Clinical outcomes associated with neoadjuvant therapy for the treatment of resectable non-small cell lung cancer in real-world practice
CONCLUSIONS: Neoadjuvant treatment with a combination of immunotherapy plus chemotherapy appears to achieve higher radiological and pathological responses than monotherapy for IIA-IIIB NSCLC. Log-rank analysis showed that a better outcome could be expected in patients with the addition of immunotherapy to neoadjuvant chemotherapy if compared with patients with chemotherapy alone in terms of DFS.PMID:38693705 | DOI:10.1111/crj.13761 (Source: Respiratory Care)
Source: Respiratory Care - May 2, 2024 Category: Respiratory Medicine Authors: Xiaojie Huang Guanchao Pang Zhirong Mao Baizhou Li Zhihua Teng Yan Yang Zijian Qiu Xiuxiu Chen Pingli Wang Source Type: research
Preoperative frailty screening in elderly patients with non-small cell lung cancer surgery: an essential step for a good surgical outcome
Expert Rev Respir Med. 2024 May 1. doi: 10.1080/17476348.2024.2349579. Online ahead of print.ABSTRACTINTRODUCTION: Non-small cell lung cancer (NSCLC) is a disease commonly diagnosed in the elderly, often in advanced stages. However, elderly patients with lung cancer can benefit from surgery, provided that postoperative risks are assessed appropriately before surgery. Frailty is a measure of age-related impaired functional status and a predictor of mortality and morbidity. However, its importance as a preoperative marker is not well defined.AREAS COVERED: This systematic review discusses the importance of preoperative frail...
Source: Respiratory Care - May 1, 2024 Category: Respiratory Medicine Authors: Sabina Antonela Antoniu Radu Iacobescu Alina Delia Popa Mariana Pavel-Tanase Teodora Alexa Stratulat Source Type: research
Watching an Evolution in Progress, Cutting-Edge Research Transforming Outcomes in Interstitial Lung Disease: Introduction to an < em > AJRCCM < /em > Special Issue
Am J Respir Crit Care Med. 2024 May 1;209(9):1049-1050. doi: 10.1164/rccm.202404-0675ED.NO ABSTRACTPMID:38690973 | DOI:10.1164/rccm.202404-0675ED (Source: Respiratory Care)
Source: Respiratory Care - May 1, 2024 Category: Respiratory Medicine Authors: Toby M Maher Anna J Podolanczuk Wonder P Drake Patricia J Sime Oliver Eickelberg Dawn L DeMeo Luca Richeldi Source Type: research
May 1 Highlight
Am J Respir Crit Care Med. 2024 May 1;209(9):xxxii-xxxiv. doi: 10.1164/rccm.209i9xxxii.NO ABSTRACTPMID:38690974 | DOI:10.1164/rccm.209i9xxxii (Source: Respiratory Care)
Source: Respiratory Care - May 1, 2024 Category: Respiratory Medicine Source Type: research
Enrichment Strategies for Systemic Sclerosis-Interstitial Lung Disease Trials
Am J Respir Crit Care Med. 2024 May 1;209(9):1067-1068. doi: 10.1164/rccm.202401-0246ED.NO ABSTRACTPMID:38690975 | DOI:10.1164/rccm.202401-0246ED (Source: Respiratory Care)
Source: Respiratory Care - May 1, 2024 Category: Respiratory Medicine Authors: Elizabeth R Volkmann Donald P Tashkin Source Type: research
The Controversy Continues: Whether to Perform Plasma Exchange, and with What Dose of Steroids, in the PEXIVAS Trial
Am J Respir Crit Care Med. 2024 May 1;209(9):1062-1064. doi: 10.1164/rccm.202402-0424ED.NO ABSTRACTPMID:38690976 | DOI:10.1164/rccm.202402-0424ED (Source: Respiratory Care)
Source: Respiratory Care - May 1, 2024 Category: Respiratory Medicine Authors: Marilyn K Glassberg Alissa Ali Gina Gregorini Source Type: research
The Fats and the Furious: Unraveling the Role of Macrophage Lipid Metabolism in Sarcoidosis
Am J Respir Crit Care Med. 2024 May 1;209(9):1064-1066. doi: 10.1164/rccm.202402-0287ED.NO ABSTRACTPMID:38690977 | DOI:10.1164/rccm.202402-0287ED (Source: Respiratory Care)
Source: Respiratory Care - May 1, 2024 Category: Respiratory Medicine Authors: Anneka Hutton Jessy S Deshane Source Type: research
Cough in Fibrotic Interstitial Lung Disease: Effects and Implications
Am J Respir Crit Care Med. 2024 May 1. doi: 10.1164/rccm.202404-0683ED. Online ahead of print.NO ABSTRACTPMID:38691820 | DOI:10.1164/rccm.202404-0683ED (Source: Respiratory Care)
Source: Respiratory Care - May 1, 2024 Category: Respiratory Medicine Authors: Jessica E Channick Jeff Swigris Source Type: research
Reconsidering the Role of Isoniazid in Drug-resistant Tuberculosis
Am J Respir Crit Care Med. 2024 May 1. doi: 10.1164/rccm.202403-0628ED. Online ahead of print.NO ABSTRACTPMID:38691825 | DOI:10.1164/rccm.202403-0628ED (Source: Respiratory Care)
Source: Respiratory Care - May 1, 2024 Category: Respiratory Medicine Authors: Geraint R Davies Source Type: research
Early Mortality in Clinical Trials of Acute Respiratory Distress Syndrome
Am J Respir Crit Care Med. 2024 May 1. doi: 10.1164/rccm.202402-0318LE. Online ahead of print.NO ABSTRACTPMID:38691826 | DOI:10.1164/rccm.202402-0318LE (Source: Respiratory Care)
Source: Respiratory Care - May 1, 2024 Category: Respiratory Medicine Authors: Vassilis G Giannakoulis Edward J Schenck Eleni Papoutsi David R Price Jes ús Villar Hina Sarwath Frank Schmidt B Taylor Thompson Augustine M K Choi Ilias I Siempos Source Type: research
Risk factors for asthma-related hospital and intensive care admissions in children, adolescents and adults: a cohort study using primary and secondary care data
CONCLUSIONS: There are significant sociodemographic inequalities in the rates of asthma-related hospital and ICU admissions. Treating age-specific modifiable risk factors should be considered an integral part of asthma management, which could potentially reduce the rate of avoidable hospital admissions.PMID:38692709 | DOI:10.1136/bmjresp-2023-001746 (Source: Respiratory Care)
Source: Respiratory Care - May 1, 2024 Category: Respiratory Medicine Authors: Nikita Simms-Williams Prasad Nagakumar Rasiah Thayakaran Nicola J Adderley Richard Hotham Adel H Mansur Krishnarajah Nirantharakumar Shamil Haroon Source Type: research
Lack of racial and ethnic disparities in mortality in minority patients hospitalised with COVID-19 in a mid-Atlantic healthcare system
DISCUSSION: In this large multihospital cohort of patients admitted with COVID-19, non-Hispanic black and Hispanic patients did not have worse outcomes than white patients. Such findings likely reflect how the complex range of factors that resulted in a life-threatening and disproportionate impact of incidence on certain vulnerable populations by COVID-19 in the community was offset through admission at well-resourced hospitals and healthcare systems. However, there continues to remain a need for efforts to address the significant pre-existing race and ethnicity inequities highlighted by the COVID-19 pandemic to be better ...
Source: Respiratory Care - May 1, 2024 Category: Respiratory Medicine Authors: Panagis Galiatsatos Brian Garibaldi Dapeng Yao Yanxun Xu Jamie Perin Andi Shahu John W Jackson Damani Piggott Oluwaseun Falade-Nwulia Jocelyn Shubella Henry Michtalik Harolyn M E Belcher Nadia N Hansel Sherita Golden Source Type: research
Mixed-methods evaluation of an enhanced asthma biologics clinical pathway in the West Midlands UK
We report a mixed-methods evaluation of an enhanced severe asthma pathway implemented in Staffordshire and Stoke-on-Trent, UK which aimed to optimise primary care referrals through training/education, and increased capacity in specialist clinics. Quantitative analysis assessed patient wait times between pathway stages, prescribing changes, exacerbations, hospital admissions and asthma control. Interviews with 12 stakeholders evaluated perceptions of the enhanced pathway across settings. In 12 months, 564 patients from 28 general practices were reviewed for biologics eligibility, of whom 125 (22.2%) were referred for specia...
Source: Respiratory Care - May 1, 2024 Category: Respiratory Medicine Authors: Sarah Damery Janet Jones Elfatih Idris Angela Cooper Holly Minshall Chris Clowes Kate Jolly Source Type: research
Preoperative frailty screening in elderly patients with non-small cell lung cancer surgery: an essential step for a good surgical outcome
Expert Rev Respir Med. 2024 May 1. doi: 10.1080/17476348.2024.2349579. Online ahead of print.ABSTRACTINTRODUCTION: Non-small cell lung cancer (NSCLC) is a disease commonly diagnosed in the elderly, often in advanced stages. However, elderly patients with lung cancer can benefit from surgery, provided that postoperative risks are assessed appropriately before surgery. Frailty is a measure of age-related impaired functional status and a predictor of mortality and morbidity. However, its importance as a preoperative marker is not well defined.AREAS COVERED: This systematic review discusses the importance of preoperative frail...
Source: Respiratory Care - May 1, 2024 Category: Respiratory Medicine Authors: Sabina Antonela Antoniu Radu Iacobescu Alina Delia Popa Mariana Pavel-Tanase Teodora Alexa Stratulat Source Type: research
Causal influence of gut microbiota on small cell lung cancer: a Mendelian randomization study
CONCLUSION: We identified potential causal relationships between certain gut microbiota and SCLC, offering new insights into microbiome-mediated mechanisms of SCLC pathogenesis, resistance, mutations, and more.PMID:38685730 | DOI:10.1111/crj.13764 (Source: Respiratory Care)
Source: Respiratory Care - April 30, 2024 Category: Respiratory Medicine Authors: Wenjing Yang Xinxia Fan Wangshu Li Yan Chen Source Type: research
