A versatile delivery vehicle for cellular oxygen and fuels, or metabolic sensor? - A review and perspective on the functions of myoglobin
Physiol Rev. 2024 May 2. doi: 10.1152/physrev.00031.2023. Online ahead of print.ABSTRACTA canonical view of the primary physiological function of myoglobin (Mb) is that it is an oxygen (O2) storage protein supporting mitochondrial oxidative phosphorylation, especially as the tissue O2 partial pressure (pO2) drops and Mb offloads O2. Besides O2 storage/transport, recent findings support functions for Mb in lipid trafficking and sequestration, interacting with cellular glycolytic metabolites such as lactate (LAC) and pyruvate (PYR) , and "ectopic" expression in some types of cancer cells and in brown adipose tissue (BAT). Da...
Source: Physiological Reviews - May 2, 2024 Category: Physiology Authors: Kiran Kumar Adepu Andriy Anishkin Sean H Adams Sree V Chintapalli Source Type: research
A versatile delivery vehicle for cellular oxygen and fuels, or metabolic sensor? - A review and perspective on the functions of myoglobin
Physiol Rev. 2024 May 2. doi: 10.1152/physrev.00031.2023. Online ahead of print.ABSTRACTA canonical view of the primary physiological function of myoglobin (Mb) is that it is an oxygen (O2) storage protein supporting mitochondrial oxidative phosphorylation, especially as the tissue O2 partial pressure (pO2) drops and Mb offloads O2. Besides O2 storage/transport, recent findings support functions for Mb in lipid trafficking and sequestration, interacting with cellular glycolytic metabolites such as lactate (LAC) and pyruvate (PYR) , and "ectopic" expression in some types of cancer cells and in brown adipose tissue (BAT). Da...
Source: Physiological Reviews - May 2, 2024 Category: Physiology Authors: Kiran Kumar Adepu Andriy Anishkin Sean H Adams Sree V Chintapalli Source Type: research
A versatile delivery vehicle for cellular oxygen and fuels, or metabolic sensor? - A review and perspective on the functions of myoglobin
Physiol Rev. 2024 May 2. doi: 10.1152/physrev.00031.2023. Online ahead of print.ABSTRACTA canonical view of the primary physiological function of myoglobin (Mb) is that it is an oxygen (O2) storage protein supporting mitochondrial oxidative phosphorylation, especially as the tissue O2 partial pressure (pO2) drops and Mb offloads O2. Besides O2 storage/transport, recent findings support functions for Mb in lipid trafficking and sequestration, interacting with cellular glycolytic metabolites such as lactate (LAC) and pyruvate (PYR) , and "ectopic" expression in some types of cancer cells and in brown adipose tissue (BAT). Da...
Source: Physiological Reviews - May 2, 2024 Category: Physiology Authors: Kiran Kumar Adepu Andriy Anishkin Sean H Adams Sree V Chintapalli Source Type: research
Neuronal glucose sensing mechanisms and circuits in the control of insulin and glucagon secretion
Physiol Rev. 2024 Apr 25. doi: 10.1152/physrev.00038.2023. Online ahead of print.ABSTRACTGlucose homeostasis is mainly under the control of the pancreatic islet hormones insulin and glucagon, which, respectively, stimulate glucose uptake and utilization by liver, fat, and muscle or glucose production by the liver. The balance between the secretion of these hormones is under the control of blood glucose concentrations. Indeed, pancreatic islet b-cells and a-cells can sense variations in glycemia and respond by an appropriate secretory response to restore euglycemia. However, the secretory activity of these cells is also und...
Source: Physiological Reviews - April 25, 2024 Category: Physiology Authors: Bernard Thorens Source Type: research
Neuronal glucose sensing mechanisms and circuits in the control of insulin and glucagon secretion
Physiol Rev. 2024 Apr 25. doi: 10.1152/physrev.00038.2023. Online ahead of print.ABSTRACTGlucose homeostasis is mainly under the control of the pancreatic islet hormones insulin and glucagon, which, respectively, stimulate glucose uptake and utilization by liver, fat, and muscle or glucose production by the liver. The balance between the secretion of these hormones is under the control of blood glucose concentrations. Indeed, pancreatic islet b-cells and a-cells can sense variations in glycemia and respond by an appropriate secretory response to restore euglycemia. However, the secretory activity of these cells is also und...
Source: Physiological Reviews - April 25, 2024 Category: Physiology Authors: Bernard Thorens Source Type: research
Neuronal glucose sensing mechanisms and circuits in the control of insulin and glucagon secretion
Physiol Rev. 2024 Apr 25. doi: 10.1152/physrev.00038.2023. Online ahead of print.ABSTRACTGlucose homeostasis is mainly under the control of the pancreatic islet hormones insulin and glucagon, which, respectively, stimulate glucose uptake and utilization by liver, fat, and muscle or glucose production by the liver. The balance between the secretion of these hormones is under the control of blood glucose concentrations. Indeed, pancreatic islet b-cells and a-cells can sense variations in glycemia and respond by an appropriate secretory response to restore euglycemia. However, the secretory activity of these cells is also und...
Source: Physiological Reviews - April 25, 2024 Category: Physiology Authors: Bernard Thorens Source Type: research
Neuronal glucose sensing mechanisms and circuits in the control of insulin and glucagon secretion
Physiol Rev. 2024 Apr 25. doi: 10.1152/physrev.00038.2023. Online ahead of print.ABSTRACTGlucose homeostasis is mainly under the control of the pancreatic islet hormones insulin and glucagon, which, respectively, stimulate glucose uptake and utilization by liver, fat, and muscle or glucose production by the liver. The balance between the secretion of these hormones is under the control of blood glucose concentrations. Indeed, pancreatic islet b-cells and a-cells can sense variations in glycemia and respond by an appropriate secretory response to restore euglycemia. However, the secretory activity of these cells is also und...
Source: Physiological Reviews - April 25, 2024 Category: Physiology Authors: Bernard Thorens Source Type: research
Neuronal glucose sensing mechanisms and circuits in the control of insulin and glucagon secretion
Physiol Rev. 2024 Apr 25. doi: 10.1152/physrev.00038.2023. Online ahead of print.ABSTRACTGlucose homeostasis is mainly under the control of the pancreatic islet hormones insulin and glucagon, which, respectively, stimulate glucose uptake and utilization by liver, fat, and muscle or glucose production by the liver. The balance between the secretion of these hormones is under the control of blood glucose concentrations. Indeed, pancreatic islet b-cells and a-cells can sense variations in glycemia and respond by an appropriate secretory response to restore euglycemia. However, the secretory activity of these cells is also und...
Source: Physiological Reviews - April 25, 2024 Category: Physiology Authors: Bernard Thorens Source Type: research
Neuronal glucose sensing mechanisms and circuits in the control of insulin and glucagon secretion
Physiol Rev. 2024 Apr 25. doi: 10.1152/physrev.00038.2023. Online ahead of print.ABSTRACTGlucose homeostasis is mainly under the control of the pancreatic islet hormones insulin and glucagon, which, respectively, stimulate glucose uptake and utilization by liver, fat, and muscle or glucose production by the liver. The balance between the secretion of these hormones is under the control of blood glucose concentrations. Indeed, pancreatic islet b-cells and a-cells can sense variations in glycemia and respond by an appropriate secretory response to restore euglycemia. However, the secretory activity of these cells is also und...
Source: Physiological Reviews - April 25, 2024 Category: Physiology Authors: Bernard Thorens Source Type: research
Physiological Basis for Xenotransplantation from Genetically-Modified Pigs to Humans: A Review
Physiol Rev. 2024 Mar 22. doi: 10.1152/physrev.00041.2023. Online ahead of print.ABSTRACTThe collective efforts of scientists over multiple decades have led to advancements in molecular and cellular biology-based technologies including genetic engineering and animal cloning, that are now being harnessed to enhance the suitability of pig organs for xenotransplantation into humans. Using organs sourced from pigs with multiple gene deletions and human transgene insertions, investigators have overcome formidable immunological and physiological barriers in pig-to-non-human primate (NHP) xenotransplantation and achieved prolonge...
Source: Physiological Reviews - March 22, 2024 Category: Physiology Authors: Leigh Peterson Magdi Yacoub David Ayares Kazuhiko Yamada Daniel Eisenson Bartley P Griffith Muhammad Mohiuddin Will Eyestone J Craig Venter Ryszard T Smolenski Martine Rothblatt Source Type: research
Physiological Basis for Xenotransplantation from Genetically-Modified Pigs to Humans: A Review
Physiol Rev. 2024 Mar 22. doi: 10.1152/physrev.00041.2023. Online ahead of print.ABSTRACTThe collective efforts of scientists over multiple decades have led to advancements in molecular and cellular biology-based technologies including genetic engineering and animal cloning, that are now being harnessed to enhance the suitability of pig organs for xenotransplantation into humans. Using organs sourced from pigs with multiple gene deletions and human transgene insertions, investigators have overcome formidable immunological and physiological barriers in pig-to-non-human primate (NHP) xenotransplantation and achieved prolonge...
Source: Physiological Reviews - March 22, 2024 Category: Physiology Authors: Leigh Peterson Magdi Yacoub David Ayares Kazuhiko Yamada Daniel Eisenson Bartley P Griffith Muhammad Mohiuddin Will Eyestone J Craig Venter Ryszard T Smolenski Martine Rothblatt Source Type: research
Physiological Basis for Xenotransplantation from Genetically-Modified Pigs to Humans: A Review
Physiol Rev. 2024 Mar 22. doi: 10.1152/physrev.00041.2023. Online ahead of print.ABSTRACTThe collective efforts of scientists over multiple decades have led to advancements in molecular and cellular biology-based technologies including genetic engineering and animal cloning, that are now being harnessed to enhance the suitability of pig organs for xenotransplantation into humans. Using organs sourced from pigs with multiple gene deletions and human transgene insertions, investigators have overcome formidable immunological and physiological barriers in pig-to-non-human primate (NHP) xenotransplantation and achieved prolonge...
Source: Physiological Reviews - March 22, 2024 Category: Physiology Authors: Leigh Peterson Magdi Yacoub David Ayares Kazuhiko Yamada Daniel Eisenson Bartley P Griffith Muhammad Mohiuddin Will Eyestone J Craig Venter Ryszard T Smolenski Martine Rothblatt Source Type: research
Physiological Basis for Xenotransplantation from Genetically-Modified Pigs to Humans: A Review
Physiol Rev. 2024 Mar 22. doi: 10.1152/physrev.00041.2023. Online ahead of print.ABSTRACTThe collective efforts of scientists over multiple decades have led to advancements in molecular and cellular biology-based technologies including genetic engineering and animal cloning, that are now being harnessed to enhance the suitability of pig organs for xenotransplantation into humans. Using organs sourced from pigs with multiple gene deletions and human transgene insertions, investigators have overcome formidable immunological and physiological barriers in pig-to-non-human primate (NHP) xenotransplantation and achieved prolonge...
Source: Physiological Reviews - March 22, 2024 Category: Physiology Authors: Leigh Peterson Magdi Yacoub David Ayares Kazuhiko Yamada Daniel Eisenson Bartley P Griffith Muhammad Mohiuddin Will Eyestone J Craig Venter Ryszard T Smolenski Martine Rothblatt Source Type: research
Physiological Basis for Xenotransplantation from Genetically-Modified Pigs to Humans: A Review
Physiol Rev. 2024 Mar 22. doi: 10.1152/physrev.00041.2023. Online ahead of print.ABSTRACTThe collective efforts of scientists over multiple decades have led to advancements in molecular and cellular biology-based technologies including genetic engineering and animal cloning, that are now being harnessed to enhance the suitability of pig organs for xenotransplantation into humans. Using organs sourced from pigs with multiple gene deletions and human transgene insertions, investigators have overcome formidable immunological and physiological barriers in pig-to-non-human primate (NHP) xenotransplantation and achieved prolonge...
Source: Physiological Reviews - March 22, 2024 Category: Physiology Authors: Leigh Peterson Magdi Yacoub David Ayares Kazuhiko Yamada Daniel Eisenson Bartley P Griffith Muhammad Mohiuddin Will Eyestone J Craig Venter Ryszard T Smolenski Martine Rothblatt Source Type: research
Physiological Basis for Xenotransplantation from Genetically-Modified Pigs to Humans: A Review
Physiol Rev. 2024 Mar 22. doi: 10.1152/physrev.00041.2023. Online ahead of print.ABSTRACTThe collective efforts of scientists over multiple decades have led to advancements in molecular and cellular biology-based technologies including genetic engineering and animal cloning, that are now being harnessed to enhance the suitability of pig organs for xenotransplantation into humans. Using organs sourced from pigs with multiple gene deletions and human transgene insertions, investigators have overcome formidable immunological and physiological barriers in pig-to-non-human primate (NHP) xenotransplantation and achieved prolonge...
Source: Physiological Reviews - March 22, 2024 Category: Physiology Authors: Leigh Peterson Magdi Yacoub David Ayares Kazuhiko Yamada Daniel Eisenson Bartley P Griffith Muhammad Mohiuddin Will Eyestone J Craig Venter Ryszard T Smolenski Martine Rothblatt Source Type: research
