Dual-step pharmacological intervention for traumatic-like memories: implications from D-cycloserine and cannabidiol or clonidine in male and female rats
ConclusionsThese findings highlight the importance of NMDA receptor signaling in memory destabilization and underscore the efficacy of a dual-step pharmacological intervention in attenuating traumatic-like memories, even in a context different from the original learning environment.Graphical Abstract (Source: Psychopharmacology)
Source: Psychopharmacology - May 1, 2024 Category: Psychiatry Source Type: research
Content analysis of Reddit posts about coadministration of selective serotonin reuptake inhibitors and psilocybin mushrooms
ConclusionsPsilocybin ’s interactions with SSRIs are likely complex and may depend on multiple factors. Prospective studies are needed to evaluate whether psilocybin treatments are reliably safe and effective in the setting of SSRI use. (Source: Psychopharmacology)
Source: Psychopharmacology - April 30, 2024 Category: Psychiatry Source Type: research
In the new era of psychedelic assisted therapy: A systematic review of study methodology in randomized controlled trials
AbstractRecent years have seen a resurgence in randomized, placebo controlled trials (RCTs) utilizing non-classical psychedelics (e.g. 3,4-methyl enedioxy methamphetamine [MDMA]), and classical psychedelics (e.g. psilocybin, lysergic acid diethylamide [LSD], and N,N-dimethyltryptamine [DMT/ayahuasca]) in conjunction with assisted therapy (AT) for psychiatric disorders. A notable methodological challenge in psychedelic AT, however, is the complexity of blinding procedures. The lack of efficacious blinding can introduce considerable response bias, reduce internal validity, and compromise participant retention. This systemati...
Source: Psychopharmacology - April 29, 2024 Category: Psychiatry Source Type: research
Effects of CB1 receptor negative allosteric modulator Org27569 on oxycodone withdrawal symptoms in mice
ConclusionsOrg27569 effects on negative affective-like symptoms were confounded by locomotor effects and effects on gastrointestinal motility were not opioid withdrawal specific. Further studies are needed in a model that produces a more pronounced protracted withdrawal syndrome. (Source: Psychopharmacology)
Source: Psychopharmacology - April 27, 2024 Category: Psychiatry Source Type: research
Long-term second-generation antipsychotics decreases bone formation and resorption in male patients with schizophrenia
ConclusionLong-term SGAs medication inhibited osteogenesis in a dose- and time-dependent manner and damaged the balance of bone formation and bone resorption. (Source: Psychopharmacology)
Source: Psychopharmacology - April 22, 2024 Category: Psychiatry Source Type: research
A rat model of operant negative reinforcement in opioid-dependent males and females
ConclusionsWe introduce an operant negative reinforcement procedure where a subset of opioid-dependent rats learned to lever-press to escape withdrawal-inducing naloxone infusions. The procedure can be used to study mechanisms of individual differences in opioid negative reinforcement-related behaviors in opioid-dependent rats. (Source: Psychopharmacology)
Source: Psychopharmacology - April 20, 2024 Category: Psychiatry Source Type: research
L-DOPA and oxytocin influence the neural correlates of performance monitoring for self and others
ConclusionsThese different behavioral and neural patterns after oxytocin compared to L-DOPA administration highlight a divergent role of each neurochemical in modulating the neural mechanisms underlying social performance monitoring. (Source: Psychopharmacology)
Source: Psychopharmacology - April 19, 2024 Category: Psychiatry Source Type: research
N-(3-((3-(trifluoromethyl)phenyl)selanyl)prop-2-yn-1-yl) benzamide induces antidepressant-like effect in mice: involvement of the serotonergic system
ConclusionThis study pointed a new compound with antidepressant-like effect, and it could be considered for the development of new antidepressants. (Source: Psychopharmacology)
Source: Psychopharmacology - April 18, 2024 Category: Psychiatry Source Type: research
Coenzyme Q10 and exercise training reinstate middle cerebral artery occlusion-induced behavioral deficits and hippocampal long-term potentiation suppression in aging rats
ConclusionCollectively, the findings of the present study imply that 12 weeks of aerobic training and Q10 supplementation alone can simultaneously reverse cerebral ischemia induced neurobehavioral deficits via amelioration of synaptic plasticity and a reduction in cerebral infarction volume in senescent rats. (Source: Psychopharmacology)
Source: Psychopharmacology - April 17, 2024 Category: Psychiatry Source Type: research
Teneurin C-terminal associated peptide (TCAP)-1 attenuates the development and expression of naloxone-precipitated morphine withdrawal in male Swiss Webster mice
ConclusionsThese findings establish TCAP-1 as a potential therapeutic candidate for the prevention and treatment of morphine withdrawal. (Source: Psychopharmacology)
Source: Psychopharmacology - April 17, 2024 Category: Psychiatry Source Type: research
Coenzyme Q10 and exercise training reinstate middle cerebral artery occlusion-induced behavioral deficits and hippocampal long-term potentiation suppression in aging rats
ConclusionCollectively, the findings of the present study imply that 12 weeks of aerobic training and Q10 supplementation alone can simultaneously reverse cerebral ischemia induced neurobehavioral deficits via amelioration of synaptic plasticity and a reduction in cerebral infarction volume in senescent rats. (Source: Psychopharmacology)
Source: Psychopharmacology - April 17, 2024 Category: Psychiatry Source Type: research
Teneurin C-terminal associated peptide (TCAP)-1 attenuates the development and expression of naloxone-precipitated morphine withdrawal in male Swiss Webster mice
ConclusionsThese findings establish TCAP-1 as a potential therapeutic candidate for the prevention and treatment of morphine withdrawal. (Source: Psychopharmacology)
Source: Psychopharmacology - April 17, 2024 Category: Psychiatry Source Type: research
Leveraging meta-regression to test if medication effects on cue-induced craving are associated with clinical efficacy
ConclusionsThe preliminary results of the current study challenge the assumption that alcohol cue-reactivity alone can be used as an early efficacy indicator for AUD pharmacotherapy development. These findings suggest that a wider range of early efficacy indicators and experimental paradigms be considered for Phase II testing of novel compounds. (Source: Psychopharmacology)
Source: Psychopharmacology - April 13, 2024 Category: Psychiatry Source Type: research
