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Prediction of deleterious non-synonymous SNPs of human MDC1 gene: an in silico approach
Syst Biol Reprod Med. 2024 Dec;70(1):101-112. doi: 10.1080/19396368.2024.2325699. Epub 2024 Apr 17.ABSTRACTMDC1 (Mediator of DNA damage Checkpoint protein 1) functions to facilitate the localization of numerous DNA damage response (DDR) components to DNA double-strand break sites. MDC1 is an integral component in preserving genomic stability and appropriate DDR regulation. There haven't been systematic investigations of MDC1 mutations that induce cancer and genomic instability. Variations in nsSNPs have the potential to modify the protein chemistry and their function. Describing functional SNPs in disease-associated genes ...
Source: Systems Biology in Reproductive Medicine - April 17, 2024 Category: Reproduction Medicine Authors: Vaishnavee Thote Susha Dinesh Sameer Sharma Source Type: research

Correlation between standard sperm parameters and sperm DNA fragmentation from 11,339 samples
Syst Biol Reprod Med. 2024 Dec;70(1):91-100. doi: 10.1080/19396368.2024.2333285. Epub 2024 Apr 17.ABSTRACTConventional semen parameters have long been considered fundamental in male fertility analyses. However, doubts have been raised regarding the clinical utility of the assessment of spermatozoa (sperm) DNA damage. In this retrospective study, we investigated the potential correlation between conventional semen parameters and semen DNA fragmentation (SDF) assessed as sperm DNA damage, in 11,339 semen samples collected between January 2019 and June 2022. We observed significant negative correlations between the DNA fragme...
Source: Systems Biology in Reproductive Medicine - April 17, 2024 Category: Reproduction Medicine Authors: Tingting Yang Lin Yu Jinyan Xu Lijuan Ying Yelin Jia Yan Zheng Bin Zhou Fuping Li Source Type: research

Prediction of deleterious non-synonymous SNPs of human MDC1 gene: an in silico approach
Syst Biol Reprod Med. 2024 Dec;70(1):101-112. doi: 10.1080/19396368.2024.2325699. Epub 2024 Apr 17.ABSTRACTMDC1 (Mediator of DNA damage Checkpoint protein 1) functions to facilitate the localization of numerous DNA damage response (DDR) components to DNA double-strand break sites. MDC1 is an integral component in preserving genomic stability and appropriate DDR regulation. There haven't been systematic investigations of MDC1 mutations that induce cancer and genomic instability. Variations in nsSNPs have the potential to modify the protein chemistry and their function. Describing functional SNPs in disease-associated genes ...
Source: Systems Biology in Reproductive Medicine - April 17, 2024 Category: Reproduction Medicine Authors: Vaishnavee Thote Susha Dinesh Sameer Sharma Source Type: research

Correlation between standard sperm parameters and sperm DNA fragmentation from 11,339 samples
Syst Biol Reprod Med. 2024 Dec;70(1):91-100. doi: 10.1080/19396368.2024.2333285. Epub 2024 Apr 17.ABSTRACTConventional semen parameters have long been considered fundamental in male fertility analyses. However, doubts have been raised regarding the clinical utility of the assessment of spermatozoa (sperm) DNA damage. In this retrospective study, we investigated the potential correlation between conventional semen parameters and semen DNA fragmentation (SDF) assessed as sperm DNA damage, in 11,339 semen samples collected between January 2019 and June 2022. We observed significant negative correlations between the DNA fragme...
Source: Systems Biology in Reproductive Medicine - April 17, 2024 Category: Reproduction Medicine Authors: Tingting Yang Lin Yu Jinyan Xu Lijuan Ying Yelin Jia Yan Zheng Bin Zhou Fuping Li Source Type: research

Prediction of deleterious non-synonymous SNPs of human MDC1 gene: an in silico approach
Syst Biol Reprod Med. 2024 Dec;70(1):101-112. doi: 10.1080/19396368.2024.2325699. Epub 2024 Apr 17.ABSTRACTMDC1 (Mediator of DNA damage Checkpoint protein 1) functions to facilitate the localization of numerous DNA damage response (DDR) components to DNA double-strand break sites. MDC1 is an integral component in preserving genomic stability and appropriate DDR regulation. There haven't been systematic investigations of MDC1 mutations that induce cancer and genomic instability. Variations in nsSNPs have the potential to modify the protein chemistry and their function. Describing functional SNPs in disease-associated genes ...
Source: Systems Biology in Reproductive Medicine - April 17, 2024 Category: Reproduction Medicine Authors: Vaishnavee Thote Susha Dinesh Sameer Sharma Source Type: research

Correlation between standard sperm parameters and sperm DNA fragmentation from 11,339 samples
Syst Biol Reprod Med. 2024 Dec;70(1):91-100. doi: 10.1080/19396368.2024.2333285. Epub 2024 Apr 17.ABSTRACTConventional semen parameters have long been considered fundamental in male fertility analyses. However, doubts have been raised regarding the clinical utility of the assessment of spermatozoa (sperm) DNA damage. In this retrospective study, we investigated the potential correlation between conventional semen parameters and semen DNA fragmentation (SDF) assessed as sperm DNA damage, in 11,339 semen samples collected between January 2019 and June 2022. We observed significant negative correlations between the DNA fragme...
Source: Systems Biology in Reproductive Medicine - April 17, 2024 Category: Reproduction Medicine Authors: Tingting Yang Lin Yu Jinyan Xu Lijuan Ying Yelin Jia Yan Zheng Bin Zhou Fuping Li Source Type: research

Prediction of deleterious non-synonymous SNPs of human MDC1 gene: an in silico approach
Syst Biol Reprod Med. 2024 Dec;70(1):101-112. doi: 10.1080/19396368.2024.2325699. Epub 2024 Apr 17.ABSTRACTMDC1 (Mediator of DNA damage Checkpoint protein 1) functions to facilitate the localization of numerous DNA damage response (DDR) components to DNA double-strand break sites. MDC1 is an integral component in preserving genomic stability and appropriate DDR regulation. There haven't been systematic investigations of MDC1 mutations that induce cancer and genomic instability. Variations in nsSNPs have the potential to modify the protein chemistry and their function. Describing functional SNPs in disease-associated genes ...
Source: Systems Biology in Reproductive Medicine - April 17, 2024 Category: Reproduction Medicine Authors: Vaishnavee Thote Susha Dinesh Sameer Sharma Source Type: research

Correlation between standard sperm parameters and sperm DNA fragmentation from 11,339 samples
Syst Biol Reprod Med. 2024 Dec;70(1):91-100. doi: 10.1080/19396368.2024.2333285. Epub 2024 Apr 17.ABSTRACTConventional semen parameters have long been considered fundamental in male fertility analyses. However, doubts have been raised regarding the clinical utility of the assessment of spermatozoa (sperm) DNA damage. In this retrospective study, we investigated the potential correlation between conventional semen parameters and semen DNA fragmentation (SDF) assessed as sperm DNA damage, in 11,339 semen samples collected between January 2019 and June 2022. We observed significant negative correlations between the DNA fragme...
Source: Systems Biology in Reproductive Medicine - April 17, 2024 Category: Reproduction Medicine Authors: Tingting Yang Lin Yu Jinyan Xu Lijuan Ying Yelin Jia Yan Zheng Bin Zhou Fuping Li Source Type: research

Prediction of deleterious non-synonymous SNPs of human MDC1 gene: an in silico approach
Syst Biol Reprod Med. 2024 Dec;70(1):101-112. doi: 10.1080/19396368.2024.2325699. Epub 2024 Apr 17.ABSTRACTMDC1 (Mediator of DNA damage Checkpoint protein 1) functions to facilitate the localization of numerous DNA damage response (DDR) components to DNA double-strand break sites. MDC1 is an integral component in preserving genomic stability and appropriate DDR regulation. There haven't been systematic investigations of MDC1 mutations that induce cancer and genomic instability. Variations in nsSNPs have the potential to modify the protein chemistry and their function. Describing functional SNPs in disease-associated genes ...
Source: Systems Biology in Reproductive Medicine - April 17, 2024 Category: Reproduction Medicine Authors: Vaishnavee Thote Susha Dinesh Sameer Sharma Source Type: research

Correlation between standard sperm parameters and sperm DNA fragmentation from 11,339 samples
Syst Biol Reprod Med. 2024 Dec;70(1):91-100. doi: 10.1080/19396368.2024.2333285. Epub 2024 Apr 17.ABSTRACTConventional semen parameters have long been considered fundamental in male fertility analyses. However, doubts have been raised regarding the clinical utility of the assessment of spermatozoa (sperm) DNA damage. In this retrospective study, we investigated the potential correlation between conventional semen parameters and semen DNA fragmentation (SDF) assessed as sperm DNA damage, in 11,339 semen samples collected between January 2019 and June 2022. We observed significant negative correlations between the DNA fragme...
Source: Systems Biology in Reproductive Medicine - April 17, 2024 Category: Reproduction Medicine Authors: Tingting Yang Lin Yu Jinyan Xu Lijuan Ying Yelin Jia Yan Zheng Bin Zhou Fuping Li Source Type: research

Prediction of deleterious non-synonymous SNPs of human MDC1 gene: an in silico approach
Syst Biol Reprod Med. 2024 Dec;70(1):101-112. doi: 10.1080/19396368.2024.2325699. Epub 2024 Apr 17.ABSTRACTMDC1 (Mediator of DNA damage Checkpoint protein 1) functions to facilitate the localization of numerous DNA damage response (DDR) components to DNA double-strand break sites. MDC1 is an integral component in preserving genomic stability and appropriate DDR regulation. There haven't been systematic investigations of MDC1 mutations that induce cancer and genomic instability. Variations in nsSNPs have the potential to modify the protein chemistry and their function. Describing functional SNPs in disease-associated genes ...
Source: Systems Biology in Reproductive Medicine - April 17, 2024 Category: Reproduction Medicine Authors: Vaishnavee Thote Susha Dinesh Sameer Sharma Source Type: research

Correlation between standard sperm parameters and sperm DNA fragmentation from 11,339 samples
Syst Biol Reprod Med. 2024 Dec;70(1):91-100. doi: 10.1080/19396368.2024.2333285. Epub 2024 Apr 17.ABSTRACTConventional semen parameters have long been considered fundamental in male fertility analyses. However, doubts have been raised regarding the clinical utility of the assessment of spermatozoa (sperm) DNA damage. In this retrospective study, we investigated the potential correlation between conventional semen parameters and semen DNA fragmentation (SDF) assessed as sperm DNA damage, in 11,339 semen samples collected between January 2019 and June 2022. We observed significant negative correlations between the DNA fragme...
Source: Systems Biology in Reproductive Medicine - April 17, 2024 Category: Reproduction Medicine Authors: Tingting Yang Lin Yu Jinyan Xu Lijuan Ying Yelin Jia Yan Zheng Bin Zhou Fuping Li Source Type: research

Prediction of deleterious non-synonymous SNPs of human MDC1 gene: an in silico approach
Syst Biol Reprod Med. 2024 Dec;70(1):101-112. doi: 10.1080/19396368.2024.2325699. Epub 2024 Apr 17.ABSTRACTMDC1 (Mediator of DNA damage Checkpoint protein 1) functions to facilitate the localization of numerous DNA damage response (DDR) components to DNA double-strand break sites. MDC1 is an integral component in preserving genomic stability and appropriate DDR regulation. There haven't been systematic investigations of MDC1 mutations that induce cancer and genomic instability. Variations in nsSNPs have the potential to modify the protein chemistry and their function. Describing functional SNPs in disease-associated genes ...
Source: Systems Biology in Reproductive Medicine - April 17, 2024 Category: Reproduction Medicine Authors: Vaishnavee Thote Susha Dinesh Sameer Sharma Source Type: research

Correlation between standard sperm parameters and sperm DNA fragmentation from 11,339 samples
Syst Biol Reprod Med. 2024 Dec;70(1):91-100. doi: 10.1080/19396368.2024.2333285. Epub 2024 Apr 17.ABSTRACTConventional semen parameters have long been considered fundamental in male fertility analyses. However, doubts have been raised regarding the clinical utility of the assessment of spermatozoa (sperm) DNA damage. In this retrospective study, we investigated the potential correlation between conventional semen parameters and semen DNA fragmentation (SDF) assessed as sperm DNA damage, in 11,339 semen samples collected between January 2019 and June 2022. We observed significant negative correlations between the DNA fragme...
Source: Systems Biology in Reproductive Medicine - April 17, 2024 Category: Reproduction Medicine Authors: Tingting Yang Lin Yu Jinyan Xu Lijuan Ying Yelin Jia Yan Zheng Bin Zhou Fuping Li Source Type: research

Prediction of deleterious non-synonymous SNPs of human MDC1 gene: an in silico approach
Syst Biol Reprod Med. 2024 Dec;70(1):101-112. doi: 10.1080/19396368.2024.2325699. Epub 2024 Apr 17.ABSTRACTMDC1 (Mediator of DNA damage Checkpoint protein 1) functions to facilitate the localization of numerous DNA damage response (DDR) components to DNA double-strand break sites. MDC1 is an integral component in preserving genomic stability and appropriate DDR regulation. There haven't been systematic investigations of MDC1 mutations that induce cancer and genomic instability. Variations in nsSNPs have the potential to modify the protein chemistry and their function. Describing functional SNPs in disease-associated genes ...
Source: Systems Biology in Reproductive Medicine - April 17, 2024 Category: Reproduction Medicine Authors: Vaishnavee Thote Susha Dinesh Sameer Sharma Source Type: research