Nude blebs expose cells to phagocytes
Sci Signal. 2024 Apr 30;17(834):eadq0353. doi: 10.1126/scisignal.adq0353. Epub 2024 Apr 30.ABSTRACTDisplacement of the glycocalyx by membrane blebbing enables macrophages to recognize apoptotic cells.PMID:38687824 | DOI:10.1126/scisignal.adq0353 (Source: Science Signaling)
Source: Science Signaling - April 30, 2024 Category: Biomedical Science Authors: Annalisa M VanHook Source Type: research
Inhibiting Hippo pathway kinases releases WWC1 to promote AMPAR-dependent synaptic plasticity and long-term memory in mice
Sci Signal. 2024 Apr 30;17(834):eadj6603. doi: 10.1126/scisignal.adj6603. Epub 2024 Apr 30.ABSTRACTThe localization, number, and function of postsynaptic AMPA-type glutamate receptors (AMPARs) are crucial for synaptic plasticity, a cellular correlate for learning and memory. The Hippo pathway member WWC1 is an important component of AMPAR-containing protein complexes. However, the availability of WWC1 is constrained by its interaction with the Hippo pathway kinases LATS1 and LATS2 (LATS1/2). Here, we explored the biochemical regulation of this interaction and found that it is pharmacologically targetable in vivo. In primar...
Source: Science Signaling - April 30, 2024 Category: Biomedical Science Authors: Jens Stepan Daniel E Heinz Frederik Dethloff Svenja Wiechmann Silvia Martinelli Kathrin Hafner Tim Ebert Ellen Junglas Alexander S H äusl Max L P öhlmann Mira Jakovcevski Julius C Pape Anthony S Zannas Thomas Bajaj Anke Hermann Xiao Ma Hermann Pavenst à Source Type: research
Targeting the postsynaptic scaffolding protein PSD-95 enhances BDNF signaling to mitigate depression-like behaviors in mice
Sci Signal. 2024 Apr 30;17(834):eadn4556. doi: 10.1126/scisignal.adn4556. Epub 2024 Apr 30.ABSTRACTSignaling mediated by brain-derived neurotrophic factor (BDNF), which is supported by the postsynaptic scaffolding protein PSD-95, has antidepressant effects. Conversely, clinical depression is associated with reduced BDNF signaling. We found that peptidomimetic compounds that bind to PSD-95 promoted signaling by the BDNF receptor TrkB in the hippocampus and reduced depression-like behaviors in mice. The compounds CN2097 and Syn3 both bind to the PDZ3 domain of PSD-95, and Syn3 also binds to an α-helical region of the protei...
Source: Science Signaling - April 30, 2024 Category: Biomedical Science Authors: Xin Shi Xiao-Zhong Zhou Gang Chen Wei-Feng Luo Chengyu Zhou Tian-Ju He Mandar T Naik Qin Jiang John Marshall Cong Cao Source Type: research
TNF- α signals through ITK-Akt-mTOR to drive CD4 < sup > + < /sup > T cell metabolic reprogramming, which is dysregulated in rheumatoid arthritis
Sci Signal. 2024 Apr 23;17(833):eadg5678. doi: 10.1126/scisignal.adg5678. Epub 2024 Apr 23.ABSTRACTUpon activation, T cells undergo metabolic reprogramming to meet the bioenergetic demands of clonal expansion and effector function. Because dysregulated T cell cytokine production and metabolic phenotypes coexist in chronic inflammatory disease, including rheumatoid arthritis (RA), we investigated whether inflammatory cytokines released by differentiating T cells amplified their metabolic changes. We found that tumor necrosis factor-α (TNF-α) released by human naïve CD4+ T cells upon activation stimulated the expression o...
Source: Science Signaling - April 23, 2024 Category: Biomedical Science Authors: Emma L Bishop Nancy Gudgeon Taylor Fulton-Ward Victoria Stavrou Jennie Roberts Adam Boufersaoui Daniel A Tennant Martin Hewison Karim Raza Sarah Dimeloe Source Type: research
Glia are powerhouses for sleep
Sci Signal. 2024 Apr 23;17(833):eadp9115. doi: 10.1126/scisignal.adp9115. Epub 2024 Apr 23.ABSTRACTGlia take up and detoxify neurotoxic lipids on a wake-sleep cycle, in turn promoting healthy sleep.PMID:38652762 | DOI:10.1126/scisignal.adp9115 (Source: Science Signaling)
Source: Science Signaling - April 23, 2024 Category: Biomedical Science Authors: Leslie K Ferrarelli Source Type: research
Optogenetically controlled inflammasome activation demonstrates two phases of cell swelling during pyroptosis
Sci Signal. 2024 Apr 23;17(833):eabn8003. doi: 10.1126/scisignal.abn8003. Epub 2024 Apr 23.ABSTRACTInflammasomes are multiprotein platforms that control caspase-1 activation, which process the inactive precursor forms of the inflammatory cytokines IL-1β and IL-18, leading to an inflammatory type of programmed cell death called pyroptosis. Studying inflammasome-driven processes, such as pyroptosis-induced cell swelling, under controlled conditions remains challenging because the signals that activate pyroptosis also stimulate other signaling pathways. We designed an optogenetic approach using a photo-oligomerizable inflamm...
Source: Science Signaling - April 23, 2024 Category: Biomedical Science Authors: Julien Nadjar Sylvain Monnier Estelle Bastien Anne-Laure Huber Christiane Oddou L éa Bardoulet Hubert B Leloup Gabriel Ichim Christophe Vanbelle B énédicte F Py Olivier Destaing Virginie Petrilli Source Type: research
TNF- α signals through ITK-Akt-mTOR to drive CD4 < sup > + < /sup > T cell metabolic reprogramming, which is dysregulated in rheumatoid arthritis
Sci Signal. 2024 Apr 23;17(833):eadg5678. doi: 10.1126/scisignal.adg5678. Epub 2024 Apr 23.ABSTRACTUpon activation, T cells undergo metabolic reprogramming to meet the bioenergetic demands of clonal expansion and effector function. Because dysregulated T cell cytokine production and metabolic phenotypes coexist in chronic inflammatory disease, including rheumatoid arthritis (RA), we investigated whether inflammatory cytokines released by differentiating T cells amplified their metabolic changes. We found that tumor necrosis factor-α (TNF-α) released by human naïve CD4+ T cells upon activation stimulated the expression o...
Source: Science Signaling - April 23, 2024 Category: Biomedical Science Authors: Emma L Bishop Nancy Gudgeon Taylor Fulton-Ward Victoria Stavrou Jennie Roberts Adam Boufersaoui Daniel A Tennant Martin Hewison Karim Raza Sarah Dimeloe Source Type: research
Glia are powerhouses for sleep
Sci Signal. 2024 Apr 23;17(833):eadp9115. doi: 10.1126/scisignal.adp9115. Epub 2024 Apr 23.ABSTRACTGlia take up and detoxify neurotoxic lipids on a wake-sleep cycle, in turn promoting healthy sleep.PMID:38652762 | DOI:10.1126/scisignal.adp9115 (Source: Science Signaling)
Source: Science Signaling - April 23, 2024 Category: Biomedical Science Authors: Leslie K Ferrarelli Source Type: research
Optogenetically controlled inflammasome activation demonstrates two phases of cell swelling during pyroptosis
Sci Signal. 2024 Apr 23;17(833):eabn8003. doi: 10.1126/scisignal.abn8003. Epub 2024 Apr 23.ABSTRACTInflammasomes are multiprotein platforms that control caspase-1 activation, which process the inactive precursor forms of the inflammatory cytokines IL-1β and IL-18, leading to an inflammatory type of programmed cell death called pyroptosis. Studying inflammasome-driven processes, such as pyroptosis-induced cell swelling, under controlled conditions remains challenging because the signals that activate pyroptosis also stimulate other signaling pathways. We designed an optogenetic approach using a photo-oligomerizable inflamm...
Source: Science Signaling - April 23, 2024 Category: Biomedical Science Authors: Julien Nadjar Sylvain Monnier Estelle Bastien Anne-Laure Huber Christiane Oddou L éa Bardoulet Hubert B Leloup Gabriel Ichim Christophe Vanbelle B énédicte F Py Olivier Destaing Virginie Petrilli Source Type: research
TNF- α signals through ITK-Akt-mTOR to drive CD4 < sup > + < /sup > T cell metabolic reprogramming, which is dysregulated in rheumatoid arthritis
Sci Signal. 2024 Apr 23;17(833):eadg5678. doi: 10.1126/scisignal.adg5678. Epub 2024 Apr 23.ABSTRACTUpon activation, T cells undergo metabolic reprogramming to meet the bioenergetic demands of clonal expansion and effector function. Because dysregulated T cell cytokine production and metabolic phenotypes coexist in chronic inflammatory disease, including rheumatoid arthritis (RA), we investigated whether inflammatory cytokines released by differentiating T cells amplified their metabolic changes. We found that tumor necrosis factor-α (TNF-α) released by human naïve CD4+ T cells upon activation stimulated the expression o...
Source: Science Signaling - April 23, 2024 Category: Biomedical Science Authors: Emma L Bishop Nancy Gudgeon Taylor Fulton-Ward Victoria Stavrou Jennie Roberts Adam Boufersaoui Daniel A Tennant Martin Hewison Karim Raza Sarah Dimeloe Source Type: research
Glia are powerhouses for sleep
Sci Signal. 2024 Apr 23;17(833):eadp9115. doi: 10.1126/scisignal.adp9115. Epub 2024 Apr 23.ABSTRACTGlia take up and detoxify neurotoxic lipids on a wake-sleep cycle, in turn promoting healthy sleep.PMID:38652762 | DOI:10.1126/scisignal.adp9115 (Source: Science Signaling)
Source: Science Signaling - April 23, 2024 Category: Biomedical Science Authors: Leslie K Ferrarelli Source Type: research
Optogenetically controlled inflammasome activation demonstrates two phases of cell swelling during pyroptosis
Sci Signal. 2024 Apr 23;17(833):eabn8003. doi: 10.1126/scisignal.abn8003. Epub 2024 Apr 23.ABSTRACTInflammasomes are multiprotein platforms that control caspase-1 activation, which process the inactive precursor forms of the inflammatory cytokines IL-1β and IL-18, leading to an inflammatory type of programmed cell death called pyroptosis. Studying inflammasome-driven processes, such as pyroptosis-induced cell swelling, under controlled conditions remains challenging because the signals that activate pyroptosis also stimulate other signaling pathways. We designed an optogenetic approach using a photo-oligomerizable inflamm...
Source: Science Signaling - April 23, 2024 Category: Biomedical Science Authors: Julien Nadjar Sylvain Monnier Estelle Bastien Anne-Laure Huber Christiane Oddou L éa Bardoulet Hubert B Leloup Gabriel Ichim Christophe Vanbelle B énédicte F Py Olivier Destaing Virginie Petrilli Source Type: research
TNF- α signals through ITK-Akt-mTOR to drive CD4 < sup > + < /sup > T cell metabolic reprogramming, which is dysregulated in rheumatoid arthritis
Sci Signal. 2024 Apr 23;17(833):eadg5678. doi: 10.1126/scisignal.adg5678. Epub 2024 Apr 23.ABSTRACTUpon activation, T cells undergo metabolic reprogramming to meet the bioenergetic demands of clonal expansion and effector function. Because dysregulated T cell cytokine production and metabolic phenotypes coexist in chronic inflammatory disease, including rheumatoid arthritis (RA), we investigated whether inflammatory cytokines released by differentiating T cells amplified their metabolic changes. We found that tumor necrosis factor-α (TNF-α) released by human naïve CD4+ T cells upon activation stimulated the expression o...
Source: Science Signaling - April 23, 2024 Category: Biomedical Science Authors: Emma L Bishop Nancy Gudgeon Taylor Fulton-Ward Victoria Stavrou Jennie Roberts Adam Boufersaoui Daniel A Tennant Martin Hewison Karim Raza Sarah Dimeloe Source Type: research
Glia are powerhouses for sleep
Sci Signal. 2024 Apr 23;17(833):eadp9115. doi: 10.1126/scisignal.adp9115. Epub 2024 Apr 23.ABSTRACTGlia take up and detoxify neurotoxic lipids on a wake-sleep cycle, in turn promoting healthy sleep.PMID:38652762 | DOI:10.1126/scisignal.adp9115 (Source: Science Signaling)
Source: Science Signaling - April 23, 2024 Category: Biomedical Science Authors: Leslie K Ferrarelli Source Type: research
Optogenetically controlled inflammasome activation demonstrates two phases of cell swelling during pyroptosis
Sci Signal. 2024 Apr 23;17(833):eabn8003. doi: 10.1126/scisignal.abn8003. Epub 2024 Apr 23.ABSTRACTInflammasomes are multiprotein platforms that control caspase-1 activation, which process the inactive precursor forms of the inflammatory cytokines IL-1β and IL-18, leading to an inflammatory type of programmed cell death called pyroptosis. Studying inflammasome-driven processes, such as pyroptosis-induced cell swelling, under controlled conditions remains challenging because the signals that activate pyroptosis also stimulate other signaling pathways. We designed an optogenetic approach using a photo-oligomerizable inflamm...
Source: Science Signaling - April 23, 2024 Category: Biomedical Science Authors: Julien Nadjar Sylvain Monnier Estelle Bastien Anne-Laure Huber Christiane Oddou L éa Bardoulet Hubert B Leloup Gabriel Ichim Christophe Vanbelle B énédicte F Py Olivier Destaing Virginie Petrilli Source Type: research
