Comparison of Novel Proteomic Expression Profiles for Radiation Exposure in Male and Female C57BL6 Mice
Radiat Res. 2024 Apr 30. doi: 10.1667/RADE-23-00180.1. Online ahead of print.ABSTRACTThere is a need for point-of-care diagnostics for future mass casualty events involving radiation exposure. The development of radiation exposure and dose prediction algorithms for biodosimetry is needed for screening of large populations during these scenarios, and exploration of the potential effects which sex, age, genetic heterogeneity, and physiological comorbidities may have on the utility of biodosimetry diagnostics is needed. In the current study, proteomic profiling was used to examine sex-specific differences in age-matched C57BL...
Source: Radiation Research - April 29, 2024 Category: Physics Authors: M Sproull Y Fan Q Chen D Meerzaman K Camphausen Source Type: research
Comparison of Novel Proteomic Expression Profiles for Radiation Exposure in Male and Female C57BL6 Mice
Radiat Res. 2024 Apr 30. doi: 10.1667/RADE-23-00180.1. Online ahead of print.ABSTRACTThere is a need for point-of-care diagnostics for future mass casualty events involving radiation exposure. The development of radiation exposure and dose prediction algorithms for biodosimetry is needed for screening of large populations during these scenarios, and exploration of the potential effects which sex, age, genetic heterogeneity, and physiological comorbidities may have on the utility of biodosimetry diagnostics is needed. In the current study, proteomic profiling was used to examine sex-specific differences in age-matched C57BL...
Source: Radiation Research - April 29, 2024 Category: Physics Authors: M Sproull Y Fan Q Chen D Meerzaman K Camphausen Source Type: research
Comparison of Novel Proteomic Expression Profiles for Radiation Exposure in Male and Female C57BL6 Mice
Radiat Res. 2024 Apr 30. doi: 10.1667/RADE-23-00180.1. Online ahead of print.ABSTRACTThere is a need for point-of-care diagnostics for future mass casualty events involving radiation exposure. The development of radiation exposure and dose prediction algorithms for biodosimetry is needed for screening of large populations during these scenarios, and exploration of the potential effects which sex, age, genetic heterogeneity, and physiological comorbidities may have on the utility of biodosimetry diagnostics is needed. In the current study, proteomic profiling was used to examine sex-specific differences in age-matched C57BL...
Source: Radiation Research - April 29, 2024 Category: Physics Authors: M Sproull Y Fan Q Chen D Meerzaman K Camphausen Source Type: research
Comparison of Novel Proteomic Expression Profiles for Radiation Exposure in Male and Female C57BL6 Mice
Radiat Res. 2024 Apr 30. doi: 10.1667/RADE-23-00180.1. Online ahead of print.ABSTRACTThere is a need for point-of-care diagnostics for future mass casualty events involving radiation exposure. The development of radiation exposure and dose prediction algorithms for biodosimetry is needed for screening of large populations during these scenarios, and exploration of the potential effects which sex, age, genetic heterogeneity, and physiological comorbidities may have on the utility of biodosimetry diagnostics is needed. In the current study, proteomic profiling was used to examine sex-specific differences in age-matched C57BL...
Source: Radiation Research - April 29, 2024 Category: Physics Authors: M Sproull Y Fan Q Chen D Meerzaman K Camphausen Source Type: research
Comparison of Novel Proteomic Expression Profiles for Radiation Exposure in Male and Female C57BL6 Mice
Radiat Res. 2024 Apr 30. doi: 10.1667/RADE-23-00180.1. Online ahead of print.ABSTRACTThere is a need for point-of-care diagnostics for future mass casualty events involving radiation exposure. The development of radiation exposure and dose prediction algorithms for biodosimetry is needed for screening of large populations during these scenarios, and exploration of the potential effects which sex, age, genetic heterogeneity, and physiological comorbidities may have on the utility of biodosimetry diagnostics is needed. In the current study, proteomic profiling was used to examine sex-specific differences in age-matched C57BL...
Source: Radiation Research - April 29, 2024 Category: Physics Authors: M Sproull Y Fan Q Chen D Meerzaman K Camphausen Source Type: research
Comparison of Novel Proteomic Expression Profiles for Radiation Exposure in Male and Female C57BL6 Mice
Radiat Res. 2024 Apr 30. doi: 10.1667/RADE-23-00180.1. Online ahead of print.ABSTRACTThere is a need for point-of-care diagnostics for future mass casualty events involving radiation exposure. The development of radiation exposure and dose prediction algorithms for biodosimetry is needed for screening of large populations during these scenarios, and exploration of the potential effects which sex, age, genetic heterogeneity, and physiological comorbidities may have on the utility of biodosimetry diagnostics is needed. In the current study, proteomic profiling was used to examine sex-specific differences in age-matched C57BL...
Source: Radiation Research - April 29, 2024 Category: Physics Authors: M Sproull Y Fan Q Chen D Meerzaman K Camphausen Source Type: research
Single-dose Administration of Recombinant Human Thrombopoietin Enhances Survival and Hematopoietic Reconstruction in Canines Irradiated with 3 Gy Gamma Radiation
Radiat Res. 2024 Apr 29. doi: 10.1667/RADE-23-00206.1. Online ahead of print.ABSTRACTWe conducted this study to investigate the radioprotective effects of recombinant human thrombopoietin (rhTPO) on beagle dogs irradiated with 3.0 Gy 60Co gamma rays. Fifteen healthy adult beagles were randomly assigned to a control group with alleviating care, and 5 and 10 μg/kg rhTPO treatment group. All animals received total-body irradiation using 60Co γ-ray source at a dose of 3.0 Gy (dose rate was 69.1 cGy/min). The treatment group received intramuscular injection of rhTPO 5 and 10 μg/kg at 2 h postirradiation, and the control grou...
Source: Radiation Research - April 28, 2024 Category: Physics Authors: Jinkun Yang Hao Luan Xing Shen Guolin Xiong Xun Wang Xuewen Zhang Wenyu Ji Ying Jiang Yangyang Dai Enqi Zhang Hongling Ou Yuwen Cong Xinru Wang Shuang Xing Zuyin Yu Source Type: research
Single-dose Administration of Recombinant Human Thrombopoietin Enhances Survival and Hematopoietic Reconstruction in Canines Irradiated with 3 Gy Gamma Radiation
Radiat Res. 2024 Apr 29. doi: 10.1667/RADE-23-00206.1. Online ahead of print.ABSTRACTWe conducted this study to investigate the radioprotective effects of recombinant human thrombopoietin (rhTPO) on beagle dogs irradiated with 3.0 Gy 60Co gamma rays. Fifteen healthy adult beagles were randomly assigned to a control group with alleviating care, and 5 and 10 μg/kg rhTPO treatment group. All animals received total-body irradiation using 60Co γ-ray source at a dose of 3.0 Gy (dose rate was 69.1 cGy/min). The treatment group received intramuscular injection of rhTPO 5 and 10 μg/kg at 2 h postirradiation, and the control grou...
Source: Radiation Research - April 28, 2024 Category: Physics Authors: Jinkun Yang Hao Luan Xing Shen Guolin Xiong Xun Wang Xuewen Zhang Wenyu Ji Ying Jiang Yangyang Dai Enqi Zhang Hongling Ou Yuwen Cong Xinru Wang Shuang Xing Zuyin Yu Source Type: research
Radiation Biological Toximetry Using Circulating Cell-Free DNA (cfDNA) for Rapid Radiation/Nuclear Triage
Radiat Res. 2024 Apr 25. doi: 10.1667/RADE-23-00159.1. Online ahead of print.ABSTRACTOptimal triage biodosimetry would include risk stratification within minutes, and it would provide useful triage despite heterogeneous dosimetry, cytokine therapy, mixed radiation quality, race, and age. For regulatory approval, the U.S. Food and Drug Administration (FDA) Biodosimetry Guidance requires suitability for purpose and a validated species-independent mechanism. Circulating cell-free DNA (cfDNA) concentration assays may provide such triage information. To test this hypothesis, cfDNA concentrations were measured in unprocessed mon...
Source: Radiation Research - April 25, 2024 Category: Physics Authors: Paul Okunieff Steven G Swarts Bruce Fenton Stephen B Zhang Zhenhuan Zhang Lori Rice Daohong Zhou France Carrier Lurong Zhang Source Type: research
Radiation Biological Toximetry Using Circulating Cell-Free DNA (cfDNA) for Rapid Radiation/Nuclear Triage
Radiat Res. 2024 Apr 25. doi: 10.1667/RADE-23-00159.1. Online ahead of print.ABSTRACTOptimal triage biodosimetry would include risk stratification within minutes, and it would provide useful triage despite heterogeneous dosimetry, cytokine therapy, mixed radiation quality, race, and age. For regulatory approval, the U.S. Food and Drug Administration (FDA) Biodosimetry Guidance requires suitability for purpose and a validated species-independent mechanism. Circulating cell-free DNA (cfDNA) concentration assays may provide such triage information. To test this hypothesis, cfDNA concentrations were measured in unprocessed mon...
Source: Radiation Research - April 25, 2024 Category: Physics Authors: Paul Okunieff Steven G Swarts Bruce Fenton Stephen B Zhang Zhenhuan Zhang Lori Rice Daohong Zhou France Carrier Lurong Zhang Source Type: research
Radiation Biological Toximetry Using Circulating Cell-Free DNA (cfDNA) for Rapid Radiation/Nuclear Triage
Radiat Res. 2024 Apr 25. doi: 10.1667/RADE-23-00159.1. Online ahead of print.ABSTRACTOptimal triage biodosimetry would include risk stratification within minutes, and it would provide useful triage despite heterogeneous dosimetry, cytokine therapy, mixed radiation quality, race, and age. For regulatory approval, the U.S. Food and Drug Administration (FDA) Biodosimetry Guidance requires suitability for purpose and a validated species-independent mechanism. Circulating cell-free DNA (cfDNA) concentration assays may provide such triage information. To test this hypothesis, cfDNA concentrations were measured in unprocessed mon...
Source: Radiation Research - April 25, 2024 Category: Physics Authors: Paul Okunieff Steven G Swarts Bruce Fenton Stephen B Zhang Zhenhuan Zhang Lori Rice Daohong Zhou France Carrier Lurong Zhang Source Type: research
Updated Analysis of Radon Exposure and Lung Cancer Mortality in the Cohort of Newfoundland Fluorspar Miners (1950-2016)
Radiat Res. 2024 Apr 23. doi: 10.1667/RADE-23-00114.1. Online ahead of print.ABSTRACTThe commercial mining of fluorspar in St. Lawrence Newfoundland began in 1933. Miners who worked underground were exposed to high levels of radon progeny, especially before ventilation was introduced into the mines in 1960. The mean cumulative radon exposure for underground miners in this cohort was 380.9 working level months (WLM). A series of studies of this cohort have characterized the increased risks of lung cancer mortality due to radon. We have extended the follow-up of this cohort an additional 15 years to provide additional insigh...
Source: Radiation Research - April 22, 2024 Category: Physics Authors: Paul J Villeneuve Howard I Morrison Rachel Lane Source Type: research
Updated Analysis of Radon Exposure and Lung Cancer Mortality in the Cohort of Newfoundland Fluorspar Miners (1950-2016)
Radiat Res. 2024 Apr 23. doi: 10.1667/RADE-23-00114.1. Online ahead of print.ABSTRACTThe commercial mining of fluorspar in St. Lawrence Newfoundland began in 1933. Miners who worked underground were exposed to high levels of radon progeny, especially before ventilation was introduced into the mines in 1960. The mean cumulative radon exposure for underground miners in this cohort was 380.9 working level months (WLM). A series of studies of this cohort have characterized the increased risks of lung cancer mortality due to radon. We have extended the follow-up of this cohort an additional 15 years to provide additional insigh...
Source: Radiation Research - April 22, 2024 Category: Physics Authors: Paul J Villeneuve Howard I Morrison Rachel Lane Source Type: research
Effects of Partial-Body, Continuous/Pulse Irradiation at Dose Rates from Flash to Conventional Rates on The Level of Surviving Blood Lymphocytes: Modeling Approach II. Two- and Multiple-Pulse Irradiation
Radiat Res. 2024 Apr 16. doi: 10.1667/RADE-23-00221.1. Online ahead of print.ABSTRACTMathematical models, which describe effects of partial-body, two- and multiple-pulse irradiation at high total doses D and at average dose rates N from FLASH to conventional rates on the level of surviving blood lymphocytes in humans and mice, have been developed originating in the previously proposed approach. These models predict that levels of surviving blood lymphocytes in humans and mice increase with increasing the dose rate from N = D / TR (TR is the time of the blood flowing into or out of the irradiated segment of the blood circul...
Source: Radiation Research - April 16, 2024 Category: Physics Authors: Francis A Cucinotta Olga A Smirnova Source Type: research
Effects of Partial-Body, Continuous/Pulse Irradiation at Dose Rates from Flash to Conventional Rates on The Level of Surviving Blood Lymphocytes: Modeling Approach II. Two- and Multiple-Pulse Irradiation
Radiat Res. 2024 Apr 16. doi: 10.1667/RADE-23-00221.1. Online ahead of print.ABSTRACTMathematical models, which describe effects of partial-body, two- and multiple-pulse irradiation at high total doses D and at average dose rates N from FLASH to conventional rates on the level of surviving blood lymphocytes in humans and mice, have been developed originating in the previously proposed approach. These models predict that levels of surviving blood lymphocytes in humans and mice increase with increasing the dose rate from N = D / TR (TR is the time of the blood flowing into or out of the irradiated segment of the blood circul...
Source: Radiation Research - April 16, 2024 Category: Physics Authors: Francis A Cucinotta Olga A Smirnova Source Type: research
