Reply to comment on 'Modeling for predicting survival fraction of cells after ultra-high dose rate irradiation'
Phys Med Biol. 2024 May 3;69(10). doi: 10.1088/1361-6560/ad3edc.ABSTRACTLiew and Mairani commented on our paper 'Modeling for predicting survival fraction of cells after ultra-high dose rate irradiation' (Shiraishiet al2024aPhys. Med. Biol.69015017), which proposed a biophysical model to predict the dose-response curve of surviving cell fractions after ultra-high dose rate irradiation following conventional dose rate irradiation by considering DNA damage yields. They suggested the need to consider oxygen concentration in our prediction model and possible issues related to the data selection process used for the benchmarkin...
Source: Physics in Medicine and Biology - May 3, 2024 Category: Physics Authors: Yuta Shiraishi Yusuke Matsuya Hisanori Fukunaga Source Type: research
Comment on 'Modeling for predicting survival fraction of cells after ultra-high dose rate irradiation'
Phys Med Biol. 2024 May 3;69(10). doi: 10.1088/1361-6560/ad3edb.ABSTRACTWe comment on the recently published study 'Modeling for predicting survival fraction of cells after ultra-high dose rate irradiation' by Shiraishiet al. While the general approach of the study may be appropriate, we wish to comment on its limitations and point out issues concerning their choice of the benchmarking and fitting data. The approach by the authors could become viable in an extended form once more comprehensive data is available.PMID:38700989 | DOI:10.1088/1361-6560/ad3edb (Source: Physics in Medicine and Biology)
Source: Physics in Medicine and Biology - May 3, 2024 Category: Physics Authors: Hans Liew Andrea Mairani Source Type: research
Dynamic CBCT imaging using prior model-free spatiotemporal implicit neural representation (PMF-STINR)
Phys Med Biol. 2024 May 2. doi: 10.1088/1361-6560/ad46dc. Online ahead of print.ABSTRACTDynamic cone-beam computed tomography (CBCT) can capture high-spatial-resolution, time-varying images for motion monitoring, patient setup, and adaptive planning of radiotherapy. However, dynamic CBCT reconstruction is an extremely ill-posed spatiotemporal inverse problem, as each CBCT volume in the dynamic sequence is only captured by one or a few X-ray projections, due to the slow gantry rotation speed and the fast anatomical motion (e.g., breathing). 
Approach: We developed a machine learning-based technique, prior-model-free...
Source: Physics in Medicine and Biology - May 2, 2024 Category: Physics Authors: Hua-Chieh Shao Tielige Mengke Tinsu Pan You Zhang Source Type: research
Time conditioning for arbitrary contrast phase generation in interventional computed tomography
Phys Med Biol. 2024 May 2. doi: 10.1088/1361-6560/ad46dd. Online ahead of print.ABSTRACTMinimally invasive ablation techniques for renal cancer are becoming more popular due to their low complication rate and rapid recovery period. Despite excellent visualisation, one drawback of the use of computed tomography (CT) in these procedures is the requirement for iodine-based contrast agents, which are associated with adverse reactions and require a higher X-ray dose. The purpose of this work is to examine the use of time information to generate synthetic contrast enhanced images at arbitrary points after contrast agent injectio...
Source: Physics in Medicine and Biology - May 2, 2024 Category: Physics Authors: Mark A Pinnock Yipeng Hu Steve Bandula Dean C Barratt Source Type: research
The potential of mixed carbon-helium beams for online treatment verification: a simulation and treatment planning study
Phys Med Biol. 2024 May 2. doi: 10.1088/1361-6560/ad46db. Online ahead of print.ABSTRACTOBJECTIVE: Recently, a new and promising approach for range verification was proposed. This method requires the use of two different ion species. Due to their equal magnetic rigidity, fully ionized carbon and helium ions can be simultaneously accelerated in accelerators like synchrotrons. At sufficiently high treatment energies, helium ions can exit the patient distally, reaching approximately three times the range
of carbon ions at an equal energy per nucleon. Therefore, the proposal involves adding a small helium fluence to th...
Source: Physics in Medicine and Biology - May 2, 2024 Category: Physics Authors: Jennifer J Hardt Alexander A Pryanichnikov Noa Homolka Ethan A DeJongh Don F DeJongh Remo Cristoforetti Oliver Jaekel Joao Seco Niklas Wahl Source Type: research
Dynamic CBCT imaging using prior model-free spatiotemporal implicit neural representation (PMF-STINR)
Phys Med Biol. 2024 May 2. doi: 10.1088/1361-6560/ad46dc. Online ahead of print.ABSTRACTDynamic cone-beam computed tomography (CBCT) can capture high-spatial-resolution, time-varying images for motion monitoring, patient setup, and adaptive planning of radiotherapy. However, dynamic CBCT reconstruction is an extremely ill-posed spatiotemporal inverse problem, as each CBCT volume in the dynamic sequence is only captured by one or a few X-ray projections, due to the slow gantry rotation speed and the fast anatomical motion (e.g., breathing). 
Approach: We developed a machine learning-based technique, prior-model-free...
Source: Physics in Medicine and Biology - May 2, 2024 Category: Physics Authors: Hua-Chieh Shao Tielige Mengke Tinsu Pan You Zhang Source Type: research
Time conditioning for arbitrary contrast phase generation in interventional computed tomography
Phys Med Biol. 2024 May 2. doi: 10.1088/1361-6560/ad46dd. Online ahead of print.ABSTRACTMinimally invasive ablation techniques for renal cancer are becoming more popular due to their low complication rate and rapid recovery period. Despite excellent visualisation, one drawback of the use of computed tomography (CT) in these procedures is the requirement for iodine-based contrast agents, which are associated with adverse reactions and require a higher X-ray dose. The purpose of this work is to examine the use of time information to generate synthetic contrast enhanced images at arbitrary points after contrast agent injectio...
Source: Physics in Medicine and Biology - May 2, 2024 Category: Physics Authors: Mark A Pinnock Yipeng Hu Steve Bandula Dean C Barratt Source Type: research
The potential of mixed carbon-helium beams for online treatment verification: a simulation and treatment planning study
Phys Med Biol. 2024 May 2. doi: 10.1088/1361-6560/ad46db. Online ahead of print.ABSTRACTOBJECTIVE: Recently, a new and promising approach for range verification was proposed. This method requires the use of two different ion species. Due to their equal magnetic rigidity, fully ionized carbon and helium ions can be simultaneously accelerated in accelerators like synchrotrons. At sufficiently high treatment energies, helium ions can exit the patient distally, reaching approximately three times the range
of carbon ions at an equal energy per nucleon. Therefore, the proposal involves adding a small helium fluence to th...
Source: Physics in Medicine and Biology - May 2, 2024 Category: Physics Authors: Jennifer J Hardt Alexander A Pryanichnikov Noa Homolka Ethan A DeJongh Don F DeJongh Remo Cristoforetti Oliver Jaekel Joao Seco Niklas Wahl Source Type: research
FlexDTI: flexible diffusion gradient encoding scheme-based highly efficient diffusion tensor imaging using deep learning
Phys Med Biol. 2024 Apr 30. doi: 10.1088/1361-6560/ad45a5. Online ahead of print.ABSTRACT
Most deep neural network-based diffusion tensor imaging methods require the diffusion gradients' number and directions in the data to be reconstructed to match those in the training data. This work aims to develop and evaluate a novel dynamic-convolution-based method called FlexDTI for highly efficient diffusion tensor reconstruction with flexible diffusion encoding gradient scheme.
Approach:
FlexDTI was developed to achieve high-quality DTI parametric mapping with flexible number and directions of diffusion en...
Source: Physics in Medicine and Biology - April 30, 2024 Category: Physics Authors: ZeJun Wu Jiechao Wang Zunquan Chen Qinqin Yang Zhen Xing Dairong Cao Jian-Feng Bao Taishan Kang Jianzhong Lin Shuhui Cai Zhong Chen Congbo Cai Source Type: research
Thermometry mapping during CT-guided thermal ablations: proof of feasibility and internal validation using spectral CT
This study has demonstrated that spectral CT can be used to estimate local temperature changes for different materials and phases across temperature ranges produced by thermal ablations.PMID:38688289 | DOI:10.1088/1361-6560/ad45a3 (Source: Physics in Medicine and Biology)
Source: Physics in Medicine and Biology - April 30, 2024 Category: Physics Authors: Kuan Kevin Zhang Andrea Ferrero Myung-Ho In Christopher P Favazza Source Type: research
Mixed-size spot scanning with a compact large momentum acceptance superconducting (LMA-SC) gantry beamline for proton therapy
Phys Med Biol. 2024 Apr 30. doi: 10.1088/1361-6560/ad45a6. Online ahead of print.ABSTRACTLowering treatment costs and improving treatment quality are two primary goals for next-generation proton therapy (PT) facilities. This work will design a compact large momentum acceptance superconducting (LMA-SC) gantry beamline to reduce the footprint and expense of the PT facilities, with a novel mixed-size spot scanning method to improve the sparing of organs at risk (OAR).
Approach: For the LMA-SC gantry beamline, the movable energy slit is placed in the middle of the last achromatic bending section, and the beam momentum ...
Source: Physics in Medicine and Biology - April 30, 2024 Category: Physics Authors: Wei Wang Liu Xu Yicheng Liao Yiling Zeng Yu Chen Benzhaoxia Yu Zhiyong Yang Hao Gao Bin Qin Source Type: research
Texture preserving low dose CT image denoising using Pearson divergence
Phys Med Biol. 2024 Apr 30. doi: 10.1088/1361-6560/ad45a4. Online ahead of print.ABSTRACTThe mean squared error (MSE), also known as $L_2$ loss, has been widely used as a loss function to optimize image denoising models due to its strong performance as a mean estimator of the Gaussian noise model. Recently, various low-dose computed tomography (LDCT) image denoising methods using deep learning combined with the MSE loss have been developed; however, this approach has been observed to suffer from the regression-to-the-mean problem, leading to over-smoothed edges and degradation of texture in the image.
Approach: To ...
Source: Physics in Medicine and Biology - April 30, 2024 Category: Physics Authors: Jieun Oh Dufan Wu Boohwi Hong Dongheon Lee Minwoong Kang Quanzheng Li Kyungsang Kim Source Type: research
FlexDTI: flexible diffusion gradient encoding scheme-based highly efficient diffusion tensor imaging using deep learning
Phys Med Biol. 2024 Apr 30. doi: 10.1088/1361-6560/ad45a5. Online ahead of print.ABSTRACT
Most deep neural network-based diffusion tensor imaging methods require the diffusion gradients' number and directions in the data to be reconstructed to match those in the training data. This work aims to develop and evaluate a novel dynamic-convolution-based method called FlexDTI for highly efficient diffusion tensor reconstruction with flexible diffusion encoding gradient scheme.
Approach:
FlexDTI was developed to achieve high-quality DTI parametric mapping with flexible number and directions of diffusion en...
Source: Physics in Medicine and Biology - April 30, 2024 Category: Physics Authors: ZeJun Wu Jiechao Wang Zunquan Chen Qinqin Yang Zhen Xing Dairong Cao Jian-Feng Bao Taishan Kang Jianzhong Lin Shuhui Cai Zhong Chen Congbo Cai Source Type: research
Thermometry mapping during CT-guided thermal ablations: proof of feasibility and internal validation using spectral CT
This study has demonstrated that spectral CT can be used to estimate local temperature changes for different materials and phases across temperature ranges produced by thermal ablations.PMID:38688289 | DOI:10.1088/1361-6560/ad45a3 (Source: Physics in Medicine and Biology)
Source: Physics in Medicine and Biology - April 30, 2024 Category: Physics Authors: Kuan Kevin Zhang Andrea Ferrero Myung-Ho In Christopher P Favazza Source Type: research
Mixed-size spot scanning with a compact large momentum acceptance superconducting (LMA-SC) gantry beamline for proton therapy
Phys Med Biol. 2024 Apr 30. doi: 10.1088/1361-6560/ad45a6. Online ahead of print.ABSTRACTLowering treatment costs and improving treatment quality are two primary goals for next-generation proton therapy (PT) facilities. This work will design a compact large momentum acceptance superconducting (LMA-SC) gantry beamline to reduce the footprint and expense of the PT facilities, with a novel mixed-size spot scanning method to improve the sparing of organs at risk (OAR).
Approach: For the LMA-SC gantry beamline, the movable energy slit is placed in the middle of the last achromatic bending section, and the beam momentum ...
Source: Physics in Medicine and Biology - April 30, 2024 Category: Physics Authors: Wei Wang Liu Xu Yicheng Liao Yiling Zeng Yu Chen Benzhaoxia Yu Zhiyong Yang Hao Gao Bin Qin Source Type: research
