Pflugers Archiv : European Journal of Physiology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Long-term continuous monitoring of arrhythmias in pigs with insertable cardiac monitors
Pflugers Arch. 2024 May 4. doi: 10.1007/s00424-024-02962-9. Online ahead of print.ABSTRACTArrhythmia detection is essential when assessing the safety of novel drugs and therapies in preclinical studies. Many short-term arrhythmia monitoring methods exist, including non-invasive ECG and Holter. However, there are no reliable, long-term, non-invasive, or minimally invasive methods for cardiac arrhythmia follow-up in large animals that allows free movement with littermates. A long follow-up time is needed when estimating the impact of long-lasting drugs or therapies, such as gene therapy. We evaluated the feasibility and perf...
Source: Pflugers Archiv : European Journal of Physiology - May 4, 2024 Category: Physiology Authors: Jonna Airaksinen Satu Siimes Juha Hartikainen Seppo Yl ä-Herttuala Source Type: research
SGLT2 inhibitor as a potential therapeutic approach in hyperthyroidism-induced cardiopulmonary injury in rats
This study intended to investigate the potential therapeutic effect of SGLT2-I on hyperthyroidism-related cardiopulmonary injury, targeting the possible underlying mechanisms. The impact of the SGLT2-I, dapagliflozin (DAPA), (1 mg/kg/day, p.o) on LT4 (0.3 mg/kg/day, i.p)-induced cardiopulmonary injury was investigated in rats. The body weight, ECG, and serum hormones were evaluated. Also, redox balance, DNA fragmentation, inflammatory cytokines, and PCR quantification in heart and lung tissues were employed to investigate the effect of DAPA in experimentally induced hyperthyroid rats along with histological and immunohisto...
Source: Pflugers Archiv : European Journal of Physiology - May 3, 2024 Category: Physiology Authors: Nermeen Bastawy Aliaa E M K El-Mosallamy Samira H Aljuaydi Huda O AbuBakr Rabab Ahmed Rasheed A S Sadek R T Khattab Wael Botros Abualyamin Shereen E Abdelaal Amy F Boushra Source Type: research
SGLT2 inhibitor as a potential therapeutic approach in hyperthyroidism-induced cardiopulmonary injury in rats
This study intended to investigate the potential therapeutic effect of SGLT2-I on hyperthyroidism-related cardiopulmonary injury, targeting the possible underlying mechanisms. The impact of the SGLT2-I, dapagliflozin (DAPA), (1 mg/kg/day, p.o) on LT4 (0.3 mg/kg/day, i.p)-induced cardiopulmonary injury was investigated in rats. The body weight, ECG, and serum hormones were evaluated. Also, redox balance, DNA fragmentation, inflammatory cytokines, and PCR quantification in heart and lung tissues were employed to investigate the effect of DAPA in experimentally induced hyperthyroid rats along with histological and immunohisto...
Source: Pflugers Archiv : European Journal of Physiology - May 3, 2024 Category: Physiology Authors: Nermeen Bastawy Aliaa E M K El-Mosallamy Samira H Aljuaydi Huda O AbuBakr Rabab Ahmed Rasheed A S Sadek R T Khattab Wael Botros Abualyamin Shereen E Abdelaal Amy F Boushra Source Type: research
Cardiac hypertrophy that affects hyperthyroidism occurs independently of the NLRP3 inflammasome
Pflugers Arch. 2024 Apr 29. doi: 10.1007/s00424-024-02965-6. Online ahead of print.ABSTRACTCardiac hypertrophy (CH) is an adaptive response to maintain cardiac function; however, persistent stress responses lead to contractile dysfunction and heart failure. Although inflammation is involved in these processes, the mechanisms that control cardiac inflammation and hypertrophy still need to be clarified. The NLRP3 inflammasome is a cytosolic multiprotein complex that mediates IL-1β production. The priming step of NLRP3 is essential for increasing the expression of its components and occurs following NF-κB activation. Hypert...
Source: Pflugers Archiv : European Journal of Physiology - April 28, 2024 Category: Physiology Authors: Aline Cristina Parletta Gabriela Cavazza Cerri Claudia Ribeiro Borba Gasparini Karine Panico Denival Nascimento Vieira-Junior Larissa Maria Zacarias-Rodrigues Nathalia Senger Amanda de Almeida Silva Marina Fevereiro Gabriela Placon á Diniz Maria Cl áudi Source Type: research
Cardiac hypertrophy that affects hyperthyroidism occurs independently of the NLRP3 inflammasome
Pflugers Arch. 2024 Apr 29. doi: 10.1007/s00424-024-02965-6. Online ahead of print.ABSTRACTCardiac hypertrophy (CH) is an adaptive response to maintain cardiac function; however, persistent stress responses lead to contractile dysfunction and heart failure. Although inflammation is involved in these processes, the mechanisms that control cardiac inflammation and hypertrophy still need to be clarified. The NLRP3 inflammasome is a cytosolic multiprotein complex that mediates IL-1β production. The priming step of NLRP3 is essential for increasing the expression of its components and occurs following NF-κB activation. Hypert...
Source: Pflugers Archiv : European Journal of Physiology - April 28, 2024 Category: Physiology Authors: Aline Cristina Parletta Gabriela Cavazza Cerri Claudia Ribeiro Borba Gasparini Karine Panico Denival Nascimento Vieira-Junior Larissa Maria Zacarias-Rodrigues Nathalia Senger Amanda de Almeida Silva Marina Fevereiro Gabriela Placon á Diniz Maria Cl áudi Source Type: research
Cardiac hypertrophy that affects hyperthyroidism occurs independently of the NLRP3 inflammasome
Pflugers Arch. 2024 Apr 29. doi: 10.1007/s00424-024-02965-6. Online ahead of print.ABSTRACTCardiac hypertrophy (CH) is an adaptive response to maintain cardiac function; however, persistent stress responses lead to contractile dysfunction and heart failure. Although inflammation is involved in these processes, the mechanisms that control cardiac inflammation and hypertrophy still need to be clarified. The NLRP3 inflammasome is a cytosolic multiprotein complex that mediates IL-1β production. The priming step of NLRP3 is essential for increasing the expression of its components and occurs following NF-κB activation. Hypert...
Source: Pflugers Archiv : European Journal of Physiology - April 28, 2024 Category: Physiology Authors: Aline Cristina Parletta Gabriela Cavazza Cerri Claudia Ribeiro Borba Gasparini Karine Panico Denival Nascimento Vieira-Junior Larissa Maria Zacarias-Rodrigues Nathalia Senger Amanda de Almeida Silva Marina Fevereiro Gabriela Placon á Diniz Maria Cl áudi Source Type: research
Cardiac hypertrophy that affects hyperthyroidism occurs independently of the NLRP3 inflammasome
Pflugers Arch. 2024 Apr 29. doi: 10.1007/s00424-024-02965-6. Online ahead of print.ABSTRACTCardiac hypertrophy (CH) is an adaptive response to maintain cardiac function; however, persistent stress responses lead to contractile dysfunction and heart failure. Although inflammation is involved in these processes, the mechanisms that control cardiac inflammation and hypertrophy still need to be clarified. The NLRP3 inflammasome is a cytosolic multiprotein complex that mediates IL-1β production. The priming step of NLRP3 is essential for increasing the expression of its components and occurs following NF-κB activation. Hypert...
Source: Pflugers Archiv : European Journal of Physiology - April 28, 2024 Category: Physiology Authors: Aline Cristina Parletta Gabriela Cavazza Cerri Claudia Ribeiro Borba Gasparini Karine Panico Denival Nascimento Vieira-Junior Larissa Maria Zacarias-Rodrigues Nathalia Senger Amanda de Almeida Silva Marina Fevereiro Gabriela Placon á Diniz Maria Cl áudi Source Type: research
Cardiac hypertrophy that affects hyperthyroidism occurs independently of the NLRP3 inflammasome
Pflugers Arch. 2024 Apr 29. doi: 10.1007/s00424-024-02965-6. Online ahead of print.ABSTRACTCardiac hypertrophy (CH) is an adaptive response to maintain cardiac function; however, persistent stress responses lead to contractile dysfunction and heart failure. Although inflammation is involved in these processes, the mechanisms that control cardiac inflammation and hypertrophy still need to be clarified. The NLRP3 inflammasome is a cytosolic multiprotein complex that mediates IL-1β production. The priming step of NLRP3 is essential for increasing the expression of its components and occurs following NF-κB activation. Hypert...
Source: Pflugers Archiv : European Journal of Physiology - April 28, 2024 Category: Physiology Authors: Aline Cristina Parletta Gabriela Cavazza Cerri Claudia Ribeiro Borba Gasparini Karine Panico Denival Nascimento Vieira-Junior Larissa Maria Zacarias-Rodrigues Nathalia Senger Amanda de Almeida Silva Marina Fevereiro Gabriela Placon á Diniz Maria Cl áudi Source Type: research
Angiotensin receptors and α < sub > 1B < /sub > -adrenergic receptors regulate native IK < sub > (ACh) < /sub > and phosphorylation-deficient GIRK4 (S418A) channels through different PKC isoforms
Pflugers Arch. 2024 Apr 24. doi: 10.1007/s00424-024-02966-5. Online ahead of print.ABSTRACTSignaling of G protein-activated inwardly rectifying K+ (GIRK) channels is an important mechanism of the parasympathetic regulation of the heart rate and cardiac excitability. GIRK channels are inhibited during stimulation of Gq-coupled receptors (GqPCRs) by depletion of phosphatidyl-4,5-bisphosphate (PIP2) and/or channel phosphorylation by protein kinase C (PKC). The GqPCR-dependent modulation of GIRK currents in terms of specific PKC isoform activation was analyzed in voltage-clamp experiments in rat atrial myocytes and in CHO or H...
Source: Pflugers Archiv : European Journal of Physiology - April 24, 2024 Category: Physiology Authors: Leonie Inderwiedenstra ße Marie-C écile Kienitz Source Type: research
Angiotensin receptors and α < sub > 1B < /sub > -adrenergic receptors regulate native IK < sub > (ACh) < /sub > and phosphorylation-deficient GIRK4 (S418A) channels through different PKC isoforms
Pflugers Arch. 2024 Apr 24. doi: 10.1007/s00424-024-02966-5. Online ahead of print.ABSTRACTSignaling of G protein-activated inwardly rectifying K+ (GIRK) channels is an important mechanism of the parasympathetic regulation of the heart rate and cardiac excitability. GIRK channels are inhibited during stimulation of Gq-coupled receptors (GqPCRs) by depletion of phosphatidyl-4,5-bisphosphate (PIP2) and/or channel phosphorylation by protein kinase C (PKC). The GqPCR-dependent modulation of GIRK currents in terms of specific PKC isoform activation was analyzed in voltage-clamp experiments in rat atrial myocytes and in CHO or H...
Source: Pflugers Archiv : European Journal of Physiology - April 24, 2024 Category: Physiology Authors: Leonie Inderwiedenstra ße Marie-C écile Kienitz Source Type: research
Angiotensin receptors and α < sub > 1B < /sub > -adrenergic receptors regulate native IK < sub > (ACh) < /sub > and phosphorylation-deficient GIRK4 (S418A) channels through different PKC isoforms
Pflugers Arch. 2024 Apr 24. doi: 10.1007/s00424-024-02966-5. Online ahead of print.ABSTRACTSignaling of G protein-activated inwardly rectifying K+ (GIRK) channels is an important mechanism of the parasympathetic regulation of the heart rate and cardiac excitability. GIRK channels are inhibited during stimulation of Gq-coupled receptors (GqPCRs) by depletion of phosphatidyl-4,5-bisphosphate (PIP2) and/or channel phosphorylation by protein kinase C (PKC). The GqPCR-dependent modulation of GIRK currents in terms of specific PKC isoform activation was analyzed in voltage-clamp experiments in rat atrial myocytes and in CHO or H...
Source: Pflugers Archiv : European Journal of Physiology - April 24, 2024 Category: Physiology Authors: Leonie Inderwiedenstra ße Marie-C écile Kienitz Source Type: research
SubSol-HIe is an AMPK-dependent hypoxia-responsive subnucleus of the nucleus tractus solitarius that coordinates the hypoxic ventilatory response and protects against apnoea in mice
Pflugers Arch. 2024 Apr 18. doi: 10.1007/s00424-024-02957-6. Online ahead of print.ABSTRACTFunctional magnetic resonance imaging (fMRI) suggests that the hypoxic ventilatory response is facilitated by the AMP-activated protein kinase (AMPK), not at the carotid bodies, but within a subnucleus (Bregma -7.5 to -7.1 mm) of the nucleus tractus solitarius that exhibits right-sided bilateral asymmetry. Here, we map this subnucleus using cFos expression as a surrogate for neuronal activation and mice in which the genes encoding the AMPK-α1 (Prkaa1) and AMPK-α2 (Prkaa2) catalytic subunits were deleted in catecholaminergic cells b...
Source: Pflugers Archiv : European Journal of Physiology - April 18, 2024 Category: Physiology Authors: Sandy MacMillan David P Burns Ken D O'Halloran A Mark Evans Source Type: research
How ceramides affect the development of colon cancer: from normal colon to carcinoma
Pflugers Arch. 2024 Apr 18. doi: 10.1007/s00424-024-02960-x. Online ahead of print.ABSTRACTThe integrity of the colon and the development of colon cancer depend on the sphingolipid balance in colon epithelial cells. In this review, we summarize the current knowledge on how ceramides and their complex derivatives influence normal colon development and colon cancer development. Ceramides, glucosylceramides and sphingomyelin are essential membrane components and, due to their biophysical properties, can influence the activation of membrane proteins, affecting protein-protein interactions and downstream signalling pathways. He...
Source: Pflugers Archiv : European Journal of Physiology - April 18, 2024 Category: Physiology Authors: Nadine Merz Jennifer Christina Hartel Sabine Gr ösch Source Type: research
Murine Alox8 versus the human ALOX15B ortholog: differences and similarities
Pflugers Arch. 2024 Apr 19. doi: 10.1007/s00424-024-02961-w. Online ahead of print.ABSTRACTHuman arachidonate 15-lipoxygenase type B is a lipoxygenase that catalyzes the peroxidation of arachidonic acid at carbon-15. The corresponding murine ortholog however has 8-lipoxygenase activity. Both enzymes oxygenate polyunsaturated fatty acids in S-chirality with singular reaction specificity, although they generate a different product pattern. Furthermore, while both enzymes utilize both esterified fatty acids and fatty acid hydro(pero)xides as substrates, they differ with respect to the orientation of the fatty acid in their su...
Source: Pflugers Archiv : European Journal of Physiology - April 18, 2024 Category: Physiology Authors: Megan A Palmer Yvonne Benatzy Bernhard Br üne Source Type: research
SubSol-HIe is an AMPK-dependent hypoxia-responsive subnucleus of the nucleus tractus solitarius that coordinates the hypoxic ventilatory response and protects against apnoea in mice
Pflugers Arch. 2024 Apr 18. doi: 10.1007/s00424-024-02957-6. Online ahead of print.ABSTRACTFunctional magnetic resonance imaging (fMRI) suggests that the hypoxic ventilatory response is facilitated by the AMP-activated protein kinase (AMPK), not at the carotid bodies, but within a subnucleus (Bregma -7.5 to -7.1 mm) of the nucleus tractus solitarius that exhibits right-sided bilateral asymmetry. Here, we map this subnucleus using cFos expression as a surrogate for neuronal activation and mice in which the genes encoding the AMPK-α1 (Prkaa1) and AMPK-α2 (Prkaa2) catalytic subunits were deleted in catecholaminergic cells b...
Source: Pflugers Archiv : European Journal of Physiology - April 18, 2024 Category: Physiology Authors: Sandy MacMillan David P Burns Ken D O'Halloran A Mark Evans Source Type: research
