Electrophysiological phenotyping of left ventricular noncompaction cardiomyopathy in pediatric populations: A systematic review
AbstractLeft ventricular noncompaction cardiomyopathy (LVNC) is a structural heart defect that has been associated with generation of arrhythmias in the population and is a cause of sudden cardiac death with severe systolic dysfunction and fatal arrhythmias. LVNC has gained increasing acknowledgment with increased prevalence. We conducted a systematic review of reported electrocardiogram (ECG) results for pediatric LVNC patients. EMBASE database query was performed, yielding 4531 articles related to LVNC between 1990 and December 2023. Patient age ranged from prenatal to 18 years of age. Qualitative analyses were perfor...
Source: Physiological Reports - April 30, 2024 Category: Physiology Authors: Lindsey A. Fitzsimons,
Delanie M. Kneeland ‐Barber,
Gracie C. Hannigan,
David A. Karpe,
Lyman Wu,
Michael Colon,
Jess Randall,
Kerry L. Tucker Tags: REVIEW Source Type: research
Dynamic cerebral autoregulation is preserved during orthostasis and intrathoracic pressure regulation in healthy subjects: A pilot study
AbstractResistance breathing may restore cardiac output (CO) and cerebral blood flow (CBF) during hypovolemia. We assessed CBF and cerebral autoregulation (CA) during tilt, resistance breathing, and paced breathing in 10 healthy subjects. Blood velocities in the internal carotid artery (ICA), middle cerebral arteries (MCA, four subjects), and aorta were measured by Doppler ultrasound in 30 ° and 60° semi-recumbent positions. ICA blood flow and CO were calculated. Arterial blood pressure (ABP, Finometer), and end-tidal CO2 (ETCO2) were recorded. ICA blood flow response was assessed by mixed-models regression analysis. The...
Source: Physiological Reports - April 30, 2024 Category: Physiology Authors: M. Skytioti,
M. Wiedmann,
A. Sorteberg,
L. Romundstad,
Y. Hassan Ali,
A. Mohammad Ayoubi,
I. Zilakos,
M. Elstad Tags: ORIGINAL ARTICLE Source Type: research
Effects of maternal exercise on infant mesenchymal stem cell mitochondrial function, insulin action, and body composition in infancy
AbstractMaternal exercise (ME) has been established as a useful non-pharmacological intervention to improve infant metabolic health; however, mechanistic insight behind these adaptations remains mostly confined to animal models. Infant mesenchymal stem cells (MSCs) give rise to infant tissues (e.g., skeletal muscle), and remain involved in mature tissue maintenance. Importantly, these cells maintain metabolic characteristics of an offspring donor and provide a model for the investigation of mechanisms behind infant metabolic health improvements. We used undifferentiated MSC to investigate if ME affects infant MSC mitochond...
Source: Physiological Reports - April 30, 2024 Category: Physiology Authors: Filip Jevtovic,
Donghai Zheng,
Alex Claiborne,
Ericka M. Biagioni,
Breanna L. Wisseman,
Polina M. Krassovskaia,
David N. Collier,
Christy Isler,
James E. DeVente,
P. Darrell Neufer,
Joseph A. Houmard,
Linda E. May Tags: ORIGINAL ARTICLE Source Type: research
Obesity ‐induced skeletal muscle remodeling: A comparative analysis of exercise training and ACE‐inhibitory drug in male mice
Enalapril and aerobic exercise training have been found to shift the activity of the renin-angiotensin system (RAS) toward the counterregulatory arm and the kallikrein-kinin system (KKS) toward the bradykinin receptor subtype 2 (B2R), which in turn helps reduce apoptosis markers (BAX/Bcl-2 ratio) and improve PGC-1 α expression in muscle. However, it is worth noting that only exercise training mitigates obesity-induced myofiber atrophy. This is due to its ability to upregulate the mTOR/p70S6K pathway, boost muscle mitochondrial biogenesis marker (PGC-1α), and lower levels of muscle protein degradation marker s (MuRF-1 and...
Source: Physiological Reports - April 30, 2024 Category: Physiology Authors: Ana Beatriz Proen ça,
Beatriz Alexandre‐Santos,
Isabele Gomes Giori,
Jaime Silva Filho Alex‐Marques,
Clarice Machado‐Santos,
Marcus Machado,
D'Angelo Carlo Magliano,
Antonio Claudio Lucas da Nobrega,
Eliete Dalla Corte Frantz Tags: ORIGINAL ARTICLE Source Type: research
Increased risk of acute kidney injury in the first part of an ultra ‐trail—Implications for abandonment
AbstractAcute kidneys injuries (AKIs) have been described in marathon and trail running. The currently available data allows assessment of before/after comparisons but does not allow an analysis of what happens during the race. A multidisciplinary assessment protocol was performed during the first trail ofCl écy (Normandy France) in November 2021. This allowed an initial assay to be carried out, then at the end of each of the 6 loops of 26 km, and finally after 24 h of recovery. The race extends over 156 km in hilly terrain and 6000 m of elevation gain (D+). The level of impairment according to the RIFLE classifi...
Source: Physiological Reports - April 30, 2024 Category: Physiology Authors: Jean ‐Charles Vauthier,
Charlie Touze,
Benoit Mauvieux,
Corentin Hingrand,
Pierre‐Louis Delaunay,
Stéphane Besnard,
Romain Jouffroy,
Philippe Noirez,
Patrice Maboudou,
Cassandra Parent,
Elsa Heyman,
Mathias Poussel Tags: ORIGINAL ARTICLE Source Type: research
Issue Information
(Source: Physiological Reports)
Source: Physiological Reports - April 29, 2024 Category: Physiology Tags: ISSUE INFORMATION Source Type: research
Correction to Influence of epicardial adipose tissue inflammation and adipocyte size on postoperative atrial fibrillation in patients after cardiovascular surgery
(Source: Physiological Reports)
Source: Physiological Reports - April 27, 2024 Category: Physiology Tags: CORRECTION Source Type: research
Effect of epicatechin consumption on the inflammatory pathway and mitochondria morphology in PBMC from a R350P desminopathy patient: A case report
AbstractDesminopathy R350P is a human myopathy that is characterized by the progressive loss of muscle fiber organization. This results in the loss of muscle size, mobility, and strength. In desminopathy, inflammation affects muscle homeostasis and repair, and contributes to progressive muscle deterioration. Mitochondria morphology was also suggested to affect desminopathy progression. Epicatechin (Epi) —a natural compound found in cacao—has been proposed to regulate inflammatory signaling and mitochondria morphology in human and animal models. Hence, we hypothesize chronic Epi consumption to improve inflammatory pathw...
Source: Physiological Reports - April 25, 2024 Category: Physiology Authors: Germ án Tapia‐Curimil,
Mauricio Castro‐Sepulveda,
Hermann Zbinden‐Foncea Tags: CASE REPORT Source Type: research
Impact of methimazole ‐induced hypothyroidism on postnatal swine
The objective of this study was to evaluate the impact of hypothyroidism induced with the antithyroid medication methimazole (MMI). 10 mg/kg MMI significantly decreased circulating triiodothyronine (T3) for the duration of treatment but had only a transient effect on circulating thyroxine (T4). Thyroid tissue weight was significantly increased by more than 3.5-fold in response to MMI treatment. Histologically, the eosinophilic c olloid was largely absent from the thyroid follicle which displayed a disorganized columnar epithelium consistent with goiter. MMI induced hypothyroidism has no effect on growth rate over 28 d...
Source: Physiological Reports - April 25, 2024 Category: Physiology Authors: James C. Fazioli,
Margaret K. Mulligan,
Erin K. Ison,
J. Alex Pasternak Tags: ORIGINAL ARTICLE Source Type: research
Right ventricular preload and afterload challenge induces contractile dysfunction and arrhythmia in isolated hearts of dystrophin ‐deficient male mice
AbstractDuchenne muscular dystrophy (DMD) is an X-linked recessive myopathy due to mutations in the dystrophin gene. Diaphragmatic weakness in DMD causes hypoventilation and elevated afterload on the right ventricle (RV). Thus, RV dysfunction in DMD develops early in disease progression. Herein, we deliver a 30-min sustained RV preload/afterload challenge to isolated hearts of wild-type (Wt) and dystrophic (Dmdmdx-4Cv) mice at both young (2 –6 month) and middle-age (8–12 month) to test the hypothesis that the dystrophic RV is susceptible to dysfunction with elevated load. Young dystrophic hearts exhibited greater p...
Source: Physiological Reports - April 25, 2024 Category: Physiology Authors: Andrew Behrmann,
Jessica Cayton,
Matthew R. Hayden,
Michelle D. Lambert,
Zahra Nourian,
Keith Nyanyo,
Brooke Godbee,
Laurin M. Hanft,
Maike Krenz,
Kerry S. McDonald,
Timothy L. Domeier Tags: ORIGINAL ARTICLE Source Type: research
Diazoxide and moderate ‐intensity exercise improve skeletal muscle function by decreasing oxidants and enhancing antioxidant defenses in hypertensive male rats
AbstractHigh sodium intake is decisive in the incidence increase and prevalence of hypertension, which has an impact on skeletal muscle functionality. Diazoxide is an antihypertensive agent that inhibits insulin secretion and is an opener of KATP channels (adosine triphosphate sensitive potasium channels). For this reason, it is hypothesized that moderate-intensity exercise and diazoxide improve skeletal muscle function by reducing the oxidants in hypertensive rats. Male Wistar rats were assigned into eight groups: control (CTRL), diazoxide (DZX), exercise (EX), exercise + diazoxide (EX + DZX), hypertension (HTN),...
Source: Physiological Reports - April 24, 2024 Category: Physiology Authors: Estefan ía Bravo Sánchez,
César J. Nolasco Ruíz,
Mariana Gómez‐Barroso,
Christian Cortés Rojo,
Alain R. Rodríguez Orozco,
Alfredo Saavedra Molina,
Salvador Manzo Ávalos,
Rocío Montoya Pérez Tags: ORIGINAL ARTICLE Source Type: research
Exome sequencing in extreme altitude mountaineers identifies pathogenic variants in RTEL1 and COL6A1 previously associated with respiratory failure
AbstractAdaptation of humans to challenging environmental conditions, such as extreme temperature, malnutrition, or hypoxia, is an interesting phenomenon for both basic and applied research. Identification of the genetic factors contributing to human adaptation to these conditions enhances our understanding of the underlying molecular and physiological mechanisms. In our study, we analyzed the exomes of 22 high altitude mountaineers to uncover genetic variants contributing to hypoxic adaptation. To our surprise, we identified two putative loss-of-function variants, rs1385101139 inRTEL1 and rs1002726737 inCOL6A1 in two extr...
Source: Physiological Reports - April 24, 2024 Category: Physiology Authors: Evgeniia M. Maksiutenko,
Valeriia Merkureva,
Yury A. Barbitoff,
Victoria V. Tsay,
Mikhail V. Aseev,
Andrey S. Glotov,
Oleg S. Glotov Tags: SHORT REPORT Source Type: research
A novel mouse model carrying a gene trap insertion into the Hmgxb4 gene locus to examine Hmgxb4 expression in vivo
AbstractHMG (high mobility group) proteins are a diverse family of nonhistone chromosomal proteins that interact with DNA and a wide range of transcriptional regulators to regulate the structural architecture of DNA. HMGXB4 (also known as HMG2L1) is an HMG protein family member that contains a single HMG box domain. Our previous studies have demonstrated that HMGXB4 suppresses smooth muscle differentiation and exacerbates endotoxemia by promoting a systemic inflammatory response in mice. However, the expression ofHmgxb4 in vivo has not fully examined. Herein, we generated a mouse model that harbors a gene trap in the for...
Source: Physiological Reports - April 22, 2024 Category: Physiology Authors: Liang Wang,
Xiangqin He,
Guoqing Hu,
Jinhua Liu,
Xiuhua Kang,
Luyi Yu,
Kunzhe Dong,
Juanjuan Zhao,
Aizhen Zhang,
Wei Zhang,
Michael W. Brands,
Huabo Su,
Zeqi Zheng,
Jiliang Zhou Tags: ORIGINAL ARTICLE Source Type: research
Comparative analysis of ventricular stiffness across species
This article reviews the potential, utility, and limitations of using normalized EDPVR analysis in recent studies. Herein, we measur ed and ranked ventricular stiffness in differently sized and shaped chambers using ex vivo ventricular pressure-volume analysis data from four animals: Wistar rats, red-eared slider turtles, masu salmon, and cherry salmon. Furthermore, we have discussed the mechanical effects of intracellular and e xtracellular viscoelastic components, Titin (Connectin) filaments, collagens, physiological sarcomere length, and other factors that govern ventricular stiffness. Our review provides insights into...
Source: Physiological Reports - April 22, 2024 Category: Physiology Authors: Yuu Usui,
Akira Hanashima,
Ken Hashimoto,
Misaki Kimoto,
Momoko Ohira,
Satoshi Mohri Tags: REVIEW Source Type: research
Inhibition of superoxide and iNOS augment cutaneous nitric oxide ‐dependent vasodilation in non‐Hispanic black young adults
AbstractWe assessed the combined effect of superoxide and iNOS inhibition on microvascular function in non-Hispanic Black and non-Hispanic White participants (n = 15 per group). Participants were instrumented with four microdialysis fibers: (1) lactated Ringer's (control), (2) 10 μM tempol (superoxide inhibition), (3) 0.1 mM 1400 W (iNOS inhibition), (4) tempol + 1400 W. Cutaneous vasodilation was induced via local heating and NO-dependent vas odilation was quantified. At control sites, NO-dependent vasodilation was lower in non-Hispanic Black (45 ± 9% NO) relative to non-Hispanic White (79 ± 9% NO;p...
Source: Physiological Reports - April 20, 2024 Category: Physiology Authors: Brett J. Wong,
Casey G. Turner,
Matthew J. Hayat,
Jeffrey S. Otis,
Arshed A. Quyyumi Tags: ORIGINAL ARTICLE Source Type: research
