Acute respiratory failure due to pulmonary exacerbation in children with cystic fibrosis admitted in a pediatric intensive care unit: outcomes and factors associated with mortality
Children with advanced pulmonary disease due to cystic fibrosis (CF) are at risk of acute respiratory failure due to pulmonary exacerbations leading to their admission to pediatric intensive care units (PICU).... (Source: Respiratory Research)
Source: Respiratory Research - April 29, 2024 Category: Respiratory Medicine Authors: David Drummond, Charlotte Roy, Matthieu Cornet, Julie Bucher, V éronique Boussaud, Françoise Le Pimpec-Barthes, Margaux Pontailler, Olivier Raisky, Vanessa Lopez, Claudio Barbanti, Romain Guillemain, Sylvain Renolleau, Marion Grimaud, Mehdi Oualha, Laur Tags: Research Source Type: research
Smoking status and clinical outcome in idiopathic pulmonary fibrosis: a nationwide study
Smoking status has been linked to the development of idiopathic pulmonary fibrosis (IPF). However, the effect of smoking on the prognosis of patients with IPF is unclear. We aimed to investigate the associatio... (Source: Respiratory Research)
Source: Respiratory Research - April 29, 2024 Category: Respiratory Medicine Authors: Hee-Young Yoon, Hoseob Kim, Yoonjong Bae and Jin Woo Song Tags: Research Source Type: research
Melatonin improves influenza virus infection-induced acute exacerbation of COPD by suppressing macrophage M1 polarization and apoptosis
Influenza A viruses (IAV) are extremely common respiratory viruses for the acute exacerbation of chronic obstructive pulmonary disease (AECOPD), in which IAV infection may further evoke abnormal macrophage pol... (Source: Respiratory Research)
Source: Respiratory Research - April 27, 2024 Category: Respiratory Medicine Authors: Meng-Meng Xu, Jia-Ying Kang, Qiu-Yan Wang, Xing Zuo, Yuan-Yuan Tan, Yuan-Yuan Wei, Da-Wei Zhang, Ling Zhang, Hui-Mei Wu and Guang-He Fei Tags: Original Article Source Type: research
Predicting lung function decline in cystic fibrosis: the impact of initiating ivacaftor therapy
Modulator therapies that seek to correct the underlying defect in cystic fibrosis (CF) have revolutionized the clinical landscape. Given the heterogeneous nature of lung disease progression in the post-modulat... (Source: Respiratory Research)
Source: Respiratory Research - April 27, 2024 Category: Respiratory Medicine Authors: Grace C. Zhou, Ziyun Wang, Anushka K. Palipana, Eleni-Rosalina Andrinopoulou, Pedro Miranda Afonso, Gary L. McPhail, Christopher M. Siracusa, Emrah Gecili and Rhonda D. Szczesniak Tags: Research Source Type: research
TRPV2 modulates mechanically Induced ATP Release from Human bronchial epithelial cells
Repetitive bouts of coughing expose the large airways to significant cycles of shear stress. This leads to the release of alarmins and the tussive agent adenosine triphosphate (ATP) which may be modulated by t... (Source: Respiratory Research)
Source: Respiratory Research - April 27, 2024 Category: Respiratory Medicine Authors: Orla M. Dunne, S. Lorraine Martin, Gerard P. Sergeant, Daniel F. McAuley, Cecilia M. O ’Kane, Brian Button, Lorcan P. McGarvey and Fionnuala T. Lundy Tags: Research Source Type: research
Potential role of SIRT-1 and SIRT-3 as biomarkers for the diagnosis and prognosis of idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a debilitating and progressive lung disease of unknown aetiology, characterized by the relentless deposition of fibrotic tissue. Biomarkers may play a pivotal role as ind... (Source: Respiratory Research)
Source: Respiratory Research - April 27, 2024 Category: Respiratory Medicine Authors: Fabio Perrotta, Vito D ’Agnano, Domenica Francesca Mariniello, Giuseppe Castaldo, Maria Vitale, Mario Cazzola, Andrea Bianco and Filippo Scialò Tags: Research Source Type: research
Respiratory symptoms and outcomes among cigar smokers: findings from the Population Assessment of Tobacco and Health (PATH) study waves 2 –5 (2014–2019)
The mechanisms by which cigarette smoking increases the risk of respiratory disease have been studied. However, less is known about risks of respiratory symptoms and outcomes associated with smoking cigars, an... (Source: Respiratory Research)
Source: Respiratory Research - April 27, 2024 Category: Respiratory Medicine Authors: Eva Sharma, Kristin Lauten, Katarzyna A. Zebrak, Kathryn C. Edwards, Samantha VanEtten, Adam F. Benson, Cristine D. Delnevo, Daniela Marshall, Heather L. Kimmel, Kristie A. Taylor, Maansi Bansal-Travers, Andrew Hyland and K. Michael Cummings Tags: Research Source Type: research
Electrical Impedance Tomography as a monitoring tool during weaning from mechanical ventilation: an observational study during the spontaneous breathing trial
Prolonged weaning from mechanical ventilation is associated with poor clinical outcome. Therefore, choosing the right moment for weaning and extubation is essential. Electrical Impedance Tomography (EIT) is a ... (Source: Respiratory Research)
Source: Respiratory Research - April 25, 2024 Category: Respiratory Medicine Authors: Jantine J. Wisse, Tom G. Goos, Annemijn H. Jonkman, Peter Somhorst, Irwin K. M. Reiss, Henrik Endeman and Diederik Gommers Tags: Research Source Type: research
In vitro platform to model the function of ionocytes in the human airway epithelium
Pulmonary ionocytes have been identified in the airway epithelium as a small population of ion transporting cells expressing high levels of CFTR (cystic fibrosis transmembrane conductance regulator), the gene mut... (Source: Respiratory Research)
Source: Respiratory Research - April 25, 2024 Category: Respiratory Medicine Authors: Marta Vil à-González, Laetitia Pinte, Ricardo Fradique, Erika Causa, Heleen Kool, Mayuree Rodrat, Carola Maria Morell, Maha Al-Thani, Linsey Porter, Wenrui Guo, Ruhina Maeshima, Stephen L. Hart, Frank McCaughan, Alessandra Granata, David N. Sheppard, R. Tags: Research Source Type: research
Differential expression and analysis of extrachromosomal circular DNAs as serum biomarkers in pulmonary arterial hypertension
Extrachromosomal circular DNAs (eccDNAs) have been reported to play a key role in the occurrence and development of various diseases. However, the characterization and role of eccDNAs in pulmonary arterial hyp... (Source: Respiratory Research)
Source: Respiratory Research - April 25, 2024 Category: Respiratory Medicine Authors: Chun Zhang, Qiang Du, Xiao Zhou, Tianyu Qu, Yingying Liu, Kai Ma, Ziling Shen, Qun Wang, Zaikui Zhang and Ruifeng Zhang Tags: Research Source Type: research
Neutrophil extracellular traps promote proliferation of pulmonary smooth muscle cells mediated by CCDC25 in pulmonary arterial hypertension
Previous studies have indicated that neutrophil extracellular traps (NETs) play a pivotal role in pathogenesis of pulmonary arterial hypertension (PAH). However, the specific mechanism underlying the impact of... (Source: Respiratory Research)
Source: Respiratory Research - April 25, 2024 Category: Respiratory Medicine Authors: Hongxiao Sun, Zhanhui Du, Xu Zhang, Shuai Gao, Zhixian Ji, Gang Luo and Silin Pan Tags: Research Source Type: research
Individualized rotation of left double lumen endobronchial tube to improve placement success rate: a randomized controlled trial
In conventional practice, the left double lumen tube (DLT) is rotated 90 ° counterclockwise when the endobronchial cuff passes glottis. Success rate upon the first attempt is (Source: Respiratory Research)
Source: Respiratory Research - April 25, 2024 Category: Respiratory Medicine Authors: Huiying Zhou, Yuda Fei, Yuelun Zhang, Xiang Quan and Jie Yi Tags: Research Source Type: research
Downregulation of HMGCS2 mediated AECIIs lipid metabolic alteration promotes pulmonary fibrosis by activating fibroblasts
Abnormal lipid metabolism has recently been reported as a crucial signature of idiopathic pulmonary fibrosis (IPF). However, the origin and biological function of the lipid and possible mechanisms of increased... (Source: Respiratory Research)
Source: Respiratory Research - April 24, 2024 Category: Respiratory Medicine Authors: Juntang Yang, Xin Pan, Min Xu, Yingge Li, Chenxi Liang, Lulu Liu, Zhongzheng Li, Lan Wang and Guoying Yu Tags: Research Source Type: research
PI3K γδ inhibition suppresses key disease features in a rat model of asthma
Two isoforms of Phosphoinositide 3-kinase (PI3K), p110 γ and p110δ, are predominantly expressed in leukocytes and represent attractive therapeutic targets for the treatment of allergic asthma. The study aim was... (Source: Respiratory Research)
Source: Respiratory Research - April 23, 2024 Category: Respiratory Medicine Authors: James W. Pinkerton, Silvia Preite, Antonio Piras, Dimitrios Zervas, Thomais Markou, Mark S. Freeman, Tobias Hofving, Emil Ivarsson, Sara J. Bonvini, Wayne Brailsford, Linda Yrlid, Maria G. Belvisi and Mark A. Birrell Tags: Research Source Type: research
Bacterial interactome disturbance in chronic obstructive pulmonary disease clinical stability and exacerbations
Our understanding of airway dysbiosis in chronic obstructive pulmonary disease (COPD) remains incomplete, which may be improved by unraveling the complexity in microbial interactome. (Source: Respiratory Research)
Source: Respiratory Research - April 20, 2024 Category: Respiratory Medicine Authors: Wei Xiao, Yi-long Chen, Long-yi Du, Jiqiu Wu, Zhang Wang, Bing Mao, Fu-qiang Wen, Peter Gerard Gibson, Vanessa M. McDonald, Haopeng Yu and Juan-juan Fu Tags: Research Source Type: research
