Peptidic Compound as DNA Binding Agent: In Silico Fragment-based Design, Machine Learning, Molecular Modeling, Synthesis, and DNA Binding Evaluation
CONCLUSION: The obtained Ka value of 4.45 × 105 M-1 indicates favorable interactions. Our findings highlight the role of machine learning and molecular modeling approaches in designing new G4-binding peptides. Further research in this field could lead to targeted treatments that exploit the unique properties of G4 structures.PMID:38693737 | DOI:10.2174/0109298665305131240404072542 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - May 2, 2024 Category: Biochemistry Authors: Dara Dastan Shabnam Soleymanekhtiari Ahmad Ebadi Source Type: research
Peptidic Compound as DNA Binding Agent: In Silico Fragment-based Design, Machine Learning, Molecular Modeling, Synthesis, and DNA Binding Evaluation
CONCLUSION: The obtained Ka value of 4.45 × 105 M-1 indicates favorable interactions. Our findings highlight the role of machine learning and molecular modeling approaches in designing new G4-binding peptides. Further research in this field could lead to targeted treatments that exploit the unique properties of G4 structures.PMID:38693737 | DOI:10.2174/0109298665305131240404072542 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - May 2, 2024 Category: Biochemistry Authors: Dara Dastan Shabnam Soleymanekhtiari Ahmad Ebadi Source Type: research
Biophysical Evidence for the Amyloid Formation of a Recombinant Rab2 Isoform of Leishmania donovani
CONCLUSION: To our knowledge, this is the first study to report in vitro amyloid-like behaviour of Rab proteins in L donovani. This study provides a novel opportunity to understand the complete biophysical characteristics of Rab2 protein of the lower eukaryote, L. donovani.PMID:38661034 | DOI:10.2174/0109298665299157240327084614 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - April 25, 2024 Category: Biochemistry Authors: None Roshanara Shivani A Muthu None Gulafsha Rati Tandon Angamuthu Selvapandiyan Basir Ahmad Source Type: research
Biophysical Evidence for the Amyloid Formation of a Recombinant Rab2 Isoform of Leishmania donovani
CONCLUSION: To our knowledge, this is the first study to report in vitro amyloid-like behaviour of Rab proteins in L donovani. This study provides a novel opportunity to understand the complete biophysical characteristics of Rab2 protein of the lower eukaryote, L. donovani.PMID:38661034 | DOI:10.2174/0109298665299157240327084614 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - April 25, 2024 Category: Biochemistry Authors: None Roshanara Shivani A Muthu None Gulafsha Rati Tandon Angamuthu Selvapandiyan Basir Ahmad Source Type: research
Biophysical Evidence for the Amyloid Formation of a Recombinant Rab2 Isoform of Leishmania donovani
CONCLUSION: To our knowledge, this is the first study to report in vitro amyloid-like behaviour of Rab proteins in L donovani. This study provides a novel opportunity to understand the complete biophysical characteristics of Rab2 protein of the lower eukaryote, L. donovani.PMID:38661034 | DOI:10.2174/0109298665299157240327084614 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - April 25, 2024 Category: Biochemistry Authors: None Roshanara Shivani A Muthu None Gulafsha Rati Tandon Angamuthu Selvapandiyan Basir Ahmad Source Type: research
Biophysical Evidence for the Amyloid Formation of a Recombinant Rab2 Isoform of Leishmania donovani
CONCLUSION: To our knowledge, this is the first study to report in vitro amyloid-like behaviour of Rab proteins in L donovani. This study provides a novel opportunity to understand the complete biophysical characteristics of Rab2 protein of the lower eukaryote, L. donovani.PMID:38661034 | DOI:10.2174/0109298665299157240327084614 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - April 25, 2024 Category: Biochemistry Authors: None Roshanara Shivani A Muthu None Gulafsha Rati Tandon Angamuthu Selvapandiyan Basir Ahmad Source Type: research
Biophysical Evidence for the Amyloid Formation of a Recombinant Rab2 Isoform of Leishmania donovani
CONCLUSION: To our knowledge, this is the first study to report in vitro amyloid-like behaviour of Rab proteins in L donovani. This study provides a novel opportunity to understand the complete biophysical characteristics of Rab2 protein of the lower eukaryote, L. donovani.PMID:38661034 | DOI:10.2174/0109298665299157240327084614 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - April 25, 2024 Category: Biochemistry Authors: None Roshanara Shivani A Muthu None Gulafsha Rati Tandon Angamuthu Selvapandiyan Basir Ahmad Source Type: research
Biophysical Evidence for the Amyloid Formation of a Recombinant Rab2 Isoform of Leishmania donovani
CONCLUSION: To our knowledge, this is the first study to report in vitro amyloid-like behaviour of Rab proteins in L donovani. This study provides a novel opportunity to understand the complete biophysical characteristics of Rab2 protein of the lower eukaryote, L. donovani.PMID:38661034 | DOI:10.2174/0109298665299157240327084614 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - April 25, 2024 Category: Biochemistry Authors: None Roshanara Shivani A Muthu None Gulafsha Rati Tandon Angamuthu Selvapandiyan Basir Ahmad Source Type: research
Expression and Purification of His-Tagged Variants of Human Hepatitis A Virus 3C Protease
CONCLUSION: We demonstrated the applicability of our approach for producing recombinant, enzymatically active 3Cpro.PMID:38644721 | DOI:10.2174/0109298665293548240327082821 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - April 22, 2024 Category: Biochemistry Authors: Maria A Karaseva Vladislav A Gramma Dina R Safina Natalia A Lunina Alexey A Komissarov Sergey V Kostrov Ilya V Demidyuk Source Type: research
Expression and Purification of His-Tagged Variants of Human Hepatitis A Virus 3C Protease
CONCLUSION: We demonstrated the applicability of our approach for producing recombinant, enzymatically active 3Cpro.PMID:38644721 | DOI:10.2174/0109298665293548240327082821 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - April 22, 2024 Category: Biochemistry Authors: Maria A Karaseva Vladislav A Gramma Dina R Safina Natalia A Lunina Alexey A Komissarov Sergey V Kostrov Ilya V Demidyuk Source Type: research
Guanidinium-based Integrated Peptide Dendrimers: Pioneer Nanocarrier in Cancer Therapy
Protein Pept Lett. 2024 Apr 16. doi: 10.2174/0109298665292042240325052536. Online ahead of print.ABSTRACTThe landscape of cancer therapy has witnessed a paradigm shift with the emergence of innovative delivery systems, and Guanidinium-based Peptide Dendrimers have emerged as a vanguard in this transformative journey. With their unique molecular architecture and intrinsic biocompatibility, these dendrimers offer a promising avenue for the targeted delivery of therapeutic cargo in cancer treatment. This comprehensive review delves into the intricate world of Guanidinium- based Peptide Dendrimers, unraveling their structural ...
Source: Protein and Peptide Letters - April 17, 2024 Category: Biochemistry Authors: Dilpreet Singh Lalu Muhammad Irham Amrinder Singh Balak Das Kurmi Source Type: research
Unveiling the Molecular Mechanism of Diosmetin and its Impact on Multifaceted Cellular Signaling Pathways
CONCLUSION: The amalgamation of the review underscores diosmetin's promising role as a multifaceted therapeutic agent, highlighting its potential for drug development and clinical applications.PMID:38629379 | DOI:10.2174/0109298665294109240323033601 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - April 17, 2024 Category: Biochemistry Authors: Krishna Kumar Varshney Jeetendra Kumar Gupta Rajnish Srivastava Source Type: research
Guanidinium-based Integrated Peptide Dendrimers: Pioneer Nanocarrier in Cancer Therapy
Protein Pept Lett. 2024 Apr 16. doi: 10.2174/0109298665292042240325052536. Online ahead of print.ABSTRACTThe landscape of cancer therapy has witnessed a paradigm shift with the emergence of innovative delivery systems, and Guanidinium-based Peptide Dendrimers have emerged as a vanguard in this transformative journey. With their unique molecular architecture and intrinsic biocompatibility, these dendrimers offer a promising avenue for the targeted delivery of therapeutic cargo in cancer treatment. This comprehensive review delves into the intricate world of Guanidinium- based Peptide Dendrimers, unraveling their structural ...
Source: Protein and Peptide Letters - April 17, 2024 Category: Biochemistry Authors: Dilpreet Singh Lalu Muhammad Irham Amrinder Singh Balak Das Kurmi Source Type: research
Unveiling the Molecular Mechanism of Diosmetin and its Impact on Multifaceted Cellular Signaling Pathways
CONCLUSION: The amalgamation of the review underscores diosmetin's promising role as a multifaceted therapeutic agent, highlighting its potential for drug development and clinical applications.PMID:38629379 | DOI:10.2174/0109298665294109240323033601 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - April 17, 2024 Category: Biochemistry Authors: Krishna Kumar Varshney Jeetendra Kumar Gupta Rajnish Srivastava Source Type: research
Guanidinium-based Integrated Peptide Dendrimers: Pioneer Nanocarrier in Cancer Therapy
Protein Pept Lett. 2024 Apr 16. doi: 10.2174/0109298665292042240325052536. Online ahead of print.ABSTRACTThe landscape of cancer therapy has witnessed a paradigm shift with the emergence of innovative delivery systems, and Guanidinium-based Peptide Dendrimers have emerged as a vanguard in this transformative journey. With their unique molecular architecture and intrinsic biocompatibility, these dendrimers offer a promising avenue for the targeted delivery of therapeutic cargo in cancer treatment. This comprehensive review delves into the intricate world of Guanidinium- based Peptide Dendrimers, unraveling their structural ...
Source: Protein and Peptide Letters - April 17, 2024 Category: Biochemistry Authors: Dilpreet Singh Lalu Muhammad Irham Amrinder Singh Balak Das Kurmi Source Type: research
