Can research on entactogens contribute to a deeper understanding of human sexuality?
This study aims to analyze current and planned research on the psychophysiological effects of entactogens on human sexuality. With their prosocial potential, the pharmacokinetic and neuroendocrine effects of entactogens may recreate the subjective experience of emotional intimacy, the initiation of intimate relationships, or even feelings of 'falling in love' with previously neutral individuals while under the influence of entactogens. This includes MDMA-induced sexual arousal-like effects observed through subjective behavioral perceptions of desire and arousal and specific physiological markers such as oxytocin and prolac...
Source: Pharmacological Reports - November 7, 2023 Category: Drugs & Pharmacology Authors: Justyna Holka-Pokorska Source Type: research
The possible place for psychedelics in pharmacotherapy of mental disorders
Pharmacol Rep. 2023 Nov 7. doi: 10.1007/s43440-023-00550-9. Online ahead of print.ABSTRACTSince its emergence in the 1960s, the serotonergic theory of depression bore fruit in the discovery of a plethora of antidepressant drugs affecting the lives of millions of patients. While crucial in the history of drug development, recent studies undermine the effectiveness of currently used antidepressant drugs in comparison to placebo, emphasizing the long time it takes to initiate the therapeutic response and numerous adverse effects. Thus, the scope of contemporary pharmacological research shifts from drugs affecting the serotoni...
Source: Pharmacological Reports - November 7, 2023 Category: Drugs & Pharmacology Authors: Adam Wojtas Source Type: research
Can research on entactogens contribute to a deeper understanding of human sexuality?
This study aims to analyze current and planned research on the psychophysiological effects of entactogens on human sexuality. With their prosocial potential, the pharmacokinetic and neuroendocrine effects of entactogens may recreate the subjective experience of emotional intimacy, the initiation of intimate relationships, or even feelings of 'falling in love' with previously neutral individuals while under the influence of entactogens. This includes MDMA-induced sexual arousal-like effects observed through subjective behavioral perceptions of desire and arousal and specific physiological markers such as oxytocin and prolac...
Source: Pharmacological Reports - November 7, 2023 Category: Drugs & Pharmacology Authors: Justyna Holka-Pokorska Source Type: research
The possible place for psychedelics in pharmacotherapy of mental disorders
Pharmacol Rep. 2023 Nov 7. doi: 10.1007/s43440-023-00550-9. Online ahead of print.ABSTRACTSince its emergence in the 1960s, the serotonergic theory of depression bore fruit in the discovery of a plethora of antidepressant drugs affecting the lives of millions of patients. While crucial in the history of drug development, recent studies undermine the effectiveness of currently used antidepressant drugs in comparison to placebo, emphasizing the long time it takes to initiate the therapeutic response and numerous adverse effects. Thus, the scope of contemporary pharmacological research shifts from drugs affecting the serotoni...
Source: Pharmacological Reports - November 7, 2023 Category: Drugs & Pharmacology Authors: Adam Wojtas Source Type: research
Can research on entactogens contribute to a deeper understanding of human sexuality?
This study aims to analyze current and planned research on the psychophysiological effects of entactogens on human sexuality. With their prosocial potential, the pharmacokinetic and neuroendocrine effects of entactogens may recreate the subjective experience of emotional intimacy, the initiation of intimate relationships, or even feelings of 'falling in love' with previously neutral individuals while under the influence of entactogens. This includes MDMA-induced sexual arousal-like effects observed through subjective behavioral perceptions of desire and arousal and specific physiological markers such as oxytocin and prolac...
Source: Pharmacological Reports - November 7, 2023 Category: Drugs & Pharmacology Authors: Justyna Holka-Pokorska Source Type: research
The possible place for psychedelics in pharmacotherapy of mental disorders
Pharmacol Rep. 2023 Nov 7. doi: 10.1007/s43440-023-00550-9. Online ahead of print.ABSTRACTSince its emergence in the 1960s, the serotonergic theory of depression bore fruit in the discovery of a plethora of antidepressant drugs affecting the lives of millions of patients. While crucial in the history of drug development, recent studies undermine the effectiveness of currently used antidepressant drugs in comparison to placebo, emphasizing the long time it takes to initiate the therapeutic response and numerous adverse effects. Thus, the scope of contemporary pharmacological research shifts from drugs affecting the serotoni...
Source: Pharmacological Reports - November 7, 2023 Category: Drugs & Pharmacology Authors: Adam Wojtas Source Type: research
Can research on entactogens contribute to a deeper understanding of human sexuality?
This study aims to analyze current and planned research on the psychophysiological effects of entactogens on human sexuality. With their prosocial potential, the pharmacokinetic and neuroendocrine effects of entactogens may recreate the subjective experience of emotional intimacy, the initiation of intimate relationships, or even feelings of 'falling in love' with previously neutral individuals while under the influence of entactogens. This includes MDMA-induced sexual arousal-like effects observed through subjective behavioral perceptions of desire and arousal and specific physiological markers such as oxytocin and prolac...
Source: Pharmacological Reports - November 7, 2023 Category: Drugs & Pharmacology Authors: Justyna Holka-Pokorska Source Type: research
The possible place for psychedelics in pharmacotherapy of mental disorders
Pharmacol Rep. 2023 Nov 7. doi: 10.1007/s43440-023-00550-9. Online ahead of print.ABSTRACTSince its emergence in the 1960s, the serotonergic theory of depression bore fruit in the discovery of a plethora of antidepressant drugs affecting the lives of millions of patients. While crucial in the history of drug development, recent studies undermine the effectiveness of currently used antidepressant drugs in comparison to placebo, emphasizing the long time it takes to initiate the therapeutic response and numerous adverse effects. Thus, the scope of contemporary pharmacological research shifts from drugs affecting the serotoni...
Source: Pharmacological Reports - November 7, 2023 Category: Drugs & Pharmacology Authors: Adam Wojtas Source Type: research
Can research on entactogens contribute to a deeper understanding of human sexuality?
This study aims to analyze current and planned research on the psychophysiological effects of entactogens on human sexuality. With their prosocial potential, the pharmacokinetic and neuroendocrine effects of entactogens may recreate the subjective experience of emotional intimacy, the initiation of intimate relationships, or even feelings of 'falling in love' with previously neutral individuals while under the influence of entactogens. This includes MDMA-induced sexual arousal-like effects observed through subjective behavioral perceptions of desire and arousal and specific physiological markers such as oxytocin and prolac...
Source: Pharmacological Reports - November 7, 2023 Category: Drugs & Pharmacology Authors: Justyna Holka-Pokorska Source Type: research
The possible place for psychedelics in pharmacotherapy of mental disorders
Pharmacol Rep. 2023 Nov 7. doi: 10.1007/s43440-023-00550-9. Online ahead of print.ABSTRACTSince its emergence in the 1960s, the serotonergic theory of depression bore fruit in the discovery of a plethora of antidepressant drugs affecting the lives of millions of patients. While crucial in the history of drug development, recent studies undermine the effectiveness of currently used antidepressant drugs in comparison to placebo, emphasizing the long time it takes to initiate the therapeutic response and numerous adverse effects. Thus, the scope of contemporary pharmacological research shifts from drugs affecting the serotoni...
Source: Pharmacological Reports - November 7, 2023 Category: Drugs & Pharmacology Authors: Adam Wojtas Source Type: research
Can research on entactogens contribute to a deeper understanding of human sexuality?
This study aims to analyze current and planned research on the psychophysiological effects of entactogens on human sexuality. With their prosocial potential, the pharmacokinetic and neuroendocrine effects of entactogens may recreate the subjective experience of emotional intimacy, the initiation of intimate relationships, or even feelings of 'falling in love' with previously neutral individuals while under the influence of entactogens. This includes MDMA-induced sexual arousal-like effects observed through subjective behavioral perceptions of desire and arousal and specific physiological markers such as oxytocin and prolac...
Source: Pharmacological Reports - November 7, 2023 Category: Drugs & Pharmacology Authors: Justyna Holka-Pokorska Source Type: research
Interaction of hallucinogenic rapid-acting antidepressants with mGlu2/3 receptor ligands as a window for more effective therapies
Pharmacol Rep. 2023 Nov 7. doi: 10.1007/s43440-023-00547-4. Online ahead of print.ABSTRACTThe desire to find a gold-standard therapy for depression is still ongoing. Developing one universal and effective pharmacotherapy remains troublesome due to the high complexity and variety of symptoms. Over the last decades, the understanding of the mechanism of pathophysiology of depression and its key consequences for brain functioning have undergone significant changes, referring to the monoaminergic theory of the disease. After the breakthrough discovery of ketamine, research began to focus on the modulation of glutamatergic tran...
Source: Pharmacological Reports - November 6, 2023 Category: Drugs & Pharmacology Authors: Barbara Chru ścicka-Smaga Agata Machaczka Bernadeta Szewczyk Andrzej Pilc Source Type: research
Unraveling snake venom phospholipase A < sub > 2 < /sub > : an overview of its structure, pharmacology, and inhibitors
Pharmacol Rep. 2023 Nov 6. doi: 10.1007/s43440-023-00543-8. Online ahead of print.ABSTRACTSnake bite is a neglected disease that affects millions of people worldwide. WHO reported approximately 5 million people are bitten by various species of snakes each year, resulting in nearly 1 million deaths and an additional three times cases of permanent disability. Snakes utilize the venom mainly for immobilization and digestion of their prey. Snake venom is a composition of proteins and enzymes which is responsible for its diverse pharmacological action. Snake venom phospholipase A2 (SvPLA2) is an enzyme that is present in every ...
Source: Pharmacological Reports - November 5, 2023 Category: Drugs & Pharmacology Authors: Ganesh H Sampat Kashinath Hiremath Jagadeesh Dodakallanavar Vishal S Patil Darasaguppe R Harish Prakash Biradar Rashmi K Mahadevamurthy Manish Barvaliya Subarna Roy Source Type: research
Mindfulness meditation and psychedelics: potential synergies and commonalities
Pharmacol Rep. 2023 Nov 6. doi: 10.1007/s43440-023-00551-8. Online ahead of print.ABSTRACTThere has been increasing scientific and clinical interest in studying psychedelic and meditation-based interventions in recent years, both in the context of improving mental health and as tools for understanding the mind. Several authors suggest neurophysiological and phenomenological parallels and overlaps between psychedelic and meditative states and suggest synergistic effects of both methods. Both psychedelic-assisted therapy and meditation training in the form of mindfulness-based interventions have been experimentally validated...
Source: Pharmacological Reports - November 5, 2023 Category: Drugs & Pharmacology Authors: Pawe ł Holas Justyna Kami ńska Source Type: research
Unraveling snake venom phospholipase A < sub > 2 < /sub > : an overview of its structure, pharmacology, and inhibitors
Pharmacol Rep. 2023 Nov 6. doi: 10.1007/s43440-023-00543-8. Online ahead of print.ABSTRACTSnake bite is a neglected disease that affects millions of people worldwide. WHO reported approximately 5 million people are bitten by various species of snakes each year, resulting in nearly 1 million deaths and an additional three times cases of permanent disability. Snakes utilize the venom mainly for immobilization and digestion of their prey. Snake venom is a composition of proteins and enzymes which is responsible for its diverse pharmacological action. Snake venom phospholipase A2 (SvPLA2) is an enzyme that is present in every ...
Source: Pharmacological Reports - November 5, 2023 Category: Drugs & Pharmacology Authors: Ganesh H Sampat Kashinath Hiremath Jagadeesh Dodakallanavar Vishal S Patil Darasaguppe R Harish Prakash Biradar Rashmi K Mahadevamurthy Manish Barvaliya Subarna Roy Source Type: research
