 2024 Apr 22. doi: 10.1038/s41390-024-03215-2. Online ahead of print.NO ABSTRACTPMID:38649725 | DOI:10.1038/s41390-024-03215-2 (Source: Pediatric Research)
Source: Pediatric Research - April 22, 2024 Category: Pediatrics Authors: Edward H Hurley Source Type: research
